TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 1 of 13
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
TITANIUM DIOXIDE
SYNONYMS
O2-Ti, TiO2, "titanium oxide", "titanium (IV) oxide", "titanium (IV) oxide", "C.I.
Pigment White 6", "C.I. 77891", Titafrance, Tipaque, Tiofine, "Food Additive 171", Kronos
, "Levanox White", Unitane, Tronox, Rutiox, Austiox, Titanox, "Tiona RCL-2", RCL-3, RCL-4
, RCL-6, RCL-9, RCL-69, RCL-181, "RCL-373 RCL-472", RCL-535, RCL-628, RCL-666, RCL-464,
Runa, Bayertitan, Baytitan, "Cosmetic White"
PRODUCT USE
Used as main pigment in white and pale coloured plastics, inks, ceramics, porcelain,
vitreous enamels, paints, enamels, lacquers, fibres and fabrics. Also used in colouring
and coating of paper. Titanium dioxide is food additive 171 and is used to colour foods,
toothpaste, cosmetics. Also used in coatings for welding rods.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 2 of 13
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Limited evidence of a carcinogenic effect. Do not breathe dust.
Cumulative effects may result following Avoid contact with eyes.
exposure*.
May produce discomfort of the eyes and skin*. Wear suitable protective clothing.
* (limited evidence). To clean the floor and all objects contaminated
by this material use water and detergent.
Keep away from food drink and animal feeding
stuffs.
In case of contact with eyes rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
If swallowed IMMEDIATELY contact Doctor or
Poisons Information Centre (show this container
or label).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
titanium dioxide 13463-67-7 > 94
water 7732-18-5 <1
three crystalline forms exist
titanium dioxide (anatase) 1317-70-0
titanium dioxide (rutile) 1317-80-2
titanium dioxide (brookite) 12188-41-9
Section 4 - FIRST AID MEASURES
SWALLOWED
路 Immediately give a glass of water.
路 First aid is not generally required. If in doubt, contact a Poisons Information Centre
or a doctor.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 3 of 13
Section 4 - FIRST AID MEASURES
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If dust is inhaled, remove from contaminated area.
路 Encourage patient to blow nose to ensure clear passage of breathing.
路 If irritation or discomfort persists seek medical attention.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 There is no restriction on the type of extinguisher which may be used.
路 Use extinguishing media suitable for surrounding area.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves for fire only.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Non combustible.
路 Not considered a significant fire risk, however containers may burn.
Decomposition may produce toxic fumes of: metal oxides.
May emit poisonous fumes.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
None known.
HAZCHEM: None
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Clean up waste regularly and abnormal spills immediately.
路 Avoid breathing dust and contact with skin and eyes.
路 Wear protective clothing, gloves, safety glasses and dust respirator.
路 Use dry clean up procedures and avoid generating dust.
路 Vacuum up or sweep up. NOTE: Vacuum cleaner must be fitted with an exhaust micro filter
(HEPA type) (consider explosion-proof machines designed to be grounded during storage and
use).
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 4 of 13
Section 6 - ACCIDENTAL RELEASE MEASURES
路 Dampen with water to prevent dusting before sweeping.
路 Place in suitable containers for disposal.
MAJOR SPILLS
Moderate hazard.
路 CAUTION: Advise personnel in area.
路 Alert Emergency Services and tell them location and nature of hazard.
路 Control personal contact by wearing protective clothing.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Recover product wherever possible.
路 IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and
place in sealed plastic bags or other containers for disposal. IF WET: Vacuum/shovel up
and place in labelled containers for disposal.
路 ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise Emergency Services.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
titanium dioxide 500 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
titanium dioxide 15 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
titanium dioxide 15 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
titanium dioxide 15 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 5 of 13
Section 7 - HANDLING AND STORAGE
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
路 Polyethylene or polypropylene container.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Metals and their oxides or salts may react violently with chlorine trifluoride. Chlorine
trifluoride is a hypergolic oxidiser. It ignites on contact (without external source of
heat or ignition) with recognised fuels - contact with these materials, following an
ambient or slightly elevated temperature, is often violent and may produce ignition. The
state of subdivision may affect the results.
Avoid mixing with alkali metals such as sodium, potassium and lithium.
Reduction of the oxide by heating with aluminium, calcium, magnesium,
potassium, sodium or zinc is accompanied by incandescence.
Violent reaction with lithium at around 200 deg.C.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X + X 0 +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁
_________ _________ _____
Australia Exposure Standards titanium dioxide (Titanium 10
dioxide (a))
Australia Exposure Standards titanium dioxide (anatase) 10
(Titanium dioxide (a))
Australia Exposure Standards titanium dioxide (rutile) 10
(Titanium dioxide (a))
Australia Exposure Standards titanium dioxide (brookite) 10
(Titanium dioxide (a))
The following materials had no OELs on our records
鈥? water: CAS:7732- 18- 5
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 6 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
titanium dioxide 5, 000
titanium dioxide (anatase) 5, 000
titanium dioxide (rutile) 5, 000
titanium dioxide (brookite) 5, 000
MATERIAL DATA
It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent)
for all substances for which there is evidence of health effects at airborne
concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce adverse
health effects (as evidenced in animal experiments or clinical experience). Airborne
concentrations must be maintained as low as is practically possible and occupational
exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified
(P.N.O.S) does NOT apply.
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
WARNING: This substance has been classified by the IARC as Group 2B: Possibly
Carcinogenic to Humans.
IDLH Level: 5000 mg/m3
Animal studies at 10 mg/m3 show no significant fibrosis, possibly reversible
tissue reaction and the architecture of lung air spaces remains intact.
INGREDIENT DATA
TITANIUM DIOXIDE (ANATASE):
TITANIUM DIOXIDE (BROOKITE):
TITANIUM DIOXIDE (RUTILE):
It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their
equivalent) for all substances for which there is evidence of health effects at airborne
concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce
adverse health effects (as evidenced in animal experiments or clinical experience).
Airborne concentrations must be maintained as low as is practically possible and
occupational exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified
(P.N.O.S) does NOT apply.
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 7 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
TITANIUM DIOXIDE (ANATASE):
TITANIUM DIOXIDE (BROOKITE):
TITANIUM DIOXIDE (RUTILE):
WARNING: This substance has been classified by the IARC as Group 2B: Possibly
Carcinogenic to Humans.
TITANIUM DIOXIDE (BROOKITE):
TITANIUM DIOXIDE (RUTILE):
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
WATER:
No exposure limits set by NOHSC or ACGIH.
TITANIUM DIOXIDE (ANATASE):
ES TWA: 10 mg/m3 inspirable dust [NOHSC Australia]
TITANIUM DIOXIDE (RUTILE):
TLV TWA: 10 mg/m3
ES TWA: 10 mg/m3
(total dust containing no asbestos and < 1% crystalline silica)
At 10 mg/m3 the architecture of lung air spaces remains intact in animal
studies, there is no significant fibrosis and the tissue reaction is
possibly reversible.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 8 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Experience indicates that the following polymers are suitable as glove materials for
protection against undissolved, dry solids.
路 polychloroprene
路 nitrile rubber
路 butyl rubber
路 fluorocaoutchouc
路 polyvinyl chloride
Gloves should be examined for wear and/ or degradation constantly.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered.
Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 9 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
turn, determine the "capture velocities" of fresh circulating air required to effectively
remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Odourless fine white powder. No taste. Insoluble in water, concentrated hydrochloric,
sulfuric acids. The rutile grade is more weather resistant than the anatase form. The
difference is in crystal structure. Dispersion properties may be enhanced by
aluminium/silicon oxide coatings which do not change hazard properties. Method of
manufacture may be either chloride or sulfate process but this does not change hazard
properties.
PHYSICAL PROPERTIES
Solid.
Does not mix with water.
Sinks in water.
Molecular Weight: 79.9 Boiling Range (掳C): Not available.
Melting Range (掳C): 1825 Specific Gravity (water=1): 3.90- 4.23
Solubility in water (g/L): Immiscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): Not applicable
Volatile Component (%vol): Not applicable Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not applicable Flash Point (掳C): Not applicable
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 10 of 13
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Autoignition Temp (掳C): Not applicable Decomposition Temp (掳C): Not available
State: Divided solid Viscosity: Not Applicable
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The material has NOT been classified by EC Directives or other classification systems as
"harmful by ingestion". This is because of the lack of corroborating animal or human
evidence. The material may still be damaging to the health of the individual, following
ingestion, especially where pre-existing organ (eg. liver, kidney) damage is evident.
Present definitions of harmful or toxic substances are generally based on doses producing
mortality rather than those producing morbidity (disease, ill-health). Gastrointestinal
tract discomfort may produce nausea and vomiting. In an occupational setting however,
ingestion of insignificant quantities is not thought to be cause for concern.
EYE
There is some evidence that material may produce eye irritation in some persons and
produce eye damage 24 hours or more after instillation. Moderate inflammation may be
expected with redness; conjunctivitis may occur with prolonged exposure.
SKIN
There is some evidence to suggest that the material may cause mild but significant
inflammation of the skin either following direct contact or after a delay of some time.
Repeated exposure can cause contact dermatitis which is characterised by redness,
swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
INHALED
The material is not thought to produce adverse health effects or irritation of the
respiratory tract (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
control measures be used in an occupational setting.
Not normally a hazard due to non-volatile nature of product.
CHRONIC HEALTH EFFECTS
Long term exposure to high dust concentrations may cause changes in lung function i.e.
pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the
lung. Prime symptom is breathlessness; lung shadows show on X-ray.
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
There has been concern that this material can cause cancer or mutations, but there is not
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 11 of 13
Section 11 - TOXICOLOGICAL INFORMATION
enough data to make an assessment.
Long term exposure to titanium and several of its compounds produces lung scarring and
chronic bronchitis. Breathing is impaired and cardiac changes with right heart
enlargements occur. There is an increased chance of developing cancers of the respiratory
tract.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Skin (human) 0.3: mg/3d- I Mild
The material may produce moderate eye irritation leading to inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
WATER:
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
No significant acute toxicological data identified in literature search.
TITANIUM DIOXIDE (ANATASE):
for titanium dioxide:
TITANIUM DIOXIDE (RUTILE):
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Skin (human) 0.3: mg/3d- I Mild
TITANIUM DIOXIDE (BROOKITE):
The material may produce moderate eye irritation leading to inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
For titanium dioxide
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
titanium dioxide IARC:2B
titanium dioxide IARC:2B
(anatase)
titanium dioxide IARC:2B
(rutile)
titanium dioxide IARC:2B
(brookite)
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: titanium dioxide
Category: 2B
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: titanium dioxide
(anatase) Category: 2B
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: titanium dioxide
(rutile) Category: 2B
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: titanium dioxide
(brookite) Category: 2B
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 12 of 13
Section 12 - ECOLOGICAL INFORMATION
DO NOT discharge into sewer or waterways.
Refer to data for ingredients, which follows:
TITANIUM DIOXIDE (ANATASE):
DO NOT discharge into sewer or waterways.
TITANIUM DIOXIDE (RUTILE):
DO NOT discharge into sewer or waterways.
TITANIUM DIOXIDE (BROOKITE):
DO NOT discharge into sewer or waterways.
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Consult State Land Waste Management Authority for disposal.
路 Bury residue in an authorised landfill.
路 Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
titanium dioxide (CAS: 13463-67-7) is found on the following regulatory lists;
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia Therapeutic Goods Administration (TGA) Substances that may be used as active ingredients in Listed medicines
Australia Therapeutic Goods Administration (TGA) Sunscreening agents permitted as active ingredients in listed products
CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in Food in General, Unless Otherwise Specified, in Accordance with GMP
International Agency for Research on Cancer (IARC) Carcinogens
OECD Representative List of High Production Volume (HPV) Chemicals
titanium dioxide (CAS: 1317-70-0) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
OECD Representative List of High Production Volume (HPV) Chemicals
titanium dioxide (CAS: 1317-80-2) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
OECD Representative List of High Production Volume (HPV) Chemicals
No data available for titanium dioxide as CAS: 12188-41-9.
Section 16 - OTHER INFORMATION
INGREDIENTS WITH MULTIPLE CAS NUMBERS
Ingredient Name CAS
titanium dioxide 13463- 67- 7, 1317- 70- 0, 1317- 80- 2, 12188-
TITANIUM DIOXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 4-May-2007 CHEMWATCH 10971
NC317TCP Version No:5
CD 2007/3 Page 13 of 13
Section 16 - OTHER INFORMATION
41- 9
titanium dioxide (anatase) 1317- 70- 0, 13463- 67- 7
titanium dioxide (rutile) 1317- 80- 2, 13463- 67- 7
titanium dioxide (brookite) 12188- 41- 9, 13463- 67- 7
MSDS SECTION CHANGES
The following table displays the version number of and date on which each section was last changed.
Section Name Version Date Section Name Version Date Section Name Version Date
Ingredients 5 4- May- 2007 Storage (suitable 4 29- Sep- 2006 Acute Health 4 29- Sep- 2006
container) (inhaled)
First Aid (skin) 4 29- Sep- 2006 Engineering 4 29- Sep- 2006 Acute Health 4 29- Sep- 2006
Control (skin)
Fire Fighter 4 29- Sep- 2006 Exposure Standard 4 29- Sep- 2006 Acute Health 4 29- Sep- 2006
(extinguishing (swallowed)
media)
Fire Fighter (fire 5 4- May- 2007 Personal 4 29- Sep- 2006 Chronic Health 4 29- Sep- 2006
incompatibility) Protection (eye)
Fire Fighter 4 29- Sep- 2006 Personal 4 29- Sep- 2006 Toxicity and 5 4- May- 2007
(fire/explosion Protection Irritation
hazard) (hands/feet) (Irritation)
Spills (major) 4 29- Sep- 2006 Personal 4 29- Sep- 2006 Toxicity and 4 29- Sep- 2006
Protection (other) Irritation (Other)
Spills (minor) 4 29- Sep- 2006 Appearance 4 29- Sep- 2006 Toxicity and 5 4- May- 2007
Irritation
(Toxicity Figure)
Handling Procedure 4 29- Sep- 2006 Physical 4 29- Sep- 2006 Environmental 4 29- Sep- 2006
Properties
Storage (storage 5 4- May- 2007 Acute Health (eye) 4 29- Sep- 2006
incompatibility)
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 4-May-2007
Print Date: 4-Jan-2008
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