MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION AND USE
PRODUCT IDENTIFICATION NUMBER (PIN):
PRODUCT IDENTIFIER
Caffeine Citrated CA110X
PRODUCT USE
MANUFACTURERS NAME: SUPPLIERS NAME:
Xenex Labs XENEX LABORATORIES INC.
STREET ADDRESS: STREET ADDRESS:
2402 CANOE AVENUE
CITY: PROVINCE: CITY: PROVINCE:
COQUITLAM B.C.
POSTAL CODE: EMERGENCY TELEPHONE NO: POSTAL CODE: EMERGENCY TELEPHONE NO:
SPE100 V3K 6C2 (CHEMTREC) 1-800-424-9300
SECTION 2 - HAZARDOUS INGREDIENTS
HAZARDOUS INGREDIENTS
% CAS NUMBER LD50 / LC50 OF INGREDIENT
/ CHEMICAL FORMULA
(SPECIFY SPECIES) (SPECIFY ROUTE AND DOSE)
Caffeine Citrated 66-22-7
RAT ORAL 192 mg/kg
鈥? Caffeine 50 58-08-2
MOUSE ORAL 127mg/kg
C8H10N4O2
RABBIT ORAL 224mg/kg
MOUSE ORAL 5040mg/kg
鈥? Citric Acid 50 77-92-9
RAT ORAL 3000mg/kg
C6H8O7
SECTION 3 - PHYSICAL DATA
PHYSICAL STATE AND APPEARANCE ODOR TASTE ODOR THRESHOLD (ppm)
Solid (White Powder) Odorless Bitter, Acidic Not Available
Weighted Average 195.5掳C (383.9掳F) VAPOR DENSITY
MELTING POINT (C) VOLATILITY
Caffeine Anhydrous 238掳C (460.4掳F) Not Available Not Available
Citric Acid Anhydrous 153掳C (307.4掳F) VAPOR PRESSURE
Not Available Not Available
BOILING POINT (C)
Caffeine Anhydrous Not Available pH COEFF. WATER/OIL DIST.
Citric Acid Anhydrous Decomposes Not Available Not Available
Weighted Average 1.41
DISPERSION PROPERTIES / SOLUBILITY SPECIFIC GRAVITY
Soluble in cold water, hot water. Soluble in diethyl ether. Caffeine Anhydrous 1.23
Partially soluble in acetone. Citric Acid Anhydrous 1.665
SECTION 4 - FIRE AND EXPLOSION DATA
NO YES
FLAMMABILITY IF YES, UNDER WHAT CONDITIONS?
May be combustible at high temperature - As with most organic solids fire is possible at elevated temperatures. Slightly
flammable to flammable in presence of heat, open flames, of sparks. Fine dust dispersed in sufficient concentrations,
and in presence of an ignition source is a potential dust explosion hazard.
MEANS OF EXTINCTION
SMALL: Use DRY chemical powder.
LARGE: Use water spray, fog or foam. Do NOT use water jet.
FLASHPOINT (C) AND METHOD FLAMMABLE LIMITS (% BY VOLUME) CRITICAL TEMPERATURE
Not Available
Closed Cup > 93.3掳C (200掳F) UPPER: 2.29 kg/m鲁 LOWER: 0.28 kg/m鲁
(Caffeine) (Citric Acid) (Citric Acid)
AUTOIGNITION TEMPERATURE (C) HAZARDOUS COMBUSTION PRODUCTS
1010掳C (1850掳F) (Citric Acid) (CO,CO2,NO,NO2鈥?.) Oxides of carbon, nitrogen. Acrid smoke and fume
MATERIAL SAFETY DATA SHEET
CA110X
PRODUCT IDENTIFIER
Caffeine Citrated
SECTION 5 - REACTIVITY DATA
YES NO IF NO, UNDER WHICH CONDITIONS?
CHEMICAL STABILITY
The product is stable - Avoid excess heat and incompatible materials.
NO YES
INCOMPATIBILITY WITH OTHER SUBSTANCES IF SO, WHICH ONES?
Reactive with oxidizing agents, reducing agents, metals, alkalis.
REACTIVITY, AND UNDER WHAT CONDITIONS
Incompatible with oxidizing agents, potassium tartrate, alkali, alkaline earth carbonates and bicarbonates, acetates, and sulfides, and metal nitrates.Will
corrode copper, zinc, aluminum and their alloys.
HAZARDOUS DECOMPOSITION PRODUCTS
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are less
toxic than the product itself.
SECTION 6 - TOXICOLOGICAL PROPERTIES
ROUTE OF ENTRY
INGESTION
INHALATION
SKIN CONTACT SKIN ABSORPTION EYE CONTACT
EFFECTS OF ACUTE EXPOSURE TO PRODUCT
Hazardous in case of ingestion. Severe over-exposure can result in death.
Hazardous in case of eye contact (irritant), of inhalation (lung irritant). Slightly hazardous in case of skin contact (irritant, sensitizer).
Skin: May cause skin irritation. The amount of tissue damage depends on length of contact. Skin contact can produce inflammation and blistering. Causes
mild to moderate skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Eyes: Dust may cause mechanical irritation. Eye contact can result in corneal damage or blindness. Causes moderate to severe eye irritation and possible
injury.
Inhalation: May cause respiratory tract irritation. Inhalation causes moderate respiratory tract and mucous membrane irritation. Severe over-exposure can
produce lung damage, choking, unconsciousness or death.
Ingestion: Harmful if swallowed in large amounts. May cause gastrointestinal (digestive) tract irritation with epigastric pain, abdominal cramps, nausea,
vomiting and diarrhea. Affects metabolism and cardiovascular system with symptoms including increase in metabolism, flushing, palpitations, rapid heart rate,
dysrhythmias, hypotension, blood pressure elevation and weight loss, metabolic acidosis. May cause gastrointestinal (digestive) tract irritation with nausea,
vomiting, diarrhea. Excessive intake may cause erosion of teeth and hypocalcemia (calcium deficiency in blood).
May affect brain and behavior/central nervous system.. Symptoms may include nervousness, anxiety, restlessness, insomnia, dizziness, tremor, seizures,
convulsions, hallucinations, somnolence, toxic psychosis, tremors, convulsions, ataxia. May also affect blood, respiration (hyperventilation), and urinary sy
(mild increase in urinary volume and urinary sodium excretion), and may directly produce hypokalemia. May affect behavior/central nervous system (tremor,
convulsions, muscle contraction or spasticity).
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT
CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. May cause cancertumorigenic) based on animal data. May cause cancer
(
(tumorigen) based on animal studies.
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May affect genetic material ( mutagenic).
May cause adverse reproductive effects fetotoxicity, maternal parnutrition) and birth defects. May cause reproductive and fetal effects.
(
Repeated exposure of the eyes to a low level of dust can produce eye irritation.
Repeated skin exposure can produce local skin destruction, or dermatitis.
Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a highly toxic material may produce general
deterioration of health by an accumulation in one or many human organs.
Hazardous in case of ingestion. Hazardous in case of inhalation (lung irritant).Slightly hazardous in case of skin contact (irritant, sensitizer), of inhalation.
Frequent intake of citrated beverages may cause erosion of dental enamel and irritation of mucous membranes.
Since it is a CNS stimulant, it may also affect the Central Nervous System (CNS).
The substance may be toxic to teeth, heart, central nervous system (CNS).
May cause damage to the following organs: teeth, heart, central nervous system (CNS).
May cause digestive tract disturbances (increased gastric acid, and pepsin secretion and a decrease in lower esophageal sphincter pressure), cardiovascular
disturbances.
EXPOSURE LIMITS
No exposure guidelines have been established. ACGIH, NIOSH and OSHA have not developed exposure limits for this product. The exposure limits given
below are for particulates not otherwise classified:
ACGIH: 10 mg/m3 TWA (Total Respirable fraction); 3 mg/m3 TWA (Respirable fraction)
OSHA: 15 mg/m3 TWA (Total dust); 5 mg/m3 TWA (Respirable Fraction)
SYNERGISTIC PRODUCTS
IRRITANCY OF PRODUCT SENSITIZATION OF PRODUCT
Yes Yes Not Available
REPRODUCTIVE TOXICITY MUTAGENICITY
TERATOGENICITY CARCINOGENICITY
As Specified Not Available As Specified As Specified
MATERIAL SAFETY DATA SHEET
CA110X
PRODUCT IDENTIFIER
Caffeine Citrated
SECTION 7 - PREVENTATIVE MEASURE
PERSONAL PROTECTIVE EQUIPMENT
GLOVES (SPECIFY) RESPIRATOR (SPECIFY) EYE (SPECIFY)
Yes ( impervious ) Approved / Certified respirator Safety goggles, face shield
FOOTWEAR (SPECIFY) CLOTHING (SPECIFY) OTHER (SPECIFY)
No Coveralls / Lab coat Eyewash equipment nearby
ENGINEERING CONTROLS (SPECIFY eg. VENTILATION, ENCLOSED PROCESS)
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
LEAK AND SPILL PROCEDURE
Use appropriate tools to put the spilled solid in a convenient waste disposal container.
WASTE DISPOSAL
According to local, provincial, and federal regulations.
HANDLING PROCEDURES AND EQUIPMENT
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do
not breathe dust. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation, wear
suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep
away from incompatibles such as oxidizing agents, reducing agents, metals, alkalis.
STORAGE REQUIREMENTS
Keep container tightly closed. Keep container in a cool, dry, well-ventilated area. Container may be hazardous when
empty since they retain product residues (Dust, Solids) observe all warnings and precautions listed for the product
SPECIAL SHIPPING INFORMATION
DOT CLASS 6.1 (Caffeine) Poisonous material
WHMIS (Canada) (Citric Acid) CLASS E: Corrosive solid.
WHMIS (Canada) (Citric Acid) Classification is not available. However, it may be classified as
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
SECTION 8 - FIRST AID MEASURES
SPECIFIC MEASURES
Wash with soap and water. Cover the irritated skin with an emollient. Remove contaminated
SKIN
clothing and shoes. Get medical attention if irritation develops. Wash clothing before reuse,
thoroughly clean shoes before reuse.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of
EYES
water for at least 15 minutes. Get medical attention
If inhaled remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
INHALATION
oxygen. Get medical attention.
INGESTION Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as collar, tie, belt or waistband. Get
medical attention immediately
IF IRRITATION PERSISTS AND IN ALL OTHER CASES, GET IMMEDIATE MEDICAL ATTENTION.
SECTION 9 - PREPARATION DATE OF M.S.D.S.
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packa
If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the us
responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical
data judged to be reliable, Xenex Laboratories Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
PREPARED BY (GROUP, DEPARTMENT, ETC.) PHONE NUMBER DATE:
CONTROL DEPARTMENT (604) 552 3031 April 18 2008
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