MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION AND USE
PRODUCT IDENTIFICATION NUMBER (PIN):
PRODUCT IDENTIFIER
L-Histidine LH050X
PRODUCT USE
MANUFACTURERS NAME: SUPPLIERS NAME:
Xenex Labs XENEX LABORATORIES INC.
STREET ADDRESS: STREET ADDRESS:
2402 CANOE AVENUE
CITY: PROVINCE: CITY: PROVINCE:
COQUITLAM B.C.
POSTAL CODE: EMERGENCY TELEPHONE NO: POSTAL CODE: EMERGENCY TELEPHONE NO:
SPE100 V3K 6C2 (CHEMTREC) 1-800-424-9300
SECTION 2 - HAZARDOUS INGREDIENTS
HAZARDOUS INGREDIENTS
% CAS NUMBER LD50 / LC50 OF INGREDIENT
/ CHEMICAL FORMULA
(SPECIFY SPECIES) (SPECIFY ROUTE AND DOSE)
L-Histidine 100 71-00-1 RAT ORAL 15000 mg/kg
C6H9N3O2 MOUSE ORAL 15000 mg/kg
SECTION 3 - PHYSICAL DATA
PHYSICAL STATE AND APPEARANCE ODOR TASTE ODOR THRESHOLD (ppm)
Solid (White Crystalline solid) Odorless Not Available Not Available
MELTING POINT (C) VOLATILITY VAPOR PRESSURE VAPOR DENSITY
Decomposes 287掳C (548.6掳F) Not Available Not Available Not Available
pH SPECIFIC GRAVITY DISPERSION PROPERTIES / SOLUBILITY
Not Available 1.44 Partially soluble in cold water. Very slightly soluble in methanol. Insoluble in diethyl ether.
SECTION 4 - FIRE AND EXPLOSION DATA
NO YES
FLAMMABILITY IF YES, UNDER WHAT CONDITIONS?
May be combustible at high temperature -
MEANS OF EXTINCTION
SMALL: Use DRY chemical powder.
LARGE: Use water spray, fog or foam. Do NOT use water jet.
FLASHPOINT (C) AND METHOD FLAMMABLE LIMITS (% BY VOLUME) CRITICAL TEMPERATURE
Not Available UPPER: Not Available LOWER: Not Available Not Available
AUTOIGNITION TEMPERATURE (C) HAZARDOUS COMBUSTION PRODUCTS
Not Available (CO,CO2,NO,NO2)Oxides of carbon and nitrogen. Acrid smoke and fume
SECTION 5 - REACTIVITY DATA
YES NO IF NO, UNDER WHICH CONDITIONS?
CHEMICAL STABILITY
The product is stable
NO YES
INCOMPATIBILITY WITH OTHER SUBSTANCES IF SO, WHICH ONES?
Not Available
REACTIVITY, AND UNDER WHAT CONDITIONS
Not Available
HAZARDOUS DECOMPOSITION PRODUCTS
The products of degradation are more toxic
MATERIAL SAFETY DATA SHEET
LH050X
PRODUCT IDENTIFIER
L-Histidine
SECTION 6 - TOXICOLOGICAL PROPERTIES
ROUTE OF ENTRY
INGESTION
INHALATION
SKIN CONTACT SKIN ABSORPTION EYE CONTACT
EFFECTS OF ACUTE EXPOSURE TO PRODUCT
Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye contact
(irritant)
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT
Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant).
The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce
target organs damage. Passes through the placental barrier in human.
EXPOSURE LIMITS IRRITANCY OF PRODUCT SENSITIZATION OF PRODUCT CARCINOGENICITY
Not Available YES Not Available Not Available
REPRODUCTIVE TOXICITY MUTAGENICITY SYNERGISTIC PRODUCTS
TERATOGENICITY
Not Available Not Available Not Available Not Available
SECTION 7 - PREVENTATIVE MEASURE
PERSONAL PROTECTIVE EQUIPMENT
GLOVES (SPECIFY) RESPIRATOR (SPECIFY) EYE (SPECIFY)
Yes ( impervious ) Approved / Certified respirator Safety goggles, face shield
FOOTWEAR (SPECIFY) CLOTHING (SPECIFY) OTHER (SPECIFY)
No Coveralls / Lab coat Eyewash equipment nearby
ENGINEERING CONTROLS (SPECIFY eg. VENTILATION, ENCLOSED PROCESS)
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
LEAK AND SPILL PROCEDURE
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface.
WASTE DISPOSAL
According to local, provincial, and federal regulations.
HANDLING PROCEDURES AND EQUIPMENT
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue
under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable
protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical
advice immediately and show the container or the label.
STORAGE REQUIREMENTS
Keep container tightly closed. Keep container in a cool, dry, well-ventilated area. Container may be hazardous when
empty since they retain product residues (Dust, Solids) observe all warnings and precautions listed for the product.
Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.
SPECIAL SHIPPING INFORMATION
WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Not a DOT controlled material
MATERIAL SAFETY DATA SHEET
LH050X
PRODUCT IDENTIFIER
L-Histidine
SECTION 8 - FIRST AID MEASURES
SPECIFIC MEASURES
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the
SKIN
contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds,
crevices, creases and groin. Cold water may be used. Cover the irritated skin with an emollient. If
irritation persists, seek medical attention. Wash contaminated clothing before reusing.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of
EYES
water for at least 15 minutes keeping eye lids open. Cold water may be used. Get medical
Iftt ti
inhaled remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
INHALATION
oxygen. Seek immediate medical attention.
INGESTION Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as collar, tie, belt or waistband. Seek
immediate medical attention.
IF IRRITATION PERSISTS AND IN ALL OTHER CASES, GET IMMEDIATE MEDICAL ATTENTION.
SECTION 9 - PREPARATION DATE OF M.S.D.S.
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packa
If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the us
responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical
data judged to be reliable, Xenex Laboratories Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
PREPARED BY (GROUP, DEPARTMENT, ETC.) PHONE NUMBER DATE:
CONTROL DEPARTMENT (604) 552 3031 December 19 2006
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