MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION AND USE
PRODUCT IDENTIFICATION NUMBER (PIN):
PRODUCT IDENTIFIER
5-Fluorouracil FL190X
PRODUCT USE
MANUFACTURERS NAME: SUPPLIERS NAME:
Xenex Labs XENEX LABORATORIES INC.
STREET ADDRESS: STREET ADDRESS:
2402 CANOE AVENUE
CITY: PROVINCE: CITY: PROVINCE:
COQUITLAM B.C.
POSTAL CODE: EMERGENCY TELEPHONE NO: POSTAL CODE: EMERGENCY TELEPHONE NO:
SPE100 V3K 6C2 (CHEMTREC) 1-800-424-9300
SECTION 2 - HAZARDOUS INGREDIENTS
HAZARDOUS INGREDIENTS
% CAS NUMBER LD50 / LC50 OF INGREDIENT
/ CHEMICAL FORMULA
(SPECIFY SPECIES) (SPECIFY ROUTE AND DOSE)
5-Fluorouracil 100 51-21-8 RAT ORAL 230mg/kg
C4H3FN2O2 MOUSE ORAL 115mg/kg
SECTION 3 - PHYSICAL DATA
PHYSICAL STATE AND APPEARANCE ODOR TASTE ODOR THRESHOLD (ppm)
Solid (White crystalline powder) Odorless Not Available Not Available
MELTING POINT (C) VAPOR PRESSURE VAPOR DENSITY VOLATILITY
Decomposes 282掳C (539.6掳F) Not Applicable Not Available Not Available
pH SPECIFIC GRAVITY COEFF. WATER/OIL DIST. DISPERSION PROPERTIES / SOLUBILITY
Not Available Not Available Not Available Insoluble in diethyl ether. Partially soluble in cold water
SECTION 4 - FIRE AND EXPLOSION DATA
NO YES
FLAMMABILITY IF YES, UNDER WHAT CONDITIONS?
May be combustible at high temperature
MEANS OF EXTINCTION
SMALL: Use DRY chemical powder.
LARGE: Use water spray, fog or foam. Do NOT use water jet.
FLASHPOINT (C) AND METHOD FLAMMABLE LIMITS (% BY VOLUME) CRITICAL TEMPERATURE
Not Available UPPER: Not Available LOWER: Not Available Not Available
AUTOIGNITION TEMPERATURE (C) HAZARDOUS COMBUSTION PRODUCTS
Not Available (CO,CO2,NO,NO2鈥?.) Oxides of carbon, nitrogen. Halogenated compounds.
SECTION 5 - REACTIVITY DATA
YES NO IF NO, UNDER WHICH CONDITIONS?
CHEMICAL STABILITY
The product is stable
NO YES
INCOMPATIBILITY WITH OTHER SUBSTANCES IF SO, WHICH ONES?
Not Available
REACTIVITY, AND UNDER WHAT CONDITIONS
Not Available
HAZARDOUS DECOMPOSITION PRODUCTS
Possible hazardous short term degradation products are not likely. However, long term degradation products may arise
MATERIAL SAFETY DATA SHEET
FL190X
PRODUCT IDENTIFIER
5-Fluorouracil
SECTION 6 - TOXICOLOGICAL PROPERTIES
ROUTE OF ENTRY
INGESTION
INHALATION
SKIN CONTACT SKIN ABSORPTION EYE CONTACT
EFFECTS OF ACUTE EXPOSURE TO PRODUCT
Very hazardous in case of skin contact (irritant), of ingestion. Hazardous in case of inhalation. Slightly hazardous in case of skin contact (permeator), of eye
contact (irritant). Severe over-exposure can result in death.
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT
The substance is toxic to blood.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an highly toxic material may produce general
deterioration of health by an accumulation in one or many human organs.
EXPOSURE LIMITS IRRITANCY OF PRODUCT SENSITIZATION OF PRODUCT SYNERGISTIC PRODUCTS
Not Available Yes Not Available Not Available
TERATOGENICITY REPRODUCTIVE TOXICITY MUTAGENICITY CARCINOGENICITY
Not Available Not Available Not Available Not Available
SECTION 7 - PREVENTATIVE MEASURE
PERSONAL PROTECTIVE EQUIPMENT
GLOVES (SPECIFY) RESPIRATOR (SPECIFY) EYE (SPECIFY)
Yes ( impervious ) Approved / Certified respirator Safety goggles, face shield
FOOTWEAR (SPECIFY) CLOTHING (SPECIFY) OTHER (SPECIFY)
No Coveralls / Lab coat Eyewash equipment nearby
ENGINEERING CONTROLS (SPECIFY eg. VENTILATION, ENCLOSED PROCESS)
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user
operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
LEAK AND SPILL PROCEDURE
Use appropriate tools to put the spilled solid in a convenient waste disposal container.
WASTE DISPOSAL
According to local, provincial, and federal regulations.
HANDLING PROCEDURES AND EQUIPMENT
Do not ingest. Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. If feeling unwell seek medical advice immediately and
show the container or label.
STORAGE REQUIREMENTS
Keep container tightly closed. Keep container in a cool, dry, well-ventilated area. Container may be hazardous when empty since they retain product residues
(Dust, Solids) observe all warnings and precautions listed for the product
SPECIAL SHIPPING INFORMATION
Not a DOT controlled material
WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effectsTOXIC).
(
CLASS D-2B: Material causing other toxic effects TOXIC).
(
SECTION 8 - FIRST AID MEASURES
SPECIFIC MEASURES
SKIN After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running
water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used. Cover
the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.
EYES Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes.
Get medical attention
INHALATION If inhaled remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek immediate
medical attention.
INGESTION Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the
toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar, tie, belt
or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
IF IRRITATION PERSISTS AND IN ALL OTHER CASES, GET IMMEDIATE MEDICAL ATTENTION.
SECTION 9 - PREPARATION DATE OF M.S.D.S.
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packa
If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the us
responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical
data judged to be reliable, Xenex Laboratories Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
PREPARED BY (GROUP, DEPARTMENT, ETC.) PHONE NUMBER DATE:
CONTROL DEPARTMENT (604) 552 3031 May 07 2008
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