MATERIAL SAFETY DATA SHEET
BAYER CROP SCIENCE
P.O. Box 4913 Hawthorn Road
Kansas City, MO 64120-0013
TRANSPORTATION EMERGENCY NON-TRANSPORTATION
CALL CHEMTREC: 800-424-9300 BAYER EMERGENCY PHONE...: (800) 414-0244
INTERNATIONAL: 703-527-3887 BAYER INFORMATION PHONE.: (800) 842-8020
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1. CHEMICAL PRODUCT IDENTIFICATION:
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PRODUCT NAME........: BAYER ADVANCED GARDEN Tree & Shrub Insect Control Conc.
PRODUCT CODE........: 41723
CHEMICAL FAMILY.....: Chloronicotinyl
CHEMICAL NAME.......: 1-((6-chloro-3-pyridinyl)methyl)-N-nitro
-2-imidazolidinimine
SYNONYMS............: Imidacloprid
FORMULA.............: C9 H10 Cl N5 O2
PRODUCT USE.........: Consumer Insecticide
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2. COMPOSITION/INFORMATION ON INGREDIENTS:
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INGREDIENT NAME
/CAS NUMBER EXPOSURE LIMITS CONCENTRATION (%)
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***** HAZARDOUS INGREDIENTS *****
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Imidacloprid
138261-41-3 OSHA : Not Established 1.47 %
ACGIH: Not Established
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Ingredient 1979
Specific chemical identity is withheld as a trade secret.
OSHA : Not Established 1-3 %
ACGIH: Not Established
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Ingredient 1614
Specific chemical identity is withheld as a trade secret.
OSHA : Not Established 1-3 %
ACGIH: Not Established
Ingredient 1619 may be used as an alternate to Ingredient 1614.
Product Code: 41723 MSDS Page 1
Approval date: 06/12/2000 Continued on next page
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3. HAZARDS IDENTIFICATION:
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* EMERGENCY OVERVIEW *
* *
* CAUTION! Color: Tan; Form: Liquid; Opaque aqueous *
* suspension; Odor: Similar to white glue; Causes eye *
* irritation. *
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POTENTIAL HEALTH EFFECTS:
ROUTE(S) OF ENTRY..................: Inhalation; Skin Contact; Eye Contact;
Ingestion
HUMAN EFFECTS AND SYMPTOMS OF OVEREXPOSURE:
ACUTE EFFECTS OF EXPOSURE.....: Exposure during the labeled use of this product
is expected to be minimal. Consumers should refer to the packaging label
for proper handling procedures. No specific symptoms of acute overexposure
are known to occur in humans. Based on EPA Toxicity Category criteria,
this product is mildly toxic by the oral and dermal routes of exposure. In
addition, animal studies have shown that it is minimally irritating to the
conjunctiva of the eye but the irritation is reversible within 72 hours.
CHRONIC EFFECTS OF EXPOSURE...: Based on animal studies, no adverse effects are
expected from chronic exposure to this product.
CARCINOGENICITY...............: This product is not listed by NTP, IARC or
regulated as a carcinogen by OSHA.
MEDICAL CONDITIONS
AGGRAVATED BY EXPOSURE......: No specific medical conditions are known which
may be aggravated by exposure to this product.
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4. FIRST AID MEASURES:
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FIRST AID FOR EYES......: Hold eye open and rinse slowly and gently with water
for 15-20 minutes. Remove contact lenses, if present, after the first 5
minutes, then continue rinsing eye. Call a poison control center or doctor
for treatment advice.
FIRST AID FOR SKIN......: Take off contaminated clothing. Rinse skin
immediately with plenty of water for 15-20 minutes. Call a poison control
center or doctor for treatment advice.
Product Code: 41723 MSDS Page 2
Approval date: 06/12/2000 Continued on next page
4. FIRST AID MEASURES (Continued)
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FIRST AID FOR INHALATION: Move person to fresh air. If person is not
breathing, call 911 or an ambulance, then give artificial respiration,
preferably by mouth-to-mouth, if possible. Call a poison control center or
doctor for further treatment information.
FIRST AID FOR INGESTION.: Call poison control center or doctor immediately for
treatment advice. Have person sip a glass of water if able to swallow. Do
not induce vomiting unless told to do so by physician or poison control
center. Do not give anything by mouth to an unconscious person.
NOTE TO PHYSICIAN.......: Treat symptomatically.
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5. FIRE FIGHTING MEASURES:
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FLASH POINT.....................: Greater than 200 F (93 C)
EXTINGUISHING MEDIA.............: Water; Carbon Dioxide; Dry Chemical; Foam
SPECIAL FIRE FIGHTING PROCEDURES: Keep out of smoke, cool exposed containers
with water spray. Fight fire from upwind position. Use self-contained
breathing equipment. Contain run-off by diking to prevent entry into
sewers or waterways. Equipment or materials involved in pesticide fires
may become contaminated.
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6. ACCIDENTAL RELEASE MEASURES:
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SPILL OR LEAK PROCEDURES..........: Isolate area and keep unauthorized people
away. Do not walk through spilled material. Avoid breathing vapors and
skin contact. Remove sources of ignition if combustible or flammable
vapors may be present and ventilate area. Wear proper protective
equipment. Dike contaminated area with absorbent granules, soil, sand,
etc. If large spill, material should be recovered. Small spills can be
absorbed with absorbent granules, spill control pads, or any absorbent
material. Carefully sweep up absorbed spilled material. Place in covered
container for reuse or disposal. Scrub contaminated area with soap and
water. Use dry absorbent material such as clay granules to absorb and
collect wash solution for proper disposal. Contaminated soil may have to
be removed and disposed. Do not allow material to enter streams, sewers,
or other waterways or contact vegetation.
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7. HANDLING AND STORAGE:
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STORAGE TEMPERATURE(MIN/MAX): 32 F/30 day avg. not to exceed 100 F (38 C)
SHELF LIFE..................: Time/temperature dependent. Contact Bayer for
additional information.
SPECIAL SENSITIVITY.........: Not established
Product Code: 41723 MSDS Page 3
Approval date: 06/12/2000 Continued on next page
7. HANDLING AND STORAGE (Continued)
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HANDLING/STORAGE PRECAUTIONS: Do not allow product to contaminate material
which is intended for use or consumption by humans or animals.
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8. PERSONAL PROTECTION:
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REQUIRED WORK/HYGIENE PROCEDURES...: Exposure during the labeled use of this
product is expected to be minimal. Consumers should refer to the packaging
label for proper handling procedures. However, if exposure to this product
is possible while handling large quantities such as in subsequent
manufacturing, transportation spills or other emergencies, the following
personal protection is recommended.
EYE PROTECTION REQUIREMENTS........: Splash-proof goggles
SKIN PROTECTION REQUIREMENTS.......: Long sleeves and trousers
HAND PROTECTION REQUIREMENTS.......: Chemical-resistant gloves such as latex or
nitrile
VENTILATION REQUIREMENTS...........: Control exposure levels through the use of
general and local exhaust ventilation where needed.
RESPIRATOR REQUIREMENTS............: If needed, based on the conditions of use,
wear a NIOSH-approved particulate respirator.
ADDITIONAL PROTECTIVE MEASURES.....: Clean water should be available for
washing in case of eye or skin contamination. Educate and train employees
in safe use of the product. Follow all label instructions. Launder
clothing after use. Wash thoroughly after handling.
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9. PHYSICAL AND CHEMICAL PROPERTIES:
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PHYSICAL FORM.............: Liquid
APPEARANCE................: Opaque aqueous suspension
COLOR.....................: Tan
ODOR......................: Similar to white glue
MOLECULAR WEIGHT..........: 255.7 (for imidacloprid)
pH .......................: 7.3-8.3
BOILING POINT.............: Not established
MELTING/FREEZING POINT....: Freezing: 32 F (0 C)
VISCOSITY.................: approx. 300 cps @ 20 C
SOLUBILITY IN WATER ......: 0.51 g/L @ 20 C (for imidacloprid)
SPECIFIC GRAVITY .........: 1.06 @ 20 C/20 C
BULK DENSITY..............: Not applicable
VAPOR PRESSURE ...........: 1.5 x 10-9 mm @ 20 C (for imidacloprid)
Product Code: 41723 MSDS Page 4
Approval date: 06/12/2000 Continued on next page
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10. STABILITY AND REACTIVITY:
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STABILITY..................: This is a stable material.
HAZARDOUS POLYMERIZATION...: Will not occur.
INCOMPATIBILITIES..........: None known
INSTABILITY CONDITIONS.....: Strong exothermal reaction above 200 C
(imidacloprid)
DECOMPOSITION PRODUCTS.....: Proposed under extreme conditions such as fire:
HCl, HCN, CO, NO(x) (for imidacloprid)
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11. TOXICOLOGICAL INFORMATION:
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Acute toxicology studies have not been performed on this product as formulated.
The acute toxicology information provided are from a similar formulation
containing a higher percentage of the active ingredient, imidacloprid. The
non-acute information pertains to imidacloprid technical.
ACUTE TOXICITY
ORAL LD50..........: Male Rat: >4870 mg/kg; Female rat: 4143 mg/kg
DERMAL LD50........: Male and Female Rabbit: >2000 mg/kg
INHALATION LC50....: 4 Hr Exposure to Liquid Aerosol: Male and Female Rat:
>5.33 mg/L (analytical); 1 Hr Exposure to Liquid Aerosol (extrapolated from 4
Hr LC50): Male and Female Rat: >20 mg/L (analytical)
EYE EFFECTS........: Rabbit: Only minimal irritation to the conjunctiva was
observed with all irritation resolving within 72 hours.
SKIN EFFECTS.......: Rabbit: Not a dermal irritant.
SENSITIZATION......: Guinea Pig: Not a dermal sensitizer.
SUBCHRONIC TOXICITY...: In a 3 week dermal toxicity study, rabbits were treated
with the active ingredient, imidacloprid, at the limit dose level of 1000
mg/kg for 6 hours/day, 5 days/week. There were no local or systemic effects
observed at any of the levels tested. The no-observed-effect-level (NOEL) was
1000 mg/kg. In a 4 week inhalation study, rats were exposed to dust
concentrations of imidacloprid at 5.5, 30.5 and 191.2 mg/cubic meter for 6
hours/day, 5 days/week. Effects observed at the high concentration included
decreased body weight gains, decreased heart and thymus weights, increased
liver weights, and induction of the hepatic mixed-function oxidases.
Histopathological examinations did not reveal any organ damage or local injury
to the respiratory tract. The NOEL was 5.5 mg/cubic meter based on induction
of the hepatic mixed-functioned oxidases.
CHRONIC TOXICITY......: Dogs were administered imidacloprid for 1 year at
dietary concentrations of 200, 500 or 1250 ppm. Due to the lack of
significant effects, the high dose was increased to 2500 ppm at 17 weeks for
the remainder of the study. Effects observed at the high dose included
decreased food consumption, increased liver weights and elevated serum
chemistries. The NOEL was 500 ppm. In chronic studies using rats,
imidacloprid was administered for 2 years at dietary concentrations of 100,
Product Code: 41723 MSDS Page 5
Approval date: 06/12/2000 Continued on next page
11. TOXICOLOGICAL INFORMATION (Continued)
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300, 900 or 1800 ppm. Histopathology examinations revealed an increased
incidence of mineralization in the colloid of the thyroid follicles at
concentrations of 300 ppm and greater. At 1800 ppm, there were changes in the
serum chemistries and a slight increase in the incidence of parafollicular
hyperplasia seen in the thyroids. Body weight gains were reduced at 900 and
1800 ppm. The overall NOEL was 100 ppm.
CARCINOGENICITY.......: Imidacloprid was investigated for carcinogenicity in
chronic feeding studies using mice and rats at maximum levels of 2000 and 1800
ppm, respectively. There was no evidence of a carcinogenic potential observed
in either species.
MUTAGENICITY..........: The imidacloprid mutagenicity studies, taken
collectively, demonstrate that the active ingredient is not genotoxic or
mutagenic.
DEVELOPMENTAL TOXICITY: In a developmental toxicity study using rats,
imidacloprid was administered by oral gavage during gestation at doses of 10,
30 or 100 mg/kg. At the maternally toxic dose of 100 mg/kg, skeletal
examinations of the fetuses revealed a slight increase in the incidence of
wavy ribs. The NOELs for maternal and developmental toxicity were 10 and 30
mg/kg, respectively. Teratogenic effects were not observed at any of the
doses tested. Rabbits were administered imidacloprid during gestation at oral
doses of 8, 24 or 72 mg/kg. At the maternally toxic dose of 72 mg/kg, reduced
body weights and delayed skeletal ossification were observed in the fetuses.
The NOELs for maternal and developmental toxicity were 8 and 24 mg/kg,
respectively. Teratogenic effects were not observed at any of the doses
tested.
REPRODUCTION..........: In a reproduction study, imidacloprid was administered
to rats for 2 generations at dietary concentrations of 100, 250 or 700 ppm.
Offspring at 700 ppm, exhibited reduced mean body weights and body weights
gains. No other reproductive effects were observed. The maternal and
reproductive NOELs were 100 and 250 ppm, respectively.
NEUROTOXICITY ........: In an acute neurotoxicity screening study using rats,
imidacloprid was administered as a single oral dose at levels of 42, 151, or
307 mg/kg. Clinical observations and neurotoxicity evaluations were performed
over a period of 15 days followed by a neurohistopathological examination.
Deaths attributed to imidacloprid were observed at the high dose within a day
of treatment. The NOEL for motor and locomotor activity was 42 mg/kg for
males. Females at the low dose exhibited minimal decrease in activity in the
figure-eight maze. In a subsequent study, the NOEL for motor and locomotor
activity in females was 20 mg/kg. All clinical signs and neurobehavioral
effects were ascribed to acute cholinergic toxicity, with complete recovery at
sub-lethal doses within 7 days following treatment. The NOEL for
neurotoxicity was 307 mg/kg based on the absence of treatment-related
microscopic lesions in skeletal muscle or neural tissue. In a 13 week
neurotoxicity screening study, imidacloprid was administered to rats at
dietary concentrations of 140, 963 or 3027 ppm. At the mid- and high-dose,
effects observed included reductions in body weight and feed consumption, and
clinical chemistry findings. Neurobehavioral changes were observed only in
males at the high dose. There were no correlative micropathologic findings in
muscle or neural tissues in any animals at any treatment level. The NOEL for
neurotoxicity was 3027 ppm. The overall NOEL was 140 ppm.
Product Code: 41723 MSDS Page 6
Approval date: 06/12/2000 Continued on next page
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12. ECOLOGICAL INFORMATION:
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This product is toxic to aquatic invertebrates. Bayer will provide a summary
of specific ecological effects data upon written request. As with any
pesticide, this product should be used according to label directions and
should be kept out of streams, lakes and other aquatic habitats of concern.
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13. DISPOSAL CONSIDERATIONS
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WASTE DISPOSAL METHOD.......: Follow container label instructions for disposal
of wastes generated during use in compliance with the product label. In
other situations, bury in an EPA-approved landfill or burn in an
incinerator approved for pesticide destruction. Do not reuse container.
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14. TRANSPORTATION INFORMATION:
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TECHNICAL SHIPPING NAME........: Imidacloprid
FREIGHT CLASS PACKAGE..........: Insecticides, NOI-NMFC 102120
PRODUCT LABEL..................: Not Noted
DOT (DOMESTIC SURFACE)
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HAZARD CLASS OR DIVISION ......: Non-Regulated
IMO / IMDG CODE (OCEAN)
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HAZARD CLASS DIVISION NUMBER...: Non-Regulated
ICAO / IATA (AIR)
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HAZARD CLASS DIVISION NUMBER...: Non-Regulated
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15. REGULATORY INFORMATION:
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OSHA STATUS.................: This product is hazardous under the criteria of
the Federal OSHA Hazard Communication Standard 29
CFR 1910.1200.
TSCA STATUS.................: This product is exempt from TSCA Regulation under
FIFRA Section 3 (2)(B)(ii) when used as a
Product Code: 41723 MSDS Page 7
Approval date: 06/12/2000 Continued on next page
15. REGULATORY INFORMATION (Continued)
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pesticide.
CERCLA REPORTABLE QUANTITY..: No components listed
SARA TITLE III:
SECTION 302 EXTREMELY
HAZARDOUS SUBSTANCES..: None
SECTION 311/312
HAZARD CATEGORIES.....: Immediate Health Hazard
SECTION 313
TOXIC CHEMICALS.......: None
RCRA STATUS.................: If discarded in its purchased form, this product
would not be a hazardous waste either by listing
or by characteristic. However, under RCRA, it is
the responsibility of the product user to
determine at the time of disposal, whether a
material containing the product or derived from
the product should be classified as a hazardous
waste. (40 CFR 261.20-24)
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16. OTHER INFORMATION:
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NFPA 704M RATINGS: Health Flammability Reactivity Other
1 1 1
0=Insignificant 1=Slight 2=Moderate 3=High 4=Extreme
Bayer鈥檚 method of hazard communication is comprised of Product Labels and
Material Safety Data Sheets. NFPA ratings are provided by Bayer as a customer
service.
REASON FOR ISSUE..........: Create new MSDS
PREPARED BY...............: V. C. Standart
APPROVED BY...............: D. C. Eberhart
TITLE.....................: Director Product Safety & Stewardship
APPROVAL DATE.............: 06/12/2000
SUPERSEDES DATE...........: None
MSDS NUMBER...............: 39898
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This information is furnished without warranty, expressed or implied, except
that it is accurate to the best knowledge of Bayer Corporation. The data on
this sheet relates only to the specific material designated herein. Bayer
Corporation assumes no legal responsibility for use or reliance upon these
data.
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Product Code: 41723 MSDS Page 8
Approval date: 06/12/2000 Last page
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