Page 1/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
1 Identification of substance:
路 Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
路 Catalog number: 451013
路 Manufacturer/Supplier:
BD Discovery Labware
6 Henshaw Street
Woburn, MA 01801
Tel: 800.334.5229
路 Information department: Technical Services
路 Emergency information:
In case of a chemical emergency, spill, fire, exposure, or accident contact BD Discovery Labware at
800.334.5229, or ChemTrec at 800.424.9300.
2 Composition/Data on components:
路 Chemical characterization:
路 CAS No. Description:
83799-24-0
Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
3 Hazards identification
路 Hazard description:
Xn Harmful
路 Information pertaining to particular dangers for man and environment
R 21 Harmful in contact with skin.
R 20 Harmful by inhalation.
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
R 37 Irritating to respiratory system.
路 NFPA ratings (scale 0-4)
Health = 2
0 Fire = 0
2 0 Reactivity = 0
4 First aid measures
路 General information Move affected individual(s) out to fresh air.
(Contd. on page 2)
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Page 2/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
(Contd. of page 1)
路 After inhalation Supply fresh air; consult doctor in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for 15 minutes under running water. Then consult a doctor.
路 After swallowing If swallowed, rinse mouth with water (only if the person is conscious)
路 Information for doctor Show the product label or this MSDS.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, ABC multipurpose dry chemical or water spray. Fight larger fires with water spray or alcohol resistant
foam.
路 Special hazards caused by the material, its products of combustion or resulting gases:
During heating or in case of fire toxic gases may be produced.
路 Protective equipment:
Wear fully protective suit.
Wear self-contained respiratory protective device.
6 Accidental release measures
路 Person-related safety precautions:
Avoid formation of dust.
Use respiratory protective device against the effects of fumes/dust/aerosol.
路 Measures for environmental protection: Wipe up with damp sponge or mop.
路 Measures for cleaning/collecting:
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
路 Additional information:
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling: Prevent formation of dust.
路 Information about protection against explosions and fires: Keep respiratory protective device available.
路 Storage
路 Requirements to be met by storerooms and receptacles: -20潞 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions:
Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed containers.
USA
(Contd. on page 3)
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Page 3/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
(Contd. of page 2)
8 Exposure controls and personal protection
路 Additional information about design of technical systems:
Use only in a chemical fume hood. Safety shower and eye bath.
路 Components with limit values that require monitoring at the workplace: Not required.
路 Personal Protective Equipment
路 General protective and hygienic measures
Do not inhale dust / smoke / mist.
Avoid contact with the eyes and skin.
路 Breathing equipment:
In case of brief exposure, use a chemical fume hood or a NIOSH/MSHA-approved respirator.
路 Protection of hands:
Chemical resistant gloves (i.e. nitrile, or equivalent).
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing (lab coat).
9 Physical and chemical properties:
路 General Information
Powder
Form:
White
Color:
unkown
Odor:
路 Change in condition
Melting point/Melting range: 141-143掳C (286-289掳F)
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapor pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Insoluble
Water:
Not applicable
路 pH-value:
501.66
路 Formula Weight
USA
(Contd. on page 4)
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Page 4/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
(Contd. of page 3)
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous products of decomposition:
Carbon monoxide (CO) and carbon dioxide (CO2)
Nitrogen oxides (NOx)
11 Toxicological information
路 Acute toxicity:
路 LD/LC50 values that are relevant for classification:
Oral LD50 144 mg/kg (human)
路 Primary irritant effect:
路 on the skin: Irritant to skin and mucous membranes.
路 on the eye: Irritating effect.
路 Sensitization: No sensitizing effects known.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not been thoroughly investigated, but currently none have been identified.
13 Disposal considerations
路 Product:
路 Recommendation
Dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber.
Must not be disposed of with solid waste.
Dispose of material in accordance with federal (40 CFR 261), state and local requirements.
This product is not considered a RCRA hazardous waste.
路 Uncleaned packagings:
路 Recommendation: Disposal must be made according to state and federal regulations.
路 Recommended cleansing agent: Water, if necessary with cleansing agents.
14 Transport information
路 DOT regulations:
-
路 Hazard class:
(Contd. on page 5)
USA
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Page 5/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
(Contd. of page 4)
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 SARA Section 355 (extremely hazardous substances) Substance is not listed.
路 SARA Section 313 (specific toxic chemical listings) Substance is not listed.
路 TSCA (Toxic Substances Control Act) Substance is not listed.
路 California Proposition 65 - Chemicals known to cause cancer Substance is not listed.
路 Chemicals known to cause reproductive toxicity for females: Substance is not listed.
路 Chemicals known to cause reproductive toxicity for males: Substance is not listed.
路 Chemicals known to cause developmental toxicity: Substance is not listed.
路 Carcinogenicity categories
路 IARC (International Agency for Research on Cancer) Substance is not listed.
路 NTP (National Toxicology Program) Substance is not listed.
路 TLV (Threshold Limit Value established by ACGIH) Substance is not listed.
路 Product related hazard information:
The product has been classified and marked in accordance with regulations on hazardous materials.
路 Hazard symbols:
Xn Harmful
路 Risk phrases:
21 Harmful in contact with skin.
20 Harmful by inhalation.
22 Harmful if swallowed.
36 Irritating to eyes.
37 Irritating to respiratory system.
路 Safety phrases:
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
28 After contact with skin, wash immediately with plenty of soap and water
46 If swallowed, seek medical advice immediately and show this container or label.
63 In case of accident by inhalation: remove casualty to fresh air and keep at rest
64 If swallowed, rinse mouth with water (only if the person is conscious)
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(Contd. on page 6)
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Page 6/6
Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 05/04/2006 Reviewed on 05/04/2006
Product name: Terfenadine Carboxylate
Fexofenadine
Carboxyterfenadine
Terfenadine acid metabolite
(Contd. of page 5)
16 Other information:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton,Dickinson
and Company or any of its subsidiaries assumes any liabilities whatsoever for the accuracy or completeness of
the information contained herein. Final determination of suitability of any material is the sole responsibility of
the user. All materials may present unknown hazards and should be used with caution. Although certain hazards
are described herein, we cannot guarantee that these are the only hazards that exist.
Use of Product:
- synthetic chemical for research only
- analytical standard
- must be handled by suitably qualified personnel
路 Department issuing MSDS: Safety and Environment Department
路 Contact: Technical Service Representative
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