SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 08/JUN/2005
Date Updated: 13/MAY/2005
Version 1.0
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name FLUOROURACIL, MEETS USP TESTING
SPECIFICATIONS
Product Number F8423
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
5'-FLUOROURACIL, MEETS USP 51-21-8 200-085-6 None
TESTING SPECS.
Formula C4H3FN2O2
Molecular Weight 130.08 AMU
Synonyms Adrucil * Arumel * Effluderm (free base) *
Efudex * 5-Fluoracil (German) *
5-Fluor-2,4-dihydroxypyrimidin (Czech) *
Fluoroblastin * Fluoroplex *
5-Fluoropyrimidine-2,4-dione *
5-Fluoro-2,4-pyrimidinedione *
5-Fluoro-2,4(1H,3H)-pyrimidinedione *
5-Fluor-2,4-pyrimidindiol (Czech) *
5-Fluor-2,4(1H,3H)-pyrimidindion (Czech) *
Fluorouracil * 5-Fluorouracil * 5-Fluoruracil
(German) * Fluracil * Fluracilum * Fluril * FU *
5-FU * NSC-19893 * 2,4(1H,3H)-Pyrimidinedione,
5-fluoro- * Queroplex * Ro 2-9757 * Timazin *
U-8953 * Ulup
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
SIGMA - F8423 www.sigma-aldrich.com Page 2
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 282 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 10 mg/ml H2O Clear
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen fluoride.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YR0350000
ACUTE TOXICITY
LD50
Oral
Rat
230 mg/kg
LD50
Intraperitoneal
Rat
70 MG/KG
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Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
LD50
Subcutaneous
Rat
217 MG/KG
LD50
Intravenous
Rat
245 MG/KG
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
LD50
Intramuscular
Rat
240 MG/KG
LD50
Parenteral
Rat
500 MG/KG
LD50
Rectal
Rat
884 MG/KG
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Other changes.
LD50
Oral
Mouse
115 mg/kg
LD50 LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
100 MG/KG 100 MG/KG
LD50
Subcutaneous
Mouse
169 MG/KG
LD50
Intravenous
Mouse
81 MG/KG
LD50
Intracerebral
Mouse
41600 UG/KG
Remarks: Peripheral Nerve and Sensation:Sensory change involving
peripheral nerve. Sense Organs and Special Senses (Nose, Eye,
Ear, and Taste):Eye:Etosis. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Other.
LD50
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Oral
Dog
30 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting.
LD50
Oral
Rabbit
18.9 mg/kg
Remarks: Behavioral:Muscle weakness.
Gastrointestinal:Hypermotility, diarrhea. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
LD50
Intravenous
Guinea pig
25 MG/KG
Remarks: Vascular:BP elevation not charactertized in autonomic
section.
IRRITATION DATA
Skin
Human
84 mg
3W
SENSITIZATION
Sensitization: Causes photosensitivity. Exposure to light can
result in allergic reactions resulting in dermatologic lesions,
which can vary from sunburnlike responses to edematous,
vesiculated lesions, or bullae
SIGNS AND SYMPTOMS OF EXPOSURE
May cause nausea, vomiting, anorexia, diarrhea, stomatitis,
fever, malaise, weakness, headache, depression, skin rash,
erythema, bone marrow depression, bleeding syndrome, and renal
impairment. Deaths have occured.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Heart. Bone marrow. Immune system. Blood.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Intraperitoneal
Exposure Time: 50W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors. Blood:Tumors.
IARC CARCINOGEN LIST
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Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human Human
13 MG/L 13 MG/L
Cell Type: Other cell types Other cell types
DNA damage DNA damage
Human Human
1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
DNA damage DNA damage
Human Human
5 UMOL/L 5 UMOL/L
6H 6H
Cell Type: Other cell types Other cell types
Other mutation test systems Other mutation test systems
Human Human
2600 NMOL/L 2600 NMOL/L
Cell Type: leukocyte leukocyte
DNA DNA
Human Human
2600 NMOL/L 2600 NMOL/L
Cell Type: leukocyte leukocyte
Other mutation test systems Other mutation test systems
Human Human
20 MG/L 20 MG/L
Cell Type: Other cell types Other cell types
Unscheduled DNA synthesis Unscheduled DNA synthesis
Human Human
1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
Unscheduled DNA synthesis Unscheduled DNA synthesis
Human Human
1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
Other mutation test systems Other mutation test systems
Human Human
200 MG/L 200 MG/L
Cell Type: Other cell types Other cell types
DNA inhibition DNA inhibition
Human Human
1 UMOL/L 1 UMOL/L
Cell Type: Other cell types Other cell types
DNA inhibition DNA inhibition
Human Human
1 UMOL/L 1 UMOL/L
Cell Type: Other cell types Other cell types
Other mutation test systems Other mutation test systems
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Human Human
1 MG/L 1 MG/L
Cell Type: ovary ovary
DNA inhibition DNA inhibition
Human Human
1 PPH 1 PPH
Skin Skin
Other mutation test systems Other mutation test systems
Human Human
1 MG/L 1 MG/L
Cell Type: Other cell types Other cell types
Other mutation test systems Other mutation test systems
Human Human
50 MG/L 50 MG/L
Cell Type: HeLa cell HeLa cell
Other mutation test systems Other mutation test systems
Human Human
7 MG/KG 7 MG/KG
Cell Type: S. typhimurium S. typhimurium
Body fluid assay Body fluid assay
Human Human
100 PMOL/L 100 PMOL/L
Cell Type: lymphocyte lymphocyte
Sister chromatid exchange Sister chromatid exchange
Rat Rat
250 MG/KG 250 MG/KG
Intraperitoneal Intraperitoneal
Micronucleus test Micronucleus test
Rat Rat
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
Cytogenetic analysis Cytogenetic analysis
Mouse Mouse
12500 UG/KG 12500 UG/KG
Intraperitoneal Intraperitoneal
Micronucleus test Micronucleus test
Mouse Mouse
26018 UG/KG 26018 UG/KG
Intraperitoneal Intraperitoneal
Micronucleus test Micronucleus test
Mouse Mouse
10 UMOL/L 10 UMOL/L
24H 24H
Cell Type: Embryo Embryo
Morphological transformation. Morphological transformation.
Mouse Mouse
20 UMOL/L 20 UMOL/L
Cell Type: Bone marrow Bone marrow
DNA damage DNA damage
Mouse Mouse
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19 UMOL/L 19 UMOL/L
Cell Type: Bone marrow Bone marrow
Other mutation test systems Other mutation test systems
Mouse Mouse
66 UMOL/L 66 UMOL/L
Cell Type: lymphocyte lymphocyte
Other mutation test systems Other mutation test systems
Mouse Mouse
500 UMOL/KG 500 UMOL/KG
Intraperitoneal Intraperitoneal
Other mutation test systems Other mutation test systems
Mouse Mouse
40 MG/KG 40 MG/KG
Intravenous Intravenous
Unscheduled DNA synthesis Unscheduled DNA synthesis
Mouse Mouse
40 MG/KG 40 MG/KG
Oral Oral
Unscheduled DNA synthesis Unscheduled DNA synthesis
Mouse Mouse
40 MG/L 40 MG/L
Cell Type: Ascites tumor Ascites tumor
Unscheduled DNA synthesis Unscheduled DNA synthesis
Mouse Mouse
40 MG/L 40 MG/L
Cell Type: Ascites tumor Ascites tumor
Other mutation test systems Other mutation test systems
Mouse Mouse
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
Unscheduled DNA synthesis Unscheduled DNA synthesis
Mouse Mouse
3 MG/L 3 MG/L
Cell Type: leukocyte leukocyte
DNA inhibition DNA inhibition
Mouse Mouse
100 MG/KG 100 MG/KG
Cell Type: leukocyte leukocyte
DNA inhibition DNA inhibition
Mouse Mouse
55 UMOL/L 55 UMOL/L
Cell Type: leukocyte leukocyte
Other mutation test systems Other mutation test systems
Mouse Mouse
500 UG/L 500 UG/L
Cell Type: lymphocyte lymphocyte
DNA inhibition DNA inhibition
Mouse Mouse
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
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DNA inhibition DNA inhibition
Mouse Mouse
40 MG/KG 40 MG/KG
Oral Oral
Other mutation test systems Other mutation test systems
Mouse Mouse
100 NMOL/L 100 NMOL/L
Cell Type: Embryo Embryo
DNA inhibition DNA inhibition
Mouse Mouse
1800 NMOL/L 1800 NMOL/L
Cell Type: Bone marrow Bone marrow
DNA inhibition DNA inhibition
Mouse Mouse
7500 UMOL/L 7500 UMOL/L
Cell Type: Ascites tumor Ascites tumor
DNA inhibition DNA inhibition
Mouse Mouse
1 UG/L 1 UG/L
Cell Type: Other cell types Other cell types
DNA inhibition DNA inhibition
Mouse Mouse
50 MG/KG 50 MG/KG
Oral Oral
Cytogenetic analysis Cytogenetic analysis
Mouse Mouse
20 MG/KG 20 MG/KG
Intraperitoneal Intraperitoneal
Cytogenetic analysis Cytogenetic analysis
Mouse Mouse
250 MG/KG 250 MG/KG
Cell Type: Ascites tumor Ascites tumor
Cytogenetic analysis Cytogenetic analysis
Mouse Mouse
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
sperm sperm
Mouse Mouse
50 MG/KG 50 MG/KG
Intravenous Intravenous
sperm sperm
Hamster Hamster
41 MG/KG 41 MG/KG
Intraperitoneal Intraperitoneal
Micronucleus test Micronucleus test
Hamster Hamster
41 MG/KG 41 MG/KG
Intraperitoneal Intraperitoneal
Cytogenetic analysis Cytogenetic analysis
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Hamster Hamster
1900 UG/L 1900 UG/L
Cell Type: lung lung
Cytogenetic analysis Cytogenetic analysis
Mammal Mammal
100 UMOL/L 100 UMOL/L
Cell Type: Other cell types Other cell types
DNA inhibition DNA inhibition
ZPOS
Histidine reversion (Ames)
CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 240 MG/KG
Route of Application: Intravenous
Exposure Time: (11-14W PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 35 MG/KG
Route of Application: Oral
Exposure Time: (7-13D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system. Specific Developmental
Abnormalities: Gastrointestinal system.
Species: Rat
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
Species: Rat
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 330 MG/KG
Route of Application: Intravenous
Exposure Time: (7-17D PREG)
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Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 175 MG/KG
Route of Application: Oral
Exposure Time: (7-13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material).
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 10 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Hamster
Dose: 24 MG/KG
Route of Application: Intramuscular
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Hamster
Dose: 56 MG/KG
Route of Application: Intramuscular
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman Woman
Dose: 150 MG/KG 150 MG/KG
Route of Application: Intravenous Intravenous
Exposure Time: (20-31W PREG) (20-31W PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Other neonatal measures or effects.
Species: Rat Rat
Dose: 175 MG/KG 175 MG/KG
Route of Application: Oral Oral
Exposure Time: (7-13D PREG) (7-13D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
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Fetotoxicity (except death, e.g., stunted fetus). Effects on
Embryo or Fetus: Fetal death. Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth). Effects on
Embryo or Fetus: Fetotoxicity (except death, e.g., stunted
fetus). Effects on Embryo or Fetus: Fetal death.
Species: Rat Rat
Dose: 13500 UG/KG 15 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death. Effects
on Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants). Effects on
Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Rat Rat
Dose: 15 MG/KG 20 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Other developmental abnormalities. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants). Effects on
Embryo or Fetus: Fetotoxicity (except death, e.g., stunted
fetus). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat Mouse
Dose: 20 MG/KG 245 MG/KG
Route of Application: Intraperitoneal Oral
Exposure Time: (9D PREG) (7-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities. Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth). Effects on
Embryo or Fetus: Fetal death.
Species: Mouse Mouse
Dose: 245 MG/KG 20 MG/KG
Route of Application: Oral Intraperitoneal
Exposure Time: (7-13D PREG) (9D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetal death. Effects on Fertility: Post-implantation mortality
(e.g., dead and/or resorbed implants per total number of
implants). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Mouse Mouse
Dose: 20 MG/KG 30 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Specific Developmental Abnormalities: Other developmental
abnormalities. Effects on Fertility: Abortion.
Species: Mouse Mouse
Dose: 30 MG/KG 30 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (12D PREG)
Result: Effects on Fertility: Abortion. Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Effects on Newborn: Viability index (e.g., # alive at day 4 per
# born alive). Effects on Newborn: Growth statistics (e.g.,
reduced weight gain).
Species: Mouse Mouse
Dose: 30 MG/KG 67 MG/KG
Route of Application: Intraperitoneal Intravenous
Exposure Time: (12D PREG) (1D MALE)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Viability
index (e.g., # alive at day 4 per # born alive). Effects on
Newborn: Growth statistics (e.g., reduced weight gain). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Mouse Hamster
Dose: 67 MG/KG 28 MG/KG
Route of Application: Intravenous Intramuscular
Exposure Time: (1D MALE) (9D PREG)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Hamster Hamster
Dose: 28 MG/KG 20 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants).
Species: Hamster
Dose: 20 MG/KG
Route of Application: Intramuscular
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
SIGMA - F8423 www.sigma-aldrich.com Page 13
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D or manufacturing use. Not for prescription compound or
other uses.
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