SIGMA-ALDRICH



                         Material Safety Data Sheet



                                                 Date Printed: 19/JUN/2005

                                                 Date Updated: 15/MAR/2004

                                                               Version 1.3

                                                   According to 91/155/EEC



Classified as Hazardous according to the criteria of EU Annex 1 and

NOHSC.



1 - Product and Company Information



Product Name                   GLUCOSE OXIDASE TYPE II-S FROM

                               ASPERGILLUS NIGER

Product Number                 G6641



Company                        Sigma-Aldrich Pty. Ltd.

                               12 Anella Avenue

                               Castle Hill NSW 2154

                               Australia

Technical Phone #              +61 2 9841 0555 (1800 800 097)

Fax                            +61 2 9841 0500 (1800 800 096)

Emergency Phone #              +44 8701906777 (1800 448 465)



2 - Composition/Information on Ingredients



Product Name                         CAS #        EC no       Annex I

                                                              Index Number

GLUCOSE OXIDASE                      9001-37-0    232-601-0   None



Synonyms            Corylophyline * Deoxin-1 * E.C. 1.1.3.4 *

                    Glucose aerodehydrogenase * Glucose oxidase *

                    beta-D-Glucose oxidase * beta-D-Glucose:quinone

                    oxidoreductase * Microcid * Notatin * Penatin *

                    OXYGEN 1-OXIDOREDUCTASE



3 - Hazards Identification



SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT

   May cause sensitization by inhalation.





4 - First Aid Measures



AFTER INHALATION

   If inhaled, remove to fresh air. If breathing becomes difficult,

   call a physician.



AFTER SKIN CONTACT

   In case of skin contact, flush with copious amounts of water for

   at least 15 minutes. Remove contaminated clothing and shoes.

   Call a physician.



AFTER EYE CONTACT

   In case of contact with eyes, flush with copious amounts of

   water for at least 15 minutes. Assure adequate flushing by

   separating the eyelids with fingers. Call a physician.



AFTER INGESTION

   If swallowed, wash out mouth with water provided person is

   conscious. Call a physician.



5 - Fire Fighting Measures



EXTINGUISHING MEDIA

   Suitable: Water spray. Carbon dioxide, dry chemical powder, or

   appropriate foam.



SPECIAL RISKS

   Specific Hazard(s): Emits toxic fumes under fire conditions.



SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS

   Wear self-contained breathing apparatus and protective clothing

   to prevent contact with skin and eyes.



6 - Accidental Release Measures



PROCEDURE(S) OF PERSONAL PRECAUTION(S)

   Wear respirator, chemical safety goggles, rubber boots, and

   heavy rubber gloves.



METHODS FOR CLEANING UP

   Sweep up, place in a bag and hold for waste disposal. Avoid

   raising dust. Ventilate area and wash spill site after material

   pickup is complete.



7 - Handling and Storage



HANDLING

   Directions for Safe Handling: Avoid breathing dust. Avoid

   contact with eyes, skin, and clothing. Avoid prolonged or

   repeated exposure.



STORAGE

   Conditions of Storage: Keep tightly closed.

   Store at -20°C



8 - Exposure Controls / Personal Protection



ENGINEERING CONTROLS

   Mechanical exhaust required.



GENERAL HYGIENE MEASURES

   Wash thoroughly after handling. Wash contaminated clothing before

   reuse.



PERSONAL PROTECTIVE EQUIPMENT

   Special Protective Measures: Wear appropriate government approved

   respirator, chemical-resistant gloves, safety goggles, other

   protective clothing.



9 - Physical and Chemical Properties



Appearance              Physical State: Solid



Property                Value                 At Temperature or Pressure



pH                      N/A

BP/BP Range             N/A

MP/MP Range             N/A

Flash Point             N/A

Flammability            N/A





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Autoignition Temp         N/A

Oxidizing Properties      N/A

Explosive Properties      N/A

Explosion Limits          N/A

Vapor Pressure            N/A

SG/Density                1 g/cm3

Partition Coefficient     N/A

Viscosity                 N/A

Vapor Density             N/A

Saturated Vapor Conc.     N/A

Evaporation Rate          N/A

Bulk Density              N/A

Decomposition Temp.       N/A

Solvent Content           N/A

Water Content             N/A

Surface Tension           N/A

Conductivity              N/A

Miscellaneous Data        N/A

Solubility                N/A



10 - Stability and Reactivity



STABILITY

   Stable: Stable.

   Materials to Avoid: Oxidizing agents.



HAZARDOUS DECOMPOSITION PRODUCTS

   Hazardous Decomposition Products: Nature of decomposition products

   not known.



HAZARDOUS POLYMERIZATION

   Hazardous Polymerization: Will not occur



11 - Toxicological Information



RTECS NUMBER: RQ8452000



ACUTE TOXICITY



   LD50

   Intraperitoneal

   Mouse

   3 MG/KG



   LD50

   Subcutaneous

   Mouse

   4500 UG/KG



   LD50

   Intravenous

   Mouse

   13 MG/KG

   Remarks: Lungs, Thorax, or Respiration:Cyanosis. Blood:Change in

   clotting factors. Blood:Methemoglobinemia-Carboxyhemoglobin.



   LD50

   Subcutaneous

   Rabbit

   7500 UG/KG

   Remarks: Endocrine:Hyperglycemia.







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SENSITIZATION

   Respiratory: May cause allergic respiratory reaction.



SIGNS AND SYMPTOMS OF EXPOSURE

   To the best of our knowledge, the chemical, physical, and

   toxicological properties have not been thoroughly investigated.



ROUTE OF EXPOSURE

   Skin Contact: May cause skin irritation.

   Skin Absorption: May be harmful if absorbed through the skin.

   Eye Contact: May cause eye irritation.

   Inhalation: May be harmful if inhaled. Material may be

   irritating to mucous membranes and upper respiratory tract.

   Ingestion: May be harmful if swallowed.



12 - Ecological Information



No data available.



13 - Disposal Considerations



SUBSTANCE DISPOSAL

   Contact a licensed professional waste disposal service to dispose

   of this material. Dissolve or mix the material with a combustible

   solvent and burn in a chemical incinerator equipped with an

   afterburner and scrubber. Observe all federal, state, and local

   environmental regulations.



14 - Transport Information



RID/ADR

   Non-hazardous for road transport.



IMDG

   Non-hazardous for sea transport.



IATA

   Non-hazardous for air transport.



15 - Regulatory Information



CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES

   INDICATION OF DANGER: Xn

     Harmful.

   R-PHRASES: 42

     May cause sensitization by inhalation.

   S-PHRASES: 22 45

     Do not breathe dust. In case of accident or if you feel unwell,

     seek medical advice immediately (show the label where possible).



16 - Other Information



WARRANTY

   The above information is believed to be correct but does not

   purport to be all inclusive and shall be used only as a guide. The

   information in this document is based on the present state of our

   knowledge and is applicable to the product with regard to

   appropriate safety precautions. It does not represent any

   guarantee of the properties of the product. Sigma-Aldrich Inc.,

   shall not be held liable for any damage resulting from handling or

   from contact with the above product. See reverse side of invoice

   or packing slip for additional terms and conditions of sale.





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   Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited

   paper copies for internal use only.



DISCLAIMER

   For R&D use only. Not for drug, household or other uses.









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