SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/APR/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name METHANESULFONYL CHLORIDE,
REAGENTPLUS(TM), >=99.7%
Product Number 471259
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
METHANESULFONYL CHLORIDE 124-63-0 204-706-1 None
Formula CH3ClO2S
Molecular Weight 114.55 AMU
Synonyms Chloromethyl sulfone * Mesyl chloride *
Methanesulfonic acid chloride * Methanesulphonyl
chloride * Methyl sulfochloride * Methylsulfonyl
chloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic in contact with skin and if swallowed. Very toxic by
inhalation. Causes burns. Irritating to respiratory system.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
EXTINGUISHING MEDIA
Suitable: Carbon dioxide. Dry chemical powder.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Handle and store
under nitrogen.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
ALDRICH - 471259 www.sigma-aldrich.com Page 2
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 53 - 55 掳C 11 mmHg
MP/MP Range N/A
Flash Point 113 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 12 mmHg 53 掳C
SG/Density 1.474 g/cm3
Partition Coefficient N/A
Viscosity 0.002 Pas 25 掳C
Vapor Density 3.9 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Reactions to Avoid: Water hydrolyzes material liberating acidic
gas which in contact with metal surfaces can generate flammable
and/or explosive hydrogen gas.
Materials to Avoid: Strong bases, Oxidizing agents, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sulfur oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: PB2790000
ACUTE TOXICITY
LC50
Inhalation
Rat
25 ppm
4H
LD50
Oral
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Rat
255 mg/kg
LD50
Skin
Rabbit
*
LD50
Oral
Rat
50 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold. Kidney,
Ureter, Bladder:Hematuria.
LD50
Oral
Mouse
200 mg/kg
Remarks: Kidney, Ureter, Bladder:Hematuria.
LD50
Intraperitoneal
Mouse
10 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.
LD50
Skin
Guinea pig
100 UL/KG
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
IRRITATION DATA
Skin
Remarks: Severe irritation effect
Eyes
Remarks: Severe irritation effect
Eyes
Human
1 ppm
Remarks: Severe irritation effect
Inhalation
Human
10 ppm
Remarks: Severe irritation effect
Inhalation
0.8 ppm
15 MIN
Remarks: Severe irritation effect
Skin
Rabbit
500 mg
Remarks: Severe irritation effect
Eyes
Rabbit
100 mg
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Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be fatal if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Hamster
32 UMOL/L
Cell Type: ovary
Cytogenetic analysis
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3246
Class: 6.1
PG: I
Proper Shipping Name: Methanesulphonyl chloride
IMDG
UN#: 3246
Class: 6.1
PG: I
Subrisk: 8
Proper Shipping Name: Methanesulphonyl chloride
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 3246
Class: 6.1
PG: I
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Subrisk: 8
Proper Shipping Name: Methanesulphonyl chloride
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 24/25 26 34 37
Toxic in contact with skin and if swallowed. Very toxic by
inhalation. Causes burns. Irritating to respiratory system.
S-PHRASES: 26 28 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. After contact with skin, wash
immediately with plenty of water. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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