SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 11/APR/2005
Date Updated: 15/NOV/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-METHYL-1,4-NAPHTHOQUINONE, 98%
Product Number M57405
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-METHYL-1,4-NAPHTHOQUINONE 58-27-5 200-372-6 None
Formula C11H8O2
Molecular Weight 172.18 AMU
Synonyms Aquakay * Aquinone *
1,4-Dihydro-1,4-dioxo-2-methylnaphthalene *
Hemodal * Juva-K * Kaergona * Kanone * Kappaxan
* Kappaxin * Karcon * Kareon * Kativ-G * Kayklot
* Kaykot * Kayquinone * Kipca * Kipca, oil
soluble * Klottone * Koaxin * Kolklot *
K-Thrombyl * K-Vitan * Memodol * Menadion *
Menadione * Menaphthon * Menaphthone *
Menaquinone * Menaquinone 0 * Menaphtone *
2-Methyl-1,4-naftochinon (Czech) *
2-Methyl-1,4-naphthalenedione *
2-Methyl-1,4-naphthochinon (German) *
2-Methyl-1,4-naphthoquinone *
3-Methyl-1,4-naphthoquinone * Mitenon * Mitenone
* MNQ * 1,4-Naphthalenedione, 2-methyl- (9CI) *
NSC 4170 * Panosine * Prokayvit * Synkay *
Thyloquinone * USAF EK-5185 * Vitamin K0 *
Vitamin K2(0) * Vitamin K3
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
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Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Yellow
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 102 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: QL9100000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
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75 MG/KG
LD50
Oral
Mouse
500 mg/kg
LD50
Intraperitoneal
Mouse
50 MG/KG
LD50
Subcutaneous
Mouse
138 MG/KG
SENSITIZATION
Sensitization: Possible sensitizer.
SIGNS AND SYMPTOMS OF EXPOSURE
The chemical, physical, and toxicological properties of this
product have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Readily absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Blood. Liver. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Skin
Exposure Time: 27W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors. Tumorigenic:Tumors
at site or application.
Mouse
Route of Application: Skin
Exposure Time: 21W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
20 UMOL/L
Cell Type: fibroblast
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DNA damage
Hamster
15 UMOL/L
Cell Type: Other cell types
DNA damage
Human
10 NMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
10 UMOL/L
Cell Type: liver
DNA damage
Mouse
750 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
2 MG/L
Cell Type: lung
Cytogenetic analysis
Hamster
10 UMOL/L
Cell Type: lung
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 3 GM/KG
Route of Application: Oral
Exposure Time: (1-20D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
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14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system
and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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