SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2005
Date Updated: 18/JUN/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name GUANIDINE THIOCYANATE MOLECULAR BIOLOGY
REAGENT
Product Number G9277
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
GUANIDINE THIOCYANATE 593-84-0 209-812-1 615-004-00-3
Formula CH5N3.CHNS
Molecular Weight 118.16 AMU
Synonyms Guanidine, monothiocyanate * Guanidine
thiocyanate * Guanidinium thiocyanate * USAF
EK-705
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation, in contact with skin and if swallowed.
Contact with acids liberates very toxic gas. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Colorless White
Form: Crystals
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Odor: Odorless
Property Value At Temperature or Pressure
pH 4.5 - 7
BP/BP Range N/A
MP/MP Range 117 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:6 M in H2O, 20掳C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong acids, Strong oxidizing agents, Heating
to decomposition or contact with acids or acid vapors can liberate
poisonous cyanide vapors.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides, Hydrogen cyanide, Ammonia.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: XL1225000
ACUTE TOXICITY
LD50
Oral
Rat
593 mg/kg
LD50
Intraperitoneal
Mouse
300 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
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To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
12 - Ecological Information
No data available.
BIOACCUMULATION POTENTIAL: No indication of
bioaccumulation.
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Poecilia reticulata
Time: 96 h
Value: 89.1 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 48 h
Value: 42.4 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 615-004-00-3
NOTA: A
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 20/21/22 32 52/53
Harmful by inhalation, in contact with skin and if swallowed.
Contact with acids liberates very toxic gas. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
S-PHRASES: 13 61
Keep away from food, drink, and animal feedingstuffs. Avoid
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release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Declaration Number: 67461
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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