Inco庐 Nickel Powder HDNP
Product Information
INCO High Density Nickel Powder (Class D)
Inco INCO LIMITED
145 King Street West
Suite 1500
Material Toronto, ON
M5H 4B7
Chemtrec 24hr Emergency No. 1-800-424-9300
Safety INCO Nickel Powder Type 123 is used in alloying; and sintered powdered metallurgical
operations.
Hazardous Ingredients
Data Hazardous Calculated
TLV1,2 鈥搈g/m3
C.A.S. No Oral LD50 -rat
Ingredients Composition
Nickel (Ni)* 99.1 7440-02-0 >9000 mg/kg 1.5*
Sheet *As inhalable fraction
Physical Data
Grey, odourless powder with an average particle size of 8 to 15 microns.
Specific Sol. In H20
Ingredient Mol. Wt. m.p.掳C b.p.掳C
Gravity g/100ml
Ni 58.71 8.9 1453 2732 0
Fire or Explosion Hazard
Metal powders heat treated in reducing atmospheres may become spontaneously
combustible.
REACTIVITY DATA
Like other metals, nickel can react with acids to liberate hydrogen gas which can form
explosive mixtures in air.
Like other metal powders, nickel powder can react explosively or incandescently with
substances such as ammonium nitrate, perchlorates, phosphorous, selenium, sulfur, etc.
Under special conditions nickel can react with carbon monoxide in reducing atmospheres to
form nickel carbonyl, Ni(CO)4, a toxic gas.
CDN
Updated: 05/06
Toxicological Properties3
Nickel
LD50 ORAL RAT >9000 mg/kg
Inhalation: The National Toxicology Program has listed nickel as reasonably
anticipated to be a carcinogen based on the production of injection site
Inco tumors. The International Agency for Research on Cancer (IARC) found
there was inadequate evidence that metallic nickel is carcinogenic to
humans but since there was sufficient evidence that it is carcinogenic to
animals, IARC concluded that metallic nickel is possibly carcinogenic to
Material humans. In 1997, the ACGIH categorized elemental nickel as: A5 "Not
Suspected as a Human Carcinogen". Epidemiological studies of workers
exposed to nickel powder and to dust and fume generated in the
production of nickel alloys and of stainless steel have not indicated the
Safety presence of a significant respiratory cancer hazard.
Evidence for the association of nickel compound exposures and cancer
risk comes mainly from workers in now obsolete nickel refining
operations where very high concentrations of airborne nickel, mostly
Data present as oxidic or sub-sulphidic species at up to 100mg/m3 or more,
were associated with excess nasal and lung cancers.
The inhalation of nickel powder has not resulted in an increased
Sheet incidence of malignant lung tumors in rodents. Repeated intratracheal
instillation of nickel powder produced an increased incidence of
malignant lung tumors in rats. Repeated intratracheal instillation of nickel
powder did not produce an increased incidence of malignant lung tumors
in hamsters when administered at the maximum tolerated dose. Single
intratracheal instillations of nickel powder in hamsters at doses near the
LD50 produced an increased incidence of fibrosarcomas, mesotheliomas
and rhabdomyosarcomas.
Inhalation of nickel powder at concentrations 15 times the TLV irritated
the respiratory tract in rodents.
Inhalation of nickel may induce asthma. This effect is rare, it has been
reported in welders where exposures to nickel are often mixed with other
chemical substances. Persons with a known history of nickel sensitive
asthma should avoid such contact.
Skin Contact: Prolonged and intimate contact with metallic nickel may cause irritation
to the skin and nickel sensitivity which may result in allergic skin rashes.
One case has been reported of asthma induced by external exposure to
a nickel-containing skin clip and by skin contact with nickel.
Wounds Nickel metal powder has caused tumors at the site of injection in rodents.
However, studies do not suggest a significant risk for humans from
nickel-containing prostheses.
Ingestion: The U.S. National Institute for Occupational Safety and Health (NIOSH)
concluded there is no evidence that nickel and its inorganic compounds
are carcinogenic when ingested. The U.S. Food and Drug
Administration has affirmed that nickel is generally recognized as safe
(GRAS) as a direct human food ingredient.
CDN
Updated: 05/06
Preexisting Conditions: Prolonged and intimate skin contact can cause an allergic skin rash in
previously sensitized individuals.
Reproductive Toxicity: Animal experiments indicate that soluble nickel ingestion causes adverse
effects on fetal development at a threshold oral exposure of 2.2 mg/
Ni/kg/day by pregnant rats. Data are insufficient to determine if this effect
Inco occurs in humans and no regulatory agency has classified soluble forms
of nickel as reproductive risks for humans.
Material Preventative Measures
Do not inhale powder. Keep container closed when not in use. Ventilation is normally required when
handling or using this product to keep exposure to airborne nickel below the exposure limit. If
Safety ventilation alone cannot so control exposure, use NIOSH-approved respirators selected according
to the Selection, Care and Use of Respirators CSA Z94.4-M1993. Maintain airborne nickel levels as
low as possible.
Data Avoid repeated skin contact. Wear suitable gloves. Wash skin thoroughly after handling. Launder
clothing and gloves as needed.
Do not store near acids or reactive substances.
Sheet If spilled, collect spills by wet sweeping or by vacuuming with the vacuum exhaust passing through
a high efficiency particulate arresting (HEPA) filter if the exhaust is discharged into the workplace.
Wear appropriate NIOSH-approved respirators if collection and disposal of spills is likely to cause
the concentration of airborne contaminants to exceed the exposure limits.
Nickel-containing waste is normally collected to recover nickel values. Should waste
disposal be deemed necessary, follow the relevant governmental regulations.
First Aid Measures
If exposure to nickel carbonyl is suspected, seek medical attention immediately. For skin rashes,
seek medical attention. Cleanse wounds thoroughly to remove any particles.
Preparation Information
Prepared by:
INCO LIMITED
Product Stewardship and Quality
Tel. No.: (416) 361-7801
Note:
Inco believes that the information in this Material Safety Data Sheet is accurate. However,
Inco makes no express or implied warranty as to the accuracy of such information and
expressly disclaims any liability resulting from reliance on such information.
Footnotes:
庐 Trademark of the Inco family of companies.
1 Threshold Limit Value of the American Conference of Governmental Industrial Hygienists.
2 Exposure Limits for user operations will depend on the relevant governmental regulations.
3 Describes possible health hazards of the product supplied. If user operations change it to
other chemical forms, whether as end products, intermediates or fugitive emissions, the
possible health hazards of such forms must be determined by the user.
CDN
Updated: 05/06
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