INCO庐 Nickel Flats
Hazardous Ingredients
INCO Hazardous Calculated
PEL1 鈥搈g/m3 TLV2 鈥搈g/m3
C.A.S. No
Ingredients Composition
Nickel (Ni)* 99.97 7440-02-0 1 1.5**
Material *as inhalable fraction
Physical and Chemical Data
Safety Silver-grey, odorless metal spheres of approximately 3/16 in. (5 mm) to 3/4 in. (18 mm) diameter.
Specific Sol. In H20
Ingredient Mol. Wt. m.p.掳C b.p.掳C
Gravity g/100ml
Data Ni 58.71 8.9 1453 2732 0
Physical Hazards
Sheet Material can create slippery conditions if spilled.
Health Hazards
Nickel
LD50 ORAL RAT >9000 mg/kg
Inhalation: The National Toxicology Program has listed nickel as reasonably
anticipated to be a carcinogen based on the production of
injection site tumors. The International Agency for Research on
Cancer (IARC) found there was inadequate evidence that
metallic nickel is carcinogenic to humans but since there was
sufficient evidence that it is carcinogenic to animals, IARC
concluded that metallic nickel is possibly carcinogenic to
humans. In 1997, the ACGIH categorized elemental nickel as:
A5 "Not Suspected as a Human Carcinogen". Epidemiological
studies of workers exposed to nickel powder and to dust and
fume generated in the production of nickel alloys and of stainless
steel have not indicated the presence of a significant respiratory
cancer hazard.
Evidence for the association of nickel compound exposures and
cancer risk comes mainly from workers in now obsolete nickel
refining operations where very high concentrations of airborne
nickel, mostly present as oxidic or sub-sulphidic species at up to
100mg/m3 or more, were associated with excess nasal and lung
cancers.
The inhalation of nickel powder has not resulted in an increased
incidence of malignant lung tumors in rodents. Repeated
intratracheal instillation of nickel powder produced an increased
incidence of malignant lung tumors in rats. Repeated
intratracheal instillation of nickel powder did not produce an
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increased incidence of malignant lung tumors in hamsters when
administered at the maximum tolerated dose. Single
intratracheal instillations of nickel powder in hamsters at doses
near the LD50 produced an increased incidence of
fibrosarcomas, mesotheliomas and rhabdomyosarcomas.
Inhalation of nickel powder at concentrations 15 times the TLV
INCO irritated the respiratory tract in rodents.
Inhalation of nickel may induce asthma. This effect is rare, it has
been reported in welders where exposures to nickel are often
Material mixed with other chemical substances. Persons with a known
history of nickel sensitive asthma should avoid such contact.
Skin Contact: Prolonged and intimate contact with metallic nickel may cause
Safety irritation to the skin and nickel sensitivity which may result in
allergic skin rashes.
One case has been reported of asthma induced by external
exposure to a nickel-containing skin clip and by skin contact with
Data nickel.
Wounds: Nickel metal powder has caused tumors at the site of injection in
rodents. However, studies do not suggest a significant risk for
Sheet humans from nickel-containing prostheses.
Ingestion: The U.S. National Institute for Occupational Safety and Health
(NIOSH) concluded there is no evidence that nickel and its
inorganic compounds are carcinogenic when ingested. The U.S.
Food and Drug Administration has affirmed that nickel is
generally recognized as safe (GRAS) as a direct human food
ingredient.
Preexisting Conditions: Prolonged and intimate skin contact can cause an allergic skin
rash in previously sensitized individuals.
Reproductive Toxicity: Animal experiments indicate that soluble nickel ingestion causes
adverse effects on fetal development at a threshold oral
exposure of 2.2 mg/ Ni/kg/day by pregnant rats. Data are
insufficient to determine if this effect occurs in humans and no
regulatory agency has classified soluble forms of nickel as
reproductive risks for humans.
Precautions for safe storage, handling and use
If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne nickel
below the PEL. If ventilation alone cannot so control exposure, use NIOSH-approved respirators
selected according to OSHA 29 CFR 1910.134. Maintain airborne nickel levels as low as possible.
Avoid repeated skin contact. Wear suitable gloves. Wash skin thoroughly after handling. Launder
clothing and gloves as needed.
Do not store near acids. Like other metals, nickel can react with acids to liberate hydrogen gas
which can form explosive mixtures in air.
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Under special conditions nickel can react with carbon monoxide in reducing atmospheres to form
nickel carbonyl, Ni(CO)4, a toxic gas.
Spill, leak and disposal procedure
Pick up product and replace in original container.
INCO Nickel-containing waste is normally collected to recover nickel values. Should waste disposal be
deemed necessary, follow EPA and local regulations.
Material Emergency and first aid procedures
If exposure to nickel carbonyl is suspected, seek medical attention immediately.
For skin rashes, seek medical attention.
Safety Cleanse wounds thoroughly to remove any particles.
SARA Section 313 Supplier Notification
Data This product contains the following chemical(s) subject to the reporting requirements of Section 313
of the Emergency Planning and Community Right-to-Know Act of 1986 and of 40 CFR 372:
Sheet
Nickel
Refer to the Hazardous Ingredients section of this MSDS for the appropriate CAS numbers and
percent by weight.
INTERNATIONAL NICKEL INC.
Park 80 West, Plaza Two
Saddle Brook, NJ 07663
Chemtrec 24 hr Emergency No. 1-800-424-9300
Note:
Inco believes that the information in this Material Safety Data Sheet is accurate. However,
Inco makes no express or implied warranty as to the accuracy of such information and
expressly disclaims any liability resulting from reliance on such information.
Footnotes:
庐 Trademark of the Inco family of companies.
1 OSHA Permissible Exposure Limit
2 Threshold Limit Value of the American Conference of Governmental Industrial Hygienists.
3 Describes possible health hazards of the product supplied. If user operations change it to
other chemical forms, whether as end products, intermediates or fugitive emissions, the
possible health hazards of such forms must be determined by the user.
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