Inco庐
INCOMOND Nickel Sulphate
1. Identification of the Substance /Preparation and Company
INCOMOND Nickel Sulphate
C.A.S. Number 10101-97-0
EINECS Number 2321049
EEC Label No 232-104-9
Inco INCO Europe Ltd.
5th Floor Windsor House
50 Victoria Street
London SW1H 0XB
Material England
Tel. (44) 20 7931 7733
Emergency Tel. No.24 hr. (44) 01792 842501
Fax: (44)01792 841357
Safety 2. Composition / Information on Ingredients
Typical analysis and information on hazardous substance
Hazardous
Data TRK (1) mg/m3* TLV (2) mg/m3* MEL (3) mg/m3*
Composition
Ingredients
Nickel Sulphate
100% 0.05 0.1 0.1
Hexahydrate
Sheet 3. Hazards Identification
Xn: -Harmful if swallowed: R22.
-May cause sensitisation by inhalation and skin contact: R42/43
-Category 3 carcinogen; possible risk of irreversible effects: R40
Do not breathe dust: S22
Wear suitable protective clothing and gloves: S36/37
Ingestion Solutions of nickel sulphate are harmful and may cause nausea, vomiting
and/or diarrhoea. The LD50 for rats is >200mg/kg body weight (4)
Inhalation `Nickel sulphate aerosols may cause irritation to the upper respiratory
tract and respiratory sensitisation.
Eye Contact Nickel sulphate aerosols may cause irritation to the eyes.
Skin Contact Nickel sulphate may cause irritation to the skin and nickel sensitivity that
may result in allergies, skin rashes and/or asthma.
Environment: 鈥楧angerous for the environment鈥?
N: -Very toxic to aquatic organisms. R50
-May cause long-term adverse effects in the aquatic
environment. R53
4. First Aid Measures
Ingestion Drink large quantities of water. Seek medical attention.
Inhalation No specific first aid required
Skin Wash thoroughly with water. For rashes seek medical advice and
provide safety data sheet if possible.
Eyes Irrigate eyeballs thoroughly with water for at least 10 minutes. If
discomfort persists, seek medical attention.
Wounds Cleanse thoroughly to remove any nickel sulphate particles.
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5. Fire Fighting Measures
Non-flammable. May evolve toxic sulphur containing gases if involved in a fire. Extinguish
surrounding fires with appropriate methods.
6. Accidental Release
Wear waterproof gloves and suitable protective clothing. Do not allow spills to enter watercourses.
Collect spills by sweeping or vacuuming with the vacuum exhaust passing through a high efficiency
particulate arresting (HEPA) filter if exhaust is discharged into the work place. Environmental
precautions 鈥? collect, reclaim and recycle spills. If it is necessary to dispose of spilled material, do so
in accordance with regulations. Liquid spills should be treated with lime and the solids collected.
Inco Wear appropriate nationally approved respirators if collection and disposal of spills is likely to cause
the concentration limits of airborne nickel to exceed prescribed exposure limits.
Material 7. Handling and Storage
Keep in the container supplied and keep container closed when not in use. Nickel sulphate is subject
to the Control of Major Accident Hazards Directives 82/501EEC, 96/82/EC & 98/433/EC (The Seveso
Directive).
Safety
8. Exposure Controls / Personal Protection
For exposure limits see Section 2. Maintain airborne nickel sulphate levels as low as possible. Do
not inhale dust. Ventilation is normally required when handling or using this product to keep airborne
Data nickel below the nationally authorized limits. If ventilation alone cannot control exposure, use
nationally approved respirators.
Avoid eye contact; wear goggles or face shield. Avoid repeated skin contact; wear suitable protective
Sheet
clothing and waterproof gloves. Wash skin thoroughly after handling and before eating, drinking or
smoking. Launder clothing and gloves as needed.
9. Physical and Chemical Properties
Green/white crystals. Slight acidic odour if wet.
pH(5)
Ingredient Mol. Wt.
NiSO4.6H2O 269.9 3.4
Viscosity N/A
Freezing point / freezing range N/A
Boiling point/ boiling range N/A
Flash Point N/A
Autoflammability N/A
Explosive properties N/A
Vapour pressure N/A
1.9 g/cm3 (6)
Bulk density
Solubility cold water >50 g/l
Solubility hot water >340 g/l
Partition coefficient N/A
Other data Decomposes on heating
10. Stability and Reactivity
Stable at ambient temperatures. At high temperatures toxic sulphur containing gases may be
evolved.
11 Toxicological Information
Ingestion
The U.S. National Institute for Occupational Safety and Health (NIOSH) concluded that there is no
evidence that nickel and its inorganic compounds are carcinogenic. The LD50 rat is >200
<5000mg/kg body weight. Nickel sulphate is classified as harmful if swallowed.
Inhalation
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Cancer
Recently completed animal studies using a relevant route of exposure, performed by the National
Toxicology Program in the USA(8), have suggested that soluble nickel compounds are not
carcinogenic themselves. They can cause cell inflammation and cell proliferation. They may act as
enhancers of others compounds such as insoluble nickel compounds. Insoluble nickel compounds
are known to be carcinogenic. There is a lack of evidence of carcinogenicity of soluble nickel in the
absence of other compounds. Human data shows some evidence of carcinogenicity of soluble
compounds but only in the presence of relatively high doses of insoluble nickel compounds(9). There
is no evidence from animal studies that nickel compounds are carcinogenic by relevant routes of
exposure.
Inco ACGIH has re-evaluated the data regarding the carcinogenicity of nickel and nickel compounds and
has decided that nickel sulphate is not classifiable as a human carcinogen, Class A4(2). Prior to 1998
ACGIH(2) categorised only 鈥渘ickel sulphide roasting fume and dust as an A1 carcinogen (confirmed
human carcinogen). A re-examination in 1998 resulted in the following:
Material A1 (鈥淐onfirmed human carcinogen鈥?) 鈥? Insoluble nickel compounds and
nickel subsulfide
A4 (鈥淣ot classifiable as a human carcinogen鈥?) 鈥? Soluble
A5 (鈥淣ot suspected as a human carcinogen鈥?) 鈥? Elemental Nickel
Safety A risk assessment on soluble nickel(15) showed that 鈥?...epidemiological data suggest a role for soluble
nickel in the development of cancer... Evaluation of the role of soluble nickel is complicated by the
potentially confounding effects of smoking, a known cause of lung cancer, co-exposure to insoluble
forms of nickel as a result of the processes and the work environment, and, in some time periods,
Data exposures to other chemicals in the workplace... Consequently, the role of soluble nickel alone in
carcinogenicity to humans cannot be determined from the epidemiological studies.鈥?
Sensitisation
Sheet Nickel sulphate is a potent skin and respiratory sensitiser(11). Cases of asthma have been reported in
nickel plating workers where exposures have been mainly to soluble nickel salts.
Skin Contact
Repeated contact with nickel sulphate may cause nickel sensitivity resulting in skin allergy and/or
asthma(12).
Pre-existing Conditions
Sensitised individuals may experience an allergic skin rash and/or asthma. Persons with a known
history of nickel dermatitis or asthma should avoid contact with nickel sulphate. Persons with a
history of eczema should be warned of the risks on contact with nickel salts.
Mutagenicity/Reproductive Toxicity
There are no available human or animal studies data suitable for evaluation.
12. Ecological Information
Nickel sulphate is very toxic to green algae and to water fleas on ecotoxicity testing.
13. Disposal Information
Nickel containing material is normally collected to recover nickel values. Follow regulations if disposal
is deemed necessary. Take special note of the ecological classification.
14. Transport Information
International Maritime Dangerous Good Code Not regulated.
International Civil Aviation Organisation Technical
Not regulated.
Instructions for the Carriage of Dangerous Goods by Air
Regulated as 鈥?3077 Environmentally Hazardous
European Agreement Concerning the International
Substance, solid, n.o.s., nickel sulphate, 9,鈥︹?︹??
Carriage of Dangerous Goods by Road and/or Rail
Regulated as an 鈥淥ther regulated substance, solid,
U.S. Dept. of Transportation Regulations
n.o.s., (nickel sulfate), class 9, NA3077鈥? in quantities
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of 45.4 kg/package or more.
Regulated as an environmentally dangerous good,
Canadian Transportation of Dangerous Goods Act 鈥淣ickel sulphate, class 9.2, NA9141鈥? in quantities of
230 kg/package or more.
15. Regulatory Information
Nickel sulphate is classified as a Category 3 carcinogen, "a substance which causes concern for man
owing to the possible carcinogenic effect but in respect of which the available information is not adequate
for making a satisfactory assessment", by the EU in Directive 67/548/EEC (Classification, Packaging and
Labelling Directive) and in the UK in the Chemicals Hazard Information and Packaging for Supply
Inco Regulations (14) and, as such, it requires to be labelled with the following risk and safety phrases.
鈥淗armful鈥? symbol
Xn: -Harmful if swallowed. R22
Material -May cause sensitisation by inhalation and skin contact. R42/43
-Category 3 carcinogen. Harmful, possible risk of irreversible effects. R40
Do not breathe dust. S22
Wear suitable protective clothing and gloves. S36/37
Safety Nickel sulphate is classified as 鈥楧angerous to the Environment鈥? by EU Directive 67/548/EEC
(Classification, Packaging and Labelling Directive) and the UK Chemicals Hazard Information and
Packaging for Supply Regulations(14). Labelling information is:
-Toxic to aquatic organisms. R51
Data -May cause adverse long term effects in the aquatic environment. R53
16. Other Information
Sheet Medical staff should note that this data sheet has been lodged with the following Poisons Information
Centre: The Welsh National Poisons Unit,
Ward West 5,
Llandough Hospital,
Penarth, Cardiff.
CF6 1XX Tel. No. 01222709901
17. Notes and Bibliography
INCO is the Trademark of the INCO family of companies.
Disclaimer: INCO believes the information in this Material Safety Data Sheet is accurate. However, there is no
implied or express warranty as to its accuracy and INCO disclaims any liability resulting from reliance on the accuracy
of the information.
1 T.R.K. is Technische Richtkonzentrationen as defined in the Deutsche Forschungsgemeinschaft, List of MAK & BAT
values. 1999
2 Threshold Limit Values of the American Conference of Governmental Industrial Hygienists. 1999
3 Maximum Exposure Limit of the Health and Safety Executive in the U.K. in EH40 1999.
4 Mastromatteo E. Nickel. Am. Ind. Hyg. Assoc. 47(10) 589-601. 1986.
5 pH of a 40% solution
6 Bulk density of INCO material.
7 Describes possible health hazards of the nickel product supplied. If user operations change it to other hemical forms,
whether as end products, intermediates or fugitive emissions, the user must determine the possible health hazards of
such forms.
8 National Toxicology Program NTP Draft Report on the toxicology and carcinogenicity of nickel sulphate in F344/N rats
by inhalation. Springfield VA 1994. Publication No. 94-3370
9 Doll R. Report of the International Committee on Nickel Carcinogenesis in Man. Scand. J. of Work Environ. and Health.
1990.
10 NiPERA/NiDI. Safe use of nickel in the work place guide. 1998
11 Fairhurst S., Illing H.P.A. The toxicity of nickel and its inorganic compounds.
Health and Safety Executive. HMSO. 1987.
12 Fisher J.R., Rosenblum G.A., Thomson B.D. Asthma induced by nickel. JAMA, 248 1065-1066. 1982
13 Approved guide for the classification and labelling of substances and preparations dangerous for supply. Health &
Safety Executive. HMSO 1999.
14 Toxicology Excellence for Risk Assessment (TERA), 鈥淭oxicological Review of Soluble Nickel Salts鈥?, Report prepared
for US EPA, Health Canada and the Metal Finishing Association of Southern California, March 1999
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