Inco庐 Nano Nickel Powder
Hazardous Ingredients
PEL1 鈥?
Hazardous Calculated Percent TLV2 鈥?
C.A.S. No
mg/m3 mg/m3
Ingredients Composition
Inco Nickel (Ni)* 40-100% 7440-02-0 40-100% 1 1.5*
*as inhalable fraction
Material Physical and Chemical Data
Grey, odourless, powder with an average particle size of 5 to 20 nanometers.
Safety Specific Sol. In H20
Ingredient Mol. Wt. m.p.掳C b.p.掳C
Gravity g/100ml
Ni 58.71 8.9 1453 2732 0
Data Physical Hazards
Metal powders heat treated in reducing atmospheres may become spontaneously combustible.
Sheet Fire Flammable hazard. Any very finely divided particles (ultra-fine
powder) may burn in air when exposed to heat or flame.
Pyrophoric/
Autoignition Yes
Explosion This material, like most materials in powder form, is capable of
creating a dust explosion.
Health Hazards
Acute toxicity:
Oral LD 50 rat Inhalation LC Dermal LD 50 rat
Ingredient Formula
(mg/kg) (6) rat (mg / 录 h) (mg/kg)
Nickel Metal Ni >9000 Unknown Unknown
Nickel
LD50 ORAL RAT >9000 mg/kg
Inhalation May be harmful if inhaled. Material may be irritating to mucous membranes
and upper respiratory tract. May cause asthmatic attacks due to allergic
sensitization of the reparatory tract. Inhalation of fumes may cause metal
fume fever, which is characterized by flu-like symptoms with metallic taste,
fever, chills, cough, weakness, chest pain, muscle pain and increased white
blood cell count. May cause loss of smell.
The National Toxicology Program has listed nickel as reasonably
anticipated to be a carcinogen based on the production of injection site
tumors. The International Agency for Research on Cancer (IARC) found
there was inadequate evidence that metallic nickel is carcinogenic to
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Nano Nickel Powder
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humans but since there was sufficient evidence that it is carcinogenic to
animals, IARC concluded that metallic nickel is possibly carcinogenic to
humans. In 1997, the ACGIH categorized elemental nickel as: A5 "Not
Suspected as a Human Carcinogen". Epidemiological studies of workers
exposed to nickel powder and to dust and fume generated in the production
of nickel alloys and of stainless steel have not indicated the presence of a
significant respiratory cancer hazard.
Evidence for the association of nickel compound exposures and cancer risk
comes mainly from workers in now obsolete nickel refining operations
where very high concentrations of airborne nickel, mostly present as oxidic
Inco or sub-sulphidic species at up to 100mg/m3 or more, were associated with
excess nasal and lung cancers.
Material
The inhalation of nickel powder has not resulted in an increased incidence
of malignant lung tumors in rodents. Repeated intratracheal instillation of
nickel powder produced an increased incidence of malignant lung tumors in
rats. Repeated intratracheal instillation of nickel powder did not produce an
increased incidence of malignant lung tumors in hamsters when
Safety administered at the maximum tolerated dose. Single intratracheal
instillations of nickel powder in hamsters at doses near the LD50 produced
an increased incidence of fibro sarcomas, mesotheliomas and
rhabdomyosarcomas.
Data Inhalation of nickel powder at concentrations 15 times the TLV irritated the
respiratory tract in rodents.
Inhalation of nickel may induce asthma. This effect is rare, it has been
Sheet reported in welders where exposures to nickel are often mixed with other
chemical substances. Persons with a known history of nickel sensitive
asthma should avoid such contact.
Skin Contact Prolonged and intimate contact with metallic nickel may cause irritation to
the skin and nickel sensitivity, which may result in allergic skin rashes.
One case has been reported of asthma induced by external exposure to a
nickel-containing skin clip and by skin contact with nickel.
Wounds Nickel metal powder has caused tumors at the site of injection in rodents.
However, studies do not suggest a significant risk for humans from nickel-
containing prostheses.
Ingestion May be harmful if swallowed. May cause gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause tremors and convulsions.
Ingestion of large amounts may cause gastroenteritis.
The U.S. National Institute for Occupational Safety and Health (NIOSH)
concluded there is no evidence that nickel and its inorganic compounds are
carcinogenic when ingested. The U.S. Food and Drug Administration has
affirmed that nickel is generally recognized as safe (GRAS) as a direct
human food ingredient.
Pre-existing Prolonged and intimate skin contact can cause an allergic skin rash in
Conditions previously sensitized individuals.
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Reproductive Animal experiments indicate that soluble nickel ingestion causes adverse
Toxicity effects on fetal development at a threshold oral exposure of 2.2 mg/
Ni/kg/day by pregnant rats. Data are insufficient to determine if this
effect occurs in humans and no regulatory agency has classified soluble
forms of nickel as reproductive risks for humans.
Precautions for safe storage, handling and use
Do not inhale powder. . Keep in a tightly closed container, away from heat, sparks, electrostatic
discharge and open flame. Store in a cool, dry place. Protect from physical damage. Handle and
store under nitrogen and avoid exposure to air and moisture. Isolate from incompatible substances.
Containers of this material may be hazardous when empty since they retain product residues (dust,
Inco solids); observe all warnings and precautions listed for the product.
Ventilation is normally required when handling or using this product to keep exposure to airborne
nickel below the exposure limit. If ventilation alone cannot so control exposure, use NIOSH-approved
Material respirators selected according to OSHA 29 CFR 1910.134. Maintain airborne nickel levels as low as
possible.
Avoid contact with skin, eyes and clothing. Avoid prolonged or repeated exposure. Wear suitable
Safety gloves. Wash skin thoroughly after handling. Launder clothing and gloves as needed.
Do not store near acids or reactive substances. Like other metals, nickel can react with acids to
liberate hydrogen gas, which can form explosive mixtures in air. Like other metal powders, nickel
Data powder can react explosively or incandescently with substances such as ammonium nitrate, per
chlorates, phosphorous, selenium, sulphur, etc.
Under special conditions nickel can react with carbon monoxide in reducing atmospheres to form
nickel carbonyl, Ni(CO)4, a toxic gas.
Sheet Spill, leak and disposal procedure
Collect spills by wet sweeping or by vacuuming with the vacuum exhaust passing through a high
efficiency particulate arresting (HEPA) filter if the exhaust is discharged into the workplace.
Wear appropriate NIOSH-approved respirators if collection and disposal of spills is likely to cause the
concentration of airborne contaminants to exceed the exposure limits.
Nickel-containing waste is normally collected to recover nickel values. Should waste disposal be
deemed necessary follow EPA and local regulations?
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the
material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and
scrubber. Processing, use our contamination of this product may change the waste management
options. Observe all federal, state, and local environmental regulations.
Emergency and first aid procedures
If exposure to nickel carbonyl is suspected, seek medical attention immediately. For skin rashes, seek
medical attention. Cleanse wounds thoroughly to remove any particles.
Ingestion Do not induce vomiting. Wash out mouth with water and give 2-4 cups of
milk or water. Never give anything by mouth to an unconscious person.
Seek medical attention immediately.
Stability and Reactivity
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Hazardous Decomposition Products
Nickel oxides, carbon monoxide, carbon dioxide, toxic and highly flammable nickel carbonyl.
Conditions to Avoid
Ignition sources, excess heat, dust generation, incompatibles and exposure to moisture
Transport Information
US DOT Canada TDG
Metal Powder, Flammable, NOS (Nickel) Metal Powder, Flammable, NOS (Nickel)
Shipping Name
Inco 4.1 4.1
Hazard Class
UN3089 UN3089
UN Number
Material II II
Packing Group
SARA Section 313 Supplier Notification
Safety This product contains the following chemical(s) subject to the reporting requirements of Section 313
of the Emergency Planning and Community Right-to-Know Act of 1986 and of 40 CFR 372:
Nickel
Data Refer to the Hazardous Ingredients section of this MSDS for the appropriate CAS numbers and
percent by weight.
INTERNATIONAL NICKEL INC.
Park 80 West, Plaza Two
Sheet Saddle Brook, NJ 07663
Chemtrec 24 Hour Emergency No. 1-800-424-9300
Note:
Inco believes that the information in this Material Safety Data Sheet is accurate. However, Inco
makes no express or implied warranty as to the accuracy of such information and expressly
disclaims any liability resulting from reliance on such information.
Footnotes:
庐 Trademark of the Inco family of companies.
1 OSHA Permissible Exposure Limit
2 Threshold Limit Value of the American Conference of Governmental Industrial Hygienists.
3 Describes possible health hazards of the product supplied. If user operations change it to
other chemical forms, whether as end products, intermediates or fugitive emissions, the user
must determine the possible health hazards of such forms.
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Nano Nickel Powder
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