Inco庐 Nickel Oxide Sinter 75
Product Information
INCO Nickel Oxide Sinter 75 (Class D)
INCO LIMITED
145 King Street West
Suite 1500
Toronto, ON
Inco M5H 4B7
(416) 361-7801
INCO Nickel Oxide Sinter 75 is used in the production of stainless and alloy steels.
Material Hazardous Ingredients
Calculated
TLV1,2 鈥搈g/m3
Hazardous Ingredients C.A.S. No Oral LD50 -rat
Composition
Safety Nickel Oxide (NiO)* 96.7 1313-99-1 >5000 mg/kg 0.2* as Ni
Cobaltous Oxide (CoO) 1.5 1307-96-6 202mg/kg 0.05as Co
* As inhalable fraction
Data Physical Data
Dark grey, odorless granules averaging 0.2 to 0.4 mm in diameter.
Specific Sol. In H20
Ingredient Mol. Wt. m.p.掳C
Sheet Gravity g/100ml
Nickel Oxide 74.71 6.67 1990 0
Cobaltus Oxide 74.93 6.45 1935 0
Fire or Explosion Hazard
Not applicable.
Reactivity Data
Not applicable.
Toxicological Properties3
Nickel Oxide
Inhalation: Evidence for the association of nickel compound exposures and
cancer risk comes mainly from workers in now obsolete nickel
refining operations. The studies of nickel workers suggest that
respiratory cancer risks are primarily related to exposure to
relatively insoluble forms of nickel notably sulphidic and oxidic
nickel at concentrations greater than 10mg/m3. Toxic respiratory
effects in animals may be caused by reduced particle clearance
capacity.
The International Agency for Research on Cancer (IARC) (ref. 4) in
1990 and the U.S. Tenth Report on Carcinogens (ref. 5) in 2002
concluded there was sufficient evidence that nickel compounds
are carcinogenic to humans. The Report of the International
Committee on Nickel Carcinogenesis in Man reported that
workers who have been primarily exposed to nickel oxide
showed some evidence of increased lung cancer.
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The European Union Commission in 1991 classified nickel
oxide and work involving exposure to dusts, fumes and
sprays produced during the roasting and electrorefining of
nickel-copper mattes as carcinogenic processes.
ACGIH has re-evaluated the data regarding the carcinogenicity of
nickel and nickel compounds and has classified nickel oxide as a
confirmed human carcinogen, Class A1.
There is some evidence that the inhalation of nickel oxide has
Inco resulted in an increased incidence of malignant lung
tumors in rats. Inhalation of nickel oxide at concentrations
50 times the TLV, produced pneumoconiosis in hamsters.
Material Repeated intratracheal instillation of nickel oxide produced
an increased incidence of malignant lung tumors in rats.
Wounds: Nickel oxide has caused tumors at the site of injection in rodents.
Safety Ingestion: The U.S. National Institute for Occupational Safety and Health
(NIOSH) concluded there is no evidence that nickel and its
inorganic compounds are carcinogenic when ingested. The
U.S. Food and Drug Administration has affirmed that nickel
Data is generally recognized as safe (GRAS) as a direct human
food ingredient.
Preexisting Conditions: Prolonged and intimate skin contact can cause an allergic skin
Sheet rash in previously sensitized individuals.
Reproductive Toxicity: There is no evidence of mutagenesis. Animal experiments
indicate that soluble nickel ingestion causes adverse effects on
fetal development at a threshold oral exposure of 2.2
mg/Ni/kg/day by pregnant rats. Data are insufficient to
determine if this effect occurs in humans and no regulatory
agency has classified soluble forms of nickel as
reproductive risks for humans.
Cobaltous Oxide CoO
LD50 ORAL RAT: 202 mg/kg
Inhalation: Causes irritation to the respiratory tract, symptoms may include
coughing, shortness of breath, and nausea. Respiratory
hypersensitivity, asthma may appear. Inhalation of cobalt dust
and fumes is associated with an increased incidence of lung
disease.
Ingestion Causes abdominal pain, nausea, vomiting, flushing of the face
and ears, mild hypotension, rash, and ringing in the ears. May
have cumulative toxic action where elimination cannot keep pace
with absorption. Large amounts depress erythrocyte production.
Skin Contact: May cause dermatitis. Causes irritation to skin. Symptoms
include redness, itching, and pain.
Eye Contact: Causes irritation, redness, and pain.
Chronic Exposure: Repeated oral administration may produce goiter and reduced
thyroid activity. Prolonged or repeated skin exposure may cause
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dermatitis. Chronic exposure associated with kidney, heart and
lung damage.
Pre-existing Conditions: Persons with pre-existing skin disorders or eye problems, or
impaired liver; kidney or respiratory function may be more
susceptible to the effects of the substance. Persons with
allergies or sensitivity to cobalt may also be more susceptible to
the effects of the substance.
Preventative Measures
Do not inhale dust. Keep container closed when not in use. If user operations generate dust, fume
Inco or mist, use ventilation to keep exposure to airborne contaminants below the exposure limits. If
ventilation alone cannot so control exposure, use NIOSH-approved respirators selected according
to the Selection, Care and Use of Respirators CSA Z94.4-M1993. Maintain the airborne
concentration of nickel oxide as low as possible.
Material If spilled, collect spills by wet sweeping or by vacuuming with the vacuum exhaust passing through
a high efficiency particulate arresting (HEPA) filter if the exhaust is discharged into the workplace.
Wear appropriate NIOSH-approved respirators if collection and disposal of spills is likely to cause
Safety the concentration of airborne contaminants to exceed the exposure limits.
Nickel-containing waste is normally collected to recover nickel values. Should waste disposal be
deemed necessary, follow the relevant governmental regulations.
Data First Aid Measures
Cleanse wounds thoroughly to remove any particles.
Preparation Information
Sheet Prepared by:
INCO LIMITED
Product Stewardship
Tel. No.: (416) 361-7801
MSDS available online at www.inco.com
Note:
Inco believes that the information in this Material Safety Data Sheet is accurate. However,
Inco makes no express or implied warranty as to the accuracy of such information and
expressly disclaims any liability resulting from reliance on such information.
Footnotes:
庐 Trademark of the Inco family of companies.
1 Threshold Limit Value of the American Conference of Governmental Industrial Hygienists.
2 Exposure Limits for user operations will depend on the relevant governmental regulations.
3 Describes possible health hazards of the product supplied. If user operations change it to other chemical forms,
whether as end products, intermediates or fugitive emissions, the possible health hazards of such forms must be
determined by the user.
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