Inco庐 Nickel Powder Type 123
Hazardous Ingredients
Hazardous Calculated
PEL1 鈥搈g/m3 TLV2 鈥搈g/m3
Inco C.A.S. No
Ingredients Composition
Nickel (Ni)* 99.1 7440-02-0 1 1.5*
Material *as inhalable fraction
Physical and Chemical Data
Safety Grey, odourless, powder with an average particle size of 3 to 7 microns.
Specific Sol. In H20
Ingredient Mol. Wt. m.p.掳C b.p.掳C
Gravity g/100ml
Data Ni 58.71 8.9 1453 2732 0
Physical Hazards
Sheet Metal powders heat treated in reducing atmospheres may become spontaneously combustible.
Health Hazards
Nickel
LD50 ORAL RAT >9000 mg/kg
Inhalation: The National Toxicology Program has listed nickel as reasonably
anticipated to be a carcinogen based on the production of injection site
tumors. The International Agency for Research on Cancer (IARC) found
there was inadequate evidence that metallic nickel is carcinogenic to
humans but since there was sufficient evidence that it is carcinogenic to
animals, IARC concluded that metallic nickel is possibly carcinogenic to
humans. In 1997, the ACGIH categorized elemental nickel as: A5 "Not
Suspected as a Human Carcinogen". Epidemiological studies of workers
exposed to nickel powder and to dust and fume generated in the
production of nickel alloys and of stainless steel have not indicated the
presence of a significant respiratory cancer hazard.
Evidence for the association of nickel compound exposures and cancer
risk comes mainly from workers in now obsolete nickel refining
operations where very high concentrations of airborne nickel, mostly
present as oxidic or sub-sulphidic species at up to 100mg/m3 or more,
were associated with excess nasal and lung cancers.
The inhalation of nickel powder has not resulted in an increased
incidence of malignant lung tumors in rodents. Repeated intratracheal
instillation of nickel powder produced an increased incidence of
malignant lung tumors in rats. Repeated intratracheal instillation of nickel
powder did not produce an increased incidence of malignant lung tumors
in hamsters when administered at the maximum tolerated dose. Single
intratracheal instillations of nickel powder in hamsters at doses near the
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LD50 produced an increased incidence of fibrosarcomas, mesotheliomas
and rhabdomyosarcomas.
Inhalation of nickel powder at concentrations 15 times the TLV irritated
the respiratory tract in rodents.
Inhalation of nickel may induce asthma. This effect is rare, it has been
inco reported in welders where exposures to nickel are often mixed with other
chemical substances. Persons with a known history of nickel sensitive
asthma should avoid such contact.
Material Skin Contact: Prolonged and intimate contact with metallic nickel may cause irritation
to the skin and nickel sensitivity, which may result in allergic skin rashes.
One case has been reported of asthma induced by external exposure to
Safety a nickel-containing skin clip and by skin contact with nickel.
Wounds: Nickel metal powder has caused tumors at the site of injection in rodents.
However, studies do not suggest a significant risk for humans from
nickel-containing prostheses.
Data Ingestion: The U.S. National Institute for Occupational Safety and Health (NIOSH)
concluded there is no evidence that nickel and its inorganic compounds
are carcinogenic when ingested. The U.S. Food and Drug
Sheet Administration has affirmed that nickel is generally recognized as safe
(GRAS) as a direct human food ingredient.
Preexisting Conditions: Prolonged and intimate skin contact can cause an allergic skin rash in
previously sensitized individuals.
Reproductive Toxicity: Animal experiments indicate that soluble nickel ingestion causes adverse
effects on fetal development at a threshold oral exposure of 2.2 mg/
Ni/kg/day by pregnant rats. Data are insufficient to determine if this effect
occurs in humans and no regulatory agency has classified soluble forms
of nickel as reproductive risks for humans.
California Proposition 65
a NSRL (No Significant Risk Level) has not been adopted for nickel
hydroxide as a carcinogen
a MADL (Maximum Allowable Dose Level) has not been adopted for
nickel hydroxide as a chemical causing reproductive toxicity
鈥淣ickel and certain nickel compounds鈥? is on the Second Priority List for
NSRL Development
Nickel hydroxide is not on any Priority List for MADL Development
Precautions for safe storage, handling and use
Do not inhale powder. Keep container closed when not in use. Ventilation is normally required when
handling or using this product to keep exposure to airborne nickel below the exposure limit. If
ventilation alone cannot so control exposure, use NIOSH-approved respirators selected according
to OSHA 29 CFR 1910.134. Maintain airborne nickel levels as low as possible.
Avoid repeated skin contact. Wear suitable gloves. Wash skin thoroughly after handling. Launder
clothing and gloves as needed.
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Do not store near acids or reactive substances. Like other metals, nickel can react with acids to
liberate hydrogen gas which can form explosive mixtures in air. Like other metal powders, nickel
powder can react explosively or incandescently with substances such as ammonium nitrate,
perchlorates, phosphorous, selenium, sulfur, etc.
Under special conditions nickel can react with carbon monoxide in reducing atmospheres to form
nickel carbonyl, Ni(CO)4, a toxic gas.
inco
Spill, leak and disposal procedure
Material Collect spills by wet sweeping or by vacuuming with the vacuum exhaust passing through a high
efficiency particulate arresting (HEPA) filter if the exhaust is discharged into the workplace.
Wear appropriate NIOSH-approved respirators if collection and disposal of spills is likely to cause
Safety the concentration of airborne contaminants to exceed the exposure limits.
Nickel-containing waste is normally collected to recover nickel values. Should waste disposal be
deemed necessary follow EPA and local regulations.
Data Emergency and first aid procedures
If exposure to nickel carbonyl is suspected, seek medical attention immediately. For skin rashes,
seek medical attention. Cleanse wounds thoroughly to remove any particles.
Sheet
SARA Section 313 Supplier Notification
This product contains the following chemical(s) subject to the reporting requirements of Section 313
of the Emergency Planning and Community Right-to-Know Act of 1986 and of 40 CFR 372:
Nickel
Refer to the Hazardous Ingredients section of this MSDS for the appropriate CAS numbers and
percent by weight.
INTERNATIONAL NICKEL INC.
Park 80 West, Plaza Two
Saddle Brook, NJ 07663
Chemtrec 24 Hour Emergency No. 1-800-424-9300
Note:
Inco believes that the information in this Material Safety Data Sheet is accurate. However,
Inco makes no express or implied warranty as to the accuracy of such information and
expressly disclaims any liability resulting from reliance on such information.
Footnotes:
庐 Trademark of the Inco family of companies.
1 OSHA Permissible Exposure Limit
2 Threshold Limit Value of the American Conference of Governmental Industrial Hygienists.
3 Describes possible health hazards of the product supplied. If user operations change it to
other chemical forms, whether as end products, intermediates or fugitive emissions, the
possible health hazards of such forms must be determined by the user.
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