MATERIAL SAFETY DATA SHEET
IDENTIFICATION
Stratagene Date of last update: 6/06/2007
11011 N. Torrey Pines Rd. Phone #: 800-894-1304
La Jolla, CA 92037 Fax #: 858-535-0071
Part # : 1045-13 Guanidine Thiocyanate
CAS # : 593-84-0
HAZARDOUS COMPONENTS
Chemical Name & Synonyms: Guanidine Thiocyanate (Guanidine Monothiocynate, Guanidium
Thiocyanate, Guanidine Isothiocyanate (GIT), USAF EK-705)
OSHA PEL Limits: N/A
ACGIH TLV: N/A
Other Limits Recommended: N/A
KIT Guanidine Thiocyanate -containing %
component
200343 Micro RNA Isolation Kit 200344-16 Denaturing solution �50%
200344 Micro RNA Isolation Kit 200344-16 Denaturing solution �50%
200345 RNA Isolation Kit 200345-14 Denaturing solution �50%
200346 RNA Isolation Kit 200345-14 Denaturing solution �50%
200347 Messenger RNA Isolation Kit 200347-18 Denaturing solution �50%
211186 PCR-Script® Amp Cloning Kit 400771-14 DNA-binding solution �50%
211188 PCR-Script® Amp Cloning Kit 400771-14 DNA-binding solution �50%
211189 PCR-Script® Amp Cloning Kit 400771-13 DNA-binding solution �50%
211190 PCR-Script® Amp Cloning Kit 400771-14 DNA-binding solution �50%
211192 PCR-Script® Cam Cloning Kit 400771-14 DNA-binding solution �50%
211199 pCMV-Script® PCR Cloning Cloning Kit 400771-14 DNA-binding solution �50%
252009 FairPlay® III Microarray Labeling Kit 400771-14 DNA-binding solution �50%
252012 FairPlay® III Microarray Labeling Kit 400771-13 DNA-binding solution �50%
302106 MycoSensor� QPCR Assay Kit 400771-13 DNA-binding solution �50%
400721 StrataPrep® EF Plasmid Midiprep Kit 400721-16 Solution 4 �50%
400722 StrataPrep® EF Plasmid Midiprep Kit 400722-16 Solution 4 �50%
400723 Endonuclease A Removal Buffer 400723-13 Endonuclease A Removal �50%
Buffer
400753 Absolutely RNA® NanoPrep Kit 400711-13 Lysis buffer �50%
400711-14 High-salt wash buffer �50%
400761 StrataPrep® Plasmid Miniprep Kit 400761-15 Solution 3 �50%
400761-17 Nuclease Removal Buffer �50%
400763 StrataPrep® Plasmid Miniprep Kit 400763-15 Solution 3 �50%
400763-17 Nuclease Removal Buffer �50%
400766 StrataPrep® DNA Gel Extraction Kit 400766-13 DNA extraction buffer �50%
400768 StrataPrep® DNA Gel Extraction Kit 400768-13 DNA extraction buffer �50%
400771 StrataPrep® PCR Purification Kit 400771-13 DNA-binding solution �50%
400773 StrataPrep® PCR Purification Kit 400773-13 DNA-binding solution �50%
400774 StrataPrep® PCR Purification Kit 900775-13 DNA-binding solution �50%
400775 StrataPrep® 96 PCR Purification Kit 400773-13 DNA-binding solution �50%
400776 StrataPrep® 96 PCR Purification Kit 400776-13 DNA-binding solution �50%
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400792 RNA Lysis Buffer 400791-13 Lysis buffer �50%
400793 Absolutely RNA® 96 Micro Prep Kit 400790-13 Lysis buffer �50%
400790-14 High-salt wash buffer �50%
400794 Absolutely RNA® 96 Micro Prep Kit 400791-13 Lysis Buffer �50%
400791-14 High Salt Wash Buffer �50%
400800 Absolutely RNA® RT-PCR Miniprep Kit 400711-13 Lysis buffer �50%
400711-14 High-salt wash buffer �50%
400805 Absolutely RNA® Micro Prep Kit 400711-13 Lysis buffer �50%
400711-14 High-salt wash buffer �50%
400809, 400811 Absolutely RNA® FFPE Kit 400809-13 RNA Binding Buffer �50%
400711-14 High Salt Wash Buffer �50%
400813, 400815 miRACLE� miRNA Isolation 400813-13 miRACLE� miRNA Lysis �50%
Kit Buffer �50%
900775 StrataPrep® PCR Purification Kit 900775-13 DNA-binding solution �50%
929752 Absolutely RNA® Micro Prep Kit 400791-13 Lysis buffer �50%
400791-14 High-salt wash buffer �50%
TOXICITY DATA
Irritation Data:
No data available.
Toxicity Data:
IPR-MUS LD50: 300 mg/kg
Reviews, Standards, and Regulations:
EPA TSCA Chemical Inventory, June 1990
Target Organ Data:
No data available.
Health Hazard Data
Acute Effects:
Irritation of the eyes, skin, mucous membranes, and upper respiratory tract.
Chronic Effects:
No data available.
First Aid:
Eyes: Immediately flush with copious amounts of water for at least 15 minutes.
Skin: Wash off with soap and water. Rinse area with copious water for 15 minutes.
Inhalation: Remove to fresh air. If breathing difficult, give oxygen. If not breathing, give
artificial respiration.
Ingestion: If conscious wash out mouth with large amounts of water.
In all cases contact a physician.
To the best of our knowledge, the chemical, physical, and toxicological properties of this
compound have not been thoroughly investigated.
RTECS No. XL1225000
RTECS Name: Thiocyanic Acid, compounded with guanidine (1:1)
Physical Data
Melting Point: 120-122°C Solubility in water: Soluble
Appearance and Odor: Odorless white powder.
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Fire and Explosion Hazard Data
Extinguishing Media:
Water spray, carbon dioxide, dry chemical powder, alcohol or polymer foam.
Special Firefighting Procedures:
Wear self-contained breathing apparatus and protective clothing to prevent contact with eyes and
skin.
Unusual Fire and Explosion Hazards:
Emits toxic fumes under fire conditions.
Reactivity Data
Incompatibilities:
All strong acids.
Strong oxidizing agents.
Hazardous Combustion or Decomposition Products:
Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides.
Stability:
Avoid heat.
Stable under normal temperatures and pressures.
Hazardous polymerization:
Will not occur.
Spill or Leak Procedures
Steps to be taken if Material is Released or Spilled:
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Avoid raising
dust. Sweep up and place in a sealed container and hold for waste disposal. Ventilate area and
wash spill following material pickup.
Isolate hazard area and deny entry to unnecessary or unprotected personnel.
Waste Disposal Method:
Dissolve or mix the chemical with a combustible solvent and burn in a chemical incinerator
equipped with an afterburner and scrubber. Dispose of in accordance with all federal, state and
local regulations.
Precautions to be Taken in Handling and Storage
Label Precautionary Statements: No data available.
Irritant.
Avoid contact with skin, eyes and clothing.
Avoid breathing dust.
Avoid contact with acid.
Store in a cool dry place apart from incompatible materials. Keep tightly closed.
Use NIOSH/MSHA approved dust/mist respirators.
Mechanical exhaust is required.
Eye wash station and safety shower facilities should be available.
Wash hands thoroughly after handling.
Wash contaminated clothing before reuse.
Wear heavy rubber gloves, chemical safety goggles, and protective clothing.
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The above information is believed to be correct but does not purport to be all inclusive and shall be used
only as a guide. Stratagene shall not be held liable for any damage resulting from handling or from contact
with the above product.
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