MATERIAL SAFETY DATA SHEET
IDENTIFICATION
Stratagene Date of last update: 6/2/2004
11011 N. Torrey Pines Rd. Phone #: 800-894-1304
La Jolla, CA 92037 Fax #: 858-535-0071
Catalog # : 1071-13 Product Name: DMSO
CAS # : 67-68-5
HAZARDOUS COMPONENTS
Chemical Name & Synonyms: Dimethyl Sulfoxide* A 10846* Deltan* Demeso* Demasorb, Demavet*
Demsodrox, Dermasorb* Dimethyl Sulfoxide* Dimethyl Sulphoxide* Dimexide* Dipirartril-Tropico*
DMS-70* DMS-90* DMSO* Dolicur* Domoso* Dromisol* Durasorb* Gamasol 90* Hyadur* Infiltrina*
M 176* Methane, Sulfinylbis-* Methylsulfinylmethane* NSC-763* RIMSO-50* Somipront* SQ 9453*
Sulfinylbis (Methane)* Syntexan* Topsym*
OSHA PEL Limits: N/A
ACGIH TLV: N/A
Other Limits Recommended: N/A
KIT DMSO-containing component %
200124-41 TKX1 Competent Cells <10%
200124 Epicurian Coli TKX1 Competent
Cells
200129-41 XL1-Red Competent Cells <10%
200129 Epicurian Coli XL1-Red
200236-41 XL1-Blue Competent Cells
Competent Cells
200130-41 XL1-Blue Subcloning <10%
200130 Epicurian Coli XL1-Blue
Competent Cells
Subcloning-Grade Competent
Cells
200131-41 BL-21 (DE3) Cells <10%
200131 Epicurian Coli BL21(DE3)
Competent Cells
200132-41 BL-21 (DE3) pLysS Cells <10%
200132 Epicurian Coli BL21(DE3)pLysS
Competent Cells
200133-41 BL-21 Competent Cells <10%
200133 Epicurian Coli BL21 Competent
Cells
200134-41 TKB1 Competent Cells <10%
200134 Epicurian Coli TKB1 Competent
Cells
200150-41 Ultra Comp XLII-Blue <10%
200150 Epicurian Coli XL2-Blue
Ultracompetent Cells
<10%
200152 Epicurian Coli SURE 2 200152-41 Ultra Comp SURE
Supercompetent Cells
<10%
200170 Epicurian Coli ABLE 200171-41 ABLE C
Competent Cells 200172-41 ABLE K
<10%
200171 Epicurian Coli ABLE C 200171-41 ABLE C
Competent Cells
200230-41 XL1-Blue MRF <10%
200230 Epicurian Coli XL1-Blue MRF
Super Competent Cells
200230-41 SCS1 <10%
200231 Epicurian Coli SCS 1
Supercompetent Cells
200233-41 NM522 Competent Cells <10%
200233 Epicurian Coli NM522
Competent Cells
1
200234-41 JM101 Competent Cells <10%
200234 Epicurian Coli JM101 Competent
Cells
200235-41 JM109 Competent Cells <10%
200235 Epicurian Coli JM109 Competent
Cells
200236-41 XL1-Blue Competent Cells <10%
200236 Epicurian Coli XL1-Blue
Supercompetent Cells
<10%
200238 Epicurian Coli SURE 200238-41 SURE Competent Cells
Competent Cells
<10%
200247-41 SCS110 Competent Cells
200247 Epicurian Coli SCS110
Competent Cells
200248-41 XL1-Blue MRF Kan <10%
200248 Epicurian Coli XL1-Blue MRF
Kan Supercompetent Cells
200236-41 XL1-Blue Competent Cells <10%
200249 Epicurian Coli XL1-Blue
Competent Cells
200315-41 XL10-Gold Competent Cells <10%
200314 Epicurian Coli XL10-Gold
Ultracompetent Cells
200315-41 XL10-Gold Competent Cells <10%
200315 Epicurian Coli XL10-Gold
Ultracompetent Cells
<10%
200317 Epicurian Coli XL10-Gold KANr 200317-41 XL10-Gold KANr
<10%
230130-41 BL21-Gold Competent Cells
230130 Epicurian Coli BL21-Gold
Competent Cells
<10%
230132-41 BL21-Gold(DE3) Competent
230132 Epicurian Coli BL21-Gold(DE3)
Cells
Competent Cells
<10%
230134-41 BL21-Gold(DE3)
230134 Epicurian Coli BL21-Gold(DE3)
PLysS Competent Cells
PLysS competent Cells
<10%
230135-41 BL21-Gold(DE3)
230135 Epicurian Coli BL21-Gold(DE3)
LacZ Competent Cells
LacZ Competent Cells
230240-41 BL21- CodonPlusTM-RIL <10%
230240 Epicurian Coli BL21-
CodonPlusTM-RIL Competent Cells
230245-41 BL21 (DE3) RIL Competent <10%
230245 Epicurian Coli BL21-
CodonPlusTM(DE3)-RIL Cells
230250-41 Codon Plus RP Competent Cells <10%
230250 Epicurian Coli BL21-
CodonPlusTM-RP 230255-41 Codon Plus DE3 RP Competent
Cells
230255-41 Codon Plus DE3 RP Competent <10%
230255 Epicurian Coli BL21-
CodonPlusTM(DE3)-RP Cells
230265-41 Codon Plus RIL (DE3) MET <10%
230265 Epicurian Coli BL21-
CodonPlusTM(DE3)-RIL-X Cell
230275-41 Codon Plus RP (DE3) MET- <10%
230275 Epicurian Coli BL21-
CodonPlusTM(DE3)-RP-X Cell
<10%
230325 Epicurian Coli SoloPack Gold 230325-41 SoloPack Gold Cells
Cells
<10%
230350 Epicurian Coli SoloPack Gold 230350-41 SoloPack Gold
Cells SuperCompetent Cells
2
TOXICITY DATA
Irritation Data:
SKN-RBT 10 mg/24H open Mld. AIHAAP 23,95,62
SKN-RBT 500 mg/24H Mld. 85JCAE -,1044,86
EYE-RBT 100 mg TXAPA9 39,129,77
EYE-RBT 500 mg/24H Mld. 85JCAE -,1044,86
Toxicity Data:
ORL.-RAT LD50: 14,500 mg/kg TXAPA9 15,74,69
SKN-RAT LD50: 40 gm/kg ANYAA9 141,96,67
IPR-RAT LD50: 8200 mg/kg FCTOD7 22,665,84
SCU-RAT LD50: 12 gm/kg ARZNAD 14,1050,64
IVN-RAT LD50: 5360 mg/kg TXAPA9 7,104,65
UNR-RAT LD50: 1300 mg/kg NTIS** AD-A159-418
SKN-MUS LD50: 50 gm/kg ANYAA9 141,96,67
ORL-MUS LD50: 7920 mg/kg CHTPBA 3,10,68
IPR-MUS LD50: 2500 mg/kg RPTOAN 35,300,72
SCU-MUS LD50: 14 gm/kg ANYAA9 141,96,67
IVN-MUS LD50: 3100 mg/kg TXAPA9 15,74,69
ORL-DOG LD50: >10 gm/kg ANYAA9 141,96,67
IVN-DOG LD50: 2500 mg/kg CNCRA6 31,7,63
ORL-CKN LD50: 12 gm/kg JPPMAB 15,688,63
ORL-MAM LD50: 21,400 mg/kg GISAAA 39(4),86,74
ORL-BWD LD50: 100 mg/kg TXAPA9 21,315,72
3
Reviews, Standards, and Regulations:
OEL=MAK
OEL-RUSSIA: STEL 20 mg/m3 JAN 93
OEL-SWITZERLAND: TWA 50 ppm (160 mg/m3); SKIN JAN 93
NOHS 1974: HZD 80564; NIS 11; TNF 476; NOS 25; TNE 22461
NOES 1983: HZD 80564; NIS 29; TNF 3507; NOS 40; TNE 44947; TFE 16837
EPA GENETOX program 1988, Positive: Aspergillus-Aneuploidy; S. Cerevisiae gene conversion.
EPA GENETOX program 1988, Negative: SHE-clonal assay; Cell transform. - mouse embryo.
EPA GENETOX program 1988, Negative: Cell transform. - RLV F344 Rat embryo.
EPA GENETOX program 1988, Negative: D. melanogaster - Whole sex chrom. Loss; Host -mediated
assay.
EPA GENETOX program 1988, Negative: N. crassa - aneuploidy; E. coli PolA with S9.
EPA GENETOX program 1988, Negative: Histidine reversion - Ames test; in vitro SCE-nonhuman.
EPA GENETOX program 1988, Negative: D. melanogaster sex-linked lethal.
EPA GENETOX program 1988, Inconclusive: Aspergillus - Recombination; Carcinogenicity -
Mouse/Rat
EPA GENETOX program 1988, Inconclusive: D. melanogaster - reciprocal translocation.
EPA GENETOX program 1988, Inconclusive: Rodent dominant lethal; B. subtilis REC assay.
EPA GENETOX program 1988, Inconclusive: E. coli PolA without S9.
EPA TSCA Section 8(B) Chemical Inventory
EPA TSCA Section 8(D) Unpublished health/safety studies
EPA TSCA Test Submission (TSCATS) Data Base, January 1997
Target Organ Data:
Behavioral (altered sleep time)
Gastrointestinal (nausea or vomiting)
Liver (jaundice, other or unclassified)
Effects on fertility (pre-implantation mortality)
Effects on embryo or fetus (Fetotoxicity)
Specific developmental abnormalities (musculoskeletal system)
Only selected Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See
actual entry in RTECS for complete information.
RTECS #: PV6210000, Methyl Sulfoxide
Health Hazard Data
Acute Effects:
May be harmful if swallowed, inhaled or absorbed through skin.
Vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract.
Causes skin irritation.
Avoid contact with DMSO solutions containing toxic materials or materials with unknown
toxicological properties. Dimethyl Sulfoxide is readily absorbed through skin and may carry such
materials into the body.
Chronic Effects:
Target Organs: Eyes, Skin
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
First Aid:
Eyes : In case of contact, immediately flush with copious amounts of water for at least 15 minutes.
Skin : In case of contact, immediately flush with copious amounts of water for at least 15 minutes while
removing contaminated clothing and shoes.
Inhalation: Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
oxygen.
Ingestion: Wash out mouth with water provided person is conscious.
4
Wash contaminated clothing before reuse.
In all cases, call a physician.
Physical Data
MF: C2H6OS
Boiling point......................: 189oC
Melting point.....................: 18.4oC
Specific Gravity (H2O = 1): 1.101
Vapor Density....................: 2.7
Vapor Pressure...................: 0.42 mm @ 20oC
Flashpoint...........................: 185掳F (85oC)
Autoignition Temperature..: 573oF (300oC)
Explosion Limits in Air:
Lower .........: 3.5%
Upper .........: 63%
Fire and Explosion Hazard Data
Extinguishing Media:
Water Spray.
Carbon Dioxide, Dry chemical powder, or appropriate Foam
Special Firefighting Procedures:
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Combustible liquid.
Unusual Fire and Explosion Hazards:
Emits toxic fumes under fire conditions.
Reactivity Data
Incompatibilities:
Acid chlorides
Phosphorus halides
Strong acids
Strong oxidizing agents
Strong reducing agents
Sensitive to moisture
Hazardous Combustion or Decomposition Products:
Toxic fumes of :
Carbon monoxide and carbon dioxide
Sulfur oxides
Stability: Stable
Hazardous polymerization: Will not occur.
Additional Information: Methyl Sulfoxide (DMSO) undergoes a violent exothermic reaction on mixing
with copper wool and trichloroacetic acid. On mixing with potassium permanganate, it will flash
instantaneously. It reacts violently with: acid halides, cyanuric chloride, silicon tetrachloride, phosphorus
trichloride and trioxide, thionyl chloride, magnesium perchlorate, silver fluoride, methyl bromide, iodine
pentafluoride, nitrogen periodate, diborane, sodium hydride, perchloric and periodic acids. When heated
above its boiling point, methyl sulfoxide degrades, giving off formaldehyde, methyl mercaptan, and sulfur
dioxide.
Spill or Leak Procedures
Steps to be taken if Material is Released or Spilled:
Evacuate area.
5
Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves.
Absorb on sand or vermiculite and place in closed containers until proper disposal is possible.
Ventilate the area and wash spill site after material pickup is complete.
Waste Disposal Method:
This combustible material may be burned in a chemical incinerator equipped with an afterburner
and scrubber.
Observe all federal, state and local environmental regulations.
Precautions to be Taken in Handling and Storage
Wear appropriate NIOSH/MSHA-approved respirator, chemical-resistant gloves, safety goggles and other
protective clothing.
Ensure that a safety shower and eye bath are available.
Use only in a chemical fume hood.
Do not breathe vapor.
Avoid contact with eyes, skin and clothing.
Avoid prolonged or repeated exposure.
Readily absorbed through skin.
Wash thoroughly after handling.
Keep tightly closed.
Keep away from heat and open flame.
Store in a cool, dry place.
Label Precautionary Statements:
Irritant.
Irritating to eyes, respiratory system, and skin.
Combustible.
Target Organs: eyes, skin
Readily absorbed through skin.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Do not breathe vapor.
The above information is believed to be correct but does not purport to be all-inclusive and shall be used
only as a guide. Stratagene shall not be held liable for any damage resulting from handling or from contact
with the above product.
6
This document was created with Win2PDF available at http://www.daneprairie.com.
The unregistered version of Win2PDF is for evaluation or non-commercial use only.
|