MATERIAL SAFETY DATA SHEET 2-ETHOXYETHANOL
PRODUCT CODE NUMBER(S): 4500-1, 4501-2
PRODUCT IDENTIFICATION and other oxidizing agents to form explosive peroxides. Do
not distill to dryness. Avoid excessive temperatures or pro-
Chemical Name and Synonyms: 2-Ethoxyethanol; Ethyl- longed reflux in distillation process.
ene glycol monoethyl ether; Cellosolve Hazardous Decomposition Products: COx, peroxides
Chemical Family: Aliphatic glycol ether; Aliphatic ether al-
cohol
FIRE AND EXPLOSION DATA
Chemical Formula: C2H5OC2H4OH
Flammability: Combustible liquid and vapour. Can form
Product Use: Laboratory solvent
explosive mixtures with air at, or above 43掳C. Can accumu-
Manufacturer鈥檚 Name and Address: late in confined spaces, causing a flammability and toxicity
Caledon Laboratories Ltd. hazard. Can form explosive peroxides. Use care in ele-
40 Armstrong Avenue vated temperature processes. Sudden release of heated
Georgetown, Ontario L7G 4R9 vapours or mist may result in autoignition below published
autoignition temperature. Analysis of actual process condi-
Telephone No: (905) 877-0101
tions is necessary to establish safe operating conditions.
Fax No: (905) 877-6666
Extinguishing Media: Alcohol or polymer foam, CO2, dry
Emergency Telephone No: CANUTEC (613) 996-6666 chemical. Use water spray to cool containers, disperse va-
pours, and flush spill away from ignition sources. Fight fire
HAZARDOUS INGREDIENTS OF MATERIALS from a safe distance, from upwind direction. Firefighters
must wear NIOSH approved full face-piece, posi-
Ingredients % TLV-TWA CAS No. tive-pressure self-contained breathing apparatus and
encapsulating chemical splash suit (Bunker Gear is not ade-
2-Ethoxyethanol >99 5 ppm 110-80-5
quate). Containers may explode in heat of fire; withdraw
(includes skin expo-sure)
immediately in case of rising sound from vent or discolor-
ation of tank.
PHYSICAL DATA
Flash Point (Method Used): 43掳C (CC)
Physical State: Liquid Autoignition Temperature: 235掳C (See Flammability)
Odour and Appearance: Colourless liquid; mild, Upper Flammable Limit (% by volume): 15.6
non-residual, sweet odour
Lower Flammable Limit (% by volume): 1.7
Odour Threshold (ppm): 0.3 to 24 ppm (detection) 0.54 to
Hazardous Combustion Products: COx
79 ppm (recognition). Poor warning qualities, wide range of
Sensitivity to Impact: None idenified
values.
Sensitivity to Static discharge: Probably will not accumu-
Vapour Pressure (mm Hg): 3.8 mm Hg at 20掳C
late static discharge; electrical conductivity of gycol ethers is
Vapour Density (Air = 1): 3.1
high.
Evaporation Rate (bu ac=1): ~0.4
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Boiling Point (掳C): 135掳C
Freezing Point (掳C): -70掳C
Toxicological Data:
pH: Not available, probably neutral
LD50: (oral, rat) 2,125 mg/kg; (dermal, rabbit) 3,310 mg/kg
Specific Gravity: 0.93 @ 20掳C
LC50: (rat) 2,000 ppm/7h
Coefficient of Water/Oil distribution: LogP (oct)=-0.54
SHIPPING DESCRIPTION Effects of Acute Exposure to Product:
Inhaled: No human information available. Animal informa-
UN: 1171
tion indicates material can be irritating to upper respiratory
T.D.G. Class: 3
tract. May cause headache, nausea, vomiting, narcotic ef-
Pkg. Group: III fect, muscle weakness. Very high concentrations could
cause unconsciousness and death.
REACTIVITY DATA In contact with skin: No human information available.
Probably mild irritant. Readily absorbed by skin, possible
Chemical Stability: Normally stable. May form explosive
causing symptoms as in 鈥淚nhaled鈥?.
peroxides on exposure to air and light; rate and extent of re-
In contact with eyes: No human information available.
action not known.
Animal information shows it to be a moderate eye irritant.
Incompatibility with other substances: May react vio-
Ingested: Not a typical route of occupational exposure.
lently with increased risk of fire and explosion with strong
Would be expected to cause CNS effects as in 鈥淚nhaled鈥?.
oxidizers, strong bases, strong acids. Corrosive to alumi-
One accidental ingestion caused weakness, restlessness,
num, zinc, galvanized metals. Not corrosive to cast iron,
rapid breathing and pulse, metabolic acidosis, muscle
steel, stainless steel, copper, nickel and its alloys. May at-
spasms, reversible kidney insufficiency and liver damage
tack some forms of plastics, rubbers and coatings.
(2-3 weeks after ingestion), persistent fatigue, insomnia,
Reactivity: Avoid heat, sparks, open flames and all
numbness and tingling in the extremities.
sources of ignition, all incompatible or combustible materi-
als, generation of mist. May form explosive peroxides on
exposure to light and air. Reacts with hydrogen peroxide
2-ETHOXYETHANOL
MSDS
CODE: 4500-1, 4501-2
Effects of Chronic Exposure to Product: mist. Avoid all contact with eyes, skin or clothing. Keep away
from all incompatible and combustible materials. Keep contain-
Prolonged exposure may cause damage to liver, kidneys, ers closed when not in use. Empty containers may contain
bone marrow, blood, lungs, testes, causing anemia, hazardous residues; treat with caution.
hemolysis, immunosuppression. Studies have been on ex- Storage Requirements: Store in suitable, labelled containers,
posure to organic solvents including, but not exclusively in a cool, dry, well-ventilated area, out of direct sunlight and
ethoxyethanol. No studies have been done on away from all sources of ignition and incompatible materials.
ethoxyethanol alone; thus results are inconclusive. Keep tightly closed when not in use. Protect from damage; in-
spect regularly for signs of leaking or bulging. Keep storage
Carcinogenicity: No human or animal information avail-
area clear of combustible materials. Storage area should be
able
made of non-combustible material and should have raised sills
Teratogenicity: Fetotoxicity, birth defects, at doses
or ramps at doorways, and a trench which drains to a safe loca-
non-toxic to mother, have been observed (RTECS No.
tion.
KK8050000) in animal testing .
Reproductive Effects: No conclusive human information
FIRST AID MEASURES
available. Damage to reproductive organs cited in animal
studies. Increased frequency of abortion reported in women
Specific Measures:
working with solvents of which 2-ethoxyethanl was one. No
direct causal relationship was established. Eyes: Immediately flush eyes with gently running water for ten
Mutagenicity: No human information available. Negative to twenty (10-20) minutes, holding eyelids open during flushing,
in Ames test. Positive in some in vitro mammalian tests, but until no trace of chemical remains. Take care not to flush con-
negative in others. taminated water into unafffected eye. Wear protective gloves to
avoid contact. Get medical attention immediately.
Synergistic Products: Ethanol may enhance the toxic ef-
fects of ethoxyethanol. Skin: Remove contaminated clothing(including shoes,
watches, belts, and rings). Wash affected areas with large
PREVENTIVE MEASURES amounts of running water for five to ten (5-10) minutes, or until
no trace of chemical remains. Wear gloves to avoid contact.
Respiratory Protection: Local exhaust ventilation system Get medical attention . Decontaminate clothing before reuse,
required. or discard.
Engineering Controls: Up to 5 ppm: NIOSH approved Inhalation: IMMEDIATELY remove to fresh air (caution must
supplied-air respirator; to 12.5 ppm: continuous-flow sup- be used by rescuers to avoid exposure to contaminating
plied-air respirator; to 25 ppm: full face-piece self-contained fumes). Give oxygen for breathing difficulty. If breathing has
breathing apparatus or full face-piece supplied-air respirator; STOPPED give artificial respiration. If breathing and pulse are
to 500 ppm: positive-pressure supplied-air respirator; higher ABSENT, give CPR. IMMEDIATELY OBTAIN MEDICAL AT-
or unknown concentrations, as in fire or spill conditions, pos- TENTION. Stay with casualty until medical assistance is
itive pressure, full face-piece self-contained breathing reached.
apparatus or supplied-air respirator with an auxiliary positive
Ingestion: DO NOT INDUCE VOMITING. If casualty is alert
pressure self-contained breathing apparatus.
and NOT convulsing, rinse out mouth with water. Give 2 to 4
Eye Protection: Chemical goggles and/or face shield. glasses of water to dilute material. IMMEDIATELY GET MEDI-
Skin Protection: Butyl rubber, Barrier, Responder脭 CAL ATTENTION. If spontaneous vomiting occurs have
casualty lean forward with head down to avoid breathing in of
Tychem脭BR/LV, Tychem脭SL, Tychem脭TK gloves. Other
vomitus.
impervious protective clothing (apron, sleeves, coveralls,
splash suit, boots) sufficient to prevent contact.
REFERENCES USED
Other Personal Protective Equipment: Safety shower
and eye bath located close to chemical exposure area.
NIOSH Pocket Guide to Chemical Hazards; Pub. # 2005-151
Leak and Spill Procedure: Eliminate all sources of igni-
CCINFO disc: Cheminfo, MSDS鈥檚
tion. Evacuate area. Cleanup personnel must be thoroughly
Budavari: The Merck Index, 12th ed., 1997
trained in the hazards of this chemical and must wear pro-
tective equipment and clothing sufficient to prevent Royal Society of Chemistry, Chemical Safety Data Sheets, Vol. 1,
inhalation of vapours or mists and contact with skin and 1992
eyes. Do not touch spilled material. Stop or reduce dis-
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th ed.,
charge if safe to do so. Contain spill with inert absorbent
1987
(sand, earth). Prevent from entering sewers or waterways.
Sax: Dangerous Properties of Industrial Materials, 5th ed., 1979
Collect product and contaminated absorbent for disposal.
Contaminated absorbent may pose the same hazards as the Suppliers鈥? Material Safety Data Sheets
spilled product. Flush area of spill with copious amounts of
running water. ADDITIONAL INFORMATION
Waste Disposal: Follow all federal, provincial, and local
Date Issued: March 1, 1989
regulations.
Revision: September 2007
Handling Procedures and Equipment: TOXIC, COM-
BUSTIBLE, TERATOGEN; REPRODUCTIVE HAZARD. MSDS: 4500-1, 4501-2
Workers must be thoroughly trained in the hazards of this Proposed WHMIS Designation: B3; D1B; D2A; D2B
material, and its safe use, and must wear protective equip-
ment and clothing sufficient to prevent inhalation of mists or
Prepared by:Caledon Laboratories Ltd. (905) 877-0101
vapours and contact with skin and eyes. May form explosive
Caledon Laboratories Ltd. believes the information contained
peroxides on long standing; open containers with caution.
herein is reliable and accurate. Caledon makes no warranty with
Ground and bond all equipment to prevent static charge ac-
cumulation. Use non-sparking tools. Post 鈥淣o Smoking鈥? respect thereto and expressly disclaims all liability for reliance
signs. Use smallest amount possible for the purpose in an thereon. Such information is solely for your consideration, investi-
area with appropriate ventilation. Avoid generating vapour or gation, and verification.
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