MATERIAL SAFETY DATA SHEET 2-MERCAPTOETHANOL
PRODUCT CODE NUMBER(S): 4990-5
PRODUCT IDENTIFICATION Hazardous Decomposition Products: SOx, COx
Chemical Name and Synonyms: 2-Mercaptoethanol;
FIRE AND EXPLOSION DATA
thioethylene glycol; 2-hydroxy-1-ethanethiol,
Beta-mercaptoethanol, 2-thioethanol Flammability: Combustible liquid and vapour. Vapors may
be heavier than air, and may spread along the ground and
Chemical Family: Alkyl mercapto alcohol
collect in low or confined areas, creating a fire or toxicity
Chemical Formula: HSCH2CH2OH
hazard.
Product Use: Laboratory reagent
Extinguishing Media: Alcohol foam, CO2, dry chemical,
Manufacturer鈥檚 Name and Address: water spray. Water may be ineffective for extinguishing fire,
Caledon Laboratories Ltd. but may be used to cool containers, disperse vapours, and
40 Armstrong Avenue flush spills or vapours away from ignition sources. Fight fire
from upwind, from a safe distance. FIrefighters must wear
Georgetown, Ontario L7G 4R9
protective equipment (positive-pressure, full face-piece
Telephone No: (905) 877-0101
self-contained breathing apparatus) and clothing (chemical
Fax No: (905) 877-6666 splash suit) sufficient to prevent inhalation of mist or va-
Emergency Telephone No: CANUTEC (613) 996-6666 pours, and contact with skin and eyes. Closed containers
may explode in heat of fire; withdraw immediately in case of
HAZARDOUS INGREDIENTS OF MATERIALS rising sound from venting device, or discolouration in con-
tainer.
Ingredients % TLV Units CAS No. Flash Point (Method Used): 68掳C (OC)
Autoignition Temperature: 295掳C
2-Mercaptoethanol 99 Not established 60-24-2
Upper Flammable Limit (% by volume): 2.7
PHYSICAL DATA Lower Flammable Limit (% by volume): 1.1
Hazardous Combustion Products: SOx, COx, H2S
Physical State: Liquid
Sensitivity to Impact: None identified
Odour and Appearance: Water white liquid, very strong
disagreeable sulphide odour Sensitivity to Static discharge: No information available
Odour Threshold (ppm): 0.383 to 2.04 mg/m3. Normally
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
detectable before harmful levels are reached.
Vapour Pressure (mm Hg): 1 mm Hg @ 20掳C
Toxicological Data:
Vapour Density (Air = 1): 2.69
LD50: (oral, rat) 244 mg/kg; (oral, mouse) 190 mg/kg; (der-
Evaporation Rate (Bu ac=1): <1
mal, rabbit) 150 mL/kg
Boiling Point (degrees C): 157掳C (may decompose)
LC50: (mouse) 13,200 mg/m3 (duration not specified). Ex-
Freezing Point (degrees C): <-73.5掳C
posure of rats to saturated vapour at room temperature for
pH: ~5.2 (0.1M, aqueous)(calculated) maximum 4 h produced no deaths.
Specific Gravity: 1.114 @ 20掳C Irritation: (skin, rabbit) 10 mg/24h open; (eye, rabbit) 2 mg
Coefficient of Water/Oil distribution: logP=-0.20 severe
SHIPPING DESCRIPTION Effects of Acute Exposure to Product:
VERY TOXIC. May be fatal if absorbed through the skin or
UN: 2966
swallowed. CORROSIVE to the eyes and skin. May cause
T.D.G. Class: 6.1
permanent eye injury.
Pkg. Group: II
Inhaled: Toxic and irritating. Low concentrations of vapour
cause irritation, headcahe, nausea. High concentrations can
REACTIVITY DATA be extremely destructive to tissue, causing spasm, inflam-
mation and edema of the larynx and bronchi, chemical
Chemical Stability: Stable
pneumonitis and pulmonary edema with shortness of breath,
Incompatibility with other substances: May react vio-
eventual cyamosis, and respiratory failure.Systemic effects
lently with oxidizing agents, causing ignition. Reaction with
of ingestion, inhalation or absorption include CNS effects
fumong nitric acid can be explosive. May react vigorously or
such as headache, nausea and vomiting, tremors, muscle
violently with reducing agents, strong alkalis, strong acids,
paralysis, convulsions, eventual coma and death,
alkali metals, aliphatic amines, isocyanates. Reacts with
In contact with skin: Corrosive. Concentrated liquid or va-
.
moisture to produce toxic material.
pours may cause severe irritation, redness, pain, chemical
Reactivity: Avoid excessive heat, all ignition sources, all in-
burns. Toxic if absorbed, with systemic effects as in 鈥淚n-
compatible materials, generation of mist.
haled鈥?.
2-MERCAPTOETHANOL
MSDS
CODE: 4990-5
In contact with eyes: Corrosive May cause severe irritation, Storage Requirements: Store in suitable, labelled contain-
burns and corneal opacities, possible permanent damage. ers, in a cool, dry, well-ventilated area, out of direct sunlight
and away from all sources of ignition and incompatible materi-
Ingested: Toxic and irritating. Causes severe irritation with
als. Keep tightly closed when not in use. Protect from
nausea, vomiting, abdominal pain, systemic effects as in 鈥淚n-
damage. Inspect regularly for signs of leaking or damage.
haled鈥?. Can cause severe burns to mouth and gastrointestinal
Keep storage area clear of combustible materials. Ground
tract with risk of perforation. Not a typical route of industrial
and bond equipment and containers to prevent a static charge
exposure.
buildup. Storage area should be made of non-combustible
material and should have raised sills or ramps at doorways,
Effects of Chronic Exposure to Product:
with trenching to a safe area.
Prolonged or repeated skin contact may cause defatting and
FIRST AID MEASURES
dermatitis. Repeated or prolonged inhalation may cause CNS
stimulation.
Specific Measures:
Carcinogenicity: Not evaluated as a carcinogen
Teratogenicity: No human or animal information available. Eyes: IMMEDIATELY flush eyes with gently running water for
at least thirty (30) minutes, holding eyelids open while flush-
Reproductive Effects: No human or animal information
ing. Take care not to flush contaminated water into unaffected
available.
eye. Wear protective gloves to avoid contact during first aid
Mutagenicity: Some evidence of mutagenicity, inconclusive
procedures. Obtain medical attention immediately.
Synergistic Products: None found
Skin: Remove contaminated clothing (including rings,
watches, belts and shoes). IMMEDIATELY flush exposed
PREVENTIVE MEASURES area with large amounts of warm running water for at least
twenty (20) minutes. Wear protective gloves to avoid contact
Engineering Controls: Non-sparking, grounded ventilation
during first aid procedures. Get medical attention immedi-
system, separate from other ventilation systems, and electri-
ately. Discard contaminated clothing.
cal equipment that does not provide a source of ignition.
Inhalation: Remove to fresh air (caution must be used by
Respiratory Protection: Dust/mist mask. Fumehood.
rescuers to avoid exposure to contaminating fumes). Give ox-
NIOSH approved respirator for conditions where local ventila-
ygen for breathing difficulty. If breathing has STOPPED give
tion is not sufficient to prevent inhalation of vapours. For
artificial respiration; use mouth guard to avoid possible con-
higher or unknown concentratioasn, as in fire or spill condi-
tact with chemical. If breathing and pulse are ABSENT give
tions, positive-pressure, full face-piece self-contained
CPR. IMMEDIATELY OBTAIN MEDICAL ATTENTION. Stay
breathing apparatus, or full face-piece supplied-air respirator
with casualty until medical assistance is reached.
with auxiliary positive-pressure self-contained breathing appa-
Ingestion: DO NOT INDUCE VOMITING. If the casualty is
ratus.
alert and not convulsing, have him drink 2 to 4 glasses of wa-
Eye Protection: Chemical safety goggles, face shield.
ter to dilute the material. Obtain medical attention
Skin Protection: Silver Shield/4H脭(polyethylene/ethylene
immediately. If spontaneous vomiting occurs, have casualty
vinyl alcohol) gloves. Other impermeable protective clothing, lean forward to avoid breathing in of emesis. Rinse mouth
apron, sleeves, coveralls, boots, as required to prevent con- and administer more water.
tact.
Other Personal Protective Equipment: Safety shower and REFERENCES USED
eye-wash fountain in work area.
CCINFO disc: Cheminfo
Leak and Spill Procedure: Evacuate area. Ventilate area.
Cleanup personnel must wear protective equipment and cloth- Budavari: The Merck Index, 12th ed., 1997
ing sufficient to prevent inhalation of vapours or mist and Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
contact with skin, eyes, or clothing. Do not touch spilled ma- ed., 1987
terial. Use non-sparking tools. Prevent from entering sewers
Sax: Dangerous Properties of Industrial Materials, 5th ed., 1979
or wtaerways. Absorb on inert absorbent, transfer carefully
into container and arrange removal by disposal company. Suppliers鈥? Material Safety Data Sheets
Wash site of spillage thoroughly with water and detergent.
ADDITIONAL INFORMATION
Ventilate area to dispel residual vapour. Contaminated absor-
bent may pose the same hazards as the material; treat with
Date Issued: February 20, 1990
caution.
Revision: February 2008
Waste Disposal: Follow all federal, provincial and local regu-
lations for disposal. MSDS: 4990-5
Handling Procedures and Equipment: COMBUSTIBLE, Proposed WHMIS Designation: B3; D1A; D2B
VERY TOXIC, VERY IRRITATING. Workers must be thor-
oughly trained in the hazards of this material, and its safe use,
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
and must wear appropriate protective equipment and clothing.
Caledon Laboratories Ltd. believes the information contained
Ground and bond all equipment to prevent static charge accu-
herein is reliable and accurate. Caledon makes no warranty with
mulation. Use non-sparking tools. Post 鈥淣o Smoking鈥? signs.
respect thereto and expressly disclaims all liability for reliance
Use smallest amount possible for the purpose in a designated
thereon. Such information is solely for your consideration, inves-
area with appropriate ventilation. Avoid generating vapour or
mist. Avoid all contact with eyes, skin or clothing. Avoid inha- tigation, and verification.
lation. Keep away from all incompatible and combustible
materials. Keep containers closed when not in use. Empty
containers may contain hazardous residues; treat with cau-
tion.
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