MATERIAL SAFETY DATA SHEET HEXANE
PRODUCT CODE NUMBER(S):5500-1, 5500-2, 5500-3, 5500-4, 5501-2, 5501-7, 5502-2. 5503-2,
5503-7, 5505-1, 5508-2, 5509-1
PRODUCT IDENTIFICATION Reactivity:
Avoid heat, sparks, open flame, all ignition sources, and incom-
Chemical Name and Synonyms: Hexane; Normal hexane;
patible or combustible materials. Avoid generation of mist. Con-
Hexanes
fined materials may explode upon heating.
Chemical Family: Saturated aliphatic hydrocarbon
Hazardous Decomposition Products: COx
Chemical Formula: C6H14
Product Use: Laboratory solvent FIRE AND EXPLOSION DATA
Manufacturer鈥檚 Name and Address:
Flammability: Extremely flammable liquid and vapour. Vapours
Caledon Laboratories Ltd.
form flammable/explosive mixtures with air at or above -21掳C.
40 Armstrong Avenue Vapour is heavier than air and may travel considerable distance to
Georgetown, Ontario, L7G 4R9 source of ignition and flash back. Liquid can float on water and
may spread fire. Can accumulate in confined spaces and cause
Telephone No: (905) 877-0101
flammability or toxicity hazard. Closed containers may rupture vio-
Fax No: (905) 877-6666
lently when heated.
Emergency Telephone No: CANUTEC (613) 996-6666
Extinguishing Media: CO2, dry chemical, foam. Water may be
ineffective for extinguishing, but as spray or fog may be used to
HAZARDOUS INGREDIENTS OF MATERIALS cool containers and disperse vapours. Fight fire from upwind,
from a safe distance. Firefighters must wear protective equipment
Ingredients % TLV Units CAS No. (NIOSH/MSHA approved self-contained breathing apparatus) and
clothing (Bunker Gear) sufficient to prevent inhalation of mists or
n-Hexane 62-65 50 ppm 110-54-3
vapours, and contact with skin and eyes. Closed containers may
Hexane isomers of rupture violently during fire; withdraw immediately in case of rising
methylpentanes <21 500 ppm 107-83-5 sound from vent or discoloration of tank.
(2-methylpentane, <7 Flash Point (Method Used): -21掳C (TCC)
3-methylpentane <14)
Autoignition Temperature: 225掳C
Methylcyclopentane <17 Not established 96-37-7 Upper Flammable Limit (% by volume): 7.5
Lower Flammable Limit (% by volume): 1.1
PHYSICAL DATA
Hazardous Combustion Products: COx
Physical State: Liquid Sensitivity to Impact: Probably not sensitive
Odour and Appearance: Clear, colourless volatile liquid, Sensitivity to Static discharge: Vapour is readily ignited by
gasoline-like odour static discharge. Liquid can accumulate static charge by flow or
Odour Threshold (ppm): 64-244 ppm; poor warning prop- agitation.
erties, odour threshold exceeds TLV.
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Vapour Pressure (mm Hg): 124 mm Hg at 20掳C
Vapour Density (Air = 1): 2.97
Toxicological Data:
Evaporation Rate (Ethyl ether = 1): 1.4
LD50: (oral, adult rat) 28,710 mg/kg; (oral, 14-day old rat) 15,840
Boiling Point (掳C): 67-69掳C
mg/kg; (dermal, rabbit) >2g/kg
Freezing Point (掳C): -95掳C
LC50: ( rat) 48,000 ppm/4h
pH: Not applicable
Specific Gravity: 0.659 at 20掳C Effects of Acute Exposure to Product:
Coefficient of Water/Oil distribution: LogP(oct)= 3.6
Inhaled: Limited information specific to hexane available; most
information relates to mixtures of solvents. Available information
SHIPPING DESCRIPTION
suggests low toxicity. Exposure to high vapour concentrations
may cause CNS depression with nausea, and headache, dizzi-
UN: 1208
ness, unconsciousness. In studies with human volunteers, 10
T.D.G. Class: 3
minute exposure at 2000 ppm produced no symptoms, 10 min-
Pkg. Group: II utes at 5000 ppm caused dizziness and giddiness. If atmospheric
oxygen is displaced by hexane, where vapour concentrations are
REACTIVITY DATA high, life-threatening asphyxiation can occur. Symptoms are
drowsiness, loss of coordination, loss of judgement, sometimes
Chemical Stability: Normally stable.
masked by a state of euphoria, eventual loss of consciousness
Incompatibility with other substances: Reacts vigorously and death.
with chlorine, oxygen and strong oxidizing agents (perox-
In contact with skin: May cause irritation, burning sensation,
ides, nitrates, perchlorates), increasing risk of fire and
reddening. May be absorbed through skin, but not likely in harmful
explosion. Explodes violently in contact with fluorine. May
amounts.
explode with nitrogen tetroxide. Not corrosive to most met-
In contact with eyes: Vapour and liquid may cause mild irrita-
als. May attack some forms of plastic, rubber, and coatings.
tion, with tearing, redness, and pain. No human or animal
information available.
HEXANE
MSDS
CODE:5500-1, 5500-2, 5500-3, 5500-4, 5501-2, 5501-7, 5502-2. 5503-2, 5503-7, 5505-1, 5508-2, 5509-1
Ingested No specific human information available. May cause ignition. Post 鈥淣o Smoking鈥? signs. Ground and bond drums, transfer
burning sensation in the mouth and throat, nausea, and vomiting. vessels, hoses and piping, during liquid transfer. Ground clips must
Animal testing indicates low oral toxicity. However, may be aspi- contact bare metal. Use non-sparking tools. Use inert gas in contain-
rated into the lungs during ingestion or vomiting, which can cause ers or storage vessels to reduce fire/explosion hazard Keep work
pulmonary edema, chemical pneumonitis, and death. area free of other materials that can burn. Keep aisles and exits clear
of obstruction. Keep storage and work areas free of combustible or
incompatible materials. Use the smallest amount possible for the pur-
Effects of Chronic Exposure to Product:
pose, in a designated area with adequate ventilation. Keep
Causes harm to the nervous system producing numbness or tin- containers closed when not in use. Empty containers may contain
gling in the extremities, spasms in the legs, tiredness, muscle hazardous residues; treat with caution. Do not return contaminated
weakness and more severe nerve damage. Peripheral neuropa- material to the original container. Have absorbents readily availabe
thy developed within 7 months in mice at 250 ppm. Methyl for leaks or spills. Have appropriate fire extinguishers available.
pentanes have produced kidney damage in male rats only, but no Storage Requirements: Store in suitable, labelled containers, in a
comparable health hazard for kidney disease is known to occur in cool, dry, well-ventilated area, out of direct sunlight, and away from
humans. Prolonged skin contact can cause dermatitis. Abnormal heat and ignition sources, and all incompatible materials. Protect
from damage. Keep containers tightly closed when not in use. Inpsect
colour perception and pigment changes in the eyes have been
regularly for leaks or damage. Storage facilities should be made of
reported in workers exposed to 423 to 1,280 ppm for five years or
fire-resistant materials, and have raised sills or ramps, with trenching
more. Mild forms of anemia have been associated with exposure
to a safe area.
- reversible on termination of exposure.
Carcinogenicity: Insufficient information available
FIRST AID MEASURES
Teratogenicity: Has shown fetotoxic effects in animal testing at
maternally toxic levels only (RTECS No. MN 9275000). Specific Measures:
Reproductive Effects: Testicular damage in male rats at con-
Eyes: Immediately flush eyes with gently running water, holding
centrations that produced other toxicity. No human information
eyelids open while flushing, for five to ten (5-10) minutes, or until no
available.
trace of chemical remains. Take care not to flush contaminated water
Mutagenicity: Negative results in animal testing, and in cultured
into unaffected eye. If irritation persists, get medical attention.
human cells with or without metabolic activation.
Skin: Remove contaminated clothing(including shoes, watches,
Synergistic Products: Neurotoxic and respiratory effects en-
belts, and rings). Wash affected areas with large amounts of running
hanced by both methyl ethyl ketone and lead acetate, but
water and non-abrasive soap, for five to ten (5-10) minutes, or until
decreased by toluene.
no trace of chemical remains. If irritation persists, get medical atten-
tion.
PREVENTIVE MEASURES
Inhalation: IMMEDIATELY remove casualty from contaminated area
to fresh air (caution must be used by rescuers to avoid exposure to
Engineering Controls: Non-sparking, grounded, separate, ex-
contaminating fumes). Remove any sources of ignition. Give oxygen
haust ventilation required.
and get medical attention for any breathing difficulty. If reathing has
Respiratory Protection: Dust/mist mask. Fumehood. To 500
stopped give artificial respiration. If breathing and pulse are absent
ppm: NIOSH/MSHA approved supplied-air respirator or
give CPR. Immediately obtain medical attention. Stay with casualty
self-contained breathing apparatus. To 1,100 ppm: continuous
until medical assistance is reached.
flow supplied-air respirator, or full face-piece supplied-air respira-
Ingestion: DO NOT INDUCE VOMITING. Danger of aspiration with
tor or self-contained breathing apparatus. Higher or unknown
emesis. If casualty is alert and NOT convulsing, rinse mouth with wa-
concentrations, as in fire or spill conditions, full-face-piece posi-
ter and give 1 to 2 cups of water to drink to dilute material.
tive-pressure self-contained breathing apparatus or positive
IMMEDIATELY get medical attention. If spontaneous vomiting occurs,
pressure, full face-piece air-supplied respirator with an auxiliary
have casualty lean forward with head down to avoid breathing in of
positive pressure self-contained breathing apparatus.
vomitus. Rinse mouth and give more water to drink.
Eye Protection: Chemical safety goggles and/or face shield.
Skin Protection: Nitrile rubber, polyvinyl alcohol, Viton鈩?,
REFERENCES USED
Viton脭/Butyl rubber, Teflon鈩?, Barrier (PE/PA/PE), Silver
Shield/4H鈩?(polyethylene/ethylene vinyl alcohol), Responder脭, CCINFO disc: MSDS鈥檚, January 2007
Trellchem鈩PS, Tychem鈩? BR/LV, Tychem鈩? TK gloves. Other Budavari: The Merck Index, 12th ed., 1997
impervious or resistant protective clothing sufficient to prevent
Royal Society of Chemistry: Material Safety Data Sheets, Vol. 1, 1992
contact.
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th ed., 1987
Other Personal Protective Equipment: Safety shower and eye
Sax: Dangerous Properties of Industrial Materials, 5th ed., 1979
wash in work area.
Leak and Spill Procedure: Evacuate and ventilate area. Elimi- Suppliers鈥? Material Safety Data Sheets
nate all sources of ignition. Cleanup personnel must be
ADDITIONAL INFORMATION
thoroughly trained in the hazards of this material and must wear
protective equipment and clothing sufficient to prevent inhalation
Date Issued: January 31, 1989
of vapours or mists, and contact with skin, eyes or clothing. Con-
tain spill and collect using inert absorbent material. Prevent from Revision: January 2007
entering sewers or waterways. Do not touch spilled material or MSDS: 5500-1, 5500-2, 5500-3, 5500-4, 5501-2, 5501-7, 5502-2.
contaminated absorbent. Contaminated absorbent may pose the 5503-2, 5503-7, 5505-1, 5508-2, 5509-1
same hazards as the chemical; treat with caution. Flush area of
Proposed WHMIS Designation: B2; D2B
spill with copious amounts of running water.
Waste Disposal: Follow all federal, provincial, and local regula-
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
tions.
Caledon Laboratories Ltd. believes the information contained herein is
Handling Procedures and Equipment: EXTREMELY FLAM-
reliable and accurate. Caledon makes no warranty with respect thereto
MABLE, TOXIC. Personnel working with this substance must be
and expressly disclaims all liability for reliance thereon. Such informa-
thoroughly trained in its hazards and its safe use, and must wear
tion is solely for your consideration, investigation, and verification.
appropriate protective equipment and clothing suitable for the ap-
plication. Keep away from heat, sparks, flame, and all sources of
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