MATERIAL SAFETY DATA SHEET PROTEINASE K
PRODUCT CODE NUMBER(S): 6680-5
PRODUCT IDENTIFICATION Extinguishing Media: Use extinguishing media appropri-
ate to the surrounding fire. Water in flooding amounts can
Chemical Name and Synonyms: Proteinase K be used to cool containers, prevent dust formation, flush
Chemical Family: Enzyme chemcial away from fire. Fight fire from upwind, from a safe
distance. Firefighters should wear protective equipment and
Chemical Formula: Not available
clothing sufficient to prevent inhalation of dust or fumes and
Product Use: Laboratory reagent
contact with skin and eyes.
Manufacturer鈥檚 Name and Address: Flash Point (Method Used): Not applicable
Caledon Laboratories Ltd.
Autoignition Temperature: Not applicable
40 Armstrong Avenue
Upper Flammable Limit (% by volume): Not applicable
Georgetown, Ontario L7G 4R9
Lower Flammable Limit (% by volume): Not applicable
Telephone No: (905) 877-0101
Hazardous Combustion Products: Not available
Fax No: (905) 877-6666
Sensitivity to Impact: None identified
Emergency Telephone No: CANUTEC (613) 996-6666
Sensitivity to Static discharge: As with most organic pow-
ders, mixtures of dust with air may be sensitive under
HAZARDOUS INGREDIENTS OF MATERIALS
certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.
Ingredients % TLV Units CAS No.
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Proteinase K >98 Not established 39450-01-6
To the best of our knowledge, the physical, chemical and
toxicological properties of this substance have not yet been
PHYSICAL DATA
thoroughly investigated.
Physical State: Solid
Toxicological Data:
Odour and Appearance: White to off-white powder
Odour Threshold (ppm): Not available LD50: Not available
Vapour Pressure (mm Hg): Not available LC50: Not available
Vapour Density (Air = 1): Not available
Effects of Acute Exposure to Product:
Evaporation Rate: Not available
Boiling Point (degrees C): Not available Inhaled: May be mildly irritating to upper respiratory tract,
causing sore throat, coughing, shortness of breath. Inhala-
Melting Point (degrees C): Not available
tion of large amounts may be harmful. May cause
pH: Not available
sensitization by inhalation, causing allergic asthmatic reac-
Specific Gravity: Not available tion.
Coefficient of Water/Oil distribution: Not available In contact with skin: May cause mild mild irritation. May
cause sensitization by skin contact.
SHIPPING DESCRIPTION In contact with eyes: May cause mild irritation, with red-
ness, itching, tearing, pain.
UN: Not regulated
Ingested: No information available. Ingestion of large
T.D.G. Class: Not regulated
amounts may cause gastrointestinal irritation, with nausea,
Pkg. Group: Not regulated vomiting, diarrhea. May be harmful.
REACTIVITY DATA Effects of Chronic Exposure to Product:
Chemical Stability: Stable. Prolonged or repeated exposures may cause allergic reac-
tions, asthma, lung damage, skin sensitization.
Incompatibility with other substances: Strong oxidizing
agents. Carcinogenicity: No information available
Reactivity Avoid excessive heat, ignition sources, incom- Teratogenicity: No information available
patible materials, moisture. Avoid generation of dust.
Reproductive Effects: No information available
Hazardous Decomposition Products: Not available
Mutagenicity: No information available
FIRE AND EXPLOSION DATA Synergistic Products: None known
PREVENTIVE MEASURES
Flammability: Not combustible. As with most organic com-
pounds, fine dust dispersed in air in the presence of an
Engineering Controls: Local exhaust ventilation required.
ignition source is a potential dust explosion hazard.
PROTEINASE K
MSDS
CODE: 6680-5
REFERENCES USED
Respiratory Protection: Dust/mist mask. For conditions
where dust or mist is present, to the maximum use specified
CCINFO disc
by the respirator supplier, NIOSH approved half- face
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
high-efficiency dust/mist filter respirator, or NIOSH approved
full face-piece high-efficiency dust/mist filter respirator. ed., 1987
Higher or unknown concentrations, or for fire or spill condi- Suppliers鈥? Material Safety Data Sheets
tions, self-contained breathing apparatus, or full face-piece,
positive-pressure supplied-air respirator.
ADDITIONAL INFORMATION
Eye Protection: Chemical safety glasses. Do not wear
Date Issued: March 1999
contact lenses when working with chemicals.
Skin Protection: Wear protective gloves and clean Revision: March 2008
body-covering clothing, long-sleeved shirt, trousers, apron MSDS: 6680-5
or lab coat.
Proposed WHMIS Designation: D2B
Other Personal Protective Equipment: Safety shower
and eye-wash fountain in work area.
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Leak and Spill Procedure: Ventilate area. Eliminate
Caledon Laboratories Ltd. believes the information contained
sources of ignition. Cleanup personnel should be trained in
herein is reliable and accurate. Caledon makes no warranty
the handling of hazardous chemicals and should wear pro-
with respect thereto and expressly disclaims all liability for reli-
tective equipment and clothing sufficient to prevent
inhalation of dust, mist or fumes, and contact with skin and ance thereon. Such information is solely for your consider-
eyes. Prevent from entering sewers or waterways. Collect ation, investigation, and verification.
in a manner that does not raise dust, transfer carefully into
container, and arrange removal by disposal company. Wash
site of spillage thoroughly with water and detergent.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: COMBUSTIBLE
DUST. Workers using this chemical must be properly
trained in its hazards and its safe use, and must wear appro-
priate protective equipment and clothing. Avoid generating
dust. If there is dust, keep away from heat, sparks, and all
sources of ignition; avoid the accumulation of static charge,
use anti-sparking tools and ground and bond equipment and
containers. Use the smallest amount possible for the pur-
pose, in a designated area with adequate ventilation. Use
good housekeeping to prevent accumulations of dust. Avoid
contact with skin and eyes. Avoid inhalation. Wash thor-
oughly after handling.
Storage Requirements: Store in freezer (-15 to -22掳C), in
suitable, labelled containers. Keep containers tightly closed.
Store away from incompatible materials. Protect from dam-
age and inspect frequently for signs of leaking.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with gently running water,
holding eyelids open while flushing, for five to ten (5-10)
minutes, or until no trace of chemical remains. Get medical
attention if irritation develops.
Skin: Remove contaminated clothing. Brush or wipe off dry
material. Flush skin with plenty of running water until no evi-
dence of chemical remains. If irritation develops, if
exposure was severe, or if person has a history of allergies,
get medical attention.
Inhalation: Remove to fresh air. Give oxygen and get
medical attention for any breathing difficulty, or if person has
a history of allergic reactions.
Ingestion: If victim is alert and NOT convulsing, rinse
mouth, give several glasses of water to drink to dilute. If dis-
comfort occurs, if person has a history of allergies, or if a
large amount has been ingested, get medical attention.
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