MATERIAL SAFETY DATA SHEET (-)-QUININE ANHYDROUS
PRODUCT CODE NUMBER(S): 7140-5
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: Quinine anhydrous Flammability: May be combustible if strongly heated. As
with most organic compounds, fine dust dispersed in air in
Chemical Family: Quinies, quinidines
the presence of an ignition source is a potential dust explo-
Chemical Formula: C20H24N2O2 sion hazard.
Product Use: Laboratory reagent Extinguishing Media: Use extinguisher appropriate to sur-
Manufacturer鈥檚 Name and Address: rounding fire. Fight fire from upwind, from a safe distance.
Firefighters must wear protective equipment (posi-
Caledon Laboratories Ltd.
tive-pressure, full face-piece self-contained breathing
40 Armstrong Avenue
apparatus) and clothing sufficient to prevent inhalation of
Georgetown, Ontario L7G 4R9
dust or fumes and contact with skin and eyes.
Telephone No: (905) 877-0101
Flash Point (Method Used): Not applicable
Fax No: (905) 877-6666
Autoignition Temperature: Not applicable
Emergency Telephone No: CANUTEC (613) 996-6666
Upper Flammable Limit (% by volume): Not applicable
Lower Flammable Limit (% by volume): Not applicable
HAZARDOUS INGREDIENTS OF MATERIALS
Hazardous Combustion Products: Toxic, irritating fumes,
COx, NOx.
Ingredients % TLV Units CAS No.
Sensitivity to Impact: None identified
Quinine anhydrous ~98 Not established 130-95-0
Sensitivity to Static discharge: As with most organic pow-
ders, mixtures of dust with air may be sensitive under
PHYSICAL DATA
certain conditions, when ignited by an electrostatic or other
Physical State: Solid high-voltage spark, or other ignition source.
Odour and Appearance: White powder, odourless
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Odour Threshold (ppm): Not applicable
Vapour Pressure (mm Hg): Not applicable Toxicological Data:
Vapour Density (Air = 1): Not applicable
LD50: Not available
Evaporation Rate: Not available
LC50: Not available
Boiling Point (掳C): Not available
Melting Point (掳C): 173掳C Effects of Acute Exposure to Product:
pH: 6.5 (1%)
Inhaled: Irritates respiratory tract, causing sneezing and
Specific Gravity: Not available coughing. May cause respiratory sensitization. Severe
overexposure can be harmful, causing shortness of breath,
Coefficient of Water/Oil distribution: Not available
cyanosis, respiratory depression.
SHIPPING DESCRIPTION In contact with skin: May cause mild irritation, with itching,
reddening. Sensitization dermatitis may result from skin
UN: Not regulated contact, resulting in severe reaction to future minor expo-
T.D.G. Class: Not regulated sures.
In contact with eyes: Causes eye irritation with swelling,
Pkg. Group: Not regulated
tearing, exuding of sticky viscous liquid which forms yellow-
REACTIVITY DATA ish crusts. Causes blurred vision, disturbed color perception,
photophobia, night blindness, constricted visual fields, even
Chemical Stability: Stable. May discolour on exposrue to blindness.
light. Ingested: Harmful;. irritating to gastrointestinal tract. May
Incompatibility with other substances: May react vigor- cause nausea, vomiting, diarrhea, abdominal cramps. May
ously or violently with strong oxidizers, bases, alkalis, cause kidney damage, and visual and hearing disturbances,
carbonates, iodides, tannic acid. tinnitus, and central nervous system depression, with excite-
ment, headache, dizziness, drowsiness, nausea. In
Reactivity: Avoid generation of dust, all incompatible mate-
advanced stages of toxicity, there may be collapse, uncon-
rials, exposure to sunlight or ultraviolet light, temperatures
sciousness, coma and possible death due to respiratory
above 40掳C.
failure.
Hazardous Decomposition Products: None identified
MSDS (-)-QUININE ANHYDROUS
CODE: 7140-5
Effects of Chronic Exposure to Product: running water until no trace of chemical remains. Get
medical attention if irritation develops.
Prolonged or repeated contact may cause effects as in 鈥淚n-
Inhalation: Remove to fresh air. Give oxygen and get
gested鈥?.
medical attention for any breathing difficulty.
Carcinogenicity: Not listed as a carcinogen by NTP, IARC Ingestion: If victim is alert and not convulsing, rinse mouth
or OSHA thoroughly with water and give 2 to 4 glsses of water to
Teratogenicity: No human or animal information available drink to dilute. Do not induce vomiting. Get medical atten-
Reproductive Effects: No human or animal information tion. If spontaneous vomiting occurs, rinse mouth and give
available more water to drink. Get medical attention.
Mutagenicity: No information available
REFERENCES USED
Synergistic Products: None known
CCINFO disc: MSDS鈥檚, January 2007
PREVENTIVE MEASURES Budavari: The Merck Index, 12th ed., 1997
Engineering Controls: Local exhaust ventilation recom- Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
mended ed., 1987
Respiratory Protection: Dust mask. Up to maximum use Suppliers鈥? Material Safety Data Sheets
specified by the respirator supplier, NIOSH/MSHA approved
half-face or full face-piece dust/mist respirator, depending ADDITIONAL INFORMATION
on concentration present. Higher or unknown concentra-
tions, or for fire or spill conditions, self-contained breathing Date Issued: January 2001
apparatus, or full face-piece, positive-pressure supplied-air Revision: January 2007
respirator.
MSDS: 7140-5
Eye Protection: Chemical safety goggles
Proposed WHMIS Designation: D2B
Skin Protection: Rubber or plastic gloves. Other protec-
tive, body-covering clothing sufficient to prevent contact.
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Other Personal Protective Equipment: Safety shower
Caledon Laboratories Ltd. believes the information contained
and eye-wash fountain in work area.
herein is reliable and accurate. Caledon makes no warranty
Leak and Spill Procedure: Eliminate all sources of igntion.
with respect thereto and expressly disclaims all liability for reli-
Evacuate area. Ventilate area. Cleanup personnel must be
ance thereon. Such information is solely for your consider-
thoroughly trained in the hazards of this material and must
ation, investigation, and verification.
wear protective equipment and clothing sufficient to prevent
inhalation of dust or fumes, and contact with skin and eyes.
Mix with sand or inert absorbent, collect in a manner that
does not raise dust, and transfer carefully into labelled, cov-
ered container(s) for removal by disposal company. Wash
site of spillage thoroughly with water and detergent.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: Workers using this
chemical must be trained in its hazards and its safe use, and
must wear appropriate protective clothing and equipment.
Follow routine safe handling procedures and good house-
keeping procedures. Avoid generating dust. Avoid contact
with skin and eyes. Use the smallest amount possible for
the purpose, in designated areas with adequate ventilation.
Keep containers closed when not in use and when empty.
Wash thoroughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight.
Store away from incompatible material. Keep containers
tightly closed when not in use and when empty. Protect
from damage.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with running water for at least
fifteen (15) minutes, holding eyelids open while flushing.
Take care not to flush contaminated water into unaffected
eye. Wear protective gloves to avoid contact during first aid
procedures. Get medical attention .
Skin: Remove contaminated clothing. Wear protective
gloves to minimizes contact during first aid procedures.
Brush or wipe off dry material. Flush skin thoroughly with
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