MATERIAL SAFETY DATA SHEET 1,2-PROPANEDIOL
PRODUCT CODE NUMBER(S): 6840-5
PRODUCT IDENTIFICATION Reactivity: Avoid incompaitlbe materials, excessiv e heat,
ignition sources, moisture.
Chemical Name and Synonyms: 1,2-Propanediol; Hazardous Decomposition Products: COx,
1,2-Propylene glycol; 1,2-Dihydroxpropane; Methyl glycol propionaldehyde
Chemical Family: Aliphatic dihydric alcohol/glycol
FIRE AND EXPLOSION DATA
Chemical Formula: C3H8O2
Product Use: Laboratory reagent Flammability: Not combustible; can probably burn if
Manufacturer鈥檚 Name and Address: strongly heated.
Caledon Laboratories Ltd. Extinguishing Media: Water spray, carbon dioxide, dry
40 Armstrong Avenue chemical, alcohol or polymer foam. Water as spray or fog
will cause frothing, which can blanket and smother the fire.
Georgetown, Ontario L7G 4R9
Water can also be used to cool containers, disperse va-
Telephone No: (905) 877-0101
pours, and flush materials away from fire. Fight fire from
Fax No: (905) 877-6666 upwind, from a safe distance. Firefighters must wear protec-
Emergency Telephone No: CANUTEC (613) 996-6666 tive equipment and clothings ufficient to prevent inhalation of
mist or fumes and contact with skin and eyes.
HAZARDOUS INGREDIENTS OF MATERIALS Flash Point (Method Used): 99掳C (CC)
Autoignition Temperature: 371掳C
Ingredients % TLV Units CAS No.
Upper Explosion Limit (% by volume): 2.6
1,2 Propanediol 99.5 Not established 57-55-6 Lower Explosion Limit (% by volume): 12.5
Hazardous Combustion Products: COx, propionaldehyde,
PHYSICAL DATA acrid smoke, fumes
Physical State: Liquid Sensitivity to Impact: None identified
Odour and Appearance: Colourless, practically odourless, Sensitivity to Static discharge: Not likely to be ignited by
viscous liquid static discharge - high flash point.
Odour Threshold (ppm): Not applicable
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Vapour Pressure (mm Hg): 0.08 mm Hg at 20掳C
Vapour Density (Air = 1): Not applicable Toxicological Data:
Evaporation Rate (butyl acetate = 1): 0.01
LD50: (oral, rat) 21,800 mg/kg; (dermal, rabbit) 14,800
Boiling Point (degrees C): 187.6掳C mg/kg
Freezing Point (degrees C): -60掳C LC50: Not available
pH: Not available, probably neutral
Effects of Acute Exposure to Product:
Specific Gravity: 1.0381 (20掳C)
Coefficient of Water/Oil distribution: logP(oct)= -0.92 Inhaled: Practically non-toxic. Vapour and mist are unlikely
to cause adverse effects. No adverse effects reported
SHIPPING DESCRIPTION among humans exposed to 10% mist for 1 hour.
In contact with skin: May irritate if sealed to skin for a pro-
UN: Not regulated
longed period by gloves, shoes or tight clothing. Not
T.D.G. Class: Not regulated considered irritating when uncovered.
Pkg. Group: Not regulated In contact with eyes: Undiluted liquid may cause mild irri-
tation, stinging and tearing, temporary congestion of eye
REACTIVITY DATA tissue.
Ingested: Essentially non-toxic. May cause mild irritation
Chemical Stability: Stable, strongly hygroscopic, absorbs
of stomach lining. Doses in excess of 600-700 g per day
moisture from air.
could cause CNS effects and liver damage.
Incompatibility with other substances: May react vio-
lently with strong oxidizing materials: can increase the risk of
Effects of Chronic Exposure to Product:
fire and explosion. Decomposes violently in contact with
perchloric acid. May explode with mixtures of hydrofluoric Prolonged or repeated exposure to vapour and mist has not
acid, nitric acid, and silver nitrate. Corrosive to iron, steel, been shown to pose a health hazard in animal testing. Re-
copper, aluminum if contact is prolonged. Will not corrode peated skin contact may cause drying and mild irritation.
stainless steel 316 grade or above, vinyl or epoxy-caoted Propylene glycol is used clinically as a solvent for the admin-
black iron. Attacks some kinds of plastics and coatings. istration of medicine. A patient receiveing 15-30 mL daily for
4 months experienced no adverse effects.
1,2-PROPANEDIOL
MSDS
CODE: 6840-5
Carcinogenicity: Not carcinogenic in animal studies; no ous vomiting occurs, have casualty lean forward to avoid
human information available. breathing in of emesis. Rinse mouth and administer more
water. If discomfort occurs, get medical attention.
Teratogenicity: No human information available; no evi-
dence of effects in animal testing.
REFERENCES USED
Reproductive Effects: No human information available; no
evidence of effects in animal testing. CCINFO disc: Cheminfo, MSDS鈥檚, April 2006
Mutagenicity: No human information available; no evi-
Budavari: The Merck Index, 12th ed., 1997
dence of effects in animal testing.
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
Synergistic Products: None known
ed., 1987
PREVENTIVE MEASURES Sax: Dangerous Properties of Industrial Materials, 5th ed.,
1979
Engineering Controls: Local exhaust ventilation recom-
Suppliers鈥? Material Safety Data Sheets
mended.
Respiratory Protection: Dust/mist mask; fumehood.
ADDITIONAL INFORMATION
NIOSH/MSHA approved air-purifying respirator or
self-contained breathing apparatus for high or unknown con- Date Issued: July 22, 1991
centrations, as in fire or spill conditions.
Revision: April 2006
Eye Protection: Chemical safety glasses or goggles.
MSDS: 6840-5
Skin Protection: 4H鈩? (polyethylene/ethylene vinyl alco-
Proposed WHMIS Designation: Not controlled. Not re-
hol) gloves. Other protective clothing sufficient to limit
quired to be updated every three years (WHMIS 1992, B-40,
contact.
Section 29,2)
Other Personal Protective Equipment: An eyewash and
safety shower should be nearby and ready for use.
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Leak and Spill Procedure: Ventilate area. Restrict access
Caledon Laboratories Ltd. believes the information contained
to area of spill. Cleanup personnel should be trained in the
herein is reliable and accurate. Caledon makes no warranty
handling of hazardous materials, and should wear protective
with respect thereto and expressly disclaims all liability for reli-
equipment and clothing sufficient to prevent inhalation of
ance thereon. Such information is solely for your consider-
mist and vapours and contact with skin and eyes. Contain
spill with earth, sand or inert absorbent. Collect contami- ation, investigation, and verification.
nated material and transfer to steel drums for recovery or
disposal. Prevent from entering sewers or waterways.
Flush area of spill with copious amounts of water.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: Workers handling
this product should be trained in its hazards and its safe
use, and must wear apprpriate protective equipment and
clothing. Follow routine safe handling and good
housekeeping procedures. Keep work area clean and free
of extraneous, particularly combustible, materials. Use the
smallest amount possible for the purpose, in designated ar-
eas with adequate ventilation. Avoid generating mist. Avoid
inhalation and contact. Wash thoroughly after handling.
Keep away from all incompatible materials.
Storage Requirements: Store in suitable, labelled contain-
ers in a cool, dry, well-ventilated area, out of direct sunlight
and away from incompatible materials. Keep air out of con-
tainer. Keep container tightly closed. Protect from damage.
Inspect periodically for leaks.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes with warm running water for five to ten
(5-10) minutes, holding eyelids open during flushing. If irri-
tation persists, obtain medical advice.
Skin: Remove contaminated clothing (including rings,
watches, belts, and shoes). Flush exposed area with large
amounts of warm running water for five to ten (5-10) min-
utes. If irritation persists, obtain medical advice.
Inhalation: Remove to fresh air. Give oxygen and get
medical attention for breathing difficullty.
Ingestion: Do not induce vomiting. If the casualty is alert
and not convulsing, rinse mouth thoroughly and give 1 to 2
glasses of water to drink to dilute the material. If spontane-
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