MATERIAL SAFETY DATA SHEET N-METHYL-2-PYRROLIDONE
PRODUCT CODE NUMBER(S): 7500-1, 7500-4, 7501-2, 7502-2
PRODUCT IDENTIFICATION There are no reports of explosions or fires caused by
peroxides in NMP.
Chemical Name and Synonyms: n-Methyl-2-pyrrolidone; Reactivity: Avoid temperatures above 86掳C, moisture,
1-Methyl-2-pyrrolidone; m-Pyrol heat, sparks, flame, and all ignition sources or incompatible
Chemical Family: Cyclic amide materials. Avoid generation of mist.
Chemical Formula: C5H9NO Hazardous Decomposition Products: Fumes of COx and
NOx when heated to decomposition
Product Use: Laboratory solvent
Manufacturer鈥檚 Name and Address:
FIRE AND EXPLOSION DATA
Caledon Laboratories Ltd.
40 Armstrong Avenue Flammability: Combustible liquid; Can form explosive mix-
tures with air at or above 93掳C.
Georgetown, Ontario L7G 4R9
Extinguishing Media: Water spray, alcohol or polymer
Telephone No: (905) 877-0101
foam, dry chemical, or CO2. Water may cause frothing,
Fax No: (905) 877-6666
however, with a gentle spray or fog the froth will blanket and
Emergency Telephone No: CANUTEC (613) 996-6666 extinguish the fire. Use water spray to cool containers, dis-
perse vapours, and flush spills away from fire area. Fight
HAZARDOUS INGREDIENTS OF MATERIALS fire from upwind, from a safe distance. Firefighters must
wear protective equipment (NIOSH/MSHA approved
Ingredients % TLV Units CAS No. self-contained breathing apparatus) and clothing (Bunker
Gear) sufficient to prevent inhalation of mist or vapours, and
n-Methyl-2-pyrrolidone >99 Not established 872-50-4
contact with skin and eyes. Containers may explode in heat
of fire; withdraw immediately in case of rising sound from
PHYSICAL DATA vent or discoloration of tank.
Flash Point (Method Used): 93掳C (CC)
Physical State: Liquid
Autoignition Temperature: 270掳C
Odour and Appearance: Colourless to pale yellow; amine
odour Upper Flammable Limit (% by volume): 9.5
Odour Threshold (ppm): Not available Lower Flammable Limit (% by volume): 1.3
Vapour Pressure (mm Hg): 0.29 mm Hg at 20掳C Hazardous Combustion Products: COx and NOx
Vapour Density (Air = 1): 3.4 Sensitivity to Impact: None identified
Evaporation Rate (Butyl acetate = 1): 0.06 Sensitivity to Static discharge: Mixtures of vapour and air
Boiling Point (degrees C): 203掳C at concentrations in the flammable range may be ignited by
static discharge.
Freezing Point (degrees C): -23掳C
pH: 7.7 to 8.0(10%, aqueous)
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Specific Gravity: 1.028 at 25掳C
Coefficient of Water/Oil distribution: Not available. Toxicological Data:
LD50: (oral, rat) 4,150 mg/kg; (dermal, rat) 7,000 mg/kg
SHIPPING DESCRIPTION
LC50: (rat) >6.0 mg/L/4h
UN: Not regulated
Effects of Acute Exposure to Product:
T.D.G. Class: Not regulated
Pkg. Group: Not regulated Inhaled: Irritating to respiratory tract. May be harmful. May
cause headache, giddiness, fatigue, mental confusion,
REACTIVITY DATA shortness of breath. No human information available; re-
sults were reported on animal testing.
Chemical Stability: Stable under normal conditions. Hy-
In contact with skin: Non-irritating in 24-hour patch test on
groscopic; absorbs water from air. Slowly oxidizes on
50 human subjects.
exposure to air, with the formation of hydroperoxides; pro-
In contact with eyes: Mist or vapour may be irritating to
cess is accelerated by sunlight.
eyes. Liquid is very irritating and will cause burning or sting-
Incompatibility with other substances: May ignite spon-
ing of eyes and lids, watering of the eyes, inflammation of
taneously with oxidizing agents. Strong acids or strong
conjunctiva, clouding of cornea, possible permanent dam-
bases can cause hydrolysis. Incompatible with many types
age. No human information is available; these results were
of rubber or plastic. Can form peroxides on storage in the
reported on animal testing.
presence of air and sunlight. However, the peroxides
Ingested: No human information available. Ingestion may
formed from related chemicals are readily degradable and
cause irritation and burning of the mouth and throat, abdomi-
do not accululate to a hazardous level (Bretherick, 1985).
nal pain and central nervous system depression. Aspiration
MSDS N-METHYL-2-PYRROLIDONE
CODE: 7500-1, 7500-4, 7501-2, 7502-2
of the liquid into the lungs during ingestion or vomiting may and away from heat, and all ignition sources. Keep away
cause severe lung irritation or damage, chemical pneumoni- from incompatible materials. Protect from damage, and
tis, pulmonary edema and even death. ispect regularly for signs of leaking. Limit quantity of mate-
rial in storage, and dispose of old material. Storage area
should have raised sills or ramps to contain leaks and/or
Effects of Chronic Exposure to Product:
conduct them to a safe area.
Studies with animals showed effects on liver, kidney, bone
marrow, thymus, spleen and lymphatic system. Prolonged or FIRST AID MEASURES
repeated skin contact can cause severe dermatitis.
Specific Measures:
Carcinogenicity: Not listed as carcinogenic
Teratogenicity: No human information available. Develop- Eyes: Immediately flush eyes with gently running water for
mental abnormalities in animal studies. at least fifteen (15) minutes, holding eyelids open while
Reproductive Effects: No human or animal information flushing. Take care not to flush contaminated water into un-
available. affected eye. Get medical attention immediately.
Mutagenicity: Negative in Ames test (salmonella). Skin: Remove contaminated clothing (including watches,
rings, belts, and shoes). Immediately flush skin with running
Synergistic Products: May enhance skin penetration of
water for five to ten (5-10) minutes, or until no trace of
other substances; used in pharmaceutical applications.
chemcial remains. If irritation persists, get medical attention.
PREVENTIVE MEASURES Decontaminate clothing before re-use, or discard.
Inhalation: Remove to fresh air. Give oxygen and get med-
Engineering Controls: Non-sparking, grounded ventilation ical attention for any breathing difficulty. If breathing has
system, separate from other ventilation systems, and elec- stopped, begin artificial respiration immediately. If breathing
trical equipment that does not provide a source of ignition. and pulse are absent, begin CPR. Get medical attention im-
Respiratory Protection: Use only in a fume hood. mediately.
NIOSH/MSHA approved air-purifying respirator with organic Ingestion: If person is conscious and not convulsing, rinse
vapour cartridges or full face-piece chemical cartridge respi- mouth thoroughly with water and give 1 to 2 glasses of wa-
rator with organic vapour cartridges for concentrations that ter to drink to dilute. DO NOT INDUCE VOMITING. If
cannot be controlled by exhaust ventilation. For higher or spontaneous vomiting occurs, have person lean forward to
unknown concentrations, as in fire or spill conditions, posi- avoid breathing of vomitus, rinse mouth and give more wa-
tive-pressure, full face-piece self contained breathing ter to drink. Get medical attetnion immediately.
apparatus, or full face-piece supplied-air respirator with an
auxiliary positive-pressure self contained breathing appara- REFERENCES USED
tus.
CCINFO disc: MSDS鈥檚, October 2006
Eye Protection: Chemical goggles and/or face shield
Budavari: The Merck Index, 12th ed., 1997
Skin Protection: Butyl rubber gloves. Other impervious
protective clothing (apron, lab coat, coveralls, etc.) sufficient Royal Society of Chemistry: Chemcial Safety Data Sheets,
to prevent contact. Vol. 1, 1992
Other Personal Protective Equipment: Safety shower Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
and eyewash fountain in work area. ed., 1987
Leak and Spill Procedure: Evacuate area, provide maxi-
Sax: Dangerous Properties of Industrial Materials, 5th ed.,
mum ventilation and eliminate all sources of ignition.
1979
Cleanup personnel must be thoroughly trained in the han-
Bretherick: Hazards in the Chemical Laboratory, 3rd ed., 1981
dling of hazardous material, and must wear protective
equipment and clothing sufficient to prevent inhalation of va- Suppliers鈥? Material Safety Data Sheets
pours or mists, and contact with skin and eyes. Do not touch
spilled material. Contain spill and cover with inert absorbent ADDITIONAL INFORMATION
material. Prevent from entering sewers or waterways. Col-
lect and transfer to suitable, labelled, covered container for Date Issued: November 13, 1991
disposal. Flush area of spill with running water. Revision: October 2006
Waste Disposal: Follow all federal, provincial and local MSDS: 7500-1, 7500-4, 7501-2, 7502-2
regulations for disposal.
Proposed WHMIS Designation: B3; D2B (eye irritation)
Handling Procedures and Equipment: COMBUSTIBLE
LIQUID. Workers must be thoroughly trained in the hazards
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
of this material and its safe use, and must wear appropriate
Caledon Laboratories Ltd. believes the information contained
protective equipment and clothing. Bond and ground during
herein is reliable and accurate. Caledon makes no warranty
liquid transfer. Keep away from heat, sparks and open
flame. Use non-sparking tools. Post 鈥淣o Smoking鈥? signs. with respect thereto and expressly disclaims all liability for reli-
Use smallest amount possible for the purpose in a desig- ance thereon. Such information is solely for your consider-
nated area with appropriate ventilation. Keep work area ation, investigation, and verification.
clean and free of extraneous materials. Avoid generating
vapour or mist. Avoid all contact with eyes, skin or clothing.
Keep away from all incompatible and combustible materials.
Open containers with extreme caution; do not attempt to
open if containers are of unknown age, or if solid particles
have formed, or if contamination is suspected.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out od direct sunlight
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