MATERIAL SAFETY DATA SHEET TAE BUFFER
PRODUCT CODE NUMBER(S): 8610-5
PRODUCT IDENTIFICATION brass, aluminum, but not steel or iron. Aluminum reacts with
aqueous solutions of EDTA to release hydrogen.
Chemical Name and Synonyms: TAE Buffer concentrate Reactivity: Avoid excessive heat, generation of mist, all in-
Chemical Family: Mixture compatible materials.
Chemical Formula: Mixture Hazardous Decomposition Products: COx , NOx
Product Use: Laboratory reagent
FIRE AND EXPLOSION DATA
Manufacturer鈥檚 Name and Address:
Caledon Laboratories Ltd. Flammability: Not combustible
40 Armstrong Avenue Extinguishing Media: Use extinguishing media
Georgetown, Ontario L7G 4R9 pappropriate to the surrounding fire. Water spray can be
used to cool containers, flush chemical away from fire. Fight
Telephone No: (905) 877-0101
fire from upwind, from a safe distance. Firefighters must
Fax No: (905) 877-6666
wear protective equipment and clothing sufficient to prevent
Emergency Telephone No: CANUTEC (613) 996-6666 inhalation of mist or fumes, and contact with skin and eyes.
Flash Point (Method Used): Not available
HAZARDOUS INGREDIENTS OF MATERIALS
Autoignition Temperature: Not available
Upper Flammable Limit (% by volume): Not available
Ingredients % TLV Units CAS No.
Lower Flammable Limit (% by volume): Not available
3
Tris(hydroxymethyl) N/A 10 mg/m 77-86-1
Hazardous Combustion Products: COx, NOx, irritating
methylamine (nuisance dust)
smoke
Tris acetate N/A Not established 6850-28-8
Sensitivity to Impact: None identified
Ethylenediamine Sensitivity to Static discharge: None identified
tetraacetic acid N/A Not established 6381-92-6
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Ethylenediamine
tetraacetic acid, N/A Not established 10378-23-1
Toxicological Data:
tetrasodium salt
LD50: (oral, rat) 5,900 mg/kg (Tris); (oral, rat) 2,000 mg/kg
PHYSICAL DATA (EDTA)
LC50: Not available
Physical State: Liquid
Odour and Appearance: Colourless liquid
Effects of Acute Exposure to Product:
Odour Threshold (ppm): Not available
Inhaled: Mist may be irritating to upper respiratoy tract.
Vapour Pressure (mm Hg): Not available
Large amounts may be harmful.
Vapour Density (Air = 1): Not applicable
In contact with skin: May be irritating to skin. Severe
Evaporation Rate: Not applicable overexposure may cause drying and cracking of skin.
Boiling Point (degrees C): Not available In contact with eyes: May cause mild irritation with tem-
porary redness, itching, tearing, pain.
Melting Point (degrees C): Not available
Ingested: Large oral dosages may produce gastrointestinal
pH: Not available
disturbances, nausea, vomiting, confusion, muscular
Specific Gravity: Not available
spasms, eventual coma.
Coefficient of Water/Oil distribution: Not available
Effects of Chronic Exposure to Product:
SHIPPING DESCRIPTION
Carcinogenicity: No information available
UN: Not regulated Teratogenicity: No information available
T.D.G. Class: Not regulated Reproductive Effects: No information available
Pkg. Group: Not regulated Mutagenicity: No information available
Synergistic Products: Not known
REACTIVITY DATA
PREVENTIVE MEASURES
Chemical Stability: Stable under normal temperatures and
pressures
Engineering Controls: Local exhaust ventilation recom-
Incompatibility with other substances: May react vigor- mended.
ously with bases, oxidizing agents, acids. Tris reacts with
aldehydes to form bicyclic oxazolidines. Attacks copper,
TAE BUFFER
MSDS
CODE: 8610-5
Respiratory Protection: Dust/mist mask. For conditions Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
where dust or mist is present, to the maximum use specified ed., 1987
by the respirator supplier, NIOSH/OSHA approved half- face
Sax: Dangerous Properties of Industrial Materials, 5th ed.,
high-efficiency dust/mist filter respirator, or NIOSH/OSHA
1979
approved full face-piece high-efficiency dust/mist filter respi-
Suppliers鈥? Material Safety Data Sheets
rator. Higher or unknown concentrations, or for fire or spill
conditions, self-contained breathing apparatus, or full
ADDITIONAL INFORMATION
face-piece, positive-pressure supplied-air respirator.
Eye Protection: Chemical safety glasses. Do not wear
Date Issued: May 6, 1999
contact lenses when working with chemicals.
Revision: May 2008
Skin Protection: Wear protective gloves and clean
MSDS: 8610-5
body-covering clothing, long-sleeved shirt, trousers, apron
or lab coat. Proposed WHMIS Designation: Not controlled. Not re-
Other Personal Protective Equipment: Eyewash fountain quired to be updated every three years (WHMIS 1992, B-40,
ans safety shower in work area. Section 29,2)
Leak and Spill Procedure: Ventilate area. Cleanup per-
sonnel should be thoroughly trained in the hazards of this Prepared by: Caledon Laboratories Ltd. (905) 877-0101
material and should wear protective equipment and clothing Caledon Laboratories Ltd. believes the information contained
sufficient to prevent inhalation and contact with skin and herein is reliable and accurate. Caledon makes no warranty
eyes. Prevent from entering sewers or waterways. Mix with with respect thereto and expressly disclaims all liability for reli-
sand or inert absorbent, collect and transfer carefully into la-
ance thereon. Such information is solely for your consider-
belled, covered container(s) for removal by disposal
ation, investigation, and verification.
company. Wash site of spillage thoroughly with water and
detergent.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: Workers using this
chemical must be properly trained in its hazards and its safe
use, and must wear appropriate protective equipment and
clothing. Follow routine safe handling procedures and good
housekeeping procedures. Avoid generating mist. Avoid in-
halation and contact with skin and eyes. Use the smallest
amount possible for the purpose, in designated areas with
adequate ventilation. Keep containers closed when not in
use and when empty. Wash thoroughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight.
Store away from incompatible materials. Keep containers
tightly closed when not in use and when empty. Protect
from damage, and inspect frequently for signs of leaking.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with running water for five to
ten (5-10) minutes, or until no trace of chemical remains,
holding eyelids open while flushing. Get medical advice if ir-
ritation persists.
Skin: Flush skin thoroughly with running water until no
trace of chemical remains. Get medical attention if irritation
develops.
Inhalation: Remove to fresh air. Give oxygen and get
medical attention for breathing difficulty.
Ingestion: If victim is alert and not convulsing, give 2 to 4
glasses of water to dilute material. If vomiting occurs, rinse
mouth and give more water to drink. If victim feels unwell,
or if a large amount has been ingested, get medical atten-
tion.
REFERENCES USED
CINFO disc: Cheminfo
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