MATERIAL SAFETY DATA SHEET 2-PROPANOL
PRODUCT CODE NUMBER(S): 8600-1, 8600-2, 8600-4, 8600-6, 8601-2, 8601-7, 8600-30, 8608-1, CAL 1274
PRODUCT IDENTIFICATION gen gas. Forms explosive mixture with H2O2. Not corrosive to
steel, stainless steel, cast iron, copper and bronze at normal
Chemical Name and Synonyms: 2-Propanol; Isopropyl al- temperatures. Attacks aluminum. 2-Propanol containing water
cohol; Isopropanol; Propan-2-ol, 鈥業PA鈥? may rust steel. May attack some forms of plastics, rubber, coat-
Chemical Family: Secondary aliphatic alcohol ings.
Chemical Formula: CH3CHOHCH3 Reactivity: Avoid heat, sparks, hot surfaces, all ignition
sources, all incompatible materials, generation of mist.
Product Use: Laboratory solvent
Hazardous Decomposition Products: COx
Manufacturer鈥檚 Name and Address:
Caledon Laboratories Ltd.
FIRE AND EXPLOSION DATA
40 Armstrong Avenue
Georgetown, Ontario L7G 4R9 Flammability: Flammable liquid and vapour. Can release va-
pours that form explosive mixtures with air at, or above, 11.7掳C.
Telephone No: (905) 877-0101
Vapour is heavier than air and may travel considerable distance
Fax No: (905) 877-6666
to source of ignition and flash back. Closed containers may rup-
Emergency Telephone No: CANUTEC (613) 996-6666 ture violently when heated.
Extinguishing Media: CO2, dry chemical powder, alco-
HAZARDOUS INGREDIENTS OF MATERIALS hol-resistant foam. Water spray or fog may be used to cool
containers, disperse vapours, and flush material away from fire,
Ingredients % TLV Units CAS No. but will be ineffective for fighting fire. Fight fire from upwind,
from a safe distance. Firefighters must wear protective equip-
2-Propanol 50-99 400 ppm 67-63-0
ment (full face-piece, positive-pressure self-contained breathing
apparatus) and clothing (full Bunker gear) sufficient to prevent
PHYSICAL DATA inhalation of fumes or vapours and contact with skin and eyes.
Containers may explode in heat of fire; withdraw immediately in
Physical State: Liquid
case of rising sound from vent or discoloration of tank.
Odour and Appearance: Clear, colourless with sharp,
Flash Point (Method Used): 12掳C (CC)
musty, alcoholic odour
Autoignition Temperature: 399掳C
Odour Threshold (ppm): Reports vary widely: 3.3 to 610
ppm (detection); 7.6 to 49 ppm (recognition). Good warning Upper Flammable Limit (% by volume): 12%
properties, TLV ~10x mean odour threshold. Lower Flammable Limit (% by volume): 2.0%
Vapour Pressure (mm Hg): 33 mm Hg at 20掳C
Hazardous Combustion Products: CO2, CO
Vapour Density (Air = 1): 2.07
Sensitivity to Impact: None identified
Evaporation Rate: 1.5 (n-Butyl acetate = 1)
Sensitivity to Static discharge: Mixtures of vapour and air at
Boiling Point (degrees C): 82.3掳C concentrations in the flammable range may be ignited by static
Freezing Point (degrees C): -88.5掳C discharge. Liquid has high electrical conductivity and will prob-
ably not accumulate static charge.
pH: Weak acid
Specific Gravity: 0.79 @ 15.5掳C
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Coefficient of Water/Oil distribution: Log(P)=0.05
Toxicological Data:
SHIPPING DESCRIPTION
LD50: (oral, rat) 4,720 mg/kg; (dermal, rabbit) 12,890 mg/kg
UN: 1219 LC50: (rat) 12,000 ppm/8h
T.D.G. Class: 3
Effects of Acute Exposure to Product:
Pkg. Group: II
Inhaled: No reports of harmful effects from occupational expo-
REACTIVITY DATA sure. In human volunteers, exposure to 400 ppm for 3 to 5
minutes produced mild irritation; 800 ppm was not tolerated.
Chemical Stability: Normally stable. May form explosive
Based on animal information, and information about related al-
peroxides on standing, slowly in the dark, more rapidly in
cohols, exposure to high vapour concentrations may cause
daylight. Presence of traces of ketones (e.g. 2-butanone)
respiratory tract irritation, headache, dizziness, nausea,
greatly increases the possibility of peroxide formation.
incoordination, drowsiness and eventual loss of consciousness
Incompatibility with other substances: Increased risk of
and death.
fire and explosion with strong oxidizing agents, Lewis or
In contact with skin: No reports of irritation or toxic effects in
mineral acids, acid anhydrides, crotonaldehyde, phosgene,
human and animal testing.
potassium t-butoxide. Mixtures with any of, barium perchlor-
In contact with eyes: Moderate to severe eye irritant based on
ate, chlorine, dioxygenyl tetrafluoroborate, hypochlorous
animal testing. In human volunteers, 400 ppm for 3 to 5 minutes
acid, ethylene oxide, hexamethylene diisocyanate and other
produced mild eye irritation; 800 ppm was not tolerated.
isocyanates, nitrogen tetroxide, permonosulphuric acid,
tri-isobutyl aluminum, may explode. Reaction with alkali or Ingested: A normal component of alcoholic beverages and
alkaline earth metals releases flammable/explosive hydro- food. No adverse effects observed with daily doses (in healthy
2-PROPANOL
MSDS
CODE: 8600-1, 8600-2, 8600-4, 8600-6, 8601-2, 8601-7, 8600-30, 8608-1, CAL 1274
males) of as much as 180 mg/kg. Ingestion of large being used. Workers must be thoroughly trained regarding the haz-
amounts would probably cause symptoms of central ner-
. ards of this chemical and its safe use, and must wear appropriate
vous system, depression, nausea, vomiting, narcosis, protective equipment and clothing. Avoid any contact with eyes,
unconsciousness. Aspiration, which can easily occur during skin and clothing, and inhalation of mists or vapours. Keep away
ingestion or vomiting, can result in severe, life-threatening from heat, sparks, flame and all sources of ignition. Bond or ground
lung damage, chemical pneumonitis, or pulmonary edema. during liquid transfer. Use non-sparking tools. Use the smallest
amount possible for the purpose, in an area with adequate ventila-
tion. Keep work area clean and free of extraneous, particularly
Effects of Chronic Exposure to Product:
flammable, materials. Treat empty containers with caution; they
Prolonged and repeated contact with skin can cause may contain hazardous residues.
defatting and drying of the skin resulting in skin irritation and Storage Requirements: Store in suitable, labelled containers, in a
dermatitis. In animal testing, long-term exposure by inhala- cool, dry, well-ventilated area, away from all sources of ignition and
tion or ingestion has caused decreased body weight, signs incompatible or combustible materials. Keep containers tightly
of CNS depression, kidney damage, increased liver weight, closed. Protect from damage, and inspect frequently for signs of
increased motor activity, and incoordination. damage. Post 鈥淣O SMOKING鈥? signs. Have appropriate fire
extinguishers and spill cleanup equipment near the storage area.
Carcinogenicity: Not classifiable as carcinogenic to hu-
Storage facilities should be made of fire-resistant materials, and
mans, designation A4.
have raised sills or ramps, with trenching to a safe area.
Teratogenicity: Fetotoxicity observed in rats in the ab-
sence of maternal toxicity in one study. Other studies show
FIRST AID MEASURES
no effects. However, the incidence of fetal alcohol syndrome
in humans would indicate teratogenic effects.
Specific Measures:
Reproductive Effects: Not established, but caution is ad-
vised. Eyes: IMMEDIATELY flush eyes with warm gently running water
Mutagenicity: Both positive and negative results obtained for at least twenty (20) minutes, holding eyelids open while flush-
in cultured mammalian cells; results inconclusive. ing. Take care not to flush contaminated water into unaffected eye.
Get medical advice immediately.
Synergistic Products: Alcohols may react synergistically
with chlorinated solvents (e.g. carbon tetrachloride, chloro- Skin: Remove contaminated clothing (including rings, watches,
form) or dithiocarbamates (e.g. disulphiram, thioacetamide) belts and shoes). Immediately flush exposed area with large
amounts of gently running water for five to ten (5 to 10) minutes. If
PREVENTIVE MEASURES irritation persists, get medical advice. Decontaminate clothing be-
fore reuse, or discard.
Engineering Controls: Non-sparking, grounded ventilation Inhalation: Flammable, possible reproductive hazard. Take pre-
system, separate from other ventilation systems, and elec- cautions to ensure your own safety before attempting rescue;
trical equipment that does not provide a source of ignition. remove sources of ignition and wear appropriate protective equip-
Respiratory Protection: Up to 2,000 ppm: NIOSH/MSHA ment. Remove victim to fresh air immediately. Obtain medical
approved supplied-air respirator operated in continuous-flow attention.
mode, or full face-piece chemical cartridge respirator Ingestion: DO NOT INDUCE VOMITING. Danger of aspiration
equipped with organic vapour cartridges. Higher or unknown with vomiting. If the casualty is alert and NOT convulsing give 1 to
concentrations, as in fire or spill conditions: posi- 2 glasses of water to drink to dilute the material. Get medical at-
tive-pressure, full face-piece self-contained breathing tention immediately. If spontaneous vomiting occurs, have casualty
apparatus, or positive-pressure, full face-piece with an auxil- lean forward to avoid breathing in of emesis. Rinse mouth and ad-
iary positive-pressure self-contained b reathing apparatus. minister more water.
Eye Protection: Chemical safety goggles and/or face
shield. REFERENCES USED
Skin Protection: Use >8h: butyl or nitrile rubber, Viton鈩?,
CCINFO disc: Cheminfo, June 2006
Barrier (PE/PA/PE) Silver Shield/4H鈩?(polyethylene/ethyl-
ene vinyl alcohol), Responder鈩? gloves; use>4h: neoprene Budavari: The Merck Index, 12th ed., 1997
rubber. Other protective clothing, coat, coveralls, sleeves, Royal Society of Chemistry: Chemical Safety Data Sheets, Vol. 1,
boots, sufficient to prevent contact
1992
Other Personal Protective Equipment: Safety shower
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dict., 11th ed., 1987
and eye bath located close to chemical exposure area.
Suppliers鈥? Material Safety Data Sheets
Leak and Spill Procedure: Evacuate area, and provide
maximum ventilation. Eliminate all sources of ignition
ADDITIONAL INFORMATION
(sparks, flames, hot surfaces). Do not touch spilled material.
Cleanup must be thoroughly trained in handling hazardous
Date Issued: November 1, 1988
chemicals and must wear protective equipment and clothing
Revision: June 2006
sufficient to prevent inhalation of mists or vapours and any
contact with skin and eyes. Dike and soak up spilled mate- MSDS: 8600-1, 8600-2, 8600-4, 8600-6, 8601-2, 8601-7, 8600-30,
rial with inert absorbent. Prevent from entering sewers or 8608-1, CAL 1274
waterways. Put contaminated material in suitable, labelled, Proposed WHMIS Designation: B2; D2A (fetotoxicity); D2B (eye
closed containers for collection by disposal agency. Contam- irritant)
inated absorbent may pose the same hazards as the
product, so handle with caution. Flush area of spill thor- Prepared by: Caledon Laboratories Ltd. (905) 877-0101
oughly with copious amounts of running water. Caledon Laboratories Ltd. believes the information contained herein
Waste Disposal: Follow all federal, provincial, and local is reliable and accurate. Caledon makes no warranty with respect
regulations.
thereto and expressly disclaims all liability for reliance thereon. Such
Handling Procedures and Equipment: FLAMMABLE . information is solely for your consideration, investigation, and verifi-
TERATOGEN, SEVERE EYE IRRITANT. Before working
cation.
with this product, ensure that engineering controls are oper-
ating and that proper protective clothing and equipment is
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