MATERIAL SAFETY DATA SHEET TBE BUFFER DRY-MIX
PRODUCT CODE NUMBER(S): 8691-5
PRODUCT IDENTIFICATION reacts violently with acetic anhydride, potassium.
Incompatible with alkali carbonates, hydroxides.
Chemical Name and Synonyms: TBE Buffer dry-mix Reactivity: Avoid excessive heat, ignition sources, genera-
Chemical Family: Mixture tion of dust, all incompatible materials.
Chemical Formula: Mixture Hazardous Decomposition Products: COx , NOx, borates
Product Use: Laboratory reagent
FIRE AND EXPLOSION DATA
Manufacturer鈥檚 Name and Address:
Caledon Laboratories Ltd. Flammability: May be combustible if strongly heated. As
40 Armstrong Avenue with most organic compounds, fine dust dispersed in air in
the presence of an ignition source is a potential dust explo-
Georgetown, Ontario L7G 4R9
sion hazard.
Telephone No: (905) 877-0101
Extinguishing Media: Water fog or spray, alcohol foam,
Fax No: (905) 877-6666
dry chemical, carbon dioxide. Water or foam may cause
Emergency Telephone No: CANUTEC (613) 996-6666 frothing, which will blanket and smother the fire. Water
spray can also be used to cool containers, prevent dust for-
HAZARDOUS INGREDIENTS OF MATERIALS mation, flush chemcial away from fire. Fight fire from
upwind, from a safe distance. Firefighters must wear protec-
Ingredients % TLV Units CAS No. tive equipment and clothing sufficient to prevent inhalation of
dust or fumes, and contact with skin and eyes.
3
Tris(hydroxymethyl) N/A 10 mg/m 77-86-1
Flash Point (Method Used): Not available
methylamine (nuisance dust)
Autoignition Temperature: Not available
Boric acid N/A Not established 10043-35-3
Upper Flammable Limit (% by volume): Not available
Ethylenediamine
Lower Flammable Limit (% by volume): Not available
tetraacetic acid N/A Not established 6381-92-6
Hazardous Combustion Products: COx, NOx, irritating
smoke
PHYSICAL DATA
Sensitivity to Impact: None identified
Physical State: Solid Sensitivity to Static discharge: As with most organic pow-
Odour and Appearance: White crystalline powder; slight ders, mixtures of dust with air may be sensitive under
characteristic amine odour certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.
Odour Threshold (ppm): Not available
Vapour Pressure (mm Hg): Low at ambient temperatures
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Vapour Density (Air = 1): Not applicable
Evaporation Rate: Not applicable Toxicological Data:
Boiling Point (degrees C): Not available LD50: (oral, rat) 5,900 mg/kg (Tris); (oral, rat) 2,000 mg/kg
Melting Point (degrees C): Not available (EDTA); (oral, rat) 2,500 mg/kg (boric acid)
pH: Not available LC50: (rat) 16 mg/L (boric acid)
Specific Gravity: Not available
Effects of Acute Exposure to Product:
Coefficient of Water/Oil distribution: Not available
Inhaled: Dust may be irritating to upper respiratoy tract.
SHIPPING DESCRIPTION Large amounts may be harmful. Severe overexposure to
boric acid can be harmful, causing shortness of breath,
UN: Not regulated
cyanosis, respiratory depression.
T.D.G. Class: Not regulated In contact with skin: May be irritating to skin. Severe
Pkg. Group: Not regulated overexposure may cause drying and cracking of skin. Ab-
sorption of boric acid into blood stream through damaged
REACTIVITY DATA skin may result in erythema, macular rash, central nervous
system effects after 24 hours.
Chemical Stability: Stable under normal temperatures and In contact with eyes: May cause mild irritation with tem-
pressures porary redness, itching, tearing, pain.
Incompatibility with other substances: May react vigor- Ingested: Large oral dosages may produce gastrointestinal
ously with bases, oxidizing agents, acids. Tris reacts with disturbances, nausea, vomiting, confusion, muscular
aldehydes to form bicyclic oxazolidines. Attacks copper, spasms, eventual coma. EDTA may cause burns to the gas-
brass, aluminum, but not steel or iron. Aluminum reacts with trointestinal tract. In large quantities, may cause
aqueous solutions of EDTA to release hydrogen. Boric acid hypocalcemic tetany. May cause nausea, vomiting, diar-
TBE BUFFER DRY-MIX
MSDS
CODE: 8691-5
FIRST AID MEASURES
rhea, abdominal cramps. Large doses of boric acid may
cause circulatory collapse, tachycardia, cyanosis, delirium,
convulsions and coma. Death has been reported to occur in Specific Measures:
adults from doses of 5 to 20 grams.
Eyes: Flush eyes with warm running water for fifteen (15)
minutes, holding eyelids open during flushing. If irritation
Effects of Chronic Exposure to Product: persists, obtain medical advice.
Carcinogenicity: No information available Skin: Remove contaminated clothing. Wash skin with
plenty of water for at least ten to fifteen (10 to 15) minutes.
Teratogenicity: Boric acid is a possible teratogen (RTECS
If irritation develops, or if there are any breaks in the ex-
No. ED4550000)
posed skin (cuts or abrasions), get medical attention.
Reproductive Effects: Tests with boric acid on laboratory
Inhalation: Remove to fresh air. Give oxygen and get
animals indicate that overexposure may cause reproductive
medical advice for any breathing difficulty.
disorders.
Ingestion: If casualty is alert and not convulsing, give 2 to
Mutagenicity: No information available
4 glasses of water to dilute material. Induce vomiting under
Synergistic Products: Not known
medical supervision, with syrup of ipecac or by sticking a
finger down the throat. When vomiting occurs, rinse mouth
PREVENTIVE MEASURES and give more water to drink. Get medical attention.
Note to physician: Gastric lavage with 5% sodium bicar-
Engineering Controls: Local exhaust ventilation recom-
bonate, followed by saline catharsis, is suggested after
mended.
ingestion of boric acid. Assure adequate hydration. After
Respiratory Protection: Dust/mist mask. For conditions
ingestion of 10 g or more, symptoms may occur after 24 to
where dust or mist is present, to the maximum use specified
72 nours.
by the respirator supplier, NIOSH/OSHA approved half- face
high-efficiency dust/mist filter respirator, or NIOSH/OSHA
REFERENCES USED
approved full face-piece high-efficiency dust/mist filter respi-
rator. Higher or unknown concentrations, or for fire or spill CCINFO disc: Cheminfo
conditions, self-contained breathing apparatus, or full
Budavari: The Merck Index, 12th ed., 1997
face-piece, positive-pressure supplied-air respirator.
Royal Society of Chemistry: Chemical Safety Data Sheets,
Eye Protection: Chemical safety glasses. Do not wear
Vol. 2, 1989
contact lenses when working with chemicals.
Skin Protection: Rubber gloves. Lab coat or apron with Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
sleeves. ed., 1987
Other Personal Protective Equipment: Eyewash fountain Suppliers鈥? Material Safety Data Sheets
ans safety shower in work area.
ADDITIONAL INFORMATION
Leak and Spill Procedure: Ventilate area. Cleanup per-
sonnel should be thoroughly trained in the hazards of this
material and should wear protective equipment and clothing Date Issued: May 6, 1999
sufficient to prevent inhalation of dust or fumes, and contact Revision: May 2008
with skin and eyes. Prevent from entering sewers or water-
MSDS: 8691-5
ways. Wet ifnecessary to control dust. Collect in a manner
Proposed WHMIS Designation: D2A; D2B (boric acid)
that does not raise dust, and transfer carefully into labelled,
covered container(s) for removal by disposal company.
Wash site of spillage thoroughly with water and detergent. Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Waste Disposal: Follow all federal, provincial and local Caledon Laboratories Ltd. believes the information contained
regulations for disposal. herein is reliable and accurate. Caledon makes no warranty
Handling Procedures and Equipment: COMBUSTIBLE with respect thereto and expressly disclaims all liability for reli-
DUST. Workers using this chemical must be properly ance thereon. Such information is solely for your consider-
trained in its hazards and its safe use, and must wear appro- ation, investigation, and verification.
priate protective equipment and clothing. Avoid generating
dust. If there is dust, keep away from heat, sparks, and all
sources of ignition; avoid the accumulation of static charge,
use anti-sparking tools and ground and bond equipment and
containers. Use the smallest amount possible for the pur-
pose, in a designated area with adequate ventilation. Use
good housekeeping to prevent accumulations of dust. Avoid
contact with skin and eyes. Avoid inhalation. Wash thor-
oughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well ventilated area, away from sources of
ignition,and incompatible or combustible materials. Keep
containers tightly closed when not in use and when empty.
Protect from damage.
|