MATERIAL SAFETY DATA SHEET THIOUREA
PRODUCT CODE NUMBER(S): 8870-5
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: Thiourea; Flammability: May be combustible if strongly heated. As
Thiocarbamide; Isothiourea; Pseudothiourea with most organic compounds, fine dust dispersed in air in
the presence of an ignition source is a potential dust explo-
Chemical Family: Amide/thioamide
sion hazard.
Chemical Formula: NH2CSNH2
Extinguishing Media: Use an extinguisher appropriate to
Product Use: Laboratory reagent the surrounding material that is burning. Water fog or spray
Manufacturer鈥檚 Name and Address: can also be used to cool containers, prevent dust formation,
Caledon Laboratories Ltd. flush chemcial away from fire. Fight fire from upwind, from a
safe distance. Firefighters must wear protective equipment
40 Armstrong Avenue
and clothing sufficient to prevent inhalation of dust or fumes,
Georgetown, Ontario L7G 4R9
and contact with skin and eyes.
Telephone No: (905) 877-0101
Flash Point (Method Used): 440掳C
Fax No: (905) 877-6666
Autoignition Temperature: Not available
Emergency Telephone No: CANUTEC (613) 996-6666
Upper Flammable Limit (% by volume): Not available
HAZARDOUS INGREDIENTS OF MATERIALS Lower Flammable Limit (% by volume): Not available
Hazardous Combustion Products: Emits extremely toxic
Ingredients % TLV Units CAS No. fumes in a fire (NOx, SOx, CN,H2S)
Sensitivity to Impact: May be sensitive to mechanical
Thiocarbamide >99 Not established 62-56-6
shock
Sensitivity to Static discharge: As with most organic pow-
PHYSICAL DATA
ders, mixtures of dust with air may be sensitive under
Physical State: Solid certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.
Odour and Appearance: White, lustrous crystals, odour-
less.
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Odour Threshold (ppm): Not applicable
Vapour Pressure (mm Hg): 2.5 mm Hg @ 25掳C Toxicological Data:
Vapour Density (Air = 1): 2.6
LD50: (oral, rat) 125 mg/kg
Evaporation Rate: Not available
LC50: (rat) 2,170 mg/m3
Boiling Point (degrees C): Not applicable (decomposes)
Melting Point (degrees C): 176-178掳C Effects of Acute Exposure to Product:
pH: Not available
Inhaled: Toxic. May cause irritation to tissue of upper re-
Specific Gravity: 1.406 @ 20掳C spiratory tract, with coughing, shortness of breath, chest
Coefficient of Water/Oil distribution: logP(0ct) =-2.83 pain. Extent of irritation depends on concentration and dura-
tion of exposure.
SHIPPING DESCRIPTION In contact with skin: Irritates, causing redness and pain.
Risk of skin absorption is slight. May cause sensitization.
UN: Not regulated Sunlight may aggravate skin allergy.
T.D.G. Class: Not regulated In contact with eyes: Irritates, causing redness, tearing,
Pkg. Group: Not regulated pain. Extent of irritation depends on concentration and dura-
tion of exposure.
REACTIVITY DATA Ingested: Toxic. May cause flushing, sweating, shortness
of breath. Severe overdose may cause lowered blood
Chemical Stability: Stable preessure, heart arrythmia, difficulty in breathing, chest pain.
Incompatibility with other substances: May react vio- May cause bone marrow depression and altered red and
lently with acrolein. Incompatible with strong oxidizing white blood cell, and platelet counts.
agents, strong acids, strong bases, nitric acid, hydrogen per-
oxide, acrylaldehyde. Polymerization may occur on heating. Effects of Chronic Exposure to Product:
Reactivity: Avoid elevated temperatures, ignition sources,
Prolonged or repeated exposure may cause diminished liver
mechanical shock, incompatible.materials, generation of
function and hepatitis, altered thyroid function, bone marrow
dust.
depression with anemia, leukopenia, and thrombocytopenia.
Hazardous Decomposition Products: Toxic fumes of
May also cause toxic psychosis, central nervous system de-
COx, NOx and SOx
pression. May cause cancer according to animal studies.
THIOUREA
MSDS
CODE: 8870-5
FIRST AID MEASURES
Carcinogenicity: IARC group 3 (not classifiable as carci-
nogenic to humans); NTP reasonably anticipated to be
carcinogenic. ACGIH, no listing. Specific Measures:
Teratogenicity: No human information available. Animal Eyes: Flush eyes thoroughly with gently running water,
testing shows it may cause developmental abnormalities holding eyelids open while flushing, until no evidence of
and post-implantation mortality. May cause fetal goiter by chemical remains (at least fifteen [15] minutes). Take care
sufficient maternal exposure not to flush contaminated water into unaffected eye. Get
Reproductive Effects: No human information available. medical attention.
References cited in animal testing. Skin: Remove all contaminated clothing, including
Mutagenicity: References cited in animal testing watches, rings, belts, and shoes. Brush off dry material.
(RTECSNo. Yu2800000). Flush skin with running water for 5 to 10 minutes, or until no
Synergistic Products: None known evidence of chemical remains. If irritation persists, or if ex-
posure has been severe, get medical attention.
PREVENTIVE MEASURES Decontaminate clothing before reuse, or discard.
Inhalation: Immediately remove victim to fresh air. Give
Engineering Controls: Local exhaust ventilation required. oxygen and get medical attention for any breathing difficulty.
Respiratory Protection: NIOSH/MSHA approved dust If breathing has stopped, begin artificial respiration and get
mask, dust/mist half-face respirator or supplied-air respira- medical attention immediately.
tor. High or unknown concentrations, as in fire or spill Ingestion: If victim is alert and not convulsing, rinse mouth
conditions: positive-pressure full face-piece self-contained thoroughly, and give 2 to 4 glasses of water to drink to dilute
breathing apparatus or positive-pressure full face-piece sup- Induce vomiting, under medical supervision, by giving syrup
plied-air respirator with auxiliary positive-pressure of ipecac, or by sticking a finger down the throat. When
self-contained breathing apparatus. vomiting occurs, keep head low to avoid aspiration of
Eye Protection: Chemical safety goggles and/or face emesis, rinse mouth and administer more water to drink.
shield. Get medical attention immediately.
Skin Protection: Impervious gloves (4H鈩?). Other impervi-
REFERENCES USED
ous protective clothing, sleeves, apron, coverall, boots,
sufficient to prevent contact.
CCINFO disc: MSDS鈥檚, November 2006
Other Personal Protective Equipment: Safety shower
Budavari: The Merck Index, 12th ed., 1997
and eye-wash fountain in work area.
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
Leak and Spill Procedure: Restrict access to area of spill.
Ventilate area. Eliminate all sources of ignition. Cleanup ed., 1987
personnel must be thoroughly trained in the hazards of this Suppliers鈥? Material Safety Data Sheets
chemical and its safe use, and must wear protective equip-
ment and clothing sufficient to prevent inhalation of dust or
ADDITIONAL INFORMATION
fumes, and contact with skin and eyes. Prevent from enter-
ing sewers and waterways. Contain spill with inert Date Issued: July 15, 1991
absorbent. Avoid generating dust (wet if necessary). Col- Revision: November 2006
lect in suitable, labelled, covered containers for disposal.
MSDS: 8870-5
Contaminated absorbent may pose the same hazards as the
Proposed WHMIS Designation: D1B; D2A
chemical; treat with caution. Flush area of spill with large
amounts of running water.
Waste Disposal: Follow all federal, provincial and local Prepared by: Caledon Laboratories Ltd. (905) 877-0101
regulations for disposal. Caledon Laboratories Ltd. believes the information contained
Handling Procedures and Equipment: VERY TOXIC, herein is reliable and accurate. Caledon makes no warranty
POSSIBLE CARCINOGEN, TERATOGEN, MUTAGEN, RE- with respect thereto and expressly disclaims all liability for reli-
PRODUCTIVE EFFECTOR. Workers using this material ance thereon. Such information is solely for your consider-
must be thoroughly trained in its hazards and its safe use, ation, investigation, and verification.
and must wear appropriate protective equipment and cloth-
ing. Follow routine safe handling procedures. Use good
housekeeping practices to prevent accumulations of dust.
Use the smallest amount possible for the purpose in a des-
ignated area with suitable ventilation. Avoid all contact and
inhalation. Do not shock. Keep away from all incompatible
materials (see 鈥淚ncompatibility with other substances鈥?).
Keep work area clean and free of extraneous materials.
Keep containers closed when not in use and when empty.
Empty containers may contain hazardous residues; treat
with caution. Wash thoroughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight.
Store away from incompatible materials. Keep containers
tightly closed when not in use and when empty. Protect
from damage, and inspect frequently for signs of leaking.
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