MATERIAL SAFETY DATA SHEET TAE BUFFER DRY-MIX
PRODUCT CODE NUMBER(S): 8611-5
PRODUCT IDENTIFICATION aldehydes to form bicyclic oxazolidines. Attacks copper,
brass, aluminum, but not steel or iron. Aluminum reacts with
Chemical Name and Synonyms: TAE Buffer dry-mix aqueous solutions of EDTA to release hydrogen.
Chemical Family: Mixture Reactivity: Avoid excessive heat, ignition sources, genera-
tion of dust, all incompatible materials.
Chemical Formula: Mixture
Hazardous Decomposition Products: COx , NOx
Product Use: Laboratory reagent
Manufacturer鈥檚 Name and Address:
FIRE AND EXPLOSION DATA
Caledon Laboratories Ltd.
40 Armstrong Avenue Flammability: Negligible fire hazard when exposed to heat
or flame. As with most organic compounds, fine dust dis-
Georgetown, Ontario L7G 4R9
persed in air in the presence of an ignition source is a
Telephone No: (905) 877-0101
potential dust explosion hazard.
Fax No: (905) 877-6666
Extinguishing Media: Water fog or spray, alcohol foam,
Emergency Telephone No: CANUTEC (613) 996-6666 dry chemical, carbon dioxide. Water or foam may cause
frothing, which will blanket and smother the fire. Water
HAZARDOUS INGREDIENTS OF MATERIALS spray can also be used to cool containers, prevent dust for-
mation, flush chemcial away from fire. Fight fire from
Ingredients % TLV Units CAS No. upwind, from a safe distance. Firefighters must wear protec-
tive equipment and clothing sufficient to prevent inhalation of
3
Tris(hydroxymethyl) N/A 10 mg/m 77-86-1
dust or fumes, and contact with skin and eyes.
methylamine (nuisance dust)
Flash Point (Method Used): Not available
Tris acetate N/A Not established 6850-28-8 Autoignition Temperature: Not available
Ethylenediamine Upper Flammable Limit (% by volume): Not available
tetraacetic acid N/A Not established 6381-92-6 Lower Flammable Limit (% by volume): Not available
Ethylenediamine Hazardous Combustion Products: COx, NOx, irritating
tetraacetic acid, N/A Not established 10378-23-1 smoke
tetrasodium salt Sensitivity to Impact: None identified
Sensitivity to Static discharge: As with most organic pow-
PHYSICAL DATA ders, mixtures of dust with air may be sensitive under
certain conditions, when ignited by an electrostatic or other
Physical State: Solid
high-voltage spark, or other ignition source.
Odour and Appearance: White crystalline powder; slight
characteristic amine odour
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Odour Threshold (ppm): Not available
Vapour Pressure (mm Hg): Low at ambient temperatures Toxicological Data:
Vapour Density (Air = 1): Not applicable LD50: (oral, rat) 5,900 mg/kg (Tris); (oral, rat) 2,000 mg/kg
Evaporation Rate: Not applicable (EDTA)
LC50: Not available
Boiling Point (degrees C): Not available
Melting Point (degrees C): Not available
Effects of Acute Exposure to Product:
pH: Not available
Inhaled: Dust may be irritating to upper respiratoy tract.
Specific Gravity: Not available
Large amounts may be harmful.
Coefficient of Water/Oil distribution: Not available
In contact with skin: May be irritating to skin. Severe
overexposure may cause drying and cracking of skin.
SHIPPING DESCRIPTION
In contact with eyes: May cause mild irritation with tem-
UN: Not regulated porary redness, itching, tearing, pain.
T.D.G. Class: Not regulated Ingested: Large oral dosages may produce gastrointestinal
disturbances, nausea, vomiting, confusion, muscular
Pkg. Group: Not regulated
spasms, eventual coma. EDTA may cause burns to the gas-
trointestinal tract. In large quantities, may cause
REACTIVITY DATA
hypocalcemic tetany.
Chemical Stability: Stable under normal temperatures and
pressures Effects of Chronic Exposure to Product:
Incompatibility with other substances: May react vigor-
Carcinogenicity: No information available
ously with bases, oxidizing agents, acids. Tris reacts with
TAE BUFFER DRY-MIX
MSDS
CODE: 8611-5
Teratogenicity: No information available rinse mouth and give more water to drink. If discomfort
occurs, obtain medical attention.
Reproductive Effects: No information available
Mutagenicity: No information available
REFERENCES USED
Synergistic Products: Not known
CCINFO disc: Cheminfo
PREVENTIVE MEASURES Budavari: The Merck Index, 12th ed., 1997
Royal Society of Chemistry: Chemical Safety Data Sheets,
Engineering Controls: Local exhaust ventilation recom-
Vol. 2, 1989
mended.
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
Respiratory Protection: Dust/mist mask. For conditions
ed., 1987
where dust or mist is present, to the maximum use specified
by the respirator supplier, NIOSH/OSHA approved half- face Suppliers鈥? Material Safety Data Sheets
high-efficiency dust/mist filter respirator, or NIOSH/OSHA
approved full face-piece high-efficiency dust/mist filter respi- ADDITIONAL INFORMATION
rator. Higher or unknown concentrations, or for fire or spill
conditions, self-contained breathing apparatus, or full Date Issued: May 6, 1999
face-piece, positive-pressure supplied-air respirator. Revision: May 2008
Eye Protection: Chemical safety glasses. Do not wear
MSDS: 8611-5
contact lenses when working with chemicals.
Proposed WHMIS Designation: Not controlled. Not re-
Skin Protection: Wear protective gloves and clean
quired to be updated every three years (WHMIS 1992, B-40,
body-covering clothing, long-sleeved shirt, trousers, apron
Section 29,2)
or lab coat.
Other Personal Protective Equipment: Eyewash fountain
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
ans safety shower in work area.
Caledon Laboratories Ltd. believes the information contained
Leak and Spill Procedure: Ventilate area. Cleanup per-
herein is reliable and accurate. Caledon makes no warranty
sonnel should be thoroughly trained in the hazards of this
with respect thereto and expressly disclaims all liability for reli-
material and should wear protective equipment and clothing
ance thereon. Such information is solely for your consider-
sufficient to prevent inhalation of dust or fumes, and contact
with skin and eyes. Prevent from entering sewers or water- ation, investigation, and verification.
ways. Wet if necessary to control dust. Collect in a manner
that does not raise dust, and transfer carefully into labelled,
covered container(s) for removal by disposal company.
Wash site of spillage thoroughly with water and detergent.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: COMBUSTIBLE
DUST. Workers using this chemical must be properly
trained in its hazards and its safe use. Avoid generating
dust. If there is dust, keep away from heat, sparks, and all
sources of ignition; avoid the accumulation of static charge,
use anti-sparking tools and ground and bond equipment and
containers. Use the smallest amount possible for the pur-
pose, in a designated area with adequate ventilation. Use
good housekeeping to prevent accumulations of dust. Avoid
contact with skin and eyes. Avoid inhalation. Wash thor-
oughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight.
Store away from incompatible materials. Keep containers
tightly closed when not in use and when empty. Protect
from damage, and inspect frequently for signs of leaking.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with running water for five to
ten (5-10) minutes, or until no trace of chemical remains,
holding eyelids open while flushing. Get medical advice if ir-
ritation persists.
Skin: Remove contaminated clothing. Wash skin with
plenty of water for at least ten to fifteen (10 to 15) minutes.
If irritation develops get medical attention.
Inhalation: Remove to fresh air. Give oxygen and get
medical advice for any breathing difficulty.
Ingestion: If casualty is alert and not convulsing, give 2 to
4 glasses of water to dilute material. If vomiting occurs,
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