MATERIAL SAFETY DATA SHEET 4-METHYL-2-PENTANONE
PRODUCT CODE NUMBER(S): 7600-1, 7600-4, 7601-2
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: 4-Methyl-2-pentanone; Flammability: Flammable liquid and vapour. Vapours
Methyl isobutyl ketone; MIBK; Hexanone; Hexone forms explosive mixtures with air at, or above 13掳C. Vapour
is heavier than air and may travel considerable distance to
Chemical Family: Saturated aliphatic ketone
source of ignition and flash back. Closed containers may
Chemical Formula: CH3COCH2CH[CH3]2
rupture violently when heated.
Product Use: Laboratory solvent Extinguishing Media: Alcohol or polymer foam, dry chemi-
Manufacturer鈥檚 Name and Address: cal powder, carbon dioxide. Water is ineffective for fighting
Caledon Laboratories Ltd. fire, but as spray or fog can be used to cool containers and
disperse vapours or flush spills away from ignition sources.
40 Armstrong Avenue,
Fight fire from upwind, from a safe distance. Firefighters
Georgetown, Ontario L7G 4R9
must wear NIOSH/MSHA approved full face-piece, posi-
Telephone No: (905) 877-0101 tive-pressure self-contained breathing apparatus and
Fax No: (905) 877-6666 chemical splash suit or full Bunker Gear. Containers may
explode in heat of fire; withdraw immediately in case of ris-
Emergency Telephone No: CANUTEC (613) 996-6666
ing sound from vent or discoloration of tank.
HAZARDOUS INGREDIENTS OF MATERIALS Flash Point (Method Used): 13掳C (CC)
Autoignition Temperature: 448掳C
Ingredients % TLV Units CAS No.
Upper Flammable Limit (% by volume): 8
4-Methyl-2- >99 50 ppm 108-10-1 Lower Flammable Limit (% by volume): 1.2
pentanone Hazardous Combustion Products: Explosive peroxides,
COx
PHYSICAL DATA Sensitivity to Impact: Probably not sensitive
Physical State: Liquid Sensitivity to Static discharge: Liquid will probably not
accumulate static charge by flow or agitation. Mixtures of
Odour and Appearance: Clear, colourless liquid with a
vapour and air at concentrations in the flammable range
sweet, camphor-like odour
may be ignited by a static discharge of sufficient energy.
Odour Threshold (ppm): 0.10 to 7.8 ppm (detection); 0.27
to 16 ppm (recognition). Not reliable warning properties, val-
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
ues vary widely.
Vapour Pressure (mm Hg): 6 mm Hg at 20掳C
Toxicological Data:
Vapour Density (Air = 1): 3.45
LD50: (oral, rat) 2,080 mg/kg; (oral, male mouse) 1,200
Evaporation Rate (Bu ac = 1): Not available
mg/kg; (dermal, rabbit) >3,000 mg/kg
Boiling Point (degrees C): 116.2掳C LC50: (rat) 2,000 to 4,000 ppm/4h
Freezing Point (degrees C): -80掳C
pH: Probably neutral Effects of Acute Exposure to Product:
Specific Gravity: 0.8017 at 20掳C Inhaled: Vapours are irritating to the eyes, nose, throat and
Coefficient of Water/Oil distribution: LogP(oct)=1.38 respiratory tract, causing buring sensation, coughing, short-
ness of breath. May cause central nervous system
SHIPPING DESCRIPTION depression, with fatigue, nausea, vomiting. Exposure to 100
ppm/4h causes irritation, headache, and nausea, but no
UN: 1245 psychomotor impariment; 200 ppm/15 min. - nose, throat
T.D.G. Class: 3 and eye irritation.
In contact with skin: No human information available.
Pkg. Group: II
Mild irritant, based on animal testing. May cause defatting,
REACTIVITY DATA drying and cracking of the skin. May be absorbed through in-
tact skin, causing symptoms as in 鈥淚nhaled鈥?.
Chemical Stability: Stable. May form explosive peroxides In contact with eyes: No human information available. Liq-
when heated in air. uid and vapour may cause mild to moderate irritation,
Incompatibility with other substances: Reacts violently, lacrymation and conjunctivitis based on animal evidence.
with risk of fire and explosion, with strong oxidizing agents, Ingested: No reports of acute human ingestion. May cause
reducing agents, strong bases. MIBK vapours ignite after 3 irritation and burning of the mouth and throat, abdominal
minutes on contact with potassium t-butoxide. Probably not pain,headache, dizziness, ncoordination and other signs of
corrosive to common metals. Attacks many plastics. CNS depression. If aspirated, during ingestion or vomiting,
Reactivity: Avoid heat, sparks, open flame, all other MIBK can cause severe lung irritation, and possibly pulmo-
sources of ignition, incompatible materials, generation of nary edema, respiratory failure, cardiac arrest and death.
mist.
Hazardous Decomposition Products: Explosive perox-
ides, CO, CO2
MSDS 4-METHYL-2-PENTANONE
CODE:7600-1, 7600-4, 7601-2
Effects of Chronic Exposure to Product: plode upon concentration by distillation. Use smallest amount
possible for the purpose in a designated area with appropriate
Prolonged or repeated exposure may result in drying or flak- ventilation. Avoid generating vapour or mist. Avoid all contact
ing of the skin. Inhalation may cause weakness, loss of ap- with eyes, skin or clothing. Keep containers closed when not in
petite, nausea, vomiting, sore throat, fatigue, enlarged liver use.
or colitis, liver or kidney damage. Storage Requirements: Store in a cool, well-ventilated area
Carcinogenicity: No human or animal information avail- out of sun and away from all ignition sources. Keep storage
able area free of combustible materials and incompatible materials
such as strong oxidizers. Storage facilities should be made of
Teratogenicity: No human information available;
fire-resistant materials, and have raised sills and be trenched to
terataogenic in animal tests only at doses which are toxic to
safe location. Keep containers tightly closed. Use drums on a
the mother.
first in, first out basis. Protect from damage. Inspect frequently
Reproductive Effects: Some effects demonstrated in one
for signs of damage or leaking.
animal test. No human information available
Mutagenicity: No human information available. Most ani-
FIRST AID MEASURES
mal and bacterial tests negative.
Synergistic Products: May increase the toxicity of etha-
Specific Measures:
nol, haloalkanes (carbon tetrachloride, chloroform,
1,2-dichlorobenzene) and methyl ethyl ketone. Eyes: Immediately flush eyes with gently running water for at
least twenty (20) minutes, holding eyelids open during flushing.
PREVENTIVE MEASURES Take care not to flush contaminated water into unafffected eye.
Get medical attention.
Engineering Controls: Local exhaust ventilation required.
Skin: Remove contaminated clothing (including rings,
Use grounded, non-sparking ventilation system and electri-
watches, belts, and shoes). Flush exposed area with large
cal equipment that does not provide a source of ignition.
amounts of warm running water for 5 to 10 (5 to 10) minutes, or
Respiratory Protection: To 500 ppm: NIOSH/MSHA ap- until no evidence of chemical remains. If irritation persists, or if
proved powered air-purifying respirator equipped with exposure was excessive, get medical attention.
organic vapour cartridges or continuous-flow supplied-air
Inhalation: Immediately remove casualty to fresh air (caution
respirator, or self-contained breathing apparatus. Higher or
must be used by rescuers to avoid exposure to contaminating
unknown concentrations, as in fire or spill conditions: full
fumes). Eliminate ignition sources. Give oxygen for breathing
face-piece, positive-pressure self-contained breathing appa-
difficulty. Give artificial respiration only if breathing has
ratus or positive-pressure, full face-piece supplied-air
STOPPED. If breathing AND pulse are ABSENT give CPR. IM-
respirator with auxiliary positive-pressure self-contained
MEDIATELY obtain medical attention. Stay with casualty until
breathing apparatus.
medical assistance is reached.
Eye Protection: Chemical safety goggles.
Ingestion: DO NOT INDUCE VOMITING. If the casualty is
Skin Protection: Barrier (PE/PA/PE), Silver Shield/4H脭 alert and not convulsing, give 2 to 4 glasses of water to drink to
(polyethylene/ethylene vinyl alcohol), Responder脭, dilute the material. If spontaneous vomiting occurs, have casu-
Tychem脭BR/LV, Tychem脭TK gloves. Other impermeable alty lean forward to avoid breathing in of emesis. Rinse mouth
protective clothing, apron, coveralls, boots, sufficient to pre- and administer more water. Get medical attention.
vent contact.
REFERENCES USED
Other Personal Protective Equipment: Eye wash and
safety shower in work area.
Budavari: The Merck Index, 12th ed., 1997
Leak and Spill Procedure: Evacuate area. Ventilate area
Royal Society of Chemistry, Chemical Safety Data Sheets, Vol. 1,
before re-entering Eliminate all igniton sources. Cleanup
1992
personnel must be thoroughly trained in the hazards of this
chemical and must wear protective equipment and clothing Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th ed.,
sufficient to prevent inhalation of mist of vapours and con- 1987
tact with skin, eyes and clothing. Do not touch spilled Sax: Dangerous Properties of Industrial Chemicals, 5th ed., 1979
material. Prevent from entering sewers and waterways.
Suppliers鈥? Material Safety Data Sheets
Stop or reduce discharge if safe to do so. Contain spill with
inert absorbent (sand, earth). Transfer to container for re-
ADDITIONAL INFORMATION
moval by disposal company. Contaminated absorbent may
pose the same hazards as the spilled product; treat with
Date Issued: November 1, 1988
caution. Use water spray to disperse vapours or to flush liq-
Revision: May 2007
uid spill away from fire exposure. Wash site of spill
thoroughly with water. MSDS: 7600-1, 7600-4, 7601-2
Waste Disposal: Follow all federal, provincial and local Proposed WHMIS Designation: B2
regulations for disposal.
Handling Procedures and Equipment: FLAMMABLE LIQ- Prepared by: Caledon Laboratories Ltd. (905) 877-0101
UID & VAPOUR. Eliminate all sources of ignition and have Caledon Laboratories Ltd. believes the information contained
all engineering controls operating before handling. Person- herein is reliable and accurate. Caledon makes no warranty with
nel working with this chemical must be thoroughly trained
respect thereto and expressly disclaims all liability for reliance
regarding its hazards and its safe use, and must wear ap-
thereon. Such information is solely for your consideration, investi-
propriate protective equipment and clothing. Ground and
gation, and verification.
bond all equipment to prevent static charge accumulation.
Use non-sparking tools. Post 鈥淣o Smoking鈥? signs. May form
explosive peroxides when heated in air. Do not distill if test
shows more than 0.05% peroxides present; these may ex-
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