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File Name: gen-probe_com---301032a.asp
                                                           Date Prepared: February 10,2000




Gen-Probe Product
Nonhazardous Statement


Product name: APTIMA Combo 2
Product description: APTIMA Wash Solution

MSDS number: 301032.159


As directed by the Code of Federal Regulations, Title 29, section 1910.1200 and the
California Code of Regulations, Title 8, section 5194, Hazard Communication, Gen-
Probe Incorporated has determined that the product mentioned above is
nonhazardous. A Material Safety Data Sheet (MSDS) is not required to be provided
with this product as determined by applicable federal and state hazard
communication regulations.
The information provided herein represents the most reasonable current information
available when this determination was made and is believed to be accurate and
dependable. Nevertheless, Gen-Probe Incorporated makes no representation as to
the accuracy or sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in
humans or animals. Use only as directed on the enclosed package insert. Gen-
Probe Incorporated will assume no liability for the improper use of this product by
misfeasance or malfeasance, nor will Gen-Probe Incorporated assume liability from
any nonfeasance as a result of the use of this product. Good laboratory practices
should be observed at all times, including, but not limited to, "universal precautions"
and "work practice controls." Skin, mucous membranes, or eyes that come in
contact with this product should be washed with plenty of water. If irritation results or
persists, get medical attention.
Date Prepared: February 10,2000




Gen-Probe Product
Nonhazardous Statement


Product name: APTIMA Combo 2
Product description: Amplification Reconstitution Solution

MSDS number: 301032.222


As directed by the Code of Federal Regulations, Title 29, section 1910.1200 and the
California Code of Regulations, Title 8, section 5194, Hazard Communication, Gen-
Probe Incorporated has determined that the product mentioned above is
nonhazardous. A Material Safety Data Sheet (MSDS) is not required to be provided
with this product as determined by applicable federal and state hazard
communication regulations.
The information provided herein represents the most reasonable current information
available when this determination was made and is believed to be accurate and
dependable. Nevertheless, Gen-Probe Incorporated makes no representation as to
the accuracy or sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in
humans or animals. Use only as directed on the enclosed package insert. Gen-
Probe Incorporated will assume no liability for the improper use of this product by
misfeasance or malfeasance, nor will Gen-Probe Incorporated assume liability from
any nonfeasance as a result of the use of this product. Good laboratory practices
should be observed at all times, including, but not limited to, "universal precautions"
and "work practice controls." Skin, mucous membranes, or eyes that come in
contact with this product should be washed with plenty of water. If irritation results or
persists, get medical attention.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Selection Reagent
MSDS number: 301032.072

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Sodium tetraborate Decahydrate 4% 1303-96-4


Trition X-100 Alfenol 3 1% 9002-93-1




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.072




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.072




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0
pH: 8.5


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Sodium tetraborate: orl-man LDLO- 709 mg/kg; orl-rat LD50- 2660 mg/kg; ipr-mus LD50-
2711 mg/kg.
RTECS #: VZ2275000.
Trition X-100: orl-rat LD50- 1800 mg/kg. RTECS #: MD0907700.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.072




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Amplification Reagent, Lyophilized
MSDS number: 301032.141

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Trehalose alpa-D-glucopyranosyl 73% 6138-23-4
alpha-D-glucopyranoside

N-[2-Hydroxyethyl] piperazine- HEPES 27% 7365-45-9
N'-[2-ethanesulfonic acid]




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.141




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.141




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Lyophilized powder. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble.



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Trehalose: exposure may cause skin, eye, or respiratory irritation.
HEPES: May be harmful by inhalation, ingestion, or skin absorption.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.141




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: APTIMA Buffer for Deactivation Fluid
MSDS number: 301032.168

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Sodium bicarbonate Monosodium carbonate 7% 144-55-8


Sodium hydroxide Sodium hydrate 1% 1310-73-2




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.168




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
chemical disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.168




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0
pH: 9.3


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Sodium bicarbonate: orl-rat LD50 4220 mg/kg.
Sodium hydroxide (toxicity data): orl-rat LD50 140-340 mg/kg; ipr-mus LD50 40 mg/kg.
Sodium hydroxide (irritation data): skn-rbt 1350mg.
Contact exposure may cause skin, eye, or respiratory irritation.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.168




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: APTIMA Oil Reagent
MSDS number: 301032.169

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Polydimethylsiloxane Dimethyl silicone 100% 63148-62-9




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.169




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: If exposed to excessive levels of vapors, remove to fresh air and get medical
attention if symptoms develop.



Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: >260 C (>500 F)

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Emits toxic fumes under fire conditions.

Extinguishing instructions/media: Extinguishing media- water spray, carbon dioxide, or dry
chemical.


6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.169




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- insoluble
Specific gravity- 0.92


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: alkali and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Polydimethylsiloxane: orl-rat LD50- >35g/kg; skn-rbt LD50-3g/kg; inh-rat LC50- 11mg/l.




Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.169




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Enzyme Reconstitution Solution
MSDS number: 301032.170

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Glycerol Glycerin 20% 56-81-5


Triton X-100 Alfenol 3 10% 9002-93-1


N-[2-Hydroxyethyl] piperazine- HEPES 1% 7365-45-9
N'-[2-ethanesulfonic acid]




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.170




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.170




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0
pH: 7.0


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Glycerol: orl-rat LD50-12600 mg/kg. RTECS #: MA8050000.
Trition X-100: (toxicity) orl-rat LD50- 1800 mg/kg; (irritation) skn-hmn 2 mg/3D-I MLD; eye-
rbt 1 mg MOD.
RTECS No: MD0907700.
HEPES: May be harmful by inhalation, ingestion, or skin absorption.
Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.170




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Target Capture Reagent
MSDS number: 301032.172

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium chloride Not available 9% 7447-41-8


N-[2-Hydroxyethyl] piperazine- HEPES 2% 7365-45-9
N'-[2-ethanesulfonic acid]

Ethylenediaminetetraacetic EDTA 3% 60-00-4
acid




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.172




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.172




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0
pH: 7.5


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium chloride: orl-hmn LDLO-200 mg/kg; orl-rat LD50-526 mg/kg; ipr-rat LD50-514 mg/kg.
HEPES: May be harmful by inhalation, ingestion, or skin absorption.
EDTA: ipr-rat LD50-397 mg/kg; ipr-mus LD50-250 mg/kg.


Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.172




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Probe Reconstitution Solution
MSDS number: 301032.177

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium chloride Not available 5% 7447-41-8


Ethyl alcohol Ethanol 3% 64-17-5


Lithium lauryl sulfate Dodecyl lithium sulfate 2% 2044-56-6


Succinic acid Butanedioic acid 1% 110-15-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.177




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.177




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium lauryl sulfate: No Data Available.
Ethyl alcohol: orl-rat LD50 11.5g/kg; skn-rbt LD50 >20ml/kg.
Succinic acid: orl-rat LD50: 2260 mg/kg.
Lithium chloride: orl-hmn LDLO-200 mg/kg; orl-rat LD50-526 mg/kg; ipr-rat LD50-514 mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.177




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Probe Reagent, Lyophilized
MSDS number: 301032.186

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium lauryl sulfate Dodecyl lithium sulfate 94% 2044-56-6


Mercaptoethanesulfonic acid, 2-Mercaptoethanesulfonate 5% 19767-45-4
Sodium salt




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.186




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
chemical disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.186




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Lyophilized powder. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble.



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium lauryl sulfate: No Data Available.
Mercaptoethanesulfonic acid: orl-rat LD50-4440 mg/kg.
RTECS #: KI7968000 (ethanesulfonic acid).


Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.186




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Enzyme Reagent, Lyophilized
MSDS number: 301032.193

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Trehalose alpa-D-glucopyranosyl 75% 6138-23-4
alpha-D-glucopyranoside

N-Acetyl-L-Cysteine Acetylcysteine 20% 616-91-1


N-[2-Hydroxyethyl] piperazine- HEPES 4% 7365-45-9
N'-[2-ethanesulfonic acid]




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.193




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.193




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Lyophilized powder. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble.



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Trehalose: exposure may cause skin, eye, or respiratory irritation.
N-Acetyl-L-Cysteine: orl-rat LD50- 5050 mg/kg.
HEPES: May be harmful by inhalation, ingestion, or skin absorption.


Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.193




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Positive Control, CT
MSDS number: 301032.224

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium lauryl sulfate Dodecyl lithium sulfate 3% 2044-56-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.224




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.224




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium lauryl sulfate: No Data Available.




Contact exposure may cause skin, eye, or respiratory tract irritation.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.224




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Positive Control, NG
MSDS number: 301032.225

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium lauryl sulfate Dodecyl lithium sulfate 3% 2044-56-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.225




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.225




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium lauryl sulfate: No Data Available.




Contact exposure may cause skin, eye, or respiratory tract irritation.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.225




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: February 10,2000
Page 1 of 4




1. Chemical Product and Company Identification

Product name: APTIMA Combo 2
Product description: Target Capture Reagent, Component B
MSDS number: 301032.315

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated
(800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive
(703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362
(858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium lauryl sulfate Dodecyl lithium sulfate 3% 2044-56-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared: February 10,2000
Page 2 of 4
MSDS No: 301032.315




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared: February 10,2000
Page 3 of 4
MSDS No: 301032.315




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.

Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Specific gravity- slightly above 1.0
pH: 6.7


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium lauryl sulfate: No Data Available.




Contact exposure may cause skin, eye, or respiratory tract irritation.
Date Prepared: February 10,2000
Page 4 of 4
MSDS No: 301032.315




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.

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genome_gov---TranscriptFromToxTest.asp 02-14-0

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