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SCANNED DOCS
Product #: 286990 Name: PREDNISONE, 98%
Material Safety Data Sheet, Valid Dates 2/2004- 4/2004
Printed 10/18/2004 12:36
Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Technical Phone: 314 771 5765
Fax: 800 325 5052
Emergency Phone: 414 273 3850 Ext. 5996
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 286990
NAME: PREDNISONE, 98%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 53-03-2
MF: C21H26O5
EC NO: 200-160-3
SYNONYMS
ANCORTONE * BICORTONE * COLISONE * CORTAN * DELTA-CORTELAN *
CORTIDELT * DELTA-CORTISONE * DELTA-1-CORTISONE * DELTA(SUP 1)-
CORTISONE * DELTA-CORTONE * DACORTIN * DECORTANCYL * DECORTIN *
DECORTISYL * DELTA-1-DEHYDROCORTISONE * 1-DEHYDROCORTISONE * 1,2-
DEHYDROCORTISONE * DEKORTIN * DELTA CORTELAN * DELTACORTISONE *
DELTACORTONE * DELTA-DOME * DELTA E * DELTASONE * DELTISON *
DELTISONE * DELTRA * DI-ADRESON * 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,
11,20-TRIONE * ENCORTON * ENCORTONE * ENKORTON * HOSTACORTIN * IN-
SONE * JUVASON * LISACORT * METACORTANDRACIN * METICORTEN * NCI-
C04897 * NSC 10023 * ORASONE * PARACORT * PRECORT * PREDNICEN-M *
PREDNILONGA * PREDNISON * PREDNISONE * PREDNIZON * 1,4-PREGNADIENE-17-
ALPHA,21-DIOL-3,11,20-TRIONE * RECTODELT * SERVISONE * SK-PREDNISONE *
DELTA-SONE * SUPERCORTIL * U 6020 * ULTRACORTEN * ULTRACORTENE *
WOJTAB * ZENADRID * ZENADRID (VETERINARY) *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
TARGET ORGAN(S):
ADRENAL CORTEX
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EYES
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN IMMEDIATELY.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
NONCOMBUSTIBLE.
USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
WASH THOROUGHLY AFTER HANDLING.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
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SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 236 C TO 238 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY CAUSE SKIN IRRITATION.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
MAY CAUSE EYE IRRITATION.
MAY BE HARMFUL IF INHALED.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE HARMFUL IF SWALLOWED.
CHRONIC EFFECTS
POSSIBLE RISK OF CONGENITAL MALFORMATION IN THE FETUS.
THIS PRODUCT IS OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS
TO ITS CARCINOGENICITY BASED ON ITS IARC, ACGIH, NTP OR EPA
CLASSIFICATION.
TARGET ORGAN(S):
ADRENAL CORTEX
EYES
BONES
IMMUNE SYSTEM
RTECS #: TU4154100
PREGNA-1,4-DIENE-3,11,20-TRIONE, 17,21-HYDROXY-
TOXICITY DATA
ORL-MAN LDLO:400 UG/KG IJMSAT 155,234,1986
IPR-MUS LD50:135 MG/KG NCISP* JAN1986
SCU-MUS LD50:101 MG/KG NCISP* JAN1986
IMS-MUS LD50:600 MG/KG CNREA8 42,122,1982
TARGET ORGAN DATA
PERIPHERAL NERVE AND SENSATION (SENSORY CHANGE INVOLVING PERIPHERAL NERVE
ENDOCRINE (TUMORS)
BLOOD (HEMORRHAGE)
SKIN AND APPENDAGES (AFTER SYSTEMIC EXPOSURE: DERMATITIS, OTHER)
SKIN AND APPENDAGES (TUMORS)
EFFECTS ON NEWBORN (GROWTH STATISTICS)
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EFFECTS ON NEWBORN (BEHAVIORAL)
TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 63
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT 26,293,1981
IARC CANCER REVIEW:HUMAN INADEQUATE EVIDENCE IMEMDT 26,293,1981
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,326,1987
NOHS 1974: HZD 80494; NIS 1; TNF 68; NOS 6; TNE 2770
NOES 1983: HZD 80494; NIS 1; TNF 45; NOS 1; TNE 1266; TFE 725
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
NCI CARCINOGENESIS STUDIES (IPR);EQUIVOCAL EVIDENCE:RAT
CANCAR 40,1935,1977
NCI CARCINOGENESIS STUDIES (IPR);NO EVIDENCE:MOUSE
CANCAR 40,1935,1977
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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