CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 1 of 9
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
CALCIUM CYCLAMATE
SYNONYMS
C12-H24-N2-O6-S2.Ca, "cyclamic acid, calcium salt", "cyclohexanesulfamic acid,
monocalcium salt", "N-cyclohexylsulfamic acid calcium salt", "N-cyclohexylsulfamic acid
calcium salt", "calcium cyclohexylsulfamate", "calcium cyclohexanesulfamate", "calcium
cyclohexyl amidosulfamate", "calcium cyclohexyl sulfamate", "calcium
cyclohexylsulfamidate", "sulfamic acid, cyclohexyl-, calcium salt (1:1)", Cyclan, Cylan
, Dietil, "Sucaryl calcium"
PRODUCT USE
Non- caloric sweetening agent about 30 times as sweet as refined cane- sugar. Sweetness
perceptible at 1:10000. Government regulation may restrict its use and/or supply.
Cyclamates are currently banned as food additives in many countries (USA, UK, Canada,
Sweden, Finland etc.)
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 2 of 9
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
May produce skin discomfort*. Do not breathe dust.
Limited evidence of a carcinogenic effect*. Avoid contact with skin.
Exposure may produce irreversible effects*.
* (limited evidence).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
calcium cyclamate 139-06-0 >98
Section 4 - FIRST AID MEASURES
SWALLOWED
路 Immediately give a glass of water.
路 First aid is not generally required. If in doubt, contact a Poisons Information Centre
or a doctor.
EYE
If this product comes in contact with eyes:
路 Wash out immediately with water.
路 If irritation continues, seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin or hair contact occurs:
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If dust is inhaled, remove from contaminated area.
路 Encourage patient to blow nose to ensure clear passage of breathing.
路 If irritation or discomfort persists seek medical attention.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Water spray or fog.
路 Foam.
路 Dry chemical powder.
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 3 of 9
Section 5 - FIRE FIGHTING MEASURES
路 BCF (where regulations permit).
路 Carbon dioxide.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Combustible solid which burns but propagates flame with difficulty.
路 Avoid generating dust, particularly clouds of dust in a confined or unventilated space
as dusts may form an explosive mixture with air, and any source of ignition, i.e.
flame or spark, will cause fire or explosion. Dust clouds generated by the fine
grinding of the solid are a particular hazard; accumulations of fine dust may burn
rapidly and fiercely if ignited.
路 Dry dust can be charged electrostatically by turbulence, pneumatic transport, pouring,
in exhaust ducts and during transport.
路 Build-up of electrostatic charge may be prevented by bonding and grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
路 All movable parts coming in contact with this material should have a speed of less than
1-meter/sec.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), nitrogen
oxides (NOx), sulfur oxides (SOx), other pyrolysis products typical of burning
organic material.
May emit poisonous fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Clean up all spills immediately.
路 Avoid breathing dust and contact with skin and eyes.
路 Wear protective clothing, gloves, safety glasses and dust respirator.
路 Use dry clean up procedures and avoid generating dust.
路 Sweep up, shovel up or
路 Vacuum up (consider explosion-proof machines designed to be grounded during storage and
use).
路 Place spilled material in clean, dry, sealable, labelled container.
MAJOR SPILLS
Moderate hazard.
路 CAUTION: Advise personnel in area.
路 Alert Emergency Services and tell them location and nature of hazard.
路 Control personal contact by wearing protective clothing.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Recover product wherever possible.
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 4 of 9
Section 6 - ACCIDENTAL RELEASE MEASURES
路 IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and
place in sealed plastic bags or other containers for disposal. IF WET: Vacuum/shovel up
and place in labelled containers for disposal.
路 ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise Emergency Services.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
路 Polyethylene or polypropylene container.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ + + + + +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 5 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁
_________ _________ _____
Australia Exposure Standards calcium cyclamate (Inspirable 10
dust (Not specified))
MATERIAL DATA
It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent)
for all substances for which there is evidence of health effects at airborne
concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce adverse
health effects (as evidenced in animal experiments or clinical experience). Airborne
concentrations must be maintained as low as is practically possible and occupational
exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified
(P.N.O.S) does NOT apply.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Experience indicates that the following polymers are suitable as glove materials for
protection against undissolved, dry solids.
路 polychloroprene
路 nitrile rubber
路 butyl rubber
路 fluorocaoutchouc
路 polyvinyl chloride
Gloves should be examined for wear and/ or degradation constantly.
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 6 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
are important in the selection of gloves.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 Exhaust ventilation should be designed to prevent accumulation and recirculation of
particulates in the workplace.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered. Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks
路 Build-up of electrostatic charge on the dust particle, may be prevented by bonding and
grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to efficiently
remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 7 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White crystalline solid or powder; mixes with water.
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Molecular Weight: 396.58 Boiling Range (掳C): Not available
Melting Range (掳C): Not available Specific Gravity (water=1): Not available
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
pH (1% solution): 5.5- 7.5 Vapour Pressure (kPa): Negligible
Volatile Component (%vol): Negligible Evaporation Rate: Not applicable
Relative Vapour Density (air=1): >1 Flash Point (掳C): >300
Lower Explosive Limit (%): Not available Upper Explosive Limit (%): Not available.
Autoignition Temp (掳C): Not available Decomposition Temp (掳C): Not available.
State: Divided solid Viscosity: Not Applicable
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Although ingestion is not thought to produce harmful effects (as classified under EC
Directives), the material may still be damaging to the health of the individual,
following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 8 of 9
Section 11 - TOXICOLOGICAL INFORMATION
evident. Present definitions of harmful or toxic substances are generally based on doses
producing mortality rather than those producing morbidity (disease, ill-health).
Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational
setting however, ingestion of insignificant quantities is not thought to be cause for
concern.
This material is a photosensitiser. Certain individuals working with this substance may
show allergic reaction of the skin under sunlight. This results in sensitivity to sunburn
(may be severe) unless protective covering and 15+PF sunscreen are used. Responses may
vary from sunburn-like effects to swelling and blistering lesions.
EYE
Although the material is not thought to be an irritant (as classified by EC Directives),
direct contact with the eye may cause transient discomfort characterised by tearing or
conjunctival redness (as with windburn). Slight abrasive damage may also result. The
material may produce foreign body irritation in certain individuals.
SKIN
Open cuts, abraded or irritated skin should not be exposed to this material.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
The material is not thought to produce adverse health effects or skin irritation
following contact (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
gloves be used in an occupational setting.
INHALED
The material is not thought to produce adverse health effects or irritation of the
respiratory tract (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
control measures be used in an occupational setting.
CHRONIC HEALTH EFFECTS
There has been some concern that this material can cause cancer or mutations but there is
not enough data to make an assessment.
Long term exposure to high dust concentrations may cause changes in lung function i.e.
pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the
lung. Prime symptom is breathlessness; lung shadows show on X-ray.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Subcutaneous (rat) LD50: 100 mg/kg Nil Reported
Oral (mouse) LD50: 7200 mg/kg
Intravenous (mouse) LD50: 570 mg/kg
Intravenous (rabbit) LD50: 125 mg/kg
No significant acute toxicological data identified in literature search.
NOTE: Substance has been shown to be mutagenic in at least one assay, or belongs to a
family of chemicals producing damage or change to cellular DNA.
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
Bladder tumours, tumours at sites of application, effects on newborn
recorded.
for dihydrate:
RTECS No.: GV 7175000
CALCIUM CYCLAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 49301-1
Issue Date: 12-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 9 of 9
Section 12 - ECOLOGICAL INFORMATION
DO NOT discharge into sewer or waterways.
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material)
路 Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
calcium cyclamate (CAS: 139-06-0) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
calcium cyclamate (CAS: 5897-16-5) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
Section 16 - OTHER INFORMATION
INGREDIENTS WITH MULTIPLE CAS NUMBERS
Ingredient Name CAS
calcium cyclamate 139- 06- 0, 5897- 16- 5
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 12-Feb-2007
Print Date: 17-Dec-2007
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