CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 1 of 14
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
CYCLOHEXANONE
SYNONYMS
C6-H10-O, "Anon anone", "Hytrol o", ketohexamethylene, Nadone, "pimelic pimelin ketone",
Hexanon, "pennyroyal oil"
PROPER SHIPPING NAME
CYCLOHEXANONE
PRODUCT USE
As a solvent for cellulose acetate, nitrocellulose, natural resins, vinyl resins, rubber,
waxes, fats, shellac, and manufacture of ketone resins. In the production of adipic acid
and caprolactam; production of polymers and resins. Reagent chemical. Used in wood stains;
paint varnish and spot remover; degreasing of metals, polishes; textile dyeing and
processing and in lubricating oil additives. Occurs naturally in the herb Pennyroyal and
is responsible for the toxic effects in the misuse of Pennyroyal Oil in folk medicine,
herbal teas.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 2 of 14
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Flammable. Keep away from sources of ignition. No smoking.
Harmful by inhalation, in contact with skin and Do not breathe gas/fumes/vapour/spray.
if swallowed.
Irritating to eyes. Avoid contact with eyes.
Cumulative effects may result following Wear suitable protective clothing.
exposure*.
May produce discomfort of the respiratory system Use only in well ventilated areas.
and skin*.
Limited evidence of a carcinogenic effect*. Keep container in a well ventilated place.
Vapours potentially cause drowsiness and Do not empty into drains.
dizziness*.
* (limited evidence). To clean the floor and all objects contaminated
by this material, use water and detergent.
Keep container tightly closed.
Keep away from food, drink and animal feeding
stuffs.
Take off immediately all contaminated clothing.
In case of contact with eyes, rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
If swallowed, IMMEDIATELY contact Doctor or
Poisons Information Centre. (show this container
or label).
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
cyclohexanone 108-94-1 >99
Section 4 - FIRST AID MEASURES
SWALLOWED
路 IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.
路 For advice, contact a Poisons Information Centre or a doctor.
路 Urgent hospital treatment is likely to be needed.
路 In the mean time, qualified first-aid personnel should treat the patient following
observation and employing supportive measures as indicated by the patient's condition.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 3 of 14
Section 4 - FIRST AID MEASURES
路 If the services of a medical officer or medical doctor are readily available, the
patient should be placed in his/her care and a copy of the MSDS should be provided.
Further action will be the responsibility of the medical specialist.
路 If medical attention is not available on the worksite or surroundings send the patient
to a hospital together with a copy of the MSDS.
路 Where Medical attention is not immediately available or where the patient is more than
15 minutes from a hospital or unless instructed otherwise:
路 INDUCE vomiting with fingers down the back of the throat, ONLY IF CONSCIOUS. Lean
patient forward or place on left side (head-down position, if possible) to maintain open
airway and prevent aspiration.
NOTE: Wear a protective glove when inducing vomiting by mechanical means.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Treat symptomatically.
for simple ketones:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
路 Establish a patent airway with suction where necessary.
路 Watch for signs of respiratory insufficiency and assist ventilation as necessary.
路 Administer oxygen by non-rebreather mask at 10 to 15 l/min.
路 Monitor and treat, where necessary, for pulmonary oedema .
路 Monitor and treat, where necessary, for shock.
路 DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml
water (5mL/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
路 Give activated charcoal.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
路 Consider orotracheal or nasotracheal intubation for airway control in unconscious
patient or where respiratory arrest has occurred.
路 Consider intubation at first sign of upper airway obstruction resulting from oedema.
路 Positive-pressure ventilation using a bag-valve mask might be of use.
路 Monitor and treat, where necessary, for arrhythmias.
路 Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers
solution. Fluid overload might create complications.
路 Drug therapy should be considered for pulmonary oedema.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 4 of 14
Section 4 - FIRST AID MEASURES
路 Hypotension with signs of hypovolaemia requires the cautious administration of fluids.
Fluid overload might create complications.
路 Treat seizures with diazepam.
路 Proparacaine hydrochloride should be used to assist eye irrigation.
--------------------------------------------------------------
EMERGENCY DEPARTMENT
--------------------------------------------------------------
路 Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine,
glucose, urinalysis, baseline for serum aminotransferases (ALT and AST), calcium,
phosphorus and magnesium, may assist in establishing a treatment regime. Other useful
analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs
and electrocardiograph.
路 Positive end-expiratory pressure (PEEP)-assisted ventilation may be required for acute
parenchymal injury or adult respiratory distress syndrome.
路 Consult a toxicologist as necessary.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.
The major metabolic pathway of cyclohexanone in laboratory animals is a
reduction to cyclohexanol and a subsequent conjugation with glucuronic
acid.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 If safe, switch off electrical equipment until vapour fire hazard removed.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Liquid and vapour are flammable.
路 Moderate fire hazard when exposed to heat or flame.
路 Vapour forms an explosive mixture with air.
路 Moderate explosion hazard when exposed to heat or flame.
路 Vapour may travel a considerable distance to source of ignition.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), other
pyrolysis products typical of burning organic material.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 5 of 14
Section 5 - FIRE FIGHTING MEASURES
HAZCHEM: 3[Y]
Personal Protective Equipment
Breathing apparatus.
Chemical splash suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb small quantities with vermiculite or other absorbent material.
路 Wipe up.
路 Collect residues in a flammable waste container.
MAJOR SPILLS
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 No smoking, naked lights or ignition sources.
路 Increase ventilation.
路 Stop leak if safe to do so.
路 Water spray or fog may be used to disperse / absorb vapour.
路 Contain spill with sand, earth or vermiculite.
路 Use only spark-free shovels and explosion proof equipment.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance 15 metres
Downwind Protection Distance 100 metres
IERG Number 15
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 6 of 14
Section 6 - ACCIDENTAL RELEASE MEASURES
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 127 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
cyclohexanone 700 ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
cyclohexanone 50 ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
cyclohexanone 50 ppm
The threshold concentration below which most people will experience no appreciable risk of health effects:
cyclohexanone 50 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ X X X X +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 7 of 14
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Containers, even those that have been emptied, may contain explosive vapours.
路 Do NOT cut, drill, grind, weld or perform similar operations on or near containers.
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of overexposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 Avoid smoking, naked lights or ignition sources.
路 Avoid generation of static electricity.
路 DO NOT use plastic buckets.
路 Earth all lines and equipment.
路 Use spark-free tools when handling.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions.
DO NOT allow clothing wet with material to stay in contact with skin.
SUITABLE CONTAINER
Glass container.
Packing as supplied by manufacturer. Plastic containers may only be used if approved for
flammable liquid. Check that containers are clearly labelled and free from leaks.
路 For low viscosity materials (i) : Drums and jerry cans must be of the non-removable
head type. (ii) : Where a can is to be used as an inner package, the can must have a
screwed enclosure.
路 For materials with a viscosity of at least 2680 cSt. (23 deg. C)
路 For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
路 Manufactured product that requires stirring before use and having a viscosity of at
least 20 cSt (25 deg. C)
(i) : Removable head packaging;
(ii) : Cans with friction closures and
(iii) : low pressure tubes and cartridges may be used.
路 Where combination packages are used, and the inner packages are of glass, there must be
sufficient inert cushioning material in contact with inner and outer packages
路 In addition, where inner packagings are glass and contain liquids of packing group I
there must be sufficient inert absorbent to absorb any spillage, unless the outer
packaging is a close fitting moulded plastic box and the substances are not incompatible
with the plastic.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
路 Store in original containers in approved flammable liquid storage area.
路 DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
路 No smoking, naked lights, heat or ignition sources.
路 Keep containers securely sealed.
路 Store away from incompatible materials in a cool, dry, well-ventilated area.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 8 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak TWA
ppm mg/m鲁 ppm mg/m鲁 ppm mg/m鲁 F/CC
_________________ __________________ ______ ______ ______ ______ ______ ______ _____
Australia Exposure cyclohexanone 25 100
Standards (Cyclohexanone)
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
cyclohexanone 700
ODOUR SAFETY FACTOR (OSF)
OSF=28 (CYCLOHEXANONE)
Exposed individuals are reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class A or B.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed
individuals are aware by smell
that the Exposure Standard
(TLV- TWA for example) is
being reached, even when
distracted by working
activities
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
MATERIAL DATA
Odour Threshold Value: 0.12 ppm (detection and recognition)
Exposure at the TLV-TWA produces minimal irritation and this limit is
significantly lower than the concentration reported to just induce
demonstrable changes in the liver and kidneys of rabbits repeatedly
exposed to the substance (190 ppm).
PERSONAL PROTECTION
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 9 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
路 Overalls.
路 PVC Apron.
路 PVC protective suit may be required if exposure severe.
路 Eyewash unit.
路 Ensure there is ready access to a safety shower.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
" Forsberg Clothing Performance Index" .
The effect(s) of the following substance(s) are taken into account in the
computer- generated selection: cyclohexanone
Protective Material CPI *.
__________________________________________
PE/EVAL/PE A
BUTYL A
NITRILE C
NATURAL+NEOPRENE C
__________________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent use.
A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 10 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
ppm (volume) Factor
1000 10 A- AUS -
1000 50 - A- AUS
5000 50 Airline * -
5000 100 - A- 2
10000 100 - A- 3
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
For flammable liquids and flammable gases, local exhaust ventilation or a process
enclosure ventilation system may be required. Ventilation equipment should be explosion
-resistant.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to effectively
remove the contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow 1- 2.5 m/s (200- 500 f/min.)
booths, drum filling, conveyer loading,
crusher dusts, gas discharge (active
generation into zone of rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 11 of 14
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Clear- white to pale yellow oily flammable liquid; slightly soluble in water. With a
peppermint and acetone- like odour. Soluble in alcohol, ether and most other common
organic solvents.
PHYSICAL PROPERTIES
Liquid.
Does not mix with water.
Floats on water.
Molecular Weight: 98.14 Boiling Range (掳C): 155.6
Melting Range (掳C): - 16.4 Specific Gravity (water=1): 0.9478
Solubility in water (g/L): Partly miscible pH (as supplied): Not applicable
pH (1% solution): Not available. Vapour Pressure (kPa): 0.266 @ 20 deg
Volatile Component (%vol): 100 Evaporation Rate: Not available
Relative Vapour Density (air=1): 3.4 Flash Point (掳C): 43.9
Lower Explosive Limit (%): 1.1 Upper Explosive Limit (%): 8.1
Autoignition Temp (掳C): 420 Decomposition Temp (掳C): Not Available
State: Liquid Viscosity: Not Available
log Kow (Sangster 1997): 0.81
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be harmful; animal experiments indicate that
ingestion of less than 150 gram may be fatal or may produce serious damage to the health
of the individual.
EYE
There is evidence that material may produce eye irritation in some persons and produce
eye damage 24 hours or more after instillation. Severe inflammation may be expected with
pain. There may be damage to the cornea. Unless treatment is prompt and adequate there
may be permanent loss of vision. Conjunctivitis can occur following repeated exposure.
SKIN
Skin contact with the material may be harmful; systemic effects may result following
absorption.
There is some evidence to suggest that the material may cause mild but significant
inflammation of the skin either following direct contact or after a delay of some time.
Repeated exposure can cause contact dermatitis which is characterised by redness,
swelling and blistering.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 12 of 14
Section 11 - TOXICOLOGICAL INFORMATION
material and ensure that any external damage is suitably protected.
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the
course of normal handling, may be harmful.
There is some evidence to suggest that the material can cause respiratory irritation in
some persons. The body's response to such irritation can cause further lung damage.
Inhalation hazard is increased at higher temperatures.
Inhalation of high concentrations of gas/vapour causes lung irritation with coughing and
nausea, central nervous depression with headache and dizziness, slowing of reflexes,
fatigue and inco-ordination.
If exposure to highly concentrated solvent atmosphere is prolonged this may lead to
narcosis, unconsciousness, even coma and possible death.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by
sleepiness, reduced alertness, loss of reflexes, lack of co-ordination, and vertigo.
Ketone vapours irritate the nose, throat and mucous membrane. High concentrations depress
the central nervous system, causing headache, vertigo, poor concentration, sleep and
failure of the heart and breathing. Some ketones can cause multiple nerve disorders,
inducing "pins and needles" and weakness in the limbs.
CHRONIC HEALTH EFFECTS
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
There has been some concern that this material can cause cancer or mutations but there is
not enough data to make an assessment.
Chronic solvent inhalation exposures may result in nervous system impairment and liver
and blood changes. [PATTYS].
Long term cyclohexanone exposure may cause liver and kidney changes. Clouding of the eye
lens and cataract development may occur. Avoid all exposure in pregnancy, cyclohexanone
may cause birth defects.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (rat) LD50: 1535 mg/kg Skin (rabbit): 500 mg(open) Mild
Inhalation (human) TCLo: 75 ppm Eye (human): 75 ppm
Inhalation (rat) LC50: 8000 ppm/4h Eye (rabbit): 0.25 mg/24h SEVERE
Dermal (rabbit) LD50: 948 mg/kg Eye (rabbit): 4.74 mg SEVERE
The material may produce severe irritation to the eye causing pronounced inflammation.
Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
________________________ ____________________ ________________ ________________ ___________
cyclohexanone IARC:3
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: cyclohexanone
Category: 3
Section 12 - ECOLOGICAL INFORMATION
Algae IC50 (72hr.) (mg/l): 52- 370
log Kow (Sangster 1997): 0.81
log Pow (Verschueren 1983): 0.81
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 13 of 14
Section 12 - ECOLOGICAL INFORMATION
8s# log Kow : 0.81
Koc: 10
Half-life (hr) air: 24-100
Half-life (hr) H2O surface water: 74-100
Henry's atm m鲁 /mol: 1.20E-05
BOD 5 if unstated: 1.232,32%
COD: 100%
ThOD: 2.605
Log BCF: 0.39
Toxicity Fish: LC50(96)720-1100mg/L
Bioacculmulation: not sig
Degradation Biological: sig
processes Abiotic: RxnOH*,oxid&hydrl&photl notsig
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material)
路 Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
路 Containers may still present a chemical hazard/ danger when empty.
路 Return to supplier for reuse/ recycling if possible.
Otherwise:
路 If container can not be cleaned sufficiently well to ensure that residuals do not
remain or if the container cannot be used to store the same product, then puncture
containers, to prevent re-use, and bury at an authorised landfill.
路 Where possible retain label warnings and MSDS and observe all notices pertaining to the
product.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE LIQUID
HAZCHEM: 3[Y]
UNDG:
Dangerous Goods 3 Subrisk: None
Class:
UN Number: 1915 Packing Group: III
Shipping Name:CYCLOHEXANONE
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1915 Packing Group: III
ERG Code: 3L
Shipping Name: Cyclohexanone
CYCLOHEXANONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Jul-2006 CHEMWATCH 1915
NC317TCP CD 2006/4 Page 14 of 14
Section 14 - TRANSPORTATION INFORMATION
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1915 Packing Group: III
EMS Number: F- E, S- D
Shipping Name: CYCLOHEXANONE
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
cyclohexanone (CAS: 108-94-1) is found on the following regulatory lists;
Australia Exposure Standards
Australia Illicit Drug Reagents/Essential Chemicals - Category III
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
International Agency for Research on Cancer (IARC) Carcinogens
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for the reproductive no
-observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoint CR Adeq TLV
cyclohexanone 100 mg/m3 NA NA NA Yes
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 26-Jul-2006
Print Date: 4-Jan-2007
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