DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 1 of 16
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
DIISOBUTYL KETONE
SYNONYMS
C9-H18-O, [(CH3)2CHCH2]2CO, DIBK, "di-isobutyl ketone", s-diisopropylacetone, s
-diisopropylacetone, sym-diisopropylacetone, "isobutyl ketone", isovalerone, "4-heptanone
, 2, 6-dimethyl-", "4-heptanone, 2, 6-dimethyl-", diisobutylketone
PROPER SHIPPING NAME
DIISOBUTYL KETONE
PRODUCT USE
Solvent for nitrocellulose, rubber, synthetic resins; lacquers, coating compositions,
organic synthesis, roll- coating inks, stains.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 2 of 16
Section 2 - HAZARDS IDENTIFICATION
and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Flammable. Do not breathe gas/ fumes/ vapour/ spray.
Irritating to respiratory system and skin. Avoid contact with eyes.
HARMFUL - May cause lung damage if swallowed. Wear suitable protective clothing.
Inhalation and/or ingestion may produce health Use only in well ventilated areas.
damage*.
Cumulative effects may result following Keep container in a well ventilated place.
exposure*.
May produce discomfort of the eyes*. To clean the floor and all objects contaminated
by this material use water and detergent.
Possible skin sensitiser*. Keep container tightly closed.
Vapours potentially cause drowsiness and Keep away from food drink and animal feeding
dizziness*. stuffs.
* (limited evidence). Take off immediately all contaminated clothing.
In case of contact with eyes rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
If swallowed IMMEDIATELY contact Doctor or
Poisons Information Centre (show this container
or label).
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
diisobutyl ketone 108-83-8 > 99
Section 4 - FIRST AID MEASURES
SWALLOWED
If spontaneous vomiting appears imminent or occurs, hold patient's head down, lower than
their hips to help avoid possible aspiration of vomitus.
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 3 of 16
Section 4 - FIRST AID MEASURES
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor, without delay.
NOTES TO PHYSICIAN
Treat symptomatically.
Any material aspirated during vomiting may produce lung injury. Therefore emesis should
not be induced mechanically or pharmacologically. Mechanical means should be used if it
is considered necessary to evacuate the stomach contents; these include gastric lavage
after endotracheal intubation. If spontaneous vomiting has occurred after ingestion, the
patient should be monitored for difficult breathing, as adverse effects of aspiration
into the lungs may be delayed up to 48 hours.
for simple ketones:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
路 Establish a patent airway with suction where necessary.
路 Watch for signs of respiratory insufficiency and assist ventilation as necessary.
路 Administer oxygen by non-rebreather mask at 10 to 15 l/min.
路 Monitor and treat, where necessary, for pulmonary oedema .
路 Monitor and treat, where necessary, for shock.
路 DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml
water (5mL/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
路 Give activated charcoal.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
路 Consider orotracheal or nasotracheal intubation for airway control in unconscious
patient or where respiratory arrest has occurred.
路 Consider intubation at first sign of upper airway obstruction resulting from oedema.
路 Positive-pressure ventilation using a bag-valve mask might be of use.
路 Monitor and treat, where necessary, for arrhythmias.
路 Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers
solution. Fluid overload might create complications.
路 Drug therapy should be considered for pulmonary oedema.
路 Hypotension with signs of hypovolaemia requires the cautious administration of fluids.
Fluid overload might create complications.
路 Treat seizures with diazepam.
路 Proparacaine hydrochloride should be used to assist eye irrigation.
--------------------------------------------------------------
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 4 of 16
Section 4 - FIRST AID MEASURES
EMERGENCY DEPARTMENT
--------------------------------------------------------------
路 Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine,
glucose, urinalysis, baseline for serum aminotransferases (ALT and AST), calcium,
phosphorus and magnesium, may assist in establishing a treatment regime. Other useful
analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs
and electrocardiograph.
路 Positive end-expiratory pressure (PEEP)-assisted ventilation may be required for acute
parenchymal injury or adult respiratory distress syndrome.
路 Consult a toxicologist as necessary.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Alcohol stable foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 If safe, switch off electrical equipment until vapour fire hazard removed.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Liquid and vapour are flammable.
路 Moderate fire hazard when exposed to heat or flame.
路 Vapour forms an explosive mixture with air.
路 Moderate explosion hazard when exposed to heat or flame.
路 Vapour may travel a considerable distance to source of ignition.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), other
pyrolysis products typical of burning organic material.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: 3[Y]
Personal Protective Equipment
Gas tight chemical resistant suit.
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 5 of 16
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb small quantities with vermiculite or other absorbent material.
路 Wipe up.
路 Collect residues in a flammable waste container.
MAJOR SPILLS
Chemical Class: ketones
For release onto land: recommended sorbents listed in order of priority.
SORBENT TYPE RANK APPLICATION COLLECTION LIMITATIONS
LAND SPILL - SMALL
cross- linked 1 shovel shovel R, W, SS
polymer -
particulate
cross- linked 1 throw pitchfork R, DGC, RT
polymer - pillow
sorbent clay - 2 shovel shovel R, I, P
particulate
wood fiber - 3 throw pitchfork R, P, DGC, RT
pillow
treated wood fiber 3 throw pitchfork DGC, RT
- pillow
foamed glass - 4 throw pitchfork R, P, DGC, RT
pillow
LAND SPILL - MEDIUM
cross- linked 1 blower skiploader R, W, SS
polymer -
particulate
cross- linked 2 throw skiploader R, DGC, RT
polymer - pillow
sorbent clay - 3 blower skiploader R, I, P
particulate
polypropylene - 3 blower skiploader R, SS, DGC
particulate
expanded mineral - 4 blower skiploader R, I, W, P, DGC
particulate
polypropylene - 4 throw skiploader DGC, RT
mat
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 6 of 16
Section 6 - ACCIDENTAL RELEASE MEASURES
Legend
DGC: Not effective where ground cover is dense
R; Not reusable
I: Not incinerable
P: Effectiveness reduced when rainy
RT:Not effective where terrain is rugged
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation 1988.
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 No smoking, naked lights or ignition sources.
路 Increase ventilation.
路 Stop leak if safe to do so.
路 Water spray or fog may be used to disperse / absorb vapour.
路 Contain spill with sand, earth or vermiculite.
路 Use only spark-free shovels and explosion proof equipment.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance 15 metres
Downwind Protection Distance 100 metres
IERG Number 15
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 7 of 16
Section 6 - ACCIDENTAL RELEASE MEASURES
life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 127 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
diisobutyl ketone 200 ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
diisobutyl ketone 50 ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
diisobutyl ketone 50 ppm
The threshold concentration below which most people will experience no appreciable risk of health effects:
diisobutyl ketone 50 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Containers, even those that have been emptied, may contain explosive vapours.
路 Do NOT cut, drill, grind, weld or perform similar operations on or near containers.
DO NOT allow clothing wet with material to stay in contact with skin.
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of overexposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 Avoid smoking, naked lights or ignition sources.
路 Avoid generation of static electricity.
路 DO NOT use plastic buckets.
路 Earth all lines and equipment.
路 Use spark-free tools when handling.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 8 of 16
Section 7 - HANDLING AND STORAGE
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions.
SUITABLE CONTAINER
Glass container.
路 Packing as supplied by manufacturer.
路 Plastic containers may only be used if approved for flammable liquid.
路 Check that containers are clearly labelled and free from leaks.
路 For low viscosity materials (i) : Drums and jerry cans must be of the non-removable
head type. (ii) : Where a can is to be used as an inner package, the can must have a
screwed enclosure.
路 For materials with a viscosity of at least 2680 cSt. (23 deg. C)
路 For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
路 Manufactured product that requires stirring before use and having a viscosity of at
least 20 cSt (25 deg. C)
(i) : Removable head packaging;
(ii) : Cans with friction closures and
(iii) : low pressure tubes and cartridges may be used.
路 Where combination packages are used, and the inner packages are of glass, there must be
sufficient inert cushioning material in contact with inner and outer packages
路 In addition, where inner packagings are glass and contain liquids of packing group I
there must be sufficient inert absorbent to absorb any spillage, unless the outer
packaging is a close fitting moulded plastic box and the substances are not incompatible
with the plastic.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents, bases and strong reducing agents.
路 Ketones in this group are reactive with many acids and bases liberating heat and
flammable gases (e.g., H2).
路 Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to
produce flammable gas (H2) and heat.
路 Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and
anhydrides.
路 Ketones react violently with aldehydes, HNO3 (nitric acid), HNO3 + H2O2 (mixture of
nitric acid and hydrogen peroxide), and HClO4 (perchloric acid).
STORAGE REQUIREMENTS
路 Store in original containers in approved flammable liquid storage area.
路 DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
路 No smoking, naked lights, heat or ignition sources.
路 Keep containers securely sealed.
路 Store away from incompatible materials in a cool, dry, well-ventilated area.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X + X 0 +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 9 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA ppm TWA mg/m鲁
_________ _________ _____ _____
Australia Exposure diisobutyl ketone 25 145
Standards (Diisobutyl ketone)
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
diisobutyl ketone 500
ODOUR SAFETY FACTOR (OSF)
OSF=2.3E2 (DIISOBUTYL KETONE)
MATERIAL DATA
Exposed individuals are reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class A or B.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed individuals
are aware by smell that the
Exposure Standard (TLV- TWA for
example) is being reached, even
when distracted by working
activities
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
Odour threshold: 0.11 ppm [Eastman]
Threshold odour concentration: 100% recognition at 0.31 ppm.
Exposure at or below the TLV-TWA is thought to protect the worker
against the significant risk of eye, nose, and throat irritation
PERSONAL PROTECTION
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 10 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
NOTE: The material may produce skin sensitisation in predisposed individuals. Care must
be taken, when removing gloves and other protective equipment, to avoid all possible skin
contact.
OTHER
路 Overalls.
路 PVC Apron.
路 PVC protective suit may be required if exposure severe.
路 Eyewash unit.
路 Ensure there is ready access to a safety shower.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
" Forsberg Clothing Performance Index" .
The effect(s) of the following substance(s) are taken into account in the
computer- generated selection: diisobutyl ketone
Protective Material CPI *.
__________________________________________
BUTYL/NEOPRENE A
PVA A
NITRILE+PVC B
NEOPRENE/NATURAL B
NATURAL+NEOPRENE B
PVC C
NEOPRENE C
NATURAL RUBBER C
NITRILE C
VITON C
__________________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 11 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
of gloves which might otherwise be unsuitable following long-term or frequent use.
A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
ppm (volume) Factor
1000 10 A- AUS -
1000 50 - A- AUS
5000 50 Airline * -
5000 100 - A- 2
10000 100 - A- 3
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
For flammable liquids and flammable gases, local exhaust ventilation or a process
enclosure ventilation system may be required. Ventilation equipment should be explosion
-resistant.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to effectively
remove the contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 12 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Colourless flammable liquid; floats on water. Faint, fruity odour. Mixes with most organic
solvents. Commercial diisobutyl ketone is a mixture of isomers; 70% 2, 6- dimethyl- 4-
heptanone CAS RN 108- 83- 8, with 30% 4, 6- dimethyl- 2- heptanone CAS RN 19549- 80- 5.
PHYSICAL PROPERTIES
Liquid.
Does not mix with water.
Floats on water.
Molecular Weight: 142.27 Boiling Range (掳C): 168.1
Melting Range (掳C): - 42 Specific Gravity (water=1): 0.81
Solubility in water (g/L): Immiscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): 0.22 @ 20 C.
Volatile Component (%vol): 100 Evaporation Rate: 0.17 BuAc=1
Relative Vapour Density (air=1): 4.90 Flash Point (掳C): 49 (TCC).
Lower Explosive Limit (%): 0.8 Upper Explosive Limit (%): 7.1
Autoignition Temp (掳C): 396 Decomposition Temp (掳C): Not Available
State: Liquid Viscosity: Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be damaging to the health of the individual.
Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical
pneumonitis; serious consequences may result. (ICSC13733).
Considered an unlikely route of entry in commercial/industrial environments. The liquid
may produce gastrointestinal discomfort and may be harmful if swallowed. Ingestion may
result in nausea, pain and vomiting. Vomit entering the lungs by aspiration may cause
potentially lethal chemical pneumonitis.
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 13 of 16
Section 11 - TOXICOLOGICAL INFORMATION
EYE
Limited evidence or practical experience suggests, that the material may cause eye
irritation in a substantial number of individuals. Prolonged eye contact may cause
inflammation characterised by a temporary redness of the conjunctiva (similar to
windburn).
The liquid may produce eye discomfort and is capable of causing temporary impairment of
vision and/or transient eye inflammation, ulceration.
SKIN
The material may cause mild but significant inflammation of the skin either following
direct contact or after a delay of some time. Repeated exposure can cause contact
dermatitis which is characterised by redness, swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the
course of normal handling, may be damaging to the health of the individual.
The material can cause respiratory irritation in some persons. The body's response to
such irritation can cause further lung damage.
Inhalation hazard is increased at higher temperatures.
If exposure to highly concentrated solvent atmosphere is prolonged this may lead to
narcosis, unconsciousness, even coma and possible death.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by
sleepiness, reduced alertness, loss of reflexes, lack of co-ordination, and vertigo.
Ketone vapours irritate the nose, throat and mucous membrane. High concentrations depress
the central nervous system, causing headache, vertigo, poor concentration, sleep and
failure of the heart and breathing. Some ketones can cause multiple nerve disorders,
inducing "pins and needles" and weakness in the limbs.
Acute effects from inhalation of high vapour concentrations may be chest and nasal
irritation with coughing, sneezing, headache and even nausea.
CHRONIC HEALTH EFFECTS
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
There is limited evidence that, skin contact with this product is more likely to cause a
sensitisation reaction in some persons compared to the general population.
Sensitisation may result in allergic dermatitis responses including rash, itching, hives
or swelling of extremities.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 5750 mg/kg Skin (rabbit): 500 mg - Mild
Inhalation (human) TCLo: 50 ppm Skin (rabbit): 10 mg/24h - Mild
Inhalation (rat) LCLo: 2000 ppm/4h Eye (human): 25 ppm/15min - Mild
Dermal (rabbit) LD50: 16000 mg/kg Eye (rabbit): 500 mg
Oral (rat) LD50: >3200 mg/kg * Skin (g.pig): repeated - SEVERE
Oral (mouse) LD50: >3200 mg/kg * Skin (g.pig): Strong *
Inhalation (rat) LC50: 1979 ppm/6h *
The material may be irritating to the eye, with prolonged contact causing inflammation.
Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
Asthma-like symptoms may continue for months or even years after exposure to the material
ceases. This may be due to a non-allergenic condition known as reactive airways
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 14 of 16
Section 11 - TOXICOLOGICAL INFORMATION
dysfunction syndrome (RADS) which can occur following exposure to high levels of highly
irritating compound. Key criteria for the diagnosis of RADS include the absence of
preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the
irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to
severe bronchial hyperreactivity on methacholine challenge testing and the lack of
minimal lymphocytic inflammation, without eosinophilia, have also been included in the
criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an
infrequent disorder with rates related to the concentration of and duration of exposure
to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that
occurs as result of exposure due to high concentrations of irritating substance (often
particulate in nature) and is completely reversible after exposure ceases. The disorder
is characterised by dyspnea, cough and mucus production.
[Eastman; * for mixed isomer, ** for 2,6-dimethyl-4-heptanone]
NOEL = 400 ppm (12 exposures rat) *
LOEL = 250 ppm (30 exposures, rat) **
NOEL = 125 ppm ( " " " ) ** - target organ; kidney
LOEL = 2000 mg/kg/day (oral neurotoxicity; minor target organs - liver,
kidney, stomach) **
NOEL = 2000 mg/kg (for neurotoxicity) **
Skin sensitisation (g.pig) - moderate *
Section 12 - ECOLOGICAL INFORMATION
BCF<100: 20
Water solubility (g/l): 430
DO NOT discharge into sewer or waterways.
Koc: 155
Half-life (hr) air: 14.2
Half-life (hr) H2O surface water: 4.9-57
Henry's atm m鲁 /mol: 7.18E-04
BOD 5 if unstated: 13%-37%
BCF: 20
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material).
路 Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE LIQUID
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 15 of 16
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: 3[Y]
UNDG:
Dangerous Goods Class: 3 Subrisk: None
UN Number: 1157 Packing Group: III
Shipping Name:DIISOBUTYL KETONE
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1157 Packing Group: III
Special provisions: None
Shipping Name: DIISOBUTYL KETONE
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1157 Packing Group: III
EMS Number: F- E, S- D Special provisions: None
Shipping Name: DIISOBUTYL KETONE
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
diisobutyl ketone (CAS: 108-83-8) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
OECD Representative List of High Production Volume (HPV) Chemicals
No data available for diisobutyl ketone as CAS: 19549-80-5.
Section 16 - OTHER INFORMATION
INGREDIENTS WITH MULTIPLE CAS NUMBERS
Ingredient Name CAS
diisobutyl ketone 108- 83- 8, 19549- 80- 5
MSDS SECTION CHANGES
The following table displays the version number of and date on which each section was last changed.
Section Name Version Date Section Name Version Date Section Name Version Date
Advice to Doctor 4 2- Jun- 2006 Storage (suitable 4 2- Jun- 2006 Acute Health (eye) 4 2- Jun- 2006
container)
First Aid 4 2- Jun- 2006 Engineering 4 2- Jun- 2006 Acute Health 4 2- Jun- 2006
(inhaled) Control (inhaled)
First Aid 4 2- Jun- 2006 Exposure Standard 4 2- Jun- 2006 Acute Health 4 2- Jun- 2006
(swallowed) (skin)
Fire Fighter (fire 4 2- Jun- 2006 Personal 4 2- Jun- 2006 Acute Health 4 2- Jun- 2006
incompatibility) Protection (eye) (swallowed)
Fire Fighter 4 2- Jun- 2006 Personal 4 2- Jun- 2006 Chronic Health 4 2- Jun- 2006
(fire/explosion Protection
hazard) (hands/feet)
Spills (major) 4 2- Jun- 2006 Personal 4 2- Jun- 2006 Toxicity and 4 2- Jun- 2006
Protection (other) Irritation (Other)
Handling Procedure 4 2- Jun- 2006 Appearance 4 2- Jun- 2006 Environmental 4 2- Jun- 2006
Storage (storage 4 2- Jun- 2006 Physical 4 2- Jun- 2006 Disposal 4 2- Jun- 2006
incompatibility) Properties
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
DIISOBUTYL KETONE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 2-Jun-2006 CHEMWATCH 1157
NC317TCP Version No:4
CD 2007/3 Page 16 of 16
Section 16 - OTHER INFORMATION
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 2-Jun-2006
Print Date: 19-Dec-2007
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