CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 1 of 9
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
CARBOXYMETHYLCELLULOSE
SYNONYMS
"cellulose, carboxmethyl ether", Almelose, Apergel, Apeyel, Carbose, Collresine,
"Glycocel TA", KMTs, "carboxymethylated cellulose pulp", carboxymethylcellulose,
"carboxymethyl cellulose ether", "cellulose carboxymethylate", "celluloseglycolic acid",
"cellulose gum 7H", CMC, CM-cellulose, CMC-4LF, "glycolic acid cellulose ether", Thylose
PRODUCT USE
Used as a thickening and suspending agent. Pharmaceutical grades available. Protective
colloid, stabiliser for vinyl and acrylic polymerisation. Ingredient of concrete curing
compounds, retards evaporation of water in cements, mortars and concrete; binder in
ceramic glazes. Films and sheeting; paper and textile sizing; secondary petroleum
recovery.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 2 of 9
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
None under normal operating conditions. None under normal operating conditions.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
carboxymethylcellulose 9000-11-7 > 95
water 7732-18-5 <5
Section 4 - FIRST AID MEASURES
SWALLOWED
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin or hair contact occurs:
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Long term exposure to high dust concentrations may cause changes in lung function i.e.
pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the
lung. Prime symptom is breathlessness; lung shadows show on X-ray.
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 3 of 9
Section 4 - FIRST AID MEASURES
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves for fire only.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
Combustible.
Moderate dust explosion hazard, when exposed to flame.
May form an explosive mixture with air.
Combustion/decomposition may produce acrid/toxic fumes of carbon monoxide (CO). May emit
clouds of acrid smoke.
Other combustion products include: carbon dioxide (CO2), aldehydes and other pyrolysis
products typical of burning organic material.
FIRE INCOMPATIBILITY
Avoid mixing with strong oxidisers as ignition may result.
HAZCHEM: None
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Clean up all spills immediately. Slippery when spilt.
Remove all ignition sources.
Avoid contact with skin and eyes.
Control personal contact by using protective equipment.
Use dry clean up procedures and avoid generating dust.
Place in clean drum then flush area with water.
MAJOR SPILLS
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
Minor hazard Slippery when spilt.
Wear protective clothing, gloves, safety glasses and dust respirator., Prevent, by any
means available, spillage from entering drains or water
courses.
No smoking, naked lights or ignition sources. Increase ventilation.
Stop leak if safe to do so.
Use dry clean up procedures and avoid generating dust.
Collect recoverable product into labelled containers for recycling.
Collect residues and place in labelled polyethylene bag.
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 4 of 9
Section 6 - ACCIDENTAL RELEASE MEASURES
Wash spill area with large quantities of water.
If contamination of drains or waterways occurs, advise emergency services.
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ + + + + +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
Avoid generation of static electricity. Earth all lines and equipment.
Avoid smoking, naked lights or ignition sources.
路 Limit all unnecessary personal contact.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Multi ply paper bag with sealed plastic liner or heavy gauge plastic bag
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse. Check that all containers are clearly
labelled and free from leaks. Packing as recommended by manufacturer.
Glass container.
STORAGE INCOMPATIBILITY
Avoid storage with oxidisers.
Cellulose and its derivatives may react vigorously with calcium oxide, bleaching powder,
perchlorates, perchloric acid, sodium chlorate, fluorine, nitric acid, sodium nitrate and
sodium nitrite.
May be incompatible with aminacrine hydrochloride, chlorocresol, mercuric chloride,
phenol, resorcinol, tannic acid and silver nitrate.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 No smoking, naked lights or ignition sources.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 5 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak TWA
ppm mg/m鲁 ppm mg/m鲁 ppm mg/m鲁 F/CC
_________________ __________________ ______ ______ ______ ______ ______ ______ _____
Australia Exposure carboxymethylcellu 10
Standards lose (Inspirable
dust (Not
specified))
The following materials had no OELs on our records
鈥? water: CAS:7732-18-5
MATERIAL DATA
These "dusts" have little adverse effect on the lungs and do not produce toxic effects or
organic disease. Although there is no dust which does not evoke some cellular response at
sufficiently high concentrations, the cellular response caused by P.N.O.C.s has the
following characteristics:
路 the architecture of the air spaces remain intact,
路 scar tissue (collagen) is not synthesised to any degree,
路 tissue reaction is potentially reversible.
Extensive concentrations of P.N.O.C.s may:
路 seriously reduce visibility,
路 cause unpleasant deposits in the eyes, ears and nasal passages,
路 contribute to skin or mucous membrane injury by chemical or mechanical action, per se,
or by the rigorous skin cleansing procedures necessary for their removal. [ACGIH]
This limit does not apply:
路 to brief exposures to higher concentrations
路 nor does it apply to those substances that may cause physiological impairment at lower
concentrations but for which a TLV has as yet to be determined.
This exposure standard applies to particles which
路 are insoluble or poorly soluble* in water or, preferably, in aqueous lung fluid (if
data is available) and
路 have a low toxicity (i.e.. are not cytotoxic, genotoxic, or otherwise chemically
reactive with lung tissue, and do not emit ionizing radiation, cause immune sensitization
, or cause toxic effects other than by inflammation or by a mechanism of lung overload).
INGREDIENT DATA
WATER:
No exposure limits set by NOHSC or ACGIH.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields; or as required,
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 6 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
No special equipment needed when handling small quantities.
OTHERWISE: Wear chemical protective gloves, eg. PVC.
Safety footwear may be required.
OTHER
路 Overalls.
路 Eyewash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air
Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Use in a well-ventilated area.
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 Exhaust ventilation should be designed to prevent accumulation and recirculation of
particulates in the workplace.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered. Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks
路 Build-up of electrostatic charge on the dust particle, may be prevented by bonding and
grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to efficiently
remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow 1- 2.5 m/s (200- 500 f/min.)
booths, drum filling, conveyer loading,
crusher dusts, gas discharge (active
generation into zone of rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 7 of 9
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White to light tan powder, soluble in water. No odour. Insoluble in polar organic
solvents.
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Molecular Weight: 10000- 500000 Boiling Range (掳C): Not applicable
Melting Range (掳C): Not applicable Specific Gravity (water=1): Not available
Solubility in water (g/L): Miscible pH (as supplied): Not available
pH (1% solution): Not available Vapour Pressure (kPa): Negligible
Volatile Component (%vol): Negligible Evaporation Rate: Non Volatile
Relative Vapour Density (air=1): Not Flash Point (掳C): Not applicable
available.
Lower Explosive Limit (%): Not available. Upper Explosive Limit (%): Not available.
Autoignition Temp (掳C): Not available Decomposition Temp (掳C): Not available.
State: Divided solid
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 8 of 9
Section 11 - TOXICOLOGICAL INFORMATION
ACUTE HEALTH EFFECTS
SWALLOWED
The material is non-toxic if swallowed.
Considered an unlikely route of entry in commercial/industrial environments.
Bulk laxatives can cause temporary bloating and blockage of the oesophagus and/or
intestine. As they shorten the time of digestion, the absorption of other drugs will be
affected.
Polysaccharides are not easily absorbed from the digestive tract, but may produce a
laxative effect. Larger doses may produce intestinal or stomach blockage.
Methylcellulose may temporarily increase flatulence. Obstruction of the oesophagus may
occur if the material is swallowed dry.
Ingestion of hetastarch (hydroxyehtyl amylopectin) has reportedly produced fever, chills,
urticaria and salivary gland enlargement. Large volumes of hetastarch taken by mouth may
interfere with blood clotting, and increase the risk of bleeding. Anaphylaxis has
occurred.
Infusion of dextrans may occasionally produce allergic reactions, such as urticaria, low
blood pressure and spasm of the bronchi. Severe anaphylactic reactions may occasionally
occur and death may result from stoppage of the heart and breathing. Similarly, allergic
reactions have been reported following ingestion or inhalation of tragacanth gums.
High molecular weight material; on single acute exposure would be expected to pass
through gastrointestinal tract with little change / absorption. Occasionally accumulation
of the solid material within the alimentary tract may result in formation of a bezoar
(concretion), producing discomfort.
EYE
The dust may produce eye discomfort causing smarting, pain and redness.
SKIN
The dust is mildly discomforting to the skin.
INHALED
Not normally a hazard due to non-volatile nature of product.
The dust may be discomforting to the upper respiratory tract.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are usually by inhalation of generated dust and eye contact.
Prolonged or repeated skin contact may cause drying with cracking, irritation and
possible dermatitis following.
Studies indicate that diets containing large amounts of non-absorbable polysaccharides,
such as cellulose, might decrease absorption of calcium, magnesium, zinc and phosphorus.
This material contains a substantial amount of polymer considered to be of low concern.
These are classified under having MWs of between 1000 to 10000 with less than 25% of
molecules with MWs under 1000 and less than 10% under 500; or having a molecular weight
average of over 10000. Functional groups contained on the polymer are then classified
into risk categories. Being classified as a polymer of "low concern" does not mean that
there are no hazards associated with the chemical.
TOXICITY AND IRRITATION
No significant acute toxicological data identified in literature search.
WATER:
No significant acute toxicological data identified in literature search.
CARBOXYMETHYLCELLULOSE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 3-May-2003 CHEMWATCH 46643
NC317TCP CD 2006/4 Page 9 of 9
Section 12 - ECOLOGICAL INFORMATION
No data for carboxymethylcellulose.
Section 13 - DISPOSAL CONSIDERATIONS
路 Consult manufacturer for recycling options and recycle where possible .
路 Consult State Land Waste Management Authority for disposal.
路 Incinerate residue at an approved site.
路 Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
carboxymethylcellulose (CAS: 9000-11-7) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 3-May-2003
Print Date: 4-Jan-2007
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