DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 1 of 12
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
DIBUTYL PHTHALATE
SYNONYMS
C16-H22-O4, "o-benzenedicarboxylic acid, dibutyl ester", "o-benzenedicarboxylic acid,
dibutyl ester", "benzene-o-dicarboxylic acid di-n-butyl ester", "benzene-o-dicarboxylic
acid di-n-butyl ester", "dibutyl 1, 2-benzenediacarboxylate", "dibutyl 1, 2
-benzenediacarboxylate", "di-n-butyl phthalate", "di-n-butyl phthalate", dibutylphthalate,
"phthalic acid, dibutyl ester", "butyl phthalate"
PROPER SHIPPING NAME
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
PRODUCT USE
As a plasticizer in nitrocellulose lacquers, elastomers, explosives, nail polish and in
solid rocket propellants; solvent / fixative for perfumes. Resin solvent; paper coatings;
adhesives; insect repellent for textiles.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 2 of 12
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Very toxic to aquatic organisms may cause long- Keep locked up.
term adverse effects in the aquatic environment.
May cause long- term adverse effects in the Do not breathe gas/ fumes/ vapour/ spray.
environment.
May cause harm to the unborn child. In case of insufficient ventilation wear
suitable respiratory equipment.
Possible risk of impaired fertility. Avoid exposure - obtain special instructions
before use.
Skin contact may produce health damage*. To clean the floor and all objects contaminated
by this material use water and detergent.
* (limited evidence). This material and its container must be disposed
of in a safe way.
Keep away from food drink and animal feeding
stuffs.
Take off immediately all contaminated clothing.
Use appropriate container to avoid environment
contamination.
Avoid release to the environment. Refer to
special instructions/ safety data sheets.
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
dibutyl phthalate 84-74-2 >99
Section 4 - FIRST AID MEASURES
SWALLOWED
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 3 of 12
Section 4 - FIRST AID MEASURES
路 Seek medical advice.
EYE
If this product comes in contact with the eyes:
路 Immediately hold eyelids apart and flush the eye continuously with running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital or doctor without delay.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 Do not approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Combustible.
路 Slight fire hazard when exposed to heat or flame.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
路 May emit acrid smoke.
路 Mists containing combustible materials may be explosive.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 4 of 12
Section 5 - FIRE FIGHTING MEASURES
FIRE INCOMPATIBILITY
Avoid contamination with.
oxidising agents.
nitrates. and chlorine.
HAZCHEM: 2X
Personal Protective Equipment
Gas tight chemical resistant suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Slippery when spilt.
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb spill with sand, earth, inert material or vermiculite.
路 Wipe up.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
Slippery when spilt.
Remove all ignition sources.
Minor hazard.
路 Clear area of personnel.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Control personal contact by using protective equipment as required.
路 Prevent spillage from entering drains or water ways.
路 Contain spill with sand, earth or vermiculite.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite and place in appropriate
containers for disposal.
路 Wash area and prevent runoff into drains or waterways.
路 If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
WARNING
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance -
Downwind Protection Distance 10 metres
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 5 of 12
Section 6 - ACCIDENTAL RELEASE MEASURES
IERG Number 47
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 171 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
dibutyl phthalate 500 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
dibutyl phthalate 250 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
dibutyl phthalate 15 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
dibutyl phthalate 5 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Limit all unnecessary personal contact.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 6 of 12
Section 7 - HANDLING AND STORAGE
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
路 Metal can or drum
路 Packaging as recommended by manufacturer.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Segregate from.
oxidising agents.
nitrates. and chlorine.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 No smoking, naked lights or ignition sources.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
X X + X X +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁
_________ _________ _____
Australia Exposure Standards dibutyl phthalate (Dibutyl 5
phthalate)
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
dibutyl phthalate 4, 000
MATERIAL DATA
In animal testing the reproductive system has been the prime target.
Exposure at or below the TLV has not caused either systemic effects or
irritation in man.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 7 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields; or as required,
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Polyethylene gloves.
Wear chemical protective gloves, eg. PVC.
Wear safety footwear.
#76a-p3
OTHER
路 Overalls.
路 Barrier cream
路 Eyewash unit.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
" Forsberg Clothing Performance Index" .
The effect(s) of the following substance(s) are taken into account in the
computer- generated selection: dibutyl phthalate
Protective Material CPI *.
__________________________________________
BUTYL A
NATURAL+NEOPRENE A
NEOPRENE/NATURAL A
NITRILE A
PE/EVAL/PE A
PVA A
VITON A
NATURAL RUBBER A
NEOPRENE A
__________________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 8 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent use.
A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
ppm (volume) Factor
1000 10 A- AUS P -
1000 50 - A- AUS P
5000 50 Airline * -
5000 100 - A- 2 P
10000 100 - A- 3 P
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
None under normal operating conditions.
If inhalation risk of overexposure exists, wear SAA approved organic-vapour
respirator.
If mist is present, use air supplied breathing apparatus.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Colourless oily liquid; does not mix with water. Soluble in alcohol, ether, acetone and
benzene. No odour.
PHYSICAL PROPERTIES
Liquid.
Does not mix with water.
Sinks in water.
Molecular Weight: 278.4 Boiling Range (掳C): 340
Melting Range (掳C): - 35 Specific Gravity (water=1): 1.05
Solubility in water (g/L): Immiscible pH (as supplied): Not applicable
pH (1% solution): Not applicable Vapour Pressure (kPa): 1.64 @ 20 C
Volatile Component (%vol): Not available Evaporation Rate: Not available
Relative Vapour Density (air=1): 9.6 Flash Point (掳C): 188 OC
Lower Explosive Limit (%): 0.47 Upper Explosive Limit (%): Not available.
Autoignition Temp (掳C): 403 Decomposition Temp (掳C): Not available
State: Liquid Viscosity: Not available
log Kow (Sangster 1997): 4.72
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 9 of 12
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The liquid is mildly discomforting and is harmful if swallowed Ingestion may result in
nausea, pain, vomiting. Vomit entering the lungs by aspiration may cause potentially
lethal chemical pneumonitis.
Considered an unlikely route of entry in commercial/industrial environments.
EYE
The liquid is. moderately discomforting to the eyes and may cause conjunctivitis and
lachrymation (tears).
SKIN
The liquid is. mildly discomforting to the skin.
Toxic effects may result from skin absorption.
INHALED
Not normally a hazard due to non-volatile nature of product.
Inhalation hazard is increased at higher temperatures.
The vapour from heated material is. discomforting to the upper respiratory tract and
lungs.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are usually by.
skin contact/absorption and inhalation of vapour from heated material.
Inhalation of vapour may result in nausea, headache.
Prolonged or repeated skin contact may cause drying with cracking, irritation and
possible dermatitis following.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (human) TDLo: 140 mg/kg Nil Reported
Oral (rat) LD50: 8000 mg/kg
Inhalation (rat) LD50: 4250 mg/m鲁
Oral (rat) LOAEL: 66 mg/kg/day
Section 12 - ECOLOGICAL INFORMATION
Marine Pollutant:Not Determined
Hazardous Air Pollutant: Yes
Algae IC50 (72hr.) (mg/l): 10- 50 (24h
log Kow (Sangster 1997): 4.72
Half- life Soil - High (hours): 552
Half- life Soil - Low (hours): 48
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 10 of 12
Section 12 - ECOLOGICAL INFORMATION
Half- life Air - High (hours): 74
Half- life Air - Low (hours): 7.4
Half- life Surface water - High (hours): 336
Half- life Surface water - Low (hours): 24
Half- life Ground water - High (hours): 552
Half- life Ground water - Low (hours): 48
Aqueous biodegradation - Aerobic - High (hours): 552
Aqueous biodegradation - Aerobic - Low (hours): 24
Aqueous biodegradation - Anaerobic - High (hours): 552
Aqueous biodegradation - Anaerobic - Low (hours): 48
Aqueous biodegradation - Removal secondary treatment - High (hours): 95%
Aqueous biodegradation - Removal secondary treatment - Low (hours): 35%
Photolysis maximum light absorption - High (nano- m): 274
Photolysis maximum light absorption - Low (nano- m): 224.5
Aqueous photolysis half- life - Low (hours): 3466
Photooxidation half- life water - High (hours): 1.10E+06
Photooxidation half- life water - Low (hours): 2.10E+04
Photooxidation half- life air - High (hours): 74
Photooxidation half- life air - Low (hours): 7.4
First order hydrolysis half- life (hours): 10
The phthalate esters are distributed throughout the environment ubiquitously. They are
found complexed with fulvic acid components of the humic substances in soil and marine
and estuarine waters. Fulvic acid appears to act as a solubiliser for the otherwise
insoluble ester and serves to mediate its transport and mobilisation in water or
immobilisation in soil. Phthalate esters have been found in open ocean environments, in
deep sea jelly fish, Atlantic herring and in mackerel. Phthalic ester plasticisers are
clearly recognised as general contaminants of almost every soil and water ecosystem. In
general they have low acute toxicity but the weight of evidence supporting their
carcinogenicity is substantial. Other subtle chronic effects have also been reported. As
little as 4 ug/ml in culture medium is lethal to chick embryo heart cells. This
concentration is similar to that reached in human blood stored in vinyl plastic bags for
as little as one day. Some phthalates (notably di2-ethylhexyl phthalate and dibutyl
phthalate) may also be detrimental to the reproduction of the water flea (Daphnia magna),
zebra fish and guppies. As phthalates are present in drinking water and food, concerns
have been raised about their long term effects on humans.
log Kow: 4.72
Koc: 160-6400
Half-life (hr) air: 18
Half-life (hr) H2O surface water: 1824
Henry's atm m鲁 /mol: 4.60E-07
BOD 5 if unstated: 0.43
ThOD: 2.24
BCF: 5000
Log BCF: 1.07-1.5
Fish - Salmo gairdneri LC50 (96h): 1.6 mg/L.
Daphnia Magna EC50 (48h): 3.4 mg/L.
Algae - Selenastrum capricornutum EC50 (96h): 0.75 mg/L.
Phytotoxicity: Vapours of DBP at low concentrations can cause serious damage
to plants.
Section 13 - DISPOSAL CONSIDERATIONS
路 Consult manufacturer for recycling options and recycle where possible .
路 Consult State Land Waste Management Authority for disposal.
路 Incinerate residue at an approved site.
路 Recycle containers if possible, or dispose of in an authorised landfill.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 11 of 12
Section 14 - TRANSPORTATION INFORMATION
Labels Required: MISCELLANEOUS
HAZCHEM: 2X
UNDG:
Dangerous Goods Class: 9 Subrisk: None
UN Number: 3082 Packing Group: III
Shipping Name:ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
Air Transport IATA:
ICAO/IATA Class: 9 ICAO/IATA Subrisk: None
UN/ID Number: 3082 Packing Group: III
Special provisions: A97
Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID
N.O.S.
Maritime Transport IMDG:
IMDG Class: 9 IMDG Subrisk: None
UN Number: 3082 Packing Group: III
EMS Number: F- A, S- F Special provisions: 274 909 944
Marine Pollutant: Not Determined
Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S.
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
dibutyl phthalate (CAS: 84-74-2) is found on the following regulatory lists;
Australia - Australian Capital Territory Environment Protection Regulation Ecosystem maintenance - Organic chemicals - Non-pesticide anthropogenic organics
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
OECD Representative List of High Production Volume (HPV) Chemicals
OSPAR List of Chemicals for Priority Action
OSPAR List of Substances of Possible Concern
Section 16 - OTHER INFORMATION
Denmark Advisory list for selfclassification of dangerous substances
Substance CAS Suggested codes
dibutyl phthalate 84- 74- 2 N; R51/53
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
DIBUTYL PHTHALATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10078
NC317TCP Version No:2.0
CD 2007/3 Page 12 of 12
Section 16 - OTHER INFORMATION
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for reproductive no
-observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoi CR Adeq
nt TLV
dibutyl phthalate 0.72 mg/m3 1000 D NA -
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 26-Mar-2007
Print Date: 19-Dec-2007
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