CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 1 of 13
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
CYCLOHEXANOL
SYNONYMS
C6-H12-O, C6-H11-OH, "cyclohexyl alcohol", "hexylic alcohol", amylcarbinol,
hexahydrophenol, hydrophenol, hydroxycyclohexane, hexalin, hydralin, adronal, anol, naxol
, "phenol, hexahydro-", "cyclic aliphatic alcohol"
PRODUCT USE
Solvent for alkyd resins, phenolic resins and ethyl cellulose. Used in the manufacture of
celluloid, finishing textiles and insecticides.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 2 of 13
Section 2 - HAZARDS IDENTIFICATION
POISONS SCHEDULE
None
RISK SAFETY
May form explosive peroxides. Do not breathe gas/fumes/vapour/spray.
Harmful by inhalation and if swallowed. Avoid contact with eyes.
Irritating to eyes, respiratory system and skin. Wear suitable protective clothing.
Skin contact may produce health damage*. Use only in well ventilated areas.
Cumulative effects may result following Keep container in a well ventilated place.
exposure*.
Vapours potentially cause drowsiness and To clean the floor and all objects contaminated
dizziness*. by this material, use water and detergent.
* (limited evidence). Keep container tightly closed.
Keep away from food, drink and animal feeding
stuffs.
Take off immediately all contaminated clothing.
In case of contact with eyes, rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
If swallowed, IMMEDIATELY contact Doctor or
Poisons Information Centre. (show this container
or label).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
cyclohexanol 108-93-0 >98
Section 4 - FIRST AID MEASURES
SWALLOWED
路 IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.
路 For advice, contact a Poisons Information Centre or a doctor.
路 Urgent hospital treatment is likely to be needed.
路 In the mean time, qualified first-aid personnel should treat the patient following
observation and employing supportive measures as indicated by the patient's condition.
路 If the services of a medical officer or medical doctor are readily available, the
patient should be placed in his/her care and a copy of the MSDS should be provided.
Further action will be the responsibility of the medical specialist.
路 If medical attention is not available on the worksite or surroundings send the patient
to a hospital together with a copy of the MSDS.
路 Where Medical attention is not immediately available or where the patient is more than
15 minutes from a hospital or unless instructed otherwise:
路 INDUCE vomiting with fingers down the back of the throat, ONLY IF CONSCIOUS. Lean
patient forward or place on left side (head-down position, if possible) to maintain open
airway and prevent aspiration.
NOTE: Wear a protective glove when inducing vomiting by mechanical means.
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 3 of 13
Section 4 - FIRST AID MEASURES
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor, without delay.
NOTES TO PHYSICIAN
Treat symptomatically.
To treat poisoning by the higher aliphatic alcohols:
路 Gastric lavage with copious amounts of water.
路 It may be beneficial to instill 60 ml of mineral oil into the stomach.
路 Oxygen and artificial respiration as needed.
路 Electrolyte balance: it may be useful to start 500 ml. M/6 sodium bicarbonate
intravenously but maintain a cautious and conservative attitude toward electrolyte
replacement unless shock or severe acidosis threatens.
路 To protect the liver, maintain carbohydrate intake by intravenous infusions of glucose.
路 Haemodialysis if coma is deep and persistent. [GOSSELIN, SMITH HODGE: Clinical
Toxicology of Commercial Products, Ed 5)
-----------------------------------------------------------------
BASIC TREATMENT
-----------------------------------------------------------------
路 Establish a patent airway with suction where necessary.
路 Watch for signs of respiratory insufficiency and assist ventilation as necessary.
路 Administer oxygen by non-rebreather mask at 10 t0 15 l/min.
路 Monitor and treat, where necessary, for shock.
路 Monitor and treat, where necessary, for pulmonary oedema.
路 Anticipate and treat, where necessary, for seizures.
路 DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml
water (5 ml/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
路 Give activated charcoal.
-----------------------------------------------------------------
ADVANCED TREATMENT
-----------------------------------------------------------------
路 Consider orotracheal or nasotracheal intubation for airway control in unconscious
patient or where respiratory arrest has occurred.
路 Positive-pressure ventilation using a bag-valve mask might be of use.
路 Monitor and treat, where necessary, for arrhythmias.
路 Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers
solution. Fluid overload might create complications.
路 If the patient is hypoglycaemic (decreased or loss of consciousness, tachycardia,
pallor, dilated pupils, diaphoresis and/or dextrose strip or glucometer readings below 50
mg), give 50% dextrose.
路 Hypotension with signs of hypovolaemia requires the cautious administration of fluids.
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 4 of 13
Section 4 - FIRST AID MEASURES
Fluid overload might create complications.
路 Drug therapy should be considered for pulmonary oedema.
路 Treat seizures with diazepam.
路 Proparacaine hydrochloride should be used to assist eye irrigation.
-----------------------------------------------------------------
EMERGENCY DEPARTMENT
-----------------------------------------------------------------
路 Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine,
glucose, urinalysis, baseline for serum aminotransferases (ALT and AST), calcium,
phosphorus and magnesium, may assist in establishing a treatment regime. Other useful
analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs
and electrocardiograph.
路 Positive end-expiratory pressure (PEEP)-assisted ventilation may be required for acute
parenchymal injury or adult respiratory distress syndrome.
路 Acidosis may respond to hyperventilation and bicarbonate therapy.
路 Haemodialysis might be considered in patients with severe intoxication.
路 Consult a toxicologist as necessary. BRONSTEIN, A.C. and CURRANCE, P.L. EMERGENCY CARE
FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear full body protective clothing with breathing apparatus.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Combustible.
路 Slight fire hazard when exposed to heat or flame.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
路 May emit acrid smoke.
路 Mists containing combustible materials may be explosive.
Combustion products include: carbon dioxide (CO2), other pyrolysis products typical of
burning organic material.
May emit poisonous fumes.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Breathing apparatus.
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 5 of 13
Section 5 - FIRE FIGHTING MEASURES
Chemical splash suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb spill with sand, earth, inert material or vermiculite.
路 Wipe up.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
Moderate hazard.
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 No smoking, naked lights or ignition sources.
路 Increase ventilation.
路 Stop leak if safe to do so.
路 Contain spill with sand, earth or vermiculite.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise emergency services.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
cyclohexanol 400 ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
cyclohexanol 50 ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
cyclohexanol 50 ppm
The threshold concentration below which most people will experience no appreciable risk of health effects:
cyclohexanol 50 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 6 of 13
Section 6 - ACCIDENTAL RELEASE MEASURES
+ X + X 0 +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 Avoid smoking, naked lights or ignition sources.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to
ensure safe working conditions.
DO NOT allow clothing wet with material to stay in contact with skin.
The substance accumulates peroxides which may become hazardous only if it evaporates or
is distilled or otherwise treated to concentrate the peroxides. The substance may
concentrate around the container opening for example.
Purchases of peroxidisable chemicals should be restricted to ensure that the chemical is
used completely before it can become peroxidised.
路 A responsible person should maintain an inventory of peroxidisable chemicals or
annotate the general chemical inventory to indicate which chemicals are subject to
peroxidation. An expiration date should be determined. The chemical should either be
treated to remove peroxides or disposed of before this date.
路 The person or laboratory receiving the chemical should record a receipt date on the
bottle. The individual opening the container should add an opening date.
路 Unopened containers received from the supplier should be safe to store for 18 months.
路 Opened containers should not be stored for more than 12 months.
SUITABLE CONTAINER
路 Metal can or drum
路 Packaging as recommended by manufacturer.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
路 Avoid oxidising agents, acids, acid chlorides, acid anhydrides.
Secondary alcohols and some branched primary alcohols may produce potentially explosive
peroxides after exposure to light and/ or heat.
WARNING: Long standing in contact with air and light may result in the formation
of potentially explosive peroxides.
Especially avoid nitric acid.
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 7 of 13
Section 7 - HANDLING AND STORAGE
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 No smoking, naked lights or ignition sources.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak TWA
ppm mg/m鲁 ppm mg/m鲁 ppm mg/m鲁 F/CC
_________________ __________________ ______ ______ ______ ______ ______ ______ _____
Australia Exposure cyclohexanol 50 206
Standards (Cyclohexanol)
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
cyclohexanol 400
ODOUR SAFETY FACTOR (OSF)
OSF=3.3E2 (CYCLOHEXANOL)
Exposed individuals are reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class A or B.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed
individuals are aware by smell
that the Exposure Standard
(TLV- TWA for example) is
being reached, even when
distracted by working
activities
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
MATERIAL DATA
Odour Threshold Value: 0.155 ppm (detection)
IDLH Level: 400 ppm
The TLV-TWA is based upon the estimated acceptable air concentration for
human subjects exposed for 3 to 5 minutes to varying concentrations. The
estimated accepted concentration for eight hours was reported by the
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 8 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
volunteer subjects to be less than 100 ppm.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
" Forsberg Clothing Performance Index" .
The effect(s) of the following substance(s) are taken into account in the
computer- generated selection: cyclohexanol
Protective Material CPI *.
__________________________________________
BUTYL A
BUTYL/NEOPRENE A
NITRILE+PVC A
PE/EVAL/PE A
VITON A
PVA A
PVC A
NITRILE A
NEOPRENE B
NATURAL RUBBER B
NATURAL+NEOPRENE C
__________________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 9 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent use.
A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
ppm (volume) Factor
1000 10 A- AUS -
1000 50 - A- AUS
5000 50 Airline * -
5000 100 - A- 2
10000 100 - A- 3
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation usually required. If risk of overexposure exists, wear approved
respirator. Correct fit is essential to obtain adequate protection. Supplied-air type
respirator may be required in special circumstances. Correct fit is essential to ensure
adequate protection.
An approved self contained breathing apparatus (SCBA) may be required in some situations.
Provide adequate ventilation in warehouse or closed storage area. Air contaminants
generated in the workplace possess varying "escape" velocities which, in turn, determine
the "capture velocities" of fresh circulating air required to effectively remove the
contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow 1- 2.5 m/s (200- 500 f/min.)
booths, drum filling, conveyer loading,
crusher dusts, gas discharge (active
generation into zone of rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 10 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Clear, colourless crystals or viscous liquid with faint camphor- like odour. Hygroscopic.
Water solubility: 3.6% Resists biodegradation.
PHYSICAL PROPERTIES
Liquid.
Does not mix with water.
Floats on water.
Molecular Weight: 100.16 Boiling Range (掳C): 161
Melting Range (掳C): 23 - 25 Specific Gravity (water=1): 0.962
Solubility in water (g/L): Partly miscible pH (as supplied): Not applicable
pH (1% solution): Not available. Vapour Pressure (kPa): 0.133
Volatile Component (%vol): 100 Evaporation Rate: 0.08 BuAc=1
Relative Vapour Density (air=1): 3.5 Flash Point (掳C): 68
Lower Explosive Limit (%): 1.25 Upper Explosive Limit (%): 12.25
Autoignition Temp (掳C): 300 Decomposition Temp (掳C): Not available.
State: Liquid Viscosity: Not Available
log Kow (Prager 1995): 1.23
log Kow (Sangster 1997): 1.23
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Presence of incompatible materials.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be harmful; animal experiments indicate that
ingestion of less than 150 gram may be fatal or may produce serious damage to the health
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 11 of 13
Section 11 - TOXICOLOGICAL INFORMATION
of the individual.
Central nervous system (CNS) depression may include general discomfort, symptoms of
giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time,
slurred speech and may progress to unconsciousness. Serious poisonings may result in
respiratory depression and may be fatal.
EYE
There is evidence that material may produce eye irritation in some persons and produce
eye damage 24 hours or more after instillation. Severe inflammation may be expected with
pain. There may be damage to the cornea. Unless treatment is prompt and adequate there
may be permanent loss of vision. Conjunctivitis can occur following repeated exposure.
SKIN
Skin contact with the material may damage the health of the individual; systemic effects
may result following absorption.
The material may cause mild but significant inflammation of the skin either following
direct contact or after a delay of some time. Repeated exposure can cause contact
dermatitis which is characterised by redness, swelling and blistering.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the
course of normal handling, may be harmful.
The material can cause respiratory irritation in some persons. The body's response to
such irritation can cause further lung damage.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by
sleepiness, reduced alertness, loss of reflexes, lack of co-ordination, and vertigo.
CHRONIC HEALTH EFFECTS
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
Asthma-like symptoms may continue for months or even years after exposure to the material
ceases. This may be due to a non-allergenic condition known as reactive airways
dysfunction syndrome (RADS) which can occur following exposure to high levels of highly
irritating compound. Key criteria for the diagnosis of RADS include the absence of
preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the
irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to
severe bronchial hyperreactivity on methacholine challenge testing and the lack of
minimal lymphocytic inflammation, without eosinophilia, have also been included in the
criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an
infrequent disorder with rates related to the concentration of and duration of exposure
to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that
occurs as result of exposure due to high concentrations of irritating substance (often
particulate in nature) and is completely reversible after exposure ceases. The disorder
is characterised by dyspnea, cough and mucous production.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (rat) LD50: 2060 mg/kg Skin(rabbit):14.6mg/24h Open Mild
Inhalation (human) TCLo: 75 ppm Eye (rabbit): 2 mg - SEVERE
Inhalation (rat) LCLo: 8000 ppm/4h Eye (human): 100 ppm
Dermal (rabbit) LD50: 12300 mg/kg
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 12 of 13
Section 12 - ECOLOGICAL INFORMATION
Fish LC50 (96hr.) (mg/l): 720- 1100
BCF<100: 5.1
Water solubility (mg/l): 4.20E+04
log Kow (Prager 1995): 1.23
log Kow (Sangster 1997): 1.23
log Pow (Verschueren 1983): 1.23
BOD20: 74%
DO NOT discharge into sewer or waterways.
log Kow: 1.23
Koc: 13-111
Half-life (hr) air: 22
Half-life (hr) H2O surface water: 319.2-3480
Henry's atm m鲁 /mol: 2.77E-06
BOD 5 if unstated: 0.08-0.379,4%
COD: 2.15,95%
ThOD: 2.828
BCF: 1.5-5.1
Toxicity Fish: LC50(96)31-117mg/L
Toxicity invertebrate: cell mult. inhib.prtza >50mg/L
Nitrif. inhib.: inhib at 40mg/L
Degradation Biological: resist
processes Abiotic: Rxn OH*,photodeg,no photol
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Consult State Land Waste Authority for disposal.
路 Bury or incinerate residue at an approved site.
路 Recycle containers if possible, or dispose of in an authorised landfill.
路 Containers may still present a chemical hazard/ danger when empty.
路 Return to supplier for reuse/ recycling if possible.
Otherwise:
路 If container can not be cleaned sufficiently well to ensure that residuals do not
remain or if the container cannot be used to store the same product, then puncture
containers, to prevent re-use, and bury at an authorised landfill.
路 Where possible retain label warnings and MSDS and observe all notices pertaining to the
product.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
cyclohexanol (CAS: 108-93-0) is found on the following regulatory lists;
Australia Exposure Standards
CYCLOHEXANOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 9-Jan-2006 CHEMWATCH 22559
NC317TCP CD 2006/4 Page 13 of 13
Section 15 - REGULATORY INFORMATION
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 9-Jan-2006
Print Date: 4-Jan-2007
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