184000 2.00 EC Current 17.03.2000
1. PRODUCT AND COMPANY IDENTIFICATION
Johnson Matthey PLC
Precious Metals Division, Chemicals
+(44) 1763 253000
+(44) 1763 253155
Tetrammineplatinum(II)chloride, Pt(NH ) Cl .H O.
JM Version Number
Date of First Issue
2. COMPOSITION/INFORMATION ON THE COMPONENTS
Product Formal Name
Product Chemical Family
3. HAZARD IDENTIFICATION
The platinum ammine complex has low toxicity when ingested, but is a
moderate skin irritant. It strongly irritates the eyes and may irritate the upper
respiratory tract. The product does not cause dermatitis (Type IV
sensitisation) or allergic (Type I sensitisation) responses.
If this material is used to prepare other platinum compounds, it should be
noted that ionic platinum chloro complexes are highly allergenic and cis-
diamminedichloroplatinum(II) is highly toxic (tests on mice have shown it to
4. FIRST AID MEASURES
Over-exposure may produce the following symptoms-
Inhalation- Irritation of the respiratory tract.
Eye contact- Redness and irritation.
Skin contact- Irritation. 聽 聽
First Aid - Inhalation Remove from exposure and allow to rest in fresh air. Seek medical advice if
symptoms persist. 聽
Rinse mouth with clean water, give milk or water to drink. Seek medical
First Aid - Ingestion
advice if symptoms persist.
First Aid - Eyes Irrigate with clean water or isotonic saline solution for 15 minutes.Seek
medical advice if symptoms persist. 聽
Remove contaminated clothes and wash skin with soap and water. 聽
First Aid - Skin
5. FIRE FIGHTING MEASURES
Although the material is not flammable, toxic fumes will be produced if
involved in a fire. The residue, ash or char left after a fire may have catalytic
properties and may promote the re-ignition of flammable materials and
vapours. Wear self-contained breathing apparatus and personal protective
equipment. Use any extinguisher suitable for the surrounding fire. 聽 聽
6. ACCIDENTAL RELEASE MEASURES
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6. ACCIDENTAL RELEASE MEASURES (continued)
Wearing gloves and eye protection, sweep up the spillage and store in sealed
containers ready for disposal. Avoid mixing with flammable materials. 聽
7. HANDLING AND STORAGE
Local exhaust extraction should be used and protective clothing, including
gloves and eye protection should be worn. Do not eat, drink, smoke or apply
cosmetics whilst handling. 聽
Store in an air-tight container in a cool, dry place. 聽
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
UK MEL for halogeno-platinum compounds - 0.002 mg/m鈥?
USA ACGIH TLV-TWA for soluble platinum salts - 0.002 mg/m鈥?
German MAK for platinum compounds, measured as total dust - 0.002 mg/
Danish ELV for soluble platinum compounds - 0.002 mg/m鈥?
All values calculated as Pt. High risk of sensitization.
Local exhaust extraction should be used. Vapour and fumes from all
operations should be vented to external atmosphere via a collection or
scrubbing system. Personal filter type respiratory protection, impervious
gloves and industrial safety glasses should be worn. Work clothes should be
changed as often as necessary and at least after every working shift. Wash
hands after using this material.
Users of large amounts of the solid or its solutions should consider the
application of engineering control measures, such as total enclosure and
remote operation where possible. Workplace air and the exhaust from the
ventilation system should be monitored for airborne platinum to ensure that
exposure limit are not exceded. This monitoring should include personal
breathing zone sampling. Pre-exposure and periodic medical examinations of
persons exposed to platinum salts are recommended. Further details are
given in the HSE's Guidance Note MS22,"The Medical Monitoring of Workers
Exposed to Platinum Salts" (ISBN 0 11 883575 0). For non UK residents,
information is available from the JM Group Occupational Physician. 聽 聽 聽 聽 聽 聽 聽
9. PHYSICAL AND CHEMICAL PROPERTIES
white, crystalline powder.
Boiling Range/Point not applicable.
decomposes on heating at 250掳C, losing ammonia to become TRANS-
dichlorodiammineplatinum(II), which in turn decomposes at 340掳C, leaving
Vapour Pressure no data.
Water - 20gm/100ml.
Solubility in Water
Fat - no data. Insoluble in ethanol. 聽 聽
10. STABILITY AND REACTIVITY
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10. STABILITY AND REACTIVITY (continued)
The material is supplied in a stable condition and no reactive hazards are
11. TOXICOLOGICAL INFORMATION
LD50 (oral-rat): >15gm/kg
eye-rabbit: strong irritant
skin-rabbit: moderate irritant
Magnusson and Kligman test - no sensitisation.
12. ECOLOGICAL INFORMATION
The reproduction of daphnids is impaired (16%) by 0.014 ppm Pt in 3 weeks.
Hydrogen hexachloroplatinate is reported to be lethal to certain freshwater
species. The complex may persist for some time in the environment. 聽 聽
Return accumulated waste material to the refinery for metal recovery, or
dispose of in accordance with local and national regulations. 聽
14. TRANSPORT INFORMATION
15. REGULATORY INFORMATION
R36 Irritating to eyes.
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S39 Wear eye/face protection.
Xi - Irritant
EC Annex I Classification
16. OTHER INFORMATION
30 July 1999
MSDS first issued
17 March 2000
MSDS data revised
This information relates only to the specific material designated and may not be valid for such material used in combination
with any other materials or in any process. Such information is given in good faith, being based on the latest information
available to Johnson Matthey PLC and is to the best of Johnson Matthey PLC's knowledge and belief, accurate and reliable at
the time of preparation. However, no representation, warranty or guarantee is made as to the accuracy, liability or
completness and Johnson Matthey PLC assumes no responsibility therefore, and disclaims any liability for any loss, damage
or injury howsoever arising (including in respect of any claim brought by any third party) incurred using this information. The
product is supplied on thecondition that the user accepts responsibility to satisfy himself as to the suitability and completness
of such information for his own particular use. Freedom from patent or any other proprietary rights of any third party must not
be assumed. 聽
Registry of Toxic Effects of Chemical Substances. Published by the National Institute of Occupational Safety and Health. USA.
Oil and Hazardous Materials Technical Assistance Data System. Published by The Office of Water and Waste Management.
Environmental Protection Agency USA.
Chemical Hazard Response Information System. Published by US Coast Guard.
NIOSHTIC Occupational Safety and Health database. Published by the National Institute of Occupational Safety and Health.
HSELINE Health and Safety Executive Library and Information Service. Published by the Health and Safety Executive. UK.
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184000 2.00 EC Current 17.03.2000
16. OTHER INFORMATION (continued)
CISDOC International Occupational Safety and Health Database. Published by the International Labour Organisation. Geneva.
RISKLINE. Published by the National Chemical Inspectorate. Sweden.
TOXLINE. Published by the Chemical Abstracts Service. USA.
Developmental and Reproductive Toxicology. The National Library of Medicine. USA.
Toxicity, Bibliography. The National Library of Medicine. USA.
Environmental Mutagen Information. Oak Ridge National Laboratory. USA.
Environmental Teratology Information. Oak Ridge National Laboratory. USA
BIOSIS. Published by Biological Abstracts Inc. USA.
Epidemiology Information. The Food and Drug Administration. USA
International Pharmaceutical Abstracts. The American Society of Hospital Pharmacists. USA.
Hazardous Materials Technical Center Abstracts. Department of the Army, Hazardous Materials Technical Center. USA.
Toxicology Document and Data Depository. National Technical Information Service. USA.
Federal Research in Progress. National Technical Information Service. USA.
Toxicology Research Projects. National Institutes of Health. USA
Toxic Substances Control Act Test Submissions. The Environmental Protection Agency. USA.
Patty's Industrial Hygiene and Toxicology 3rd edition.
Handbook on the Toxicology of Metals. Friberg, Nordberg and Vouk 2nd edition.
Bretherick's Handbook of Reactive Chemical Hazards. 5th edition.
Grant's Toxicology of the Eye. 3rd edition.
Merck Index 10th edition.
Handbook on Toxicology of Inorganic Compounds. Seiler, Sigel and Sigel.
Catalog of Teratogenic Agents. Shepard. 4th edition
Reproductive Hazards of Industrial Chemicals. Barlow and Sullivan.
Royal Society of Chemistry, Chemical Safety Data Sheets.
National Sales Offices
Johnson Matthey PLC,33 Jeffreys Road, Brimsdown, ENFIELD, Middlesex EN3 7PW, United Kingdom, Tel:- 0181 8048111,
Fax:- 0181 8041918
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99, Fax:- 1 48 63 27 02
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