SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 03/07/2004
Version 1.5
Section 1 - Product and Company Information
Product Name ETHYLENEDIAMINETETRAACETIC ACID,
FOR COMPLEXOMETRY
Product Number 03610
Brand FLUKA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ETHYLENEDIAMINETETRAACETIC ACID 60-00-4 No
Formula C10H16N2O8
Synonyms Acide ethylenediaminetetracetique (French) *
Celon A * Celon ATH * Cheelox * Cheelox BF acid *
Chemcolox 340 * Clewat TAA * Complexon II *
3,6-Diazaoctanedioic acid, 3,6-bis(carboxymethyl)
* Edathamil * Edetic acid * EDTA * EDTA
(chelating agent) * EDTA acid * Endrate *
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
* Ethylenediaminetetraacetate *
Ethylenediaminetetraacetic acid *
Ethylenediamine-N,N,N',N'-tetraacetic acid *
Ethylenedinitrilotetraacetic acid * Gluma
cleanser * Glycine,
N,N'-1,2-ethanediylbis(N-(carboxymethyl)- (9CI) *
Hamp-ene acid * Havidote * ICRF 185 * Komplexon
II * Kyselina ethylendiamintetraoctova (Czech) *
Metaquest A * Nervanaid B acid * Nullapon B acid
* Nullapon BF acid * Perma kleer 50 acid *
Questex 4H * SEQ 100 * Sequestrene AA *
Sequestric acid * Sequestrol * Tetrine acid *
Titriplex * Trilon BS * Trilon BW * Versene acid
* Vinkeil 100 * Warkeelate acid * YD 30
RTECS Number: AH4025000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Irritant.
Irritating to eyes, respiratory system and skin.
HMIS RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 292.24 AMU
pH 2.5 23 掳C Concentration: 10
g/l
BP/BP Range N/A
MP/MP Range 250 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: -3.34
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1M in NaOH 1M, 20掳C complete,
colorless
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SENSITIZATION
Sensitization: Will not occur
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
4,000 mg/kg
LD50
Oral
Rat
2,580 mg/kg
LD50
Intraperitoneal
Rat
397 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Oral
Mouse
30 mg/kg
LD50
Intraperitoneal
Mouse
250 MG/KG
LD50
Intravenous
Mouse
28500 UG/KG
LD50
IRRITATION DATA
Skin
Rabbit
Remarks: No irritation effect
Eyes
Rabbit
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Remarks: Moderate irritation effect
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue). Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system. Specific Developmental Abnormalities:
Urogenital system.
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Dose: 600 UMOL/L
Cell Type: Other cell types
Mutation test: DNA inhibition
Species: Mouse
Route: Intraperitoneal
Dose: 186 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Oral
Dose: 15 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Dose: 40500 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 50 MMOL/L
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 25200 UMOL/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 100 UMOL/L
Cell Type: Embryo
Mutation test: Unscheduled DNA synthesis
Species: Hamster
Dose: 500 UG/L
Cell Type: fibroblast
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Mutation test: DNA inhibition
Species: Hamster
Dose: 30 UMOL/L
Cell Type: Embryo
Mutation test: Sister chromatid exchange
Species: Rabbit
Dose: 250 UMOL/L
Cell Type: kidney
Mutation test: DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 7632 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 3 GM/KG
Route of Application: Subcutaneous
Exposure Time: (7-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 113 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 34 - 62 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 44.2 - 76.50 mg/l
ADDITIONAL RESULTS/DATA FROM RELEVENT SCIENTIFIC EXPERIMENTS
May be harmful to aquatic organisms due to the shift
of the pH. Avoid contamination of the environment
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
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afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xi
Indication of Danger: Irritant.
R: 36
Risk Statements: Irritating to eyes.
S: 26
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Irritant.
Risk Statements: Irritating to eyes, respiratory system and skin.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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