SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/15/2005
Date Updated: 07/28/2004
Version 1.6
Section 1 - Product and Company Information
Product Name NICKEL(II) CHLORIDE HEXAHYDRATE,
REAGENTPLUS(TM),
Product Number 223387
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
NICKEL CHLORIDE HEXAHYDRATE 7791-20-0 Yes
Formula NiCl2.6H2O
RTECS Number: QR6480000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic. Dangerous for the environment.
May cause cancer. Toxic if swallowed. Irritating to eyes and skin.
May cause sensitization by skin contact. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
Target organ(s): Lungs.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
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Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.1 MG(NI)/M3
USA MSHA Standard-air TWA 1 MG(NI)/M3
USA OSHA. PEL 8H TWA 1 MG(NI)/M3
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 0.015 MG(NI)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Green
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 237.71 AMU
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
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Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Peroxides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Hydrogen chloride gas,
Nickel/nickel oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
SENSITIZATION
Sensitization: Causes dermatitis.
Sensitization: Will occur
TARGET ORGAN(S) OR SYSTEM(S)
Lungs.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Gastrointestinal disturbances. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
186 mg/kg
LD50
Oral
Rat
105 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Behavioral:Somnolence (general
depressed activity). Gastrointestinal:Hypermotility, diarrhea.
Intraperitoneal
Mouse
48 MG/KG
LD50
Intravenous
Dog
40 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
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IARC CARCINOGEN LIST
Rating: Group 1 Group 1
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 250 UMOL/L
Cell Type: HeLa cell
Mutation test: DNA damage
Species: Rat
Route: Subcutaneous
Dose: 44400 UG/KG
Mutation test: DNA damage
Species: Mouse
Dose: 800 UMOL/L
Cell Type: mammary gland
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 400 UMOL/L
Cell Type: mammary gland
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 32 MG/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1670 MG/KG
Route of Application: Oral
Exposure Time: (11D PREG-1D POST)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 4.9 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 5.3 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.51 mg/l
Test Type: LC50 Bacteria
Time: 15 min
Value: 23 mg/l
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Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Catalysts and expensive metals should be
recovered for reuse or recycling. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solid, inorganic, n.o.s.
UN#: 3288
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Keep away from food
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, inorganic, n.o.s.
IATA UN Number: 3288
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T N
Indication of Danger: Toxic. Dangerous for the environment.
R: 45 25 36/38 43 50/53
Risk Statements: May cause cancer. Toxic if swallowed.
Irritating to eyes and skin. May cause sensitization by skin
contact. Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S: 53 36/37 45 60 61
Safety Statements: Avoid exposure - obtain special instructions
before use. Wear suitable protective clothing and gloves. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic. Dangerous for the environment.
Risk Statements: May cause cancer. Toxic if swallowed.
Irritating to eyes and skin. May cause sensitization by skin
contact. Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
Safety Statements: Avoid exposure - obtain special instructions
before use. Wear suitable protective clothing and gloves. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Lungs.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
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requirements - nickel compounds.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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