SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 03/07/2004
Version 1.3
Section 1 - Product and Company Information
Product Name LEAD(II) ACETATE TRIHYDRATE,
99.999%
Product Number 316512
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
LEAD ACETATE TRIHYDRATE ACS REAGENT 6080-56-4 Yes
Formula Pb(C2H3O2)2 路 3H2O
Synonyms Acetic acid, lead(+2) salt trihydrate *
Bis(acetato)trihydroxytrilead * Bleiazetat
(German) * Lead diacetate trihydrate
RTECS Number: OF8050000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
May cause cancer. May impair fertility. May cause heritable
genetic damage. Danger of cumulative effects. Toxic by inhalation,
in contact with skin and if swallowed.
Target organ(s): Nerves. Blood.
HMIS RATING
HEALTH: 4
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 4
FLAMMABILITY: 0
REACTIVITY: 1
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Incompatible Materials: Absorbs carbon dioxide from air.
SPECIAL REQUIREMENTS
Light sensitive. Air sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
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Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator in nonventilated areas
and/or for exposure above the TLV or PEL.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA USA NIOSH NIOSH TWA TWA <0.1 MG(PB)/M3 <0.1 MG(PB)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 379.33 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 75 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.55 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions of Instability: May decompose on exposure to light.
Absorbs carbon dioxide from air.
Materials to Avoid: Strong oxidizing agents, Strong acids.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Lead/lead oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Blood. Central nervous system. Peripheral nervous system. G.I.
System. Skeletal muscle. Kidneys. Female reproductive system.
Male reproductive system.
SIGNS AND SYMPTOMS OF EXPOSURE
Lead salts have been reported to cross the placenta and to
induce embryo- and feto- mortality. They also have teratogenic
effect in some animal species. No teratogenic effects have been
reported with exposure to organometallic lead compounds. Adverse
effects of lead on human reproduction, embryonic and fetal
development, and postnatal (e.g., mental) development have been
reported. Excessive exposure can affect blood, nervous, and
digestive systems. The synthesis of hemoglobin is inhibited and
results in anemia. If left untreated, neuromuscular dysfunction,
possible paralysis, and encephalopathy can result. Additional
symptoms of overexposure include: joint and muscle pain,
weakness of the extensor muscles (frequently the hand and
wrist), headache, dizziness, abdominal pain, diarrhea,
constipation, nausea, vomiting, blue line on the gums, insomnia,
and metallic taste. High body levels produce increased
cerebrospinal pressure, brain damage, and stupor leading to coma
and often death. May cause convulsions.
TOXICITY DATA
Oral Oral
Rat Rat
4665 mg/kg 4665 mg/kg
LD50 LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
174 MG/KG 174 MG/KG
LD50 LD50
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Species: Rat Rat
Route of Application: Oral Oral
Dose: 8524 MG/KG 8524 MG/KG
Exposure Time: 78W 78W
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Frequency: C C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic Effects: Testicular
tumors. Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Tumorigenic Effects: Testicular
tumors.
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 20 GM/KG 20 GM/KG
Mutation test: DNA inhibition DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat Rat
Dose: 2219 MG/KG 2219 MG/KG
Route of Application: Oral Oral
Exposure Time: (18D POST) (18D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Behavioral.
Species: Rat Rat
Dose: 1611 MG/KG 1611 MG/KG
Route of Application: Oral Oral
Exposure Time: (1-22D PREG/17D POST) (1-22D PREG/17D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Behavioral.
Species: Rat Rat
Dose: 49780 MG/KG 49780 MG/KG
Route of Application: Oral Oral
Exposure Time: (1-22D PREG/17D POST) (1-22D PREG/17D POST)
Result: Effects on Newborn: Delayed effects. Effects on Newborn:
Delayed effects.
Species: Rat Rat
Dose: 1593 MG/KG 1593 MG/KG
Route of Application: Oral Oral
Exposure Time: (6W PRE-21D POST) (6W PRE-21D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical. Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Rat Rat
Dose: 1763 MG/KG 1763 MG/KG
Route of Application: Oral Oral
Exposure Time: (1-22D PREG/1-21D POST) (1-22D PREG/1-21D POST)
Result: Effects on Newborn: Biochemical and metabolic. Effects
on Newborn: Behavioral. Effects on Newborn: Biochemical and
metabolic. Effects on Newborn: Behavioral.
Species: Mouse Mouse
Dose: 1155 MG/KG 1155 MG/KG
Route of Application: Oral Oral
Exposure Time: (21D POST) (21D POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Other postnatal measures or
effects. Effects on Newborn: Growth statistics (e.g., reduced
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weight gain). Effects on Newborn: Other postnatal measures or
effects.
Species: Mouse
Dose: 56 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or
Fetus: Extra embryonic structures (e.g., placenta, umbilical
cord).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Lead acetate
UN#: 1616
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Keep away from food
PIH: Not PIH
IATA
Proper Shipping Name: Lead acetate
IATA UN Number: 1616
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T N
Indication of Danger: Toxic. Dangerous for the environment.
R: 61 33 48/22 50/53 62
Risk Statements: May cause harm to the unborn child. Danger of
cumulative effects. Also harmful: danger of serious damage to
health by prolonged exposure if swallowed. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Possible risk of impaired fertility.
S: 53 45 60 61
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic.
Risk Statements: May cause cancer. May impair fertility. May
cause heritable genetic damage. Danger of cumulative effects.
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Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves, and eye/face
protection. Do not breathe dust.
US Statements: Target organ(s): Nerves. Blood.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements - lead compounds.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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