SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 09/28/2004
Version 1.18
Section 1 - Product and Company Information
Product Name ETHANOL, ABSOLUTE, 200 PROOF,
99.5%, A.C.S. REAGENT
Product Number 459844
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ETHYL ALCOHOL, NON-DENATURED, 200 64-17-5 No
PROOF
Formula C2H6O
RTECS Number: KQ6300000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Irritant.
Irritating to eyes, respiratory system and skin. Highly flammable.
Target organ(s): Nerves. Liver.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
FLASH POINT
57 掳F 14 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 3.3 % Upper: 19 %
AUTOIGNITION TEMP
363 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Specific Method(s) of Fire Fighting: Use water spray to cool
fire-exposed containers.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid breathing vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame. Store in a cool dry place. Handle and store
under nitrogen.
SPECIAL REQUIREMENTS
Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 1000 PPM
USA MSHA Standard-air TWA 1000 PPM (1900 MG/M3)
USA OSHA. PEL 8H TWA 1000 PPM (1900 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 1000 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 1900 MG/M3
Poland NDSCh -
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 46.07 AMU
pH N/A
BP/BP Range 78 - 80 掳C
MP/MP Range -144 掳C
Freezing Point N/A
Vapor Pressure 44.6 mmHg 20 掳C
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 0.79 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
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Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 57 掳F 14 掳C Method: closed cup
Explosion Limits Lower: 3.3 %
Upper: 19 %
Flammability N/A
Autoignition Temp 363 掳C
Refractive Index 1.362
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Complete
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Alkali metals, Ammonia, Oxidizing agents,
Peroxides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nature of decomposition products
not known.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves. Liver. Heart.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Narcotic effect. Damage to the heart.
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Inhalation
Rat
20,000 ppm
LC50
Oral
Rat
7,060 mg/kg
LD50
Oral
Human
1,400 mg/kg
LD50
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Oral
Child
2000 mg/kg
LDLO
Remarks: Lungs, Thorax, or Respiration:Other changes.
Liver:Fatty liver degeneration. Blood:Other changes.
Oral
Human
1400 mg/kg
LDLO
Remarks: Behavioral:Sleep. Behavioral:Headache.
Gastrointestinal:Nausea or vomiting.
Subcutaneous
Infant
19440 MG/KG
LDLO
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Coma. Nutritional and Gross Metabolic:Changes in:Body
temperature decrease.
Oral
Rat
7060 mg/kg
LD50
Remarks: Lungs, Thorax, or Respiration:Other changes.
Inhalation
Rat
20,000 ppm
LC50
Intraperitoneal
Rat
3600 UG/KG
LD50
Intravenous
Rat
1440 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
Intraarterial
Rat
11 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Lungs, Thorax, or Respiration:Dyspnea.
Oral
Mouse
3450 mg/kg
LD50
Inhalation
Mouse
39,000 mg/m3
LC50
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Intraperitoneal
Mouse
528 MG/KG
LD50
Subcutaneous
Mouse
8285 MG/KG
LD50
Intravenous
Mouse
1973 MG/KG
LD50
Oral
Rabbit
6300 mg/kg
LD50
Intraperitoneal
Rabbit
963 MG/KG
LD50
Intravenous
Rabbit
2374 MG/KG
LD50
Oral
Guinea pig
5560 mg/kg
LD50
Intraperitoneal
Guinea pig
3414 MG/KG
LD50
Intraperitoneal
Hamster
5068 MG/KG
LD50
Intraperitoneal
Mammal
4300 MG/KG
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Change in motor activity (specific assay).
IRRITATION DATA
Skin
Rabbit
400 mg
Remarks: Open irritation test
Skin
Rabbit
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20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
500 mg
Remarks: Severe irritation effect
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
4S
Remarks: Rinsed
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Mouse
Route of Application: Oral
Dose: 320 MG/KG
Exposure Time: 50W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors. Blood:Lymphomas including Hodgkin's
disease.
Species: Mouse
Route of Application: Rectal
Dose: 120 GM/KG
Exposure Time: 18W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors. Liver:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 400 GM/KG
Exposure Time: 57W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 250 MG/KG
Route of Application: Oral
Exposure Time: (37W PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
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Species: Rat
Dose: 4 GM/KG
Route of Application: Oral
Exposure Time: (13D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material).
Species: Rat
Dose: 12 GM/KG
Route of Application: Oral
Exposure Time: (9-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 24 GM/KG
Route of Application: Oral
Exposure Time: (14-16D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 4 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 44 GM/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 20000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 2240 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9-12D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
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Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 4 GM/KG
Route of Application: Intravenous
Exposure Time: (6-7D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Other effects to embryo. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 4 GM/KG
Route of Application: Intravenous
Exposure Time: (6-7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Other developmental abnormalities.
Species: Mouse
Dose: 162 GM/KG
Route of Application: Oral
Exposure Time: (11-19D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Mouse
Dose: 5800 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear.
Species: Mouse
Dose: 75600 MG/KG
Route of Application: Oral
Exposure Time: (5-11D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Effects on Newborn: Live birth index (# fetuses per litter;
measured after birth). Effects on Newborn: Growth statistics
(e.g., reduced weight gain).
Species: Mouse
Dose: 5500 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 5800 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 5800 MG/KG
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Route of Application: Intraperitoneal
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
Species: Mouse
Dose: 5622 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Eye, ear. Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 4 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material).
Species: Monkey
Dose: 32400 MG/KG
Route of Application: Oral
Exposure Time: (2-19W PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Central nervous system. Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Monkey
Dose: 43200 MG/KG
Route of Application: Oral
Exposure Time: (1-24W PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rabbit
Dose: 15 MG/KG
Route of Application: Intravenous
Exposure Time: (15-29D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Other effects
to embryo.
Species: Guinea pig
Dose: 240 GM/KG
Route of Application: Oral
Exposure Time: (2-61D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Central nervous system.
Species: Guinea pig
Dose: 72 GM/KG
Route of Application: Oral
Exposure Time: (45-62D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Domestic Animals
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Dose: 94 GM/KG
Route of Application: Intravenous
Exposure Time: (14-21W PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Domestic Animals
Dose: 40 GM/KG
Route of Application: Intravenous
Exposure Time: (14-17W PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Biochemical and
metabolic.
Species: Domestic Animals
Dose: 1 GM/KG
Route of Application: Intravenous
Exposure Time: (18W PREG)
Result: Specific Developmental Abnormalities: Respiratory system.
Species: Mammal
Dose: 31500 MG/KG
Route of Application: Oral
Exposure Time: (15-35D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 220 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Human
Dose: 1160 GM/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 12000 PPM
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
Species: Human
Dose: 1 PPH/72H-C
Cell Type: leukocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 500 PPM
Exposure Time: 72H
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Rat
Route: Oral
Dose: 4 GM/KG
Mutation test: DNA damage
Species: Rat
Route: Intraperitoneal
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Dose: 250 GM/KG
Exposure Time: 16D
Mutation test: Other mutation test systems
Species: Rat
Route: Oral
Dose: 3 GM/KG
Mutation test: Other mutation test systems
Species: Rat
Route: Oral
Dose: 2 GM/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 1240 MG/KG
Exposure Time: 2D
Mutation test: Micronucleus test
Species: Mouse
Route: Oral
Dose: 40 GM/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Oral
Dose: 420 MG/KG
Exposure Time: 3W
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Oral
Dose: 5 GM/KG
Mutation test: SLN
Species: Mouse
Route: Oral
Dose: 3720 MG/KG
Exposure Time: 3D
Mutation test: Dominant lethal test
Species: Mouse
Route: Oral
Dose: 1500 MG/KG
Exposure Time: 50D
Mutation test: sperm
Species: Hamster
Dose: 100 PPM
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 1 PPH
Cell Type: Embryo
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 160 MMOL/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
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Species: Hamster
Dose: 3900 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Dog
Dose: 400 UMOL/L
Cell Type: lymphocyte
Mutation test: Micronucleus test
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 41 GM/KG
Route of Application: Oral
Exposure Time: (41W PREG)
Result: Effects on Newborn: Apgar score (human only). Effects on
Newborn: Other neonatal measures or effects. Effects on Newborn:
Drug dependence.
Species: Woman
Dose: 8 GM/KG
Route of Application: Intravenous
Exposure Time: (32W PREG)
Result: Effects on Newborn: Apgar score (human only). Effects on
Newborn: Other neonatal measures or effects.
Species: Woman
Dose: 200 MG/KG
Route of Application: Intrauterine
Exposure Time: (5D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Rat
Dose: 78 GM/KG
Route of Application: Oral
Exposure Time: (7-19D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 322 GM/KG
Route of Application: Oral
Exposure Time: (35D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 132 GM/KG
Route of Application: Oral
Exposure Time: (1-22D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain). Effects on
Newborn: Behavioral.
Species: Rat
Dose: 354 GM/KG
Route of Application: Oral
Exposure Time: (10D POST)
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Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 35295 MG/KG
Route of Application: Oral
Exposure Time: (1-15D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora
lutea). Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 15 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (8-13D PREG)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Rat
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 3 GM/KG
Route of Application: Intravenous
Exposure Time: (6-7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 5 MG/KG
Route of Application: Intracerebral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 60 GM/KG
Route of Application: Unreported
Exposure Time: (9-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 400 MG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Rat
Dose: 2400 MG/KG
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Route of Application: Intrauterine
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 642 GM/KG
Route of Application: Multiple
Exposure Time: (1-21D PREG/23D POST)
Result: Maternal Effects: Parturition. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4). Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 373 GM/KG
Route of Application: Multiple
Exposure Time: (23D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Mouse
Dose: 21 GM/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Newborn: Biochemical and metabolic. Effects
on Newborn: Behavioral.
Species: Mouse
Dose: 1680 GM/KG
Route of Application: Oral
Exposure Time: (70D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mouse
Dose: 4300 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Dog
Dose: 21600 MG/KG
Route of Application: Oral
Exposure Time: (1-60D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
Species: Dog
Dose: 260 GM/KG
Route of Application: Oral
Exposure Time: (1-62D PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Species: Dog
Dose: 221 GM/KG
Route of Application: Oral
Exposure Time: (1-47D PREG)
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Result: Effects on Fertility: Abortion.
Species: Dog
Dose: 100 MG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Monkey
Dose: 78 GM/KG
Route of Application: Oral
Exposure Time: (4-23W PREG)
Result: Effects on Fertility: Abortion.
Species: Monkey
Dose: 400 MG/KG
Route of Application: Oral
Exposure Time: (2-21W PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Monkey
Dose: 206 GM/KG
Route of Application: Oral
Exposure Time: (90D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rabbit
Dose: 3945 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Rabbit
Dose: 3750 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Pig
Dose: 2648 GM/KG
Route of Application: Oral
Exposure Time: (78W PRE/1-16W PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Growth
statistics (e.g., reduced weight gain).
Species: Guinea pig
Dose: 90 GM/KG
Route of Application: Oral
Exposure Time: (1-68D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Behavioral.
Species: Guinea pig
Dose: 264 GM/KG
Route of Application: Oral
Exposure Time: (2-67D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
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Effects on Newborn: Physical.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 13,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 9.3 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 10,400 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 15,300 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 24 h
Value: 10,000 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Ethanol [or] Ethyl alcohol [or]
Ethanol solutions [or] Ethyl alcohol solutions
UN#: 1170
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Ethanol
IATA UN Number: 1170
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F
Indication of Danger: Highly Flammable.
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R: 11
Risk Statements: Highly flammable.
S: 7 16
Safety Statements: Keep container tightly closed. Keep away from
sources of ignition - no smoking.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Irritant.
Risk Statements: Highly flammable. Irritating to eyes,
respiratory system and skin.
Safety Statements: Keep container tightly closed. Keep away from
sources of ignition - no smoking. In case of contact with eyes,
rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
US Statements: Target organ(s): Nerves. Liver.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For Industrial Use Only; Not for Beverage Consumption
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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