SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 08/18/2004
Version 1.9
Section 1 - Product and Company Information
Product Name POTASSIUM DICHROMATE, 99.95-100.05%
Product Number 309176
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
POTASSIUM DICHROMATE 7778-50-9 No
Formula K2Cr2O7
Synonyms Bichromate of potash * Dipotassium dichromate *
Iopezite * Kaliumdichromat (German) * Potassium
bichromate * Potassium dichromate * Potassium
dichromate(VI)
RTECS Number: HX7680000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Highly Toxic (USA) Very Toxic (EU).
Contact with combustible material may cause fire. Very toxic by
inhalation, in contact with skin and if swallowed. Causes burns.
May cause cancer. May cause heritable genetic damage. May cause
sensitization by inhalation and skin contact.
Target organ(s): Lungs. Kidneys.
HMIS RATING
HEALTH: 4*
FLAMMABILITY: 1
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
NFPA RATING
HEALTH: 4
FLAMMABILITY: 1
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: For fires involving this material, do not
enter any enclosed or confined fire space without proper
protective equipment. This may include self-contained breathing
apparatus to protect against the hazardous effects of the normal
products of combustion or oxygen deficiency
Specific Hazard(s): Contact with other material may cause fire.
Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame. Store in a cool dry
place.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.05 MG(CR)/M3
USA MSHA Standard-air TWA 0.5 MG(CR)/M3
USA OSHA. PEL CL 0.1 MG(CRO3)/M3
USA NIOSH TWA 0.001 MG(CR)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 294.19 AMU
pH 3.5 - 5
BP/BP Range N/A
MP/MP Range 390 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.68 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 M in H2O, 20掳C
Complete, orange
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N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Materials to Avoid: Organic materials Avoid contact with acid.,
Finely powdered metals
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Potassium oxides, Chromium (VI)
oxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be fatal
if inhaled.
Ingestion: May be fatal if swallowed.
SENSITIZATION
Respiratory: May cause allergic respiratory reaction.
Skin: May cause allergic skin reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Lungs. Kidneys. Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation of dichromate dusts can cause ulceration and
perforation of the nasal septum. Contact with breaks in the skin
can cause ulceration (chrome sores). Other symptoms of exposure
include erosion and discoloration of the teeth, nephritis,
epigastric pain (inflammation and ulceration of the
gastrointestinal tract). Material is extremely destructive to
tissue of the mucous membranes and upper respiratory tract,
eyes, and skin. Inhalation may result in spasm, inflammation and
edema of the larynxand bronchi, chemical pneumonitis, and
pulmonary edema. Symptoms of exposure may include burning
sensation, coughing, wheezing, laryngitis, shortness of breath,
headache, nausea, and vomiting. Ingestion can cause: Vomiting.
Cyanosis. Coma.
TOXICITY DATA
Inhalation
Rat
35 mg/m3
LC50
Inhalation
Rat
29 mg/m3
LC50
Oral
Child
26 mg/kg
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LDLO
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory stimulation.
Gastrointestinal:Nausea or vomiting.
Oral
Man
143 mg/kg
LDLO
Remarks: Vascular:BP lowering not charactertized in autonomic
section. Lungs, Thorax, or Respiration:Dyspnea. Kidney, Ureter,
Bladder:Urine volume decreased.
Oral
Child
50 mg/kg
LDLO
Oral
Rat
25 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Somnolence (general depressed
activity). Behavioral:Ataxia.
Intraperitoneal
Rat
28 MG/KG
LD50
Oral
Mouse
190 mg/kg
LD50
Intraperitoneal
Mouse
37 MG/KG
LD50
Skin
Rabbit
14 mg/kg
LD50
Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema.
Gastrointestinal:Hypermotility, diarrhea. Skin and
Appendages:Skin: After systemic exposure: Dermatitis, other
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
IARC CARCINOGEN LIST
Rating: Group 1
ACGIH CARCINOGEN LIST
Rating: A1
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CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (0-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 2546 MG/KG
Route of Application: Oral
Exposure Time: (14-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow).
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
Species: Human
Dose: 300 UG/L
Cell Type: lymphocyte
Mutation test: Micronucleus test
Species: Human
Dose: 200 NMOL/L
Cell Type: fibroblast
Mutation test: Morphological transformation.
Species: Human
Dose: 500 NMOL/L
Cell Type: fibroblast
Mutation test: DNA damage
Species: Human
Dose: 10 UMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Human
Dose: 1 UMOL/L
Cell Type: liver
Mutation test: DNA damage
Species: Human
Dose: 50 UMOL/L
Cell Type: fibroblast
Mutation test: Unscheduled DNA synthesis
Species: Human
Dose: 100 UMOL/L
Cell Type: fibroblast
Mutation test: DNA inhibition
Species: Human
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Dose: 13 UMOL/L
Cell Type: HeLa cell
Mutation test: DNA inhibition
Species: Human
Dose: 100 UMOL/L
Cell Type: fibroblast
Mutation test: Other mutation test systems
Species: Human
Dose: 150 UG/L
Cell Type: fibroblast
Mutation test: Other mutation test systems
Species: Human
Dose: 3 MG/L
Cell Type: lymphocyte
Mutation test: Other mutation test systems
Species: Human
Dose: 500 MG/L
Cell Type: Other cell types
Mutation test: Other mutation test systems
Species: Human
Dose: 100 UMOL/L
Exposure Time: 1H
Cell Type: Other cell types
Mutation test: Other mutation test systems
Species: Human
Dose: 500 NMOL/L
Cell Type: leukocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 300 UG/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 500 MG/L
Cell Type: Other cell types
Mutation test: Cytogenetic analysis
Species: Human
Dose: 150 UG/L
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
Species: Human
Dose: 300 UG/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Human
Dose: 100 NMOL/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Rat
Route: Intraperitoneal
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Dose: 5 MG/KG
Mutation test: Cytogenetic analysis
Species: Rat
Dose: 1200 NMOL/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Rat
Route: Intravenous
Dose: 12 MG/KG
Mutation test: Cytogenetic analysis
Species: Rat
Route: Oral
Dose: 365 MG/KG
Exposure Time: 1Y
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 50 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Dose: 200 UMOL/L
Cell Type: leukocyte
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 20 GM/KG
Mutation test: DNA inhibition
Species: Mouse
Route: Oral
Dose: 20 MG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 1 UMOL/L
Exposure Time: 48H
Cell Type: mammary gland
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 1 UMOL/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 1 UMOL/L
Cell Type: Embryo
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 1 UMOL/L
Cell Type: Other cell types
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Intraperitoneal
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Dose: 20 MG/KG
Mutation test: Dominant lethal test
Species: Mouse
Route: Unreported
Dose: 20 MG/KG
Mutation test: Dominant lethal test
Species: Mouse
Dose: 1 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Mouse
Route: Intraperitoneal
Dose: 4 MG/KG
Mutation test: sperm
Species: Hamster
Route: Intraperitoneal
Dose: 20 MG/KG
Mutation test: Micronucleus test
Species: Hamster
Dose: 200 UG/L
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 25 UG/L
Cell Type: kidney
Mutation test: Morphological transformation.
Species: Hamster
Dose: 10 MG/L
Cell Type: kidney
Mutation test: DNA damage
Species: Hamster
Dose: 10 MMOL/L
Cell Type: ovary
Mutation test: DNA damage
Species: Hamster
Dose: 10 UMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Hamster
Dose: 300 UMOL/L
Cell Type: lung
Mutation test: DNA inhibition
Species: Hamster
Dose: 1 MG/L
Cell Type: kidney
Mutation test: DNA inhibition
Species: Hamster
Dose: 100 UMOL/L
Cell Type: fibroblast
Mutation test: DNA inhibition
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Species: Hamster
Dose: 10 MG/L
Cell Type: kidney
Mutation test: Other mutation test systems
Species: Hamster
Route: Intraperitoneal
Dose: 8 MG/KG
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 500 UG/L
Cell Type: lung
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 100 UG/L
Exposure Time: 24H
Cell Type: Embryo
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 250 UG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 10 NMOL/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 800 UG/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 16 MG/L
Cell Type: lung
Mutation test: Sister chromatid exchange
Species: Hamster
Route: Intraperitoneal
Dose: 10 MG/KG
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 20 UMOL/L
Cell Type: kidney
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 100 UG/L
Cell Type: lung
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 7 UMOL/L
Cell Type: ovary
Mutation test: Mutation in mammalian somatic cells.
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CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 525 MG/KG
Route of Application: Oral
Exposure Time: (21D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (0-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Embryo or Fetus: Extra
embryonic structures (e.g., placenta, umbilical cord).
Species: Rat
Dose: 1771 MG/KG
Route of Application: Oral
Exposure Time: (90D PRE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 980 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (7W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Fertility: Pre-implantation mortality (e.g., reduction in number
of implants per female; total number of implants per corpora
lutea). Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 1710 MG/KG
Route of Application: Oral
Exposure Time: (19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (20D PRE)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
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placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse
Dose: 1697 MG/KG
Route of Application: Oral
Exposure Time: (14-19D PREG)
Result: Maternal Effects: Other effects. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus: Extra
embryonic structures (e.g., placenta, umbilical cord).
Species: Mouse
Dose: 700 MG/KG
Route of Application: Unreported
Exposure Time: (35W MALE)
Result: Effects on Fertility: Other measures of fertility
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 25 - 150 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.035 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solid, corrosive,
inorganic, n.o.s.
UN#: 3290
Class: 6.1
Packing Group: Packing Group I
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, corrosive,
inorganic, n.o.s.
IATA UN Number: 3290
Hazard Class: 6.1
Packing Group: I
Not Allowed - Aircraft: Cargo aircraft only. Not
permitted on passenger aircraft.
Section 15 - Regulatory Information
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EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T+ N
Indication of Danger: Very toxic. Dangerous for the environment.
R: 49 46 21 25 26 41 43 50/53
Risk Statements: May cause cancer by inhalation. May cause
heritable genetic damage. Also harmful in contact with skin.
Also toxic if swallowed. Also very toxic by inhalation. Risk of
serious damage to eyes. May cause sensitization by skin contact.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S: 53 45 61
Safety Statements: Avoid exposure - obtain special instructions
before use. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special
instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Highly Toxic (USA) Very Toxic
(EU).
Risk Statements: Contact with combustible material may cause
fire. Very toxic by inhalation, in contact with skin and if
swallowed. Causes burns. May cause cancer. May cause heritable
genetic damage. May cause sensitization by inhalation and skin
contact.
Safety Statements: Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible). Restricted to professional users. Attention - Avoid
exposure - obtain special instructions before use. This material
and its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Lungs. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
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knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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