SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 04/04/2004
Version 1.8
Section 1 - Product and Company Information
Product Name SODIUM NITRITE, SUPER
FREE-FLOWING, 99.5 %
Product Number 207837
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
SODIUM NITRITE 7632-00-0 Yes
Formula NaNO2
Synonyms Anti-rust * Diazotizing salts * Dusitan sodny
(Czech) * Erinitrit * Filmerine * Azotyn sodowy
(Polish) * Natrium nitrit (German) * NCI-C02084 *
Nitrite de sodium (French) * Sodium nitrite
RTECS Number: RA1225000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Toxic. Dangerous for the environment.
Contact with combustible material may cause fire. Toxic if
swallowed. Very toxic to aquatic organisms.
Target organ(s): Blood. Cardiovascular system.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 1
REACTIVITY: 3
NFPA RATING
HEALTH: 2
FLAMMABILITY: 1
REACTIVITY: 3
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
490 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Contact with other material may cause fire. May accelerate
combustion.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame.
SPECIAL REQUIREMENTS
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Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly. Discard contaminated shoes.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 69 AMU
pH 9
BP/BP Range 320 掳C
MP/MP Range 281 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.168 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp 490 掳C
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Finely powdered metals Avoid contact with
acid., Ammonia, Cyanides, Amines, Activated carbon
HAZARDOUS DECOMPOSITION PRODUCTS
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Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Blood. Cardiovascular system. Smooth muscle.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer. Exposure can cause: Headache.
Nausea. Incoordination.
TOXICITY DATA
Oral
Rat
180 mg/kg
LD50
Oral
Rabbit
186 mg/kg
LD50
24 HR
Eyes
Rabbit
500 mg/kg
MILD EYE IRRITATION
Oral
Man
321 mg/kg
LDLO
Remarks: Behavioral:Coma. Lungs, Thorax, or
Respiration:Cyanosis. Blood:Methemoglobinemia-Carboxyhemoglobin.
Oral
Human
71 mg/kg
LDLO
Remarks: Behavioral:Coma. Gastrointestinal:Nausea or vomiting.
Blood:Methemoglobinemia-Carboxyhemoglobin.
Oral
Child
22 mg/kg
LDLO
Remarks: Vascular:Other changes.
Oral
Rat
180 mg/kg
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LD50
Inhalation
Rat
5.5 mg/m3
LC50
Subcutaneous
Rat
96600 UG/KG
LD50
Intravenous
Rat
65 MG/KG
LD50
Oral
Mouse
175 mg/kg
LD50
Remarks: Vascular:BP lowering not charactertized in autonomic
section. Vascular:Regional or general arteriolar or venous
dilation.
Intraperitoneal
Mouse
158 MG/KG
LD50
Oral
Rabbit
186 mg/kg
LD50
Oral
Chicken
28.944 mg/kg
LD50
IRRITATION DATA
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Oral
Dose: 2190 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Species: Mouse
Route of Application: Oral
Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic
Effects: Uterine tumors. Lungs, Thorax, or Respiration:Tumors.
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Species: Rat
Route of Application: Oral
Dose: 63 GM/KG
Exposure Time: 95W
Frequency: C
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
Species: Rat
Route of Application: Oral
Dose: 91 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors. Tumorigenic
Effects: Testicular tumors.
Species: Rat
Route of Application: Oral
Dose: 183 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors. Tumorigenic
Effects: Testicular tumors.
Species: Rat
Route of Application: Oral
Dose: 100 GM/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Species: Rat
Route of Application: Oral
Dose: 40 GM/KG
Exposure Time: 56W
Frequency: C
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Species: Rat
Route of Application: Oral
Dose: 365 GM/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 660 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Newborn: Growth statistics (e.g., reduced weight gain).
Species: Rat
Dose: 400 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10-19D PREG)
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Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow). Effects on
Newborn: Behavioral.
Species: Mouse
Dose: 280 MG/KG
Route of Application: Oral
Exposure Time: (1-14D PREG)
Result: Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow).
Species: Cattle, Horse
Dose: 36 MG/KG
Route of Application: Intravenous
Exposure Time: (30-31W PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 6 MMOL/L
Cell Type: HeLa cell
Mutation test: Unscheduled DNA synthesis
Species: Human
Dose: 2000 PPM
Cell Type: fibroblast
Mutation test: DNA inhibition
Species: Human
Dose: 725 UMOL/L
Cell Type: Other cell types
Mutation test: DNA inhibition
Species: Human
Dose: 200 MMOL/L
Cell Type: S. typhimurium
Mutation test: Body fluid assay
Species: Hamster
Dose: 265 MG/L
Cell Type: HeLa cell
Mutation test: Cytogenetic analysis
Species: Rat
Route: Parenteral
Dose: 100 MG/KG
Exposure Time: 5D
Mutation test: Cytogenetic analysis
Species: Rat
Route: Oral
Dose: 2730 MG/KG
Exposure Time: 13D
Mutation test: Cytogenetic analysis
Species: Rat
Route: Intraperitoneal
Dose: 69 MG/KG
Mutation test: Cytogenetic analysis
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Species: Mouse
Dose: 10 MMOL/L
Cell Type: fibroblast
Mutation test: Morphological transformation.
Species: Mouse
Dose: 105 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
Species: Mouse
Route: Oral
Dose: 60 MG/KG
Exposure Time: 30D
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 10 MMOL/L
Exposure Time: 24H
Cell Type: mammary gland
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 5 MG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 70400 UMOL/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Mouse
Dose: 1 MMOL/L
Exposure Time: 2D
Cell Type: mammary gland
Mutation test: Mutation in mammalian somatic cells.
Species: Mouse
Dose: 362 UMOL/KG
Cell Type: S. pombe
Mutation test: Host-mediated assay
Species: Mouse
Route: Oral
Dose: 840 MG/KG
Exposure Time: 2W
Mutation test: sperm
Species: Hamster
Route: Oral
Dose: 500 MG/KG
Mutation test: Micronucleus test
Species: Hamster
Route: Oral
Dose: 100 MG/KG
Mutation test: Morphological transformation.
Species: Hamster
Dose: 100 MMOL/L
Exposure Time: 24H
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Cell Type: Other cell types
Mutation test: Morphological transformation.
Species: Hamster
Dose: 50 MMOL/L
Exposure Time: 3H
Cell Type: fibroblast
Mutation test: Morphological transformation.
Species: Hamster
Dose: 100 PPM
Cell Type: lung
Mutation test: DNA inhibition
Species: Hamster
Dose: 530 MG/L
Exposure Time: 34H
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 20 MMOL/L
Cell Type: Embryo
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 400 MG/L
Cell Type: lung
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 3 MMOL/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Hamster
Route: Oral
Dose: 100 MG/KG
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 1000 PPM
Cell Type: lung
Mutation test: Mutation in mammalian somatic cells.
Species: Monkey
Dose: 265 MG/L
Cell Type: liver
Mutation test: Cytogenetic analysis
Species: Mammal
Dose: 1 MOL
Cell Type: lymphocyte
Mutation test: DNA damage
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 11 GM/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
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weight gain). Effects on Newborn: Biochemical and metabolic.
Effects on Newborn: Other postnatal measures or effects.
Species: Rat
Dose: 10280 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/20D POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 6080 MG/KG
Route of Application: Oral
Exposure Time: (20D POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Other postnatal measures or
effects.
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Embryo or Fetus: Fetal
death.
Species: Mouse
Dose: 1680 MG/KG
Route of Application: Oral
Exposure Time: (14D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Mouse
Dose: 840 MG/KG
Route of Application: Oral
Exposure Time: (14D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 66 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 0.2 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
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Section 14 - Transport Information
DOT
Proper Shipping Name: Sodium nitrite
UN#: 1500
Class: 5.1
Packing Group: Packing Group III
Hazard Label: Oxidizer
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Sodium nitrite
IATA UN Number: 1500
Hazard Class: 5.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: O T N
Indication of Danger: Oxidizing. Toxic. Dangerous for the
environment.
R: 8 25 50
Risk Statements: Contact with combustible material may cause
fire. Toxic if swallowed. Very toxic to aquatic organisms.
S: 45 61
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special
instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Toxic. Dangerous for the
environment.
Risk Statements: Contact with combustible material may cause
fire. Toxic if swallowed. Very toxic to aquatic organisms.
Safety Statements: Keep away from combustible material. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Wear suitable
protective clothing, gloves, and eye/face protection. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Blood. Cardiovascular system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
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DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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