SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 04/10/2004
Version 1.7
Section 1 - Product and Company Information
Product Name SODIUM BISULFITE, A.C.S. REAGENT
Product Number 243973
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
SODIUM BISULFITE 7631-90-5 No
Ingredient Name CAS # Percent SARA 313
SODIUM METABISULFITE 7681-57-4 >= 98 No
SODIUM SULFITE ANHYDROUS 7757-83-7 <= 1.5 No
Formula NaHSO3
Synonyms Bisulfite de sodium (French) * Hydrogen sulfite
sodium * Monosodium sulfite * Sodium acid sulfite
* Sodium bisulfite (ACGIH) * Sodium bisulphite *
Sodium hydrogen sulfite * Sodium sulhydrate *
Sulfurous acid, monosodium salt
RTECS Number: VZ2000000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed. Contact with acids liberates toxic gas.
Irritating to eyes, respiratory system and skin.
Possible sensitizer.
HMIS RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Air and moisture sensitive.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 5 MG/M3
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 5 MG/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 106.1 AMU
pH 4.3 Concentration: 10 g/l
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.32 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% 0%
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. 150 掳C
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index 1.526
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:390 mg/ml H2O, 16掳C
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
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Conditions to Avoid: Air. Moisture.
Materials to Avoid: Strong acids, Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Sodium/sodium oxides, Sulfur
oxides.
Hazardous Decomposition Products Formed Upon Contact with Water:
Sulfur dioxide
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals. Persons with
allergies and/or asthma may exhibit hypersensitivity to sulfites.
Respiratory: Can cause pulmonary sensitization resulting in
hyperactive airway dysfunction and pulmonary allergy accompanied
by fatigue, malaise and aching. Significant symptoms of exposure
can persist for more than two years and can be activated by a
variety of nonspecific environmental stimuli such as automobile
exhaust, perfumes and passive smoking.
SIGNS AND SYMPTOMS OF EXPOSURE
The chemical, physical, and toxicological properties of this
product have not been thoroughly investigated.
CONDITIONS AGGRAVATED BY EXPOSURE
Warning: certain individuals with preexisting respiratory
conditions such as asthma may experience hypersensitivity to
sulfites and sulfur dioxide. The symptoms include
bronchoconstriction, bronchospasm, gastrointestinal
disturbances, flushing, hypotension, tingling sensation,
urticaria/angioedema, and shock
TOXICITY DATA
Oral
Rat
2000 mg/kg
LD50
Intraperitoneal
Rat
475 MG/KG
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold.
Intravenous
Rat
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115 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression. Lungs,
Thorax, or Respiration:Other changes.
Intraperitoneal
Mouse
675 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax, or
Respiration:Respiratory depression.
Intravenous
Mouse
130 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression. Lungs,
Thorax, or Respiration:Other changes.
Intraperitoneal
Dog
244 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax, or
Respiration:Respiratory depression.
Intraperitoneal
Rabbit
300 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax, or
Respiration:Respiratory depression.
Intravenous
Rabbit
65 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression. Lungs,
Thorax, or Respiration:Other changes.
Intraperitoneal
Guinea pig
779 MG/KG
LD50
Intraperitoneal
Hamster
487 MG/KG
LD50
Intravenous
Hamster
95 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression. Lungs,
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Thorax, or Respiration:Other changes.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 100 UMOL/L
Cell Type: lymphocyte
Mutation test: Micronucleus test
Species: Human
Dose: 50 UMOL/L
Cell Type: lymphocyte
Mutation test: Other mutation test systems
Species: Human
Dose: 375 UMOL/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 50 UMOL/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 5 MMOL/L
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 40 MMOL/L
Cell Type: Embryo
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 500 UMOL/L
Cell Type: Embryo
Mutation test: Sister chromatid exchange
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
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afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22 31
Risk Statements: Harmful if swallowed. Contact with acids
liberates toxic gas.
S: 25 46
Safety Statements: Avoid contact with eyes. If swallowed, seek
medical advice immediately and show this container or label.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed. Contact with acids
liberates toxic gas. Irritating to eyes, respiratory system and
skin.
Safety Statements: Avoid contact with eyes. In case of contact
with eyes, rinse immediately with plenty of water and seek
medical advice. Wear suitable protective clothing and gloves. If
swallowed, seek medical advice immediately and show this
container or label.
US Statements: Possible sensitizer.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
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from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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