SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 04/11/2004
Version 1.4
Section 1 - Product and Company Information
Product Name 3-METHYL-1-BUTANOL, 98.5+%, A.C.S.
REAGE NT
Product Number 320021
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
3-METHYL-1-BUTANOL 123-51-3 No
Formula C5H12O
Synonyms Alcool amilico (Italian) * Alcool isoamylique
(French) * Amylowy alkohol (Polish) *
Fermentation amyl alcohol * Isoamyl alcohol
(ACGIH) * Isoamyl alcohol, primary (OSHA) *
Isoamyl alkohol (Czech) * Iso-amylalkohol
(German) * Isoamylol * Isobutylcarbinol *
Isopentanol * Isopentyl alcohol *
2-Methyl-4-butanol * 3-Methyl butanol *
3-Methylbutan-1-ol * 3-Methyl-1-butanol *
3-Metil-butanolo (Italian)
RTECS Number: EL5425000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Combustible (USA) Flammable (EU). Harmful.
Harmful by inhalation and if swallowed. Irritating to eyes,
respiratory system and skin.
Target organ(s): Central nervous system.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 2
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 2
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
FLASH POINT
109.4 掳F 43 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 1.2 % Upper: 9 %
AUTOIGNITION TEMP
340 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Combustible liquid.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating water supply. Avoid contaminating sewers and
waterways with this material.
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Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 125 PPM
USA ACGIH TWA 100 PPM
USA MSHA Standard-air TWA 100 PPM (360 MG/M3)
USA OSHA. PEL 8H TWA 100 PPM (360 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 100 PPM
STEL 125 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 200 mg/m3
Poland NDSCh 400 mg/m3
Poland NDSP
Section 9 - Physical/Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
Molecular Weight 88.15 AMU
pH 5.6 20 掳C Concentration: 25
g/l
BP/BP Range 131 - 132 掳C
MP/MP Range -117 掳C
Freezing Point -70 掳C
Vapor Pressure 2 mmHg 20 掳C
Vapor Density > 3 g/l
Saturated Vapor Conc. N/A
SG/Density 0.809 g/cm3
Bulk Density 0.808 kg/l
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
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Water Content < 0.3 %
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 1.28
Decomposition Temp. N/A
Flash Point 109.4 掳F 43 掳C Method: closed cup
Explosion Limits Lower: 1.2 %
Upper: 9 %
Flammability N/A
Autoignition Temp 340 掳C
Refractive Index 1.407
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Acid chlorides, Acid
anhydrides, Reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. Harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged contact can cause: Nausea, headache, and vomiting. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Skin
Rabbit
> 3,000 mg/kg
LD50
Oral
Rat
> 5,000 mg/kg
LD50
Oral
Rat
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1300 mg/kg
LD50
Remarks: Liver:Fatty liver degeneration. Kidney, Ureter,
Bladder:Other changes. Blood:Other changes.
Intravenous
Mouse
234 MG/KG
LD50
Oral
Rabbit
3438 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Cardiac:Pulse rate. Lungs, Thorax, or
Respiration:Dyspnea.
Skin
Rabbit
3970 UL/KG
LD50
IRRITATION DATA
Skin
Rabbit
Remarks: Moderate irritation effect
Eyes
Rabbit
Remarks: Moderate irritation effect
Eyes
Human
150 ppm
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Oral
Dose: 27 GM/KG
Exposure Time: 75W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Blood:Leukemia
Species: Rat
Route of Application: Subcutaneous
Dose: 3800 MG/KG
Exposure Time: 85W
Frequency: I
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Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Blood:Leukemia
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 260 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 490 mg/l
ELIMINATION
Elimination: > 70 %
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: PENTANOLS
UN#: 1105
Class: 3
Packing Group: Packing Group III
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: PENTANOLS
IATA UN Number: 1105
Hazard Class: 3
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 10 20
Risk Statements: Flammable. Harmful by inhalation.
S: 24/25
Safety Statements: Avoid contact with skin and eyes.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Combustible (USA) Flammable (EU). Harmful.
Risk Statements: Harmful by inhalation and if swallowed.
Irritating to eyes, respiratory system and skin.
Safety Statements: Avoid contact with skin and eyes.
US Statements: Target organ(s): Central nervous system.
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UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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