SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 04/04/2004
Version 1.6
Section 1 - Product and Company Information
Product Name POTASSIUM CHROMATE, 99%, A.C.S.
REAGENT
Product Number 216615
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
POTASSIUM CHROMATE 7789-00-6 Yes
Formula K2CrO4
Synonyms Bipotassium chromate * Chromate of potass *
Dipotassium chromate * Dipotassium monochromate *
Neutral potassium chromate * Potassium
chromate(VI) * Tarapacaite
RTECS Number: GB2940000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Toxic. Dangerous for the environment.
Contact with combustible material may cause fire. May cause
cancer. May cause heritable genetic damage. Toxic if swallowed.
Irritating to eyes, respiratory system and skin. May cause
sensitization by skin contact. Very toxic to aquatic organisms,
may cause long-term adverse effects in the aquatic environment.
Target organ(s): Lungs. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Contact with other material may cause fire. May accelerate
combustion.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.05 MG(CR)/M3
USA MSHA Standard-air TWA 0.5 MG(CR)/M3
USA OSHA. PEL CL 0.1 MG(CRO3)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 194.2 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 971 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density 6.7 g/l
Saturated Vapor Conc. N/A
SG/Density 2.73 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
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STABILITY
Stable: Stable.
Materials to Avoid: Organic materials, Finely powdered metals,
Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nature of decomposition products
not known.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
SENSITIZATION
Skin: May cause allergic skin reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Lungs. Kidneys. Liver. Blood. Eyes. Skin.
TOXICITY DATA
Oral
Mouse
180 mg/kg
LD50
Intraperitoneal
Mouse
32 MG/KG
LD50
Intramuscular
Rabbit
11 MG/KG
LD50
Remarks: Behavioral:Food intake (animal). Behavioral:Coma.
Nutritional and Gross Metabolic:Weight loss or decreased weight
gain.
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Species: Mouse
Route of Application: Oral
Dose: 1600 MG/KG
Exposure Time: 62W
Frequency: C
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Blood:Leukemia Lungs, Thorax, or
Respiration:Bronchiogenic carcinoma.
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IARC CARCINOGEN LIST
Rating: Group 1
NTP CARCINOGEN LIST
Rating: Known to be carcinogenic.
ACGIH CARCINOGEN LIST
Rating: A1
Result: CONFIRMED HUMAN CARCINOGEN
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-10D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material).
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
Species: Human
Dose: 50 UMOL/L
Exposure Time: 4H
Cell Type: fibroblast
Mutation test: DNA damage
Species: Human
Dose: 25 UMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Human
Dose: 25 UMOL/L
Cell Type: Other cell types
Mutation test: DNA damage
Species: Human
Dose: 100 UMOL/L
Cell Type: fibroblast
Mutation test: Unscheduled DNA synthesis
Species: Human
Dose: 20 UMOL/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 4 UMOL/L
Cell Type: leukocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 100 UMOL/L
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
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Species: Human
Dose: 100 NMOL/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Intraperitoneal
Dose: 25 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Dose: 62500 NG/L
Cell Type: Other cell types
Mutation test: Micronucleus test
Species: Mouse
Route: Intraperitoneal
Dose: 30 MG/KG
Exposure Time: 3D
Mutation test: specific locus test
Species: Mouse
Dose: 25 UMOL/L
Cell Type: leukocyte
Mutation test: DNA damage
Species: Mouse
Dose: 10 UMOL/L
Cell Type: fibroblast
Mutation test: DNA inhibition
Species: Mouse
Dose: 3200 NMOL/L
Cell Type: mammary gland
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 40 MG/KG
Mutation test: Mutation in mammalian somatic cells.
Species: Mouse
Dose: 1 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Route: Intraperitoneal
Dose: 40 MG/KG
Mutation test: Micronucleus test
Species: Hamster
Dose: 10 UMOL/L
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 150 UG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
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Dose: 150 UG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 800 UG/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 26 UG/L
Cell Type: lung
Mutation test: Sister chromatid exchange
Species: Hamster
Route: Intraperitoneal
Dose: 10 MG/KG
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 133 UMOL/L
Cell Type: ovary
Mutation test: Mutation in mammalian somatic cells.
Species: Mammal
Dose: 1 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 60 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-10D PREG)
Result: Effects on Fertility: Other measures of fertility
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 40 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 15 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solid, inorganic, n.o.s.
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UN#: 3288
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Keep away from food
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, inorganic, n.o.s.
IATA UN Number: 3288
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T N
Indication of Danger: Toxic. Dangerous for the environment.
R: 49 46 36/37/38 43 50/53
Risk Statements: May cause cancer by inhalation. May cause
heritable genetic damage. Irritating to eyes, respiratory system
and skin. May cause sensitization by skin contact. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
S: 53 45 60 61
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Toxic. Dangerous for the
environment.
Risk Statements: Contact with combustible material may cause
fire. May cause cancer. May cause heritable genetic damage.
Toxic if swallowed. Irritating to eyes, respiratory system and
skin. May cause sensitization by skin contact. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Safety Statements: Keep away from combustible material. Avoid
exposure - obtain special instructions before use. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible). This material and its container
must be disposed of as hazardous waste. Avoid release to the
environment. Refer to special instructions/safety data sheets.
US Statements: Target organ(s): Lungs. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements - chromium compounds.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
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CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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